Jump to content
Acne.org
Search In
Find results that contain...
Find results in...

Why Do Some People Have Oilier Skin than Others?

A Number of Factors, Predominantly Hormones, Are to Blame

By: Dan Kern, Acne.org Founder & CSO
Last updated: January 29, 2020

The Essential Information

Two main hormonal factors are likely most at fault when it comes to why some people have oilier skin than others:

  1. Androgens - male hormones found in both males and females: Higher levels of androgens and/or higher sensitivity to androgens may lead to oilier skin.
  2. Growth hormone (IGF-1): Higher levels may lead to oilier skin.

And one factor may result in less oiliness:

  1. Estrogens - female hormones found in both males and females: Higher levels may lead to less oily skin. 

And there is one wildcard that may either increase or decrease skin oiliness:

  1. Neuropeptides: Depending on the body's response to these small but powerful proteins, we can see an increase or decrease in skin oiliness.

The Science

Oily skin (seborrhea), is a condition that results when the skin over-produces skin oil (sebum), leaving the skin looking shiny and feeling greasy.

Sebum is produced all over the body inside the skin in glands called sebaceous glands, that are attached to the sides of skin pores. The face, scalp, and upper torso are most likely to experience excess sebum production.1-3

Even though too much sebum is unwanted, it serves several purposes for the skin:

  1. It protects the skin by lubricating it, which reduces water loss and shields the skin from damage.
  2. It possesses antibacterial properties, which defend the skin from infections.
  3. It contains antioxidants, which counteract the effect of harmful chemicals.
  4. It protects the skin from harmful rays found in sunlight.
  5. It can help to regulate inflammation.
  6. It aids in the wound healing process of the skin.

Properties of Sebum (Skin Oil)

What Controls Sebum Production?

Why are some people oilier than others? There are two main factors that increase sebum production and lead to oily skin:

  1. Androgens - male hormones found in both males and females. Higher levels in the body in both males and females lead to oilier skin.
  2. Growth hormone (IGF-1). Higher levels in the body in both males and females lead to oilier skin.

There is also one factor that decreases sebum production and can lead to less oily skin:

  1. Estrogens - female hormones that are found in both males and females. Higher levels in the body in both males and females lead to less oily skin, but only females can be treated with estrogen.

There is one factor that can either increase or decrease sebum production:

  1. Neuropeptides. Depending on the body's sensitivity to various neuropeptides, both males and females may see either an increase or a decrease in skin oiliness.

Let's have a look at each.

Androgens: increase sebum production

Androgens are male sex hormones that are found in both males and females. Testosterone is the most commonly studied androgen. The majority of testosterone present in the body is produced in the gonads or adrenal glands, which are found above the kidneys, but it can also be produced in sebaceous glands themselves. Many studies show us that people with higher levels of androgens tend to have oilier skin. However, higher levels of androgens may not always be required to develop oily skin. Some people may simply be more sensitive to androgens, and thus develop oilier skin.2

Expand to read details of studies

Journal of Investigative Dermatology

A 1969 study published in the Journal of Investigative Dermatology studied the effect of testosterone on the sebaceous glands in men. To perform this study, the researchers injected testosterone into 27 adult males on a weekly basis and then measured changes in sebum production and sebaceous gland size over the course of 11 weeks. The researchers found that the testosterone injections increased both the amount of sebum produced and the size of the sebaceous gland, so they concluded that increases in testosterone can increase sebum production and likely also increase oily skin.4

The New England Journal of Medicine

Two 1983 studies published in the New England Journal of Medicine and the Journal of Investigative Dermatology studied the levels of androgens in women with acne. Both studies found that women with acne have higher androgen levels than women without acne. Therefore, the researchers concluded that acne was correlated with an excess of androgens. The researchers involved with this study did not report on whether the elevated androgen levels also caused oily skin. However, as acne is often correlated with oily skin, it is likely that women with acne and excess androgens also had oilier skin.5,6

Journal of Endocrinology and Metabolism

A 1993 study published in the Journal of Endocrinology and Metabolism studied sebum production in men without androgens in order to determine if androgens likely controlled the production of sebum. The men without androgens in this study were pseudohermaphrodites, who are unable to produce proper sex hormones. The researchers found that the pseudohermaphrodites studied lacked androgens and that because of this, they also did not produce sebum. Therefore, the researchers concluded that there was "absolute androgen control of sebum production."7

