Oral Antibiotic
Reviews
3.4
1734 Reviews
Oral Antibiotic
Efficacy
56%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Should never be used on its own and for a maximum of 3 months.
Oral Antibiotic
Side Effects
Medium-High
Oral Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show doxycycline can reduce severe acne in the short term, and as far as oral antibiotics are concerned, it’s usually the go-to, but approach with caution and stay your own advocate.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Doxycycline
Compare To Other Treatments
5
20.7%
4
32.9%
3
22.1%
2
12.7%
1
11.5%

Used Doxycycline? Rate It:

Choose from 1 to 5 stars
March 16, 2015
Definitely works...depending on what kind of acne you have
I've struggled for decades now with acne on and off, mostly of the mild-moderate variety with the occasional hormonal cystic pimple that usually would never come to the surface. Starting a few months ago, I went through a series of extremely stressful life events (relationship, work, family health issues, etc.) It was honestly the most horrible time of my life, and my skin suffered. Badly. I broke out -- oddly almost entirely on the left side of my face -- with sort of cystic looking pimples. Think bright red, super raised from the surface of my skin, like frozen peas underneath the skin. The worst part was that I'd get a cluster of a few that would basically merge together into a pulsing, throbbing mess. These "cysts" actually came to the surface. The top layer of skin would dry out and start to peel, which looked bad enough, but then I'd actually get green/yellow pus oozing from them. So horrible. I felt like I could barely leave the house! I mean, people would stare. Let me also mention that at the same time, I always had my more normal variety of very small spots, mostly around my jawline. No big deal at all with these -- easy to cover up with makeup and would usually go away on their own in a few days. Anyway, I also wound up hurting my hand taking a fall and got a scrape that became infected. My doctor basically looked at it and my face and was like, you need an oral antibiotic right now. He gave me Doxy, 2x100 mg a day. In less than 24 hours, not only did my hand scab over, turn a normal color again and stop hurting, but nearly 100% of the raised acne went down and also became way less red. They're all in a healing process right now -- and no new cystic bumps whatsoever. The improvement is dramatic. It will definitely take a few more weeks for everything to heal and start to fade, and unfortunately, I do think there is some scarring that I'll need to get a peel/laser for, but I can't recommend this antibiotic enough. BUT, I want to mention that the minor acne I always had is basically exactly the same. It seems like this should be reserved for severe infections. I obviously have had some stress-related immune suppressing things going on, and this is the backup artillery my immune system needed to fight off the bacteria that were running rampant. I'm planning on weaning off of it in a few weeks and also focusing on stress reduction in my life right now.
This Was Helpful

35 user(s) found this helpful

Report
February 10, 2015
Miracle Worker
I'm 20 year old female that one month ago, had terrible hormonal cystic acne. Acne has always been something I have battled with for years, but recently it had become worse than I had ever experienced. I decided it was time to get a prescription of an effective antibiotic and was prescibed Doxycycline (100mg 2x a day) due to the fact that my skin wasn't responding to any of the cleansers/topicals/or regimens that i had tried over the years. The first few weeks definitely had a negative effect on my skin, since my skin was at the purging stage. However, STAY WITH IT. It has only been about 5 weeks now, and i kid you not, my acne is completely gone. I haven't got a single pimple since the purging stage and I couldn't be happier. Yes, many complain about the nausea that accompanies the antibiotic, but i don't find it unbearable. As long it is taken in the morning right before breakfast, and at night right before dinner, there shouldn't be any issues. Although it has only been a month since i started, I cannot see how doxycycline could possibly have adverse effects. Im so very pleased with my results, and I cannot wait to see what it does for my skin long term! Highly recommend!
This Was Helpful

29 user(s) found this helpful

Report
February 23, 2016
How is your face now after a year
December 19, 2017
where was your hormonal acne located? Mines getting a little bit worse as well in the end of first week
January 8, 2015
3 years already
Ive taking doxycycline for 3 years already. Best thing you can try for your acne. It clear my acne in a week or so. Control my back and chest acne too. The only bad thing is you have to tape it and mostly you will get alot of pimples but its only a month. This is what i do. Take it for 5 months then one month off. And repet. I will start using retin a for better results but im pretty content with doxy. I would recomend to anyone
This Was Helpful

10 user(s) found this helpful

Report
August 24, 2014
THE SOLUTION TO CLEAR SKIN
This antibiotic is what helped me the most. No other prescription helped me reduce acne like this oral antibiotic. I remember not using any topical prescription on my face because of how well my body reacted with this antibiotic. I first used it around 5 years ago when my acne first started to worsen. My skin cleared up within weeks. I felt a little nauseas when I took this 5 years ago because I had to take it on an empty stomach, everyday. After, I took a break from this and had a really bad reaction. I took this a year after and it seemed like it wasn't helping. Since it wasn't helping, I took another break from this antibiotic. After the break, I was prescribed to this for the third time but instead of one pill a day, I had to take 2. It has been working like a charm ever since I've been taking this antibiotic twice a day. To prevent the nauseas symptom, I eat right before I take this pill (in the morning and at night) and I avoid dairy products 2 hours before/after taking this pill.
This Was Helpful

