These autologous cell injections seems to have the most potential to make a substantial difference. Not related to skin, but similar to what is being discussed by BRD, look at this :

http://uk.reuters.com/article/healthNews/i...E51D09M20090214

yea but they say that 'under local anesthesia, was associated with a marked increase in fracture healing. that doesnt really mean much. yea it increased the ehaling but by how much. marked increase could mean any small amount.

update..its been 6 days!...good things are happening to my skin. a couple of my scars seem to be fading very nicley..that mole freckle thing is gone..overall my skin just looks better..i still think im going to need the prp and stem cell from fat thing in early april but this looks like a good option for us all..and its only been 6 days...final results are 2-3 months!

nice one icaretohelp ... i hope your ski continues to imrpove over the next few months. one question ... why do you think DR khan didnt do the stem cells to begin with. if its so efective at treating scars surely he would of just done that first. i know he said that stem cells is for deeper scars but still, wouldnt it of been better to go with taht option ? also how many prp seesios do you need to have or is it just the 1

thanks

well in my case i actualy chose to do the PRP just to see what i could get out of it..im supposed to have 2..if im not satisifed with the prp results when my 2nd one is ready im going to do the last prp with stem cells from fat etc

i guess the reason is simple..hes only started doing this therapy in the last 7-8 months..hes going to be purchasing the celution mchine in the next month or so..that way he woent have to send the fat elsehwere to be cultured for stem cells and such//:) hes the only doc in the UK to be on the right track so props up

cool, i think i will book a consaultion with him within the next few weeks. how much did he charge you for your prp injcetions and has he told you how much the stem cells injections would cost ? also ... does he have to do proper liposuction like the show on tv lol or does he just take a small amount of fat ?

well in my case i actualy chose to do the PRP just to see what i could get out of it..im supposed to have 2..if im not satisifed with the prp results when my 2nd one is ready im going to do the last prp with stem cells from fat etc

i guess the reason is simple..hes only started doing this therapy in the last 7-8 months..hes going to be purchasing the celution mchine in the next month or so..that way he woent have to send the fat elsehwere to be cultured for stem cells and such//:) hes the only doc in the UK to be on the right track so props up

Does Dr. Khan offer needling?

well in my case i actualy chose to do the PRP just to see what i could get out of it..im supposed to have 2..if im not satisifed with the prp results when my 2nd one is ready im going to do the last prp with stem cells from fat etc

i guess the reason is simple..hes only started doing this therapy in the last 7-8 months..hes going to be purchasing the celution mchine in the next month or so..that way he woent have to send the fat elsehwere to be cultured for stem cells and such//:) hes the only doc in the UK to be on the right track so props up

Does Dr. Khan offer needling?

 

yup

how much the stem cells injections would cost ? also ... does he have to do proper liposuction like the show on tv lol or does he just take a small amount of fat ?

i dunno dude..didnt ask him that cost..depends..how much fat u would need..i guessing the whole thing would cost 2000 pounds

just call dude! im not in london atm

Article from New Scientist on Stem Cells

...................................

DIY stem cells could help us heal ourselves

i14 January 2009 by Andy Coghlan

iMagazine issue 2691. Subscribe and get 4 free issues.

iFor similar stories, visit the Stem Cells Topic Guide

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Read our related editorial

IT HAS been an uplifting week for stem cell research. Not only is US president-elect Barack Obama poised to sweep away restrictions on stem cells when he takes office on 20 January, but a new treatment based on the drug Mozobil promises to harness an individual's stem cells to help them heal their own bodies.

A few days ago Sara Rankin and her colleagues at Imperial College London announced that Mozobil, in combination with natural growth factors, can free up specific types of stem cells from the bone marrows of mice and send them flooding into the bloodstream.

The discovery is important because it opens up the possibility of treatments tailored to the individual, who would for example take drugs to stimulate the growth and release of specific stem cells to repair cardiac tissue after a heart attack. Such treatments would be free of the ethical baggage associated with therapies based on extracting stem cells from human embryos - though their development would not remove the need for embryonic stem cell research as they do not cover all cell types.