Archives of Dermatology

A 1994 study published in the Archives of Dermatology examined the hormones of young girls with acne who had not yet undergone puberty. Prepubescent girls often do not have the same levels of androgens as girls who have gone through puberty, so the point of this study was to understand if the girls' prepubescent acne was due to abnormal androgen levels. This study examined the hormone levels of 623 acne-prone young girls with an average age of 10 years. They found that one androgen called dehydroepiandrosterone (DHEA) was present at abnormally high levels in the prepubescent girls with acne. DHEA is a hormone that is required for testosterone synthesis. Therefore, the researchers concluded that the prepubescent girls' acne was likely caused by an elevated level of the androgen DHEA in their blood since androgens, including testosterone, stimulate sebum production. The researchers involved in this study did not report on whether the increase in DHEA also caused oilier skin. However, as acne is often correlated with oily skin, it is likely that the prepubescent girls with acne and elevated DHEA levels also had oilier skin.2,8

The Journal of Investigative Dermatology

A 1983 study published in The Journal of Investigative Dermatology investigated the levels of androgens in adult females with and without acne. The researchers found that 52% of adult acne patients showed "at least one abnormal hormone level" compared to patients without acne. They also found that androgens like testosterone and DHEA were elevated.9 Therefore, it is likely that women with elevated levels of androgens are also likely to have oilier skin.

Archives of Dermatology

A 1999 study published in the Archives of Dermatology investigated the levels of androgens and IGF-1 in both adult male and female patients with and without acne. The researchers found that androgen levels were increased in both male and female acne patients, while IGF-1 levels were similar in acne and non-acne patients. This study also examined the activities of androgen-producing proteins called 17β-hydroxysteroid dehydrogenase and 5α-reductase. These two proteins are enzymes and metabolize (work to break down) testosterone into DHT, which is a more potent, active form. However, no differences in enzyme activities were found between individuals with and without acne. Therefore, the scientists concluded that the main difference between individuals with and without acne was the levels of androgens, and that acne patients were more likely to have higher levels of androgens. Although oily skin was not a focus of this study, elevated androgen levels will likely also cause increases in sebum production and oilier skin.10,11

British Journal of Dermatology

A 2008 study published in the British Journal of Dermatology investigated the amount of sebum and IGF-1 levels in 11 male and 5 female acne patients. The researchers found that higher sebum levels were correlated with increased IGF-1 levels in men and women. However, an increase in IGF-1 levels was associated with higher acne lesion counts in women, but not men.12 Therefore, the researchers concluded that IGF-1 played an important role in sebum production, but not necessarily acne, in both men and women.

Growth hormone (IGF-1): increases sebum production

Growth hormones are hormones secreted by the pituitary gland that stimulate the body to produce insulin-like growth factor 1 (IGF-1). Scientists believe that IGF-1 is involved in acne development and sebum production because people show the highest levels of IGF-1 during adolescence, which is also when people are most likely to experience acne.

One study found that acne patients had increased levels of IGF-1 and increased sebum secretion. Another study found that IGF-1 can promote the synthesis of fats in sebaceous glands. These studies, combined with other evidence showing that growth hormone disorders are associated with higher than normal sebum levels and acne, have led researchers to believe that IGF-1 levels are directly correlated with sebum production.1

Factors that Increase Sebum Production

Estrogens: decrease sebum production

Estrogens are female sex hormones that are found in both males and females. Estrogen works to suppress sebum production, leading to less oily skin, but only females can be treated with estrogen. Researchers have proposed three hypotheses to explain how estrogens might reduce sebum production:

  1. Directly counteracting the effects of androgens already in the body.
  2. Inhibiting the production of testosterone so less testosterone is produced to begin with.
  3. Controlling the activation of genes responsible for synthesizing fats. Since sebum is made of fats, this can decrease sebum production.