15 user(s) found this helpful

Report
August 19, 2014
I'd recommend it :)
I've struggled with adult onset, hormonal, cystic acne for 15 or so years. Various things have helped at various times. However, I decided I no longer wanted to be on birth-control (Diane 35 was wonderful for my skin). Once I went off of it my skin exploded with very painful, long lasting cysts all over my face. My doctor put me on Doxycycline and that did a wonderful job for a couple months. When I went off of it, the cysts came back. So, Im back on and clear again. In the meantime, I've cut out refined sugar from my diet (and lost 10lbs in the first month). I'm also adding probiotics to my diet along with other fermented foods to increase good gut health. Hopefully these changes will do the trick in keeping the acne gone once I'm done this round of Doxy. I am thankful to the posters here that are detailing their holistic approaches and how they've worked. The whole reason for quitting birth-control was because I no longer wanted to rely on pills! (plus I hate my body being tricked into thinking it's pregnant all the time!)
This Was Helpful

6 user(s) found this helpful

Report
August 4, 2014
It works but study up on it first!
I went to my doctor because I had a bad case of bacne (back acne) but it turned out to be some sort of bacterial infection...sorry, I can't recall its name. Its from excessive sweating and possibly supplements I take. I don't really have facial acne but I do have a minor case of rosacea as well so he prescribed Doxycyline for both. Within 5 days my back is almost 90% clear and the minor redness on my face is gone. I definitely feel like my skin looks alot tighter/smooth. For those complaining about being nauseous, vomiting, stomach aches etc. are you reading the label warnings? Make sure you are taking this on a full stomach during or immediately after meal or else you will feel sick. Also my label said do not consume dairy products within two hours of taking it. Hopefully my skin will stay this way once I'm off of it!
This Was Helpful

11 user(s) found this helpful

Report
June 12, 2013
If I'm on it FOREVER .... great!?!

Pros:

effective as long as I'm taking it

Cons:

recent price increase
for me, required long term use
long term risks associated w/ antibiotics

This worked great for my cystic acne. Used it twice for extended periods of time (6 months & then 1 year). Just recently discontinued use 2 weeks ago. Exactly as with what happened the last time, not even 2 weeks later ..... 4 PAINFUL, CYSTIC pimples have already appeared on my chin (all within the last 3 days) .... and I have a huge social function to attend this weekend. I know long term antibiotics are potentially dangerous because of the possibility of drug resistant microorganisms; but ...... I WANT MY ANTIBIOTICS BACK!!!!
This Was Helpful

3 user(s) found this helpful

Report
June 7, 2013
Saved my face

Pros:

helps with pimples

Cons:

doesn't help with blackheads/whiteheads
can't take on an empty stomach

So, this is a vague review because this started years ago. I had really bad acne my whole life and I tried everything under the sun. My doctor one day prescribed doxycycline along with my birth control. 100 mg in the morning and a 100mg at night. I take a lot of medication to begin with but there is one thing I learned with this medication. Never...EVER take this on an empty stomach. You will likely get nauseous. Slowly but surely, my face cleared up and I rarely get pimples now. The reason I put down "inconsistently" is because I can't get the antibiotic anymore for the past 2 years (why, I don't know... shortage?) but, my face is still clear. I think it has a lot to do with entering my 20's. Even though it helps with the pimples, I still have blackheads and whiteheads on my face. Seriously though, this really saved my face from further damage in my teenage years because I had breakouts that would swell my face.
This Was Helpful

4 user(s) found this helpful

Report
May 12, 2013

Pros:

Can pretty much cure moderate acne

Cons:

Some slight stomach pain after taking (make sure you take with no food or it won't work as well, and with like 3 cups of water)

Started with 2 100mg doxycycline a day around a year ago. My acne nearly completely cleared up. Got lazy and tired of the stomach pain that occurred for 10-15 minutes after taking and acne got bad again. Been taking it once a day for a few weeks and I've noticed a HUGE reduction in new acne.
March 31, 2013

Pros:

Clear my face by 2 or 3 days of use
Not expensive

Cons:

No Calcium 3 hours before and after taking it.
Is not a cure, its a help, but while I'm taking it my face is clear!

Its an antibiotic, so its going to have some bad results if is consume in a wrong way. The key is very simple: don't eat anything with calcium three hours before and three hours after taking it, because CALCIUM prevents the body to absorb it. Some days I wait just 2 hours. I buy cookies without calcium to eat with the antibiotic, so my stomach not hurt. And wait 1 hour before go to bed!
This Was Helpful

7 user(s) found this helpful

Report

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.