Treatments to stimulate the bone marrow to make stem cells are already widely used to treat leukaemias and other blood cancers. Based on a natural growth factor called granulocyte colony stimulating factor (GCSF), they prompt the bone marrow to produce extra haematopoietic stem cells (HSCs), which grow into all types of blood cell. These cells can be extracted over weeks and stored ready for transplant into the bone marrow following chemotherapy to kill cancerous blood cells, where they restock the blood cells destroyed by the anti-cancer drugs.

Now Rankin's team has shown that it is possible to persuade the bone marrows of mice to produce two additional categories of stem cell - mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) - broadening considerably the types of damage and disease that might be treatable. "It's promoting self-healing," says Rankin, whose team's research was published last week in Cell Stem Cell (DOI: 10.1016/j.stem.2008.10.017). "We're simply boosting what's going on naturally, and we've shown that we can selectively mobilise different types of stem cell."

We're simply boosting what's going on naturally, and we can selectively mobilise different types of stem cell

MSCs grow into muscle and bone, and so have the potential to repair cardiac tissue following heart attacks, or to accelerate healing of broken bones or ligaments. They also damp down inflammation, and so could be used to treat autoimmune diseases. EPCs repair blood vessels and form new ones, so they have the potential to restore vital blood supplies to tissues damaged by strokes or heart attacks.

Rankin and her colleagues showed that they could persuade mouse bone marrow to release floods of both types of cell at the same time by giving the mice Mozobil plus a natural substance called vascular endothelial growth factor (VEGF). Rankin's team also used GSCF and Mozobil in mice to show that, in principle, drug therapies can be tweaked to produce either blood stem cells or those that become muscle, bone and blood vessels.

What is more, the stage is set for these treatments to be tried in people, as both growth factors are available commercially. Mozobil's maker, Genzyme of Cambridge, Massachusetts, received approval in December from the US Food and Drug Administration to sell the drug in combination with GCSF for treating lymphoma.

Genzyme told New Scientist that it is looking into other ways of using Mozobil. "Its novel mechanism of action opens the door for a rich area of research," says Richard Peters, vice-president of global medical affairs at Genzyme Transplant and Oncology.

One big question is whether the new approach will supplant or simplify other stem cell treatments in development. Many of these rely on extraction and multiplication of specific stem cells from patients' blood, a process which takes weeks and is technically difficult. Given Mozobil plus growth factors, patients could potentially make extra copies of the same cells in their own bodies.

An international registry of clinical trials run by the US National Institutes of Health included 720 new or ongoing trials which specified enriching patients' own stem cells outside the body as part of the treatment. In many cases the new drug regime could potentially be used instead.

"Ours is a much more direct approach, and doesn't have the ethical and regulatory issues associated with other types of stem cell therapy, and it would be a lot cheaper," says Rankin. But she stresses that the approach can't be used for every type of disease, and so should not be used by governments as a reason to reduce funding for other stem cell research. She points out, for example, that there are no known bone marrow stem cells that make nerve or brain cells. These can only be made from embryonic stem cells, or from induced pluripotent stem cells produced by introducing genes that coax skin and other cells back into an embryonic-like state.

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Robin Lovell-Badge of the UK's National Institute for Medical Research in London agrees. "It doesn't change the need to do embryonic stem cell research at all." Bone marrow stem cells, for example, can't make insulin-producing islet cells for treating diabetes, he adds.

Another article from New Scientist. This one highlights PRP treatment releasing the natural growth factors (NGFs).

Rapid healing trick falls foul of anti-doping rules

10:00 14 May 2005 by Andy Coghlan

PROFESSIONAL athletes who opt for an emerging treatment called "blood-spinning" in the hope of healing their injuries faster could fall foul of the World Anti-Doping Agency. The agency ruled last week that the procedure, based on concentrating and re-injecting a person's own blood, could introduce banned substances into the body.

But proponents of blood-spinning argue that the ruling may deny injured athletes access to a technique that could heal their injuries faster than existing treatments and potentially with fewer complications.

WADA, based in Montreal, Canada, already bans the concentration, storage and re-injection of an athlete's own red blood cells just prior to competition, because the procedure boosts oxygen supply and enhances performance.

