Does Tea Tree Oil Really Work to Clear Acne?
To Some Degree, Yes. Tea Tree Oil Is One of the Few "Natural" Treatments That Has Considerable Science Behind It.
The Essential Information
Tea tree oil is an essential oil with a distinct and strong scent, which is isolated from the leaves of the tea tree (Melaleuca alternifolia). Tea tree oil helps clear acne through its anti-inflammatory and antibacterial effects. It is a safe and somewhat effective topical treatment for acne with fewer side effects than most prescription medications, but it does not completely clear acne, so keep your expectations grounded.
Tea tree oil is a "natural" acne remedy that should produce at least some reduction in acne through its proven anti-inflammatory and antibacterial effects. However, it is likely the anti-inflammatory effect that helps reduce acne the most.
Anti-inflammatory effect: A chemical in this naturally-occurring oil, called terpinen-4-ol, blocks molecules that cause inflammation in the skin, thereby reducing the swelling and inflammation in acne lesions.
Antibacterial effect: Terpinen-4-ol also kills some of the bacteria found in acne lesions, called Propionibacterium acnes (P. acnes) by breaking down the bacteria's cell membrane. However, this power of tea tree oil to kill bacteria is much more impressive in the lab than it is in human skin. In other words, scientists have seen tea tree oil kill bacteria in a petri dish very well, but find that it has a harder time killing bacteria when applied to human skin.1,2
How Effective Is Tea Tree Oil?
Two studies have shown that tea tree oil can significantly reduce acne lesions, and is 3-5X more effective than a placebo. In other words, it appears to be the real deal. However, these studies also showed that acne was not completely cleared, so don't expect a dramatic improvement or completely clear skin if using only tea tree oil to treat acne.
Expand to read details of studies on tea tree oil's effectiveness
One clinical study looked at how effectively tea tree oil combined with lavender oil and jojoba oil treated acne. Scientists divided 54 college students into two groups. The researchers gave the first group a standard acne treatment as well as the tea tree, lavender, and jojoba oils treatment twice a day for four weeks. The second group was given only the standard treatment. All the students applied the treatments twice daily for four weeks. Those adding the oils to their treatment "showed significant decreases in both non-inflammatory and inflammatory lesions, whereas the control group showed a significant decrease of only the non-inflammatory lesions."The group using the oils also saw a 12% reduction in sebum production while the other group did not.2
In another study, subjects with acne applied tea tree oil as a topical 5% gel treatment twice daily for 45 days. Scientists then compared the subjects' skin with a group of people who had applied a placebo gel containing no active ingredients. They found that the group applying the tea tree oil gel saw a significant reduction in acne lesions. "The mean total acne lesions in the 5% tea tree oil group reduced from 21.16 before treatment to 11.33 after six weeks of treatment, a reduction of 43.64%...In terms of total acne lesions and acne severity index, tea tree oil gel was 3.55 times and 5.75 times more effective than placebo respectively. Side-effects with both groups were relatively similar and tolerable."3
For an apples to apples comparison, scientists have also pitted tea tree oil against common acne treatments. It was shown to be more effective than the topical antibiotic erythromycin, but not as effective as benzoyl peroxide.
Tea tree oil vs. Erythromycin
Tea tree oil was shown to be moderately more effective than erythromycin, a commonly prescribed topical antibiotic for acne. Tea tree oil also has a vastly improved safety profile when compared with erythromycin, and has fewer adverse effects. But again, the evidence shows that tea tree oil can reduce acne, but not dramatically eliminate it.
Expand to read details of studies
One clinical study found that tea tree oil reduced acne lesions by 55%, compared to 40% for erythromycin. The researchers asked 60 patients with mild to moderate acne to apply either a 5% tea tree oil gel or a 2% erythromycin gel twice daily for six weeks. "Lesion numbers were reduced by more than 50% from baseline for 87.5% of patients in the tea tree oil group and 53.8% of patients in the erythromycin group. Frequencies of side effects did not differ significantly between groups, however there were significantly more withdrawals due to adverse events in the erythromycin group," reported the researchers.4
While tea tree oil can be somewhat irritating to a small percentage of people, and can cause allergy in rare events, overall tree oil presents fewer side effects than other treatments. The author of a review article on tea tree oil-containing products said that its side effects "are typical events for topically applied acne treatments and occurred at similar, or lower, rates than the other medicated acne products...Previous patch test studies with human volunteers demonstrated that tea tree oil has both irritant and allergenic potential, although rates for both are low."4
Tea tree oil vs. Benzoyl peroxide
When tea tree oil went up against benzoyl peroxide, it did not compare quite as well, and benzoyl peroxide was significantly more effective. However, benzoyl peroxide, when used correctly, is capable of completely clearing the skin, so even competing in the same battleground is a feather in tea tree oil's cap.
