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What is Benzoic Acid and Can it Help Clear Acne?

Benzoic Acid Forms from the Breakdown of Benzoyl Peroxide on the Skin. Once it Forms, Benzoic Acid Might Work Similarly to Salicylic Acid to Clear Acne.

By: Dan Kern, Acne.org Founder & CSO
Last updated: April 26, 2020

The Essential Information

When benzoyl peroxide is applied to the skin, it breaks down into two things:

  1. Hydrogen peroxide: Hydrogen peroxide works by killing acne bacteria (C. acnes).
  2. Benzoic acid: It is unclear exactly what role benzoic acid plays in clearing acne. Some believe it might work similarly to salicylic acid, a commonly used over-the-counter acne treatment by:
    1. Exfoliating the skin
    2. Reducing inflammation
    3. Clearing clogged pores
    4. Reducing bacteria

The Science

Benzoyl peroxide is a commonly used topical acne medication. When benzoyl peroxide is applied to the skin it breaks down into two components:

  1. Hydrogen peroxide: Hydrogen peroxide works by killing off C. acnes, which is bacteria that lives inside pores and can make acne worse.
  2. Benzoic acid: The exact effects of benzoic acid are still unknown.

Benzoyl Peroxide Enters Skin Pores and Breaks Down Into Benzoyl Radicals and Benzoic Acid

Benzoyl peroxide is effective at clearing acne. But, researchers do not know whether the ability of benzoyl peroxide to clear acne is due to the bacteria-killing properties of hydrogen peroxide or might also be partly due to the unknown properties of benzoic acid.

Benzoic acid has a similar chemical structure to salicylic acid, another common topical acne medication that is somewhat effective at clearing acne. Therefore, it is hypothesized that benzoic acid may work in a similar way to salicylic acid, by:

  • Exfoliating the skin
  • Reducing inflammation
  • Clearing clogged pores
  • Reducing bacteria

To date, there is no direct scientific study that confirms this. Therefore, more research is needed to confirm that benzoic acid does indeed work to clear acne in a similar way to salicylic acid.1

Benzoic Acid's Similar Chemical Structure to Salicylic Acid

The structure of benzoic acid is so similar to that of salicylic acid that scientists can use benzoic acid as a foundation for creating salicylic acid in the laboratory. In other words, the structures are so similar that scientists can easily convert one into the other.

Because the chemical structures of benzoic acid, salicylic acid, and lipohydroxy acid are similar, and this leads scientists to predict that benzoic acid may have similar effects to that of salicylic acid and lipohydroxy acid on the skin.5-7

Structure Similarities Between Salicylic Acid and Benzoic Acid

Benzoic Acid Might Act Similarly to Salicylic Acid on the Skin

In order to understand what effects benzoic acid might have on the skin, let's explore the known effects of salicylic acid on the skin.

Salicylic acid works to clear acne by:

  • Exfoliating the skin: Skin exfoliation is a process through which a chemical, such as salicylic acid, stimulates the shedding of dead skin cells from the skin. This helps to unclog pores and clear acne. Salicylic acid stimulates skin exfoliation, which can help to unclog pores and clear acne.
  • Reducing inflammation: Acne is an inflammatory disease, and inflammation is present and important for all stages of acne lesion development. By reducing inflammation, salicylic acid can help prevent the formation of new acne lesions and help to treat already-formed acne lesions.
  • Reducing sebum (skin oil): Salicylic acid is a chemical that easily mixes with oils. Since it can easily mix with oils, it is able to completely dissolve in the skin oil called sebum. Since sebum fills clogged pores and acne lesions, salicylic acid can mix with the sebum inside acne lesions and help to clear it from the pore. This helps to clear clogged pores of sebum, which helps to clear acne.
  • Reducing bacteria: Salicylic acid has anti-bacterial properties, meaning that it can kill bacteria. In acne, C. acnes bacteria grows inside acne lesions making them worse by increasing inflammation inside the clogged pore. Reducing the amount of bacteria inside the pore may help to clear acne.2,3

Since benzoic acid has a similar chemical structure to salicylic acid, some scientists have predicted that benzoic acid might work in similar ways to salicylic acid. This means that benzoic acid might also be able to (1) exfoliate the skin, (2) reduce inflammation, (3) reduce sebum, and (4) reduce bacteria, which would help to unclog pores and partially clear acne. However, research is needed to confirm this idea.

