Tetracycline

Pregnancy

Animal studies have revealed evidence of the toxic effects of oral tetracyclines on fetus development and formation. There is no available data in human pregnancy, however, defects in newborns and toxic effects on the liver of the mother have been reported. When used during the second half of pregnancy tetracyclines may cause permanent yellow-gray-brown teeth discoloration as well as improper development of teeth.

Therefore, the use of tetracycline during pregnancy is not recommended, especially during the last half of pregnancy.

Breastfeeding

Tetracycline is excreted into human milk in small amounts. Thus, the risks of staining and inhibition of bone growth in the infant exist, although it is unlikely. One study showed that tetracycline levels were undetectable in breastfed infants. 

However, because of the risk of serious potential adverse reactions in nursing infants, a woman and her doctor should decide whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.