But blood-spinning is different: small samples of a patient's blood are centrifuged to discard red blood cells and concentrate the platelets into platelet-rich plasmas (PRPs). When the platelets are concentrated to typically five times their normal level, calcium and the enzyme thrombin are added to the mix, which makes the platelets coagulate to form a clot-like gel. The platelets then start releasing the natural growth factors (NGFs) that accelerate healing, just as they would in a natural wound, but at five times the usual concentration. The gel can be applied to a wound or injected into the site of an internal injury.

It is the NGFs produced by the procedure that concern the anti-doping agency, which already bans other NGFs such as growth hormones. Blood-spinning usually produces copious amounts of NGFs, and so the procedure contravenes WADA's criteria, even though it is not used specifically to enhance performance. "Because it is a recovery procedure, it's unlikely the athletes would benefit from it in a competition," admits Oliver Rabin, WADA's science director. "But we don't want to open the door, so for now the chapter is closed."

Robert Marx, a maxillofacial surgeon at the University of Miami's Miller School of Medicine who pioneered blood-spinning in 1998, thinks the WADA ruling is misguided. He says that the platelets and growth factors are all in the patient to start with: "You don't increase the body's number of platelets - you simply direct them to where you need them."

Marx developed the technique for use in dentistry and in facial reconstruction. By applying gels made from blood-spinning to wounds and damaged tissues, he says he can almost halve the recovery time. But importantly, the quality of healing is better too. There is less permanent scarring in skin wounds, for example. "It just heals faster and better," he says.

The technique is now working its way from periodontal and other general types of surgery into sport. Frank Stephenson of Harvest Technologies in Plymouth, Massachusetts, a company developing the treatment, says that PRPs are increasingly being used to heal tendon and ligament injuries faster. "Anecdotal reports are that it works well," he says.

Stephenson says that PRP treatments don't wear out tissue, as can happen with standard treatments for inflammation, such as steroids. Although they ease pain, "steroids are themselves degenerative and can hurt tissue", he says. But he accepts that large-scale clinical trials are needed to find out if PRP therapy heals sports injuries better than existing treatments.

In sport, the matter came to a head last month after the London soccer team Chelsea considered, but rejected, the idea of using the treatment on injured players. "No Chelsea player has undergone this treatment," says a club spokesman.

WADA has issued its verdict to all national sporting authorities. "We'll be seeking assurances from Chelsea that the technique being offered to players is in line with the rules that have been set out," says a spokesman from UK Sport, the nation's sporting authority. "In the meantime, we will continue to advise caution in the use of this technique."

In a conciliatory gesture, WADA says athletes who are injured and not competing can apply for special permission for the treatment. The agency will decide for how long after treatment the player should not compete.

Another stem cell treatment clinic is operating in the US: Stem Cell RegenMed located in Tampa, FL

http://stemcellregenmed.com/index.htm

I discovered the clinic through a thread started on the following website: http://www.stemcellpioneers.com/showthread.php?t=1488

On CNBC Today:

http://www.cnbc.com/id/15840232?video=1037442380&play=1

They talk about Stem Cells in Fat.

Well I got some interesting news. I went to visit Dr Lowe a a top dermatologist here who charges; ready, wait for it: A350 for a consultation!! Yup. Amazing. Anyway, I went to him as I am seeking various opinions before I make my next move as my last move was a nightmare.

Anyway, I asked his advice about PRP and stem cells and he send aoeany sort of injection technique wonat be suitable for mea because my scars are "diffuse and shallow." If I had deep scars he said that might be an option, but I have aoediffuse, superficial and shallowa scars, so any injection technique will not work as it wont create a smooth surface. At the end of the day, he says, I could end up more uneven if more collagen builds up in good areas. Hmmm. Donat know what to think, but thought I should share the goods of my A350 consultation with you all.

Is this technique best for deep scars that are spread apart?

BRD???

Well I got some interesting news. I went to visit Dr Lowe a top dermatologist here who charges; ready, wait for it: 350 for a consultation!! Yup. Amazing. Anyway, I went to him as I am seeking various opinions before I make my next move as my last move was a nightmare.