Expand to read details of study
Research shows that although tea tree oil has fewer side effects than benzoyl peroxide, it is less clinically effective for treating acne.5 A clinical study compared the effects of the two treatments, in which patients applied either 5% tea tree oil or 5% benzoyl peroxide treatment twice daily for eight weeks. Tea tree oil reduced inflammatory lesions by 49% compared to 68% for benzoyl peroxide.6
A reviewer of the research pointed out the importance of the fact that "significantly fewer overall side effects were reported by the TTO [tea tree oil] group (27 of 61 patients) than by the BP [benzoyl peroxide] group (50 of 63 patients)."6
Interestingly, the two treatments also had slightly different effects on the skin. "The BP group showed significantly less oiliness than the TTO group, whereas the TTO group showed significantly less scaling, [itching], and dryness," reported the reviewer.6
Using tea tree oil to beat antibiotic resistance
Acne bacteria is becoming increasingly resistant to topical and oral antibiotics. Because this resistant bacteria is easily spread through direct contact from person to person, over 50% of people now harbor resistant bacteria in their skin. The result is that traditional antibiotic treatments for acne are becoming less effective. The graphic below shows how antibiotics can create resistant bacteria, while tree oil does not.
Scientists have not yet studied whether tea tree oil specifically prevents acne bacteria (P. acnes) from becoming resistant, but research has shown that it does seem to work with other, tougher bacteria such as MRSA (methicillin-resistant Staphylococcus aureus). This suggests that tea tree oil could also prevent P. acnes from developing resistance: According to a 2006 review in the journal Clinical Microbiology Reviews, "It is likely that the multicomponent nature of TTO [tea tree oil] may reduce the potential for resistance to occur spontaneously, since multiple simultaneous mutations may be required to overcome all of the antimicrobial actions of each of the components."6
One group of researchers found that tea tree oil did not induce resistance in a variety of bacteria that had already developed resistance to classic antibiotics. Scientists reviewing this study added, "This is not the only work to suggest that exposure to tea tree oil does not induce resistance to itself or to other antimicrobial agents. Previous data showed that S. aureus, hypermutable strains of S. aureus, S. epidermidis, Staphylococcus sp. and Enterococcus faecalis all had very low frequencies of resistance to tea tree oil."7
In other words, because bacteria are unlikely to become resistant to the effects of tea tree oil, this means that it should continue to be a useful treatment, long after antibiotics have been rendered useless.
Tea tree oil is a safe and effective treatment for acne thanks to its anti-inflammatory and antibacterial properties. Clinical research has shown it to be more effective than erythromycin, but not as effective as benzoyl peroxide. However, people using tea tree oil report fewer side effects which may make it a good option for anyone who suffers from dry, itchy skin as a result of their current treatment.
Tea tree oil may also help prevent acne-causing bacteria from becoming resistant to antibiotics.
When using tea tree oil, be forewarned that it has a strong and distinctive scent. Most studies have been performed using about 5% strength tea tree oil.
- Khalil Z, et al. "Regulation of wheal and flare by tea tree oil: complementary human and rodent studies." The Journal of Investigative Dermatology. 2004; 123: 683 - 90.
- Kim BY, Shin S. "Antimicrobial and Improvement Effects of Tea Tree and Lavender Oils on Acne Lesions." Journal of Convergence Information Technology. 2013; 8: 339-345.
- Enshaieh S, et al. "The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study." Indian Journal of Dermatology, Venereology and Leprology. 2007; 73: 22 - 25.
- Hammer K. "Treatment of acne with tea tree oil (melaleuca) products: A review of efficacy, tolerability and potential modes of action." International Journal of Antimicrobial Agents. 2015; 45: 106 - 110.
- Bassett IB, Pannowitz DL, and Barnetson RS. "A comparative study of tea-tree oil versus benzoyl peroxide in the treatment of acne." The Medical Journal of Australia. 1990; 153: 455 - 458.
- Carson CF, Hammer K, and Riley TV. "Melaleuca alternifolia(Tea Tree) oil: a review of antimicrobial and other medicinal properties." Clinical Microbiology Reviews. 2006; 19: 50 - 62.
- Thomsen N, et al. "Effect of habituation to tea tree (Melaleuca alternifolia) oil on the subsequent susceptibility of Staphylococcus spp.to antimicrobials, triclosan, tea tree oil, terpinen-4-ol and carvacrol." International Journal of Antimicrobial Agents. 2013; 41: 343 - 351.
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