Possible Benefits of Benzoic Acid

It is Unclear How Effective Benzoic Acid is at Clearing Acne

There are no studies that directly investigate how well benzoic acid by itself treats acne. This means that no one knows how well benzoic acid works by itself to clear acne.

Since there are no studies investigating the effectiveness of benzoic acid, we have to rely on studies investigating the effectiveness of benzoyl peroxide, since benzoic acid is created from the breakdown of benzoyl peroxide.

Research has found that benzoyl peroxide, in concentrations of 2.5%-10%, can generally clear 45%-65% of acne lesions, and when used correctly can clear the skin 100%. It is unclear what percentage of this acne clearance is due to hydrogen peroxide and what percentage is due to benzoic acid, but it is possible that benzoic acid might be an important part of the effectiveness of benzoyl peroxide.

Side Effects of Benzoic Acid

Both benzoyl peroxide and benzoic acid are safe for human use and cause only mild side effects in most people.

Higher concentrations of benzoyl peroxide, and presumably benzoic acid, can cause more side effects, including mild skin irritation and dryness.3,4,9,10


Since scientists know that salicylic acid helps clear acne, and benzoic acid is chemically very similar, it is likely that benzoic acid has similar acne-clearing capabilities and similar mild side effects.

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  1. Nacht, S., Yeung, D., Beasley, J.N., Jr., Anjo, M.D. & Maibach, H.I. Benzoyl peroxide: percutaneous penetration and metabolic disposition. J Am Acad Dermatol 4, 31-7 (1981). https://www.ncbi.nlm.nih.gov/pubmed/7204686
  2. Dutil, M. Benzoyl peroxide: enhancing antibiotic efficacy in acne management. Skin Therapy Lett 15, 5-7 (2010). https://www.ncbi.nlm.nih.gov/pubmed/21076800
  3. Mueller, R.S., Bergvall, K., Bensignor, E. & Bond, R. A review of topical therapy for skin infections with bacteria and yeast. Vet Dermatol 23, 330-41, e62 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22731400
  4. Sagransky, M., Yentzer, B.A. & Feldman, S.R. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother 10, 2555-62 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19761357
  5. Lee, H. S. & Kim, I. H. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg 29, 1196-9; discussion 1199 (2003). https://www.ncbi.nlm.nih.gov/pubmed/14725662
  6. Grimes, P. E. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg 25, 18-22 (1999). https://www.ncbi.nlm.nih.gov/pubmed/9935087
  7. Mahendra Kumar Trivedi, A.B., Dahryn Trivedi, Harish Shettigar, Khemraj Bairwa and Snehasis Jana. Fourier Transform Infrared and Ultraviolet-Visible spectroscopic Characterization of Biofield Treated Salicylic Acid and Sparfloxacin. Natural Products Chemistry & Research 3, 6 (2015). https://www.longdom.org/open-access/fourier-transform-infrared-and-ultravioletvisible-spectroscopiccharacterization-of-biofield-treated-salicylic-acid-and-sparfloxacin-2329-6836-1000186.pdf
  8. Uhoda, E., Pierard-Franchimont, C. & Pierard, G.E. Comedolysis by a lipohydroxyacid formulation in acne-prone subjects. Eur J Dermatol 13, 65-8 (2003). https://www.ncbi.nlm.nih.gov/pubmed/12609785
  9. Webster, G.F. Acne vulgaris. BMJ 325, 475-9 (2002). https://www.ncbi.nlm.nih.gov/pubmed/12202330
  10. Sehgal, V. Dermatologic Surgery Made Easy (Jaypee Brothers Publishers, 2010).

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