Anyway, I asked his advice about PRP and stem cells and he send oeany sort of injection technique wont be suitable for me because my scars are "diffuse and shallow." If I had deep scars he said that might be an option, but I have oediffuse, superficial and shallow scars, so any injection technique will not work as it wont create a smooth surface. At the end of the day, he says, I could end up more uneven if more collagen builds up in good areas. Hmmm. Dont know what to think, but thought I should share the goods of my 350 consultation with you all.

Is this technique best for deep scars that are spread apart?

BRD???

If he thinks your scars are too shallow and "diffuse" for injections, then what did he suggest for your scarring? Oftentimes, a doctor will tell you that something won't work for you because they don't how to perform it well. It doesn't mean it won't work, it just means they can't make it work. Of course, they'll never admit that though. And for what it's worth, I heard a nightmare story about the famous Dr. Lowe. Some guy here had fat transfer done for his scars by him and he totally fucked up his face.

Also, from personal experience my scars are also very shallow and diffuse and I have gone through a round of dermal grafts, so I don't really buy that. I was worried that my scars would be too shallow for the procedure, but most were suitable for grafting. If they overfill, they can always get things even with resurfacing. Or often if you get a collagen overfill, they pop it. It's creating something that was lost that is difficult.

Was Lowe aware of the use of stem cell injections for acne scarring or was this news to him? Because from what I have read about it, it doesn't sound like a conventional filler. It also works to remodel skin, rather than just fill depressions. I wonder if he knows enough about it. These are just my thoughts as a layperson. I hope BRD can give us his professional opinion about this.

just pmed her about this..any acne scarring is due to atrophic fat loss (unless its not atrophic) its about the talent of the dr.

~forget about lowe..the man is F.O.S

just pmed her about this..any acne scarring is due to atrophic fat loss (unless its not atrophic) its about the talent of the dr.

~forget about lowe..the man is F.O.S

I'm curious. Are your scars deep or shallow or somewhere in between?

me? or Hiedi55?

me? or Hiedi55?

Yeah, I was referring to you, Icaretohelp.

i doubt dr lowe knows how to preform stem cell injections or prp properly ... has he actually doen this procedure ? did you ask to see any before and after pictures of patiets that had these injections. also if these injections were ONLY for deep scars im sure BRD would have mentioned it.

where is BRD btw lol he hasnt been on here for a while ... wait for his opinion

Well I got some interesting news. I went to visit Dr Lowe a top dermatologist here who charges; ready, wait for it: 350 for a consultation!! Yup. Amazing. Anyway, I went to him as I am seeking various opinions before I make my next move as my last move was a nightmare.

Anyway, I asked his advice about PRP and stem cells and he send any sort of injection technique wont be suitable for me because my scars are "diffuse and shallow." If I had deep scars he said that might be an option, but I have diffuse, superficial and shallow scars, so any injection technique will not work as it wont create a smooth surface. At the end of the day, he says, I could end up more uneven if more collagen builds up in good areas. Hmmm. Dont know what to think, but thought I should share the goods of my 350 consultation with you all.

Is this technique best for deep scars that are spread apart?

BRD???

I hope you got more than 15 mins of consultation for that price !

Looking at the Celution website in Japan they use these prp injections with stem cells for smile lines, wrinkles,corners of the eyes, lips etc, so i really don't know what this Dr Lowe is talking about.

i HAD one OFF ice pick scarring (around great skin) from a stpah infection..it WAS deep..right now..its faint..i still guess u can see some linear lines btu the improvment has been phenomenal..dr khan has done a great job on me.

HEre is a link about PRP from a doc in Australia that does this treatment. It is long but worth a read.

http://www.greggoodman.com.au/uploaded/23/...nescarringh.doc

Greg J Goodman

Address: 8th Floor 443 Toorak Rd

Toorak Victoria 3142

Australia

Phone (613) 98264966

Fax (613) 98277975

i HAD one OFF ice pick scarring (around great skin) from a stpah infection..it WAS deep..right now..its faint..i still guess u can see some linear lines btu the improvment has been phenomenal..dr khan has done a great job on me.

I'm really happy for you and thanks for the updates, it's given us hope !

I checked out Dr Khan's website the Harley St Medical Skin clinic but no info on PRP inj, maybe

it's not updated. Anyway i hope you get continue improvements !