What Is It?
Often known by its brand name Benzamycin®, this topical treatment is a combination of erythromycin, which is a topical antibiotic that helps slow or stop bacteria growth and reduce skin inflammation, and benzoyl peroxide, which kills acne bacteria and dries/peels the skin.
- Rallis, E., Verros, C., Katoulis, A. & Katsarou, A. Topical 5% benzoyl peroxide and 3% erythromycin gel: experience with 191 patients with papulopustular acne. Acta Dermatovenerol Croat 21, 160–167 (2013).
- Ozolins, M. et al. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. Lancet 364, 2188–2195 (2004).
- Gupta, A. K. et al. A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face. J Cutan Med Surg 7, 31–37 (2003).
- Thiboutot, D. et al. A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris. Clin Ther 24, 773–785 (2002).
- Marazzi, P., Boorman, G. C., Donald, A. E. & Davies, H. D. Clinical evaluation of Double Strength Isotrexin versus Benzamycin in the topical treatment of mild to moderate acne vulgaris. J Dermatolog Treat 13, 111–117 (2002).
- Jones, T., Mark, L., Monroe, E., Weiss, J. & Levy, S. A multicentre, double-blind, parallel-group study to evaluate 3% erythromycin/5% benzoyl peroxide dual-pouch pack for acne vulgaris. Clin. Drug Investig. 22, 455–462 (2002).
- Leyden, J. J. et al. Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris. Am J Clin Dermatol 2, 33–39 (2001).
- Chu, A., Huber, F. J. & Plott, R. T. The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and erythromycin 4%/zinc 1.2% solution in the treatment of acne vulgaris. Br J Dermatol 136, 235–238 (1997).
- Sklar, J., Jacobson, C., Rizer, R. & Gans, E. Evaluation of Triaz 10% Gel and Benzamycin in acne vulgaris. Journal of Dermatological Treatment 7, 147–152 (1996).
- Packman, A. M., Brown, R. H., Dunlap, F. E., Kraus, S. J. & Webster, G. F. Treatment of acne vulgaris: combination of 3% erythromycin and 5% benzoyl peroxide in a gel compared to clindamycin phosphate lotion. International Journal of Dermatology 35, 209–211 (1996).
- Eady, E. A. et al. The effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythromycin-resistant propionibacteria. Br J Dermatol 134, 107–113 (1996).
- Chalker, D. K., Shalita, A., Smith, J. G. & Swann, R. W. A double-blind study of the effectiveness of a 3% erythromycin and 5% benzoyl peroxide combination in the treatment of acne vulgaris. J Am Acad Dermatol 9, 933–936 (1983).