Regardless, estrogens work to reduce sebum production, and therefore different levels of estrogen may partly explain why some people's skin is oilier than others'.9

Neuropeptides: increase or decrease sebum production

Neuropeptides are small proteins found within nerve cells that help to regulate a variety of bodily functions, including sebum production. Researchers have found that sebaceous gland cells can respond to different neuropeptides. Depending on the neuropeptide the sebaceous gland cell encounters, it may activate or suppress sebum production.3 Therefore, differences in how someone's body responds to neuropeptides may also partly explain why some people have oilier skin than others.

Diet May Also Affect Sebum Production

Studies have found that two specific diets may decrease sebum production in the skin, but it's important to keep in mind that the science that looks at diet and sebum production is still coming in.

The first diet is a low glycemic load diet, which is a diet that restricts the consumption of simple carbohydrates, such as sugars, found in foods like candy, white bread, and soda. Research has found that a low-glycemic diet may cause a reduction in the amount of sebum produced. A typical Western diet contains many sugary foods, which may cause increases in IGF-1 levels.3

The second diet is an extreme caloric restriction diet, also known as fasting. Two studies have found that fasting can reduce sebum production by up to 20% in the short term. The decrease in sebum production caused by fasting is reversed when the individual returns to a normal diet.3

Therefore, diet may influence sebum production and may partly explain why some people have oilier skin than others.

A High-glycemic Diet Can Increase Insulin Production

So What Can Be Done About It?

Males & Females: There are several non-prescription treatments (e.g. Botox®, topical green tea) as well as prescription treatments that may help.

Females only: Hormonal treatments (e.g. oral contraceptives and/or anti-androgen medications) are an option.

References:

  1. Smith, K. R. & Thiboutot, D. M. Sebaceous gland lipids: friend or foe? J Lipid Res 49, 271 - 281 (2008). https://www.ncbi.nlm.nih.gov/pubmed/17975220
  2. Thibutout, D. Regulation of Human Sebaceous Glands. J Invest Dermatol 123, 1 - 12 (2004). https://www.ncbi.nlm.nih.gov/pubmed/15191536
  3. Makrantonaki, E., Ganceviciene, R. & Zouboulis, C. C. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol 3, 41 - 49 (2011). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051853/
  4. Pochi, P. E. & Stauss, J. S. Sebaceous Gland Response in Man to the Administration of Testosterone, ∆4-Androstenedione, and Dehydroisoandrosterone. J Investig Dermatol 52, 32 - 36 (1969). https://www.ncbi.nlm.nih.gov/pubmed/4236132
  5. Marynick, S. P., Chakmakjian, Z. H., McCaffree, D. L. & Herndon, J. H. Androgen Excess in Cystic Acne. New Engl J Med 308, 981 - 986 (1983). https://www.ncbi.nlm.nih.gov/pubmed/6220224
  6. Lucky, A. W., McGuire, J., Rosenfield, R. L., Lucky, P. A. & Rich, B. H. Plasma Androgens in Women with Acne Vulgaris. 81, 70 - 74 (1983). https://www.ncbi.nlm.nih.gov/pubmed/6223099
  7. Imperato-McGinley, J. et al. The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 76, 524 - 528 (1993). https://www.ncbi.nlm.nih.gov/pubmed/8381804
  8. Lucky, A. W. et al. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol 130, 308 - 314 (1994). https://www.ncbi.nlm.nih.gov/pubmed/8129408
  9. Lucky, A. W., McGuire, J., Rosenfield, R. L., Lucky, P. A. & Rich, B. H. Plasma androgens in women with acne vulgaris. J Investig Dermatol 81, 70 - 74 (1983). https://www.ncbi.nlm.nih.gov/pubmed/6223099
  10. Thiboutot, D., Gilliland, K. & Lookingbill, D. Androgen metabolism in sebaceous glands from subjects with and without acne. Arch Dermatol 135, 1041 - 1045 (1999). https://www.ncbi.nlm.nih.gov/pubmed/10490108
  11. Cappel, M., Mauger, D. & Thiboutot, D. Correlation Between Serum Levels of Insulin-like Growth Factor 1, Dehydroepiandrosterone Sulfate, and Dihydrotestosterone and Acne Lesion Counts in Adult Women. Arch Dermatol 141, 333 - 338 (2005). https://www.ncbi.nlm.nih.gov/pubmed/15781674

You May Like


  • Personalized Advice Quiz - All of Acne.org in just a few minutes

×