Minocycline

Pregnancy

Adequate and well-controlled studies on the use of oral minocycline during pregnancy are lacking.

Similar to other tetracyclines, minocycline crosses the placental barrier and may harm the fetus if given to pregnant women.
Available data includes rare spontaneous reports of congenital anomalies, such as limb reduction. Repeated or long-term use of minocycline during pregnancy may also lead to permanent discoloration of teeth because minocycline accumulates in teeth and bones.

Minocycline can cause birth defects in the baby even if the father of the child is the one using minocycline. Both males and females should inform their doctor of any medications they are on when planning a pregnancy.

Therefore, patients who may potentially become pregnant should not use oral monocycline.

Breastfeeding

Similar to other tetracyclines, minocycline is excreted in human milk. There is potential for serious adverse reactions in nursing infants from tetracyclines.

Therefore, a woman and her doctor should make a decision whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother and potential harm to the nursing infant.

Infertility in Males

Similar to other tetracyclines, oral use of minocycline should be avoided in males who are attempting to conceive a child. A fertility study in rats showed that tetracycline-like antibiotics adversely affect spermatogenesis when orally administered to male rats.