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The following side effects are expected to occur in the first few weeks of treatment, and resolve with continued use of erythromycin / benzoyl peroxide. Contact your doctor if these symptoms are severe and/or do not go away:
How Common (based on clinical studies)
| Dryness of the skin | Up to 47% of all users |
| Skin peeling or scaling | Up to 32% of all users |
| Itching | Up to 21% of all users |
| Burning, stinging, or tingling sensation | Up to 21% of all users |
| Redness and/or warmth in the area | Up to 15 % of all users |
| Sunburn | Up to 1.8% of all users |
| Increased skin oiliness | Unknown |
| Soreness or tenderness in the area | Unknown |
| Discoloration of skin | Unknown |
Erythromycin / Benzoyl peroxide may cause some side effects that are serious. If you experience any of the following uncommon side effects, get in touch with your doctor immediately or seek emergency medical treatment:
- A sudden appearance of swelling and rash (known as hives)
- Severe abdominal pain or cramps
- Irritation or swelling of the eye or eyelid
- Signs of fungal infection in the skin or nails such as discoloration, itching, or irritation
- Severe diarrhea
- Appearance of blood or mucus in stool
- Swelling of any parts of the face
Erythromycin / Benzoyl peroxide may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using erythromycin / benzoyl peroxide.
References
- UpToDate. Erythromycin (topical): drug information. Available from: https://www.uptodate.com/contents/erythromycin-topical-drug-information?source=search_result&search=erythromycin&selectedTitle=1~146. Cited 23 October, 2024.
- Chu A, Huber FJ, Plott RT.The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and erythromycin 4%/zinc 1.2% solution in the treatment of acne vulgaris. Br J Dermatol. 136(2), 235-8 (1997).
- Leyden JJ, Hickman JG, Jarratt MT, Stewart DM, and Levy SF. The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product. J. Cutan. Med. Surg. 5(1), 37-42 (2001)
- Marazzi P, Boorman GC, Donald AE, and Davies HD. Clinical evaluation of double strength Isotrexin™ versus Benzamycin® in the topical treatment of mild to moderate acne vulgaris. Journal of dermatological treatment 13(3), 111-117 (2002).
- Thiboutot D, Jarratt M, Rich P, Rist T, Rodriguez D, and Levy S. A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris. Clinical therapeutics 24(5), 773-785 (2002).
- Gupta AK, Lynde CW, Kunynetz RA, Amin S, Choi K, and Goldstein E. A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face. J. Cutan. Med. Surg. 7(1), 31-7 (2003).
- Rallis E, Verros C, Katoulis A, Katsarou A. Topical 5% benzoyl peroxide and 3% erythromycin gel: experience with 191 patients with papulopustular acne. Acta Dermatovenerol Croat. 21(3), 160-7 (2013).
- DailyMed. Erythromycin and Benzoyl Peroxide. Available from: https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=ERYTHROMYCIN+AND+BENZOYL+PEROXIDE&pagