The following side effects are expected to occur with the use of minocycline. Contact your doctor if these symptoms are severe and/or do not go away:
How Common (based on clinical studies)
|Dizziness||Up to 9% of all users|
|Fatigue or tiredness||Up to 9% of all users|
|Diarrhea||Up to 8.2% of all users|
|Heartburn or indigestion||Up to 8.2% of all users|
|Nausea and/or vomiting||Up to 6.1% of all users|
|Itching||Up to 5% of all users|
|Increased menstrual cramps||Up to 3.6% of all users|
|Changes in mood||Up to 3% of all users|
|Acne flares||Up to 2.7% of all users|
|Itching or irritation in the rectum or vagina||Up to 2% of all users|
|Hair loss||Up to 2% of all users|
|Ringing in the ears||Up to 2% of all users|
|Increased sleepiness or drowsiness||Up to 2% of all users|
|Weight gain||Up to 2% of all users|
|Oral thrush (fungal infection of the mouth)||Up to 1.5% of all users|
|Increased sensitivity to UV rays (photosensitivity)||Up to 1.4% of all users|
|Mouth ulcers||Up to 1.2% of all users|
|Muscle pain||Up to 1% of all users|
|Dryness in the mouth||Up to 1% of all users|
|Changes in the color of urine or tears||Unknown|
|Swelling of the tongue||Unknown|
|Soreness or irritation in the throat||Unknown|
|Irritation or inflammation at the tip of the penis||Unknown|
|Discoloration of skin, nails, gums, teeth, or scars||Unknown|
|Prickling or tingling sensation or numbness over any part of the body||Unknown|
Minocycline may cause some side effects that are serious. If you experience any of the following, get in touch with your doctor immediately or seek emergency medical treatment:
- Rash on the face or any other part of the body
- Skin peeling and/or blistering
- A sudden appearance of swelling and rash (known as hives)
- Blurring of vision or any other changes to vision such as seeing double or loss of vision
- Swelling of eyes, lips, tongue, throat, or face
- Trouble breathing or swallowing
- Feeling short of breath
- Chest pain and/or abnormal or irregular heartbeat
- Watery stools, blood in stool, fever, or abdominal cramps during the treatment period or up to two or more months after stopping minocycline
- Decrease in urination
- These symptoms occurring together: yellow discoloration of skin or eyes, itching, dark-colored urine, nausea, vomiting, abdominal pain, loss of appetite, pale stools, extreme fatigue, confusion
- Abnormal bruising or bleeding
- Blood in the urine
- Signs of infection, such as fever and sore throat
- Swelling of glands (lymph nodes)
- Pain, swelling, or stiffness in the joints
Minocycline may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using minocycline.
- Up to date. Minocycline: drug information. Available from: https://www.uptodate.com/contents/minocycline-drug-information?source=preview&search=minocycline&anchor=F196861#F196861. Cited 15 february 2017.
- Stainforth J, et al. A single-blind comparison of topical erythromycin/ zinc lotion and oral minocycline in the treatment of acne vulgaris. J. Dermatological Treatment 4(3), 119-122 (1993).
- Grosshans E, Belaïch S, Meynadier J, Alirezai M, and Thomas L. A comparison of the efficacy and safety of lymecycline and minocycline in patients with moderately severe acne vulgaris. Eur. J. Dermatol. 8(3), 161-6 (1998).
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- Harrison PV. A comparison of docycycline and minocycline in the treatment of acne vulgaris. Clin. Exp. Dermatol. 13(4), 242-4 (1988).
- Monk BE, et al. Efficacy of low-dose cyproterone acetate compared with minocycline in the treatment of acne vulgaris. Clin. Exp. Dermatol. 12(5), 319-22 (1987).
- DailMed. Minocycline. Available from: https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=MINOCYCLINE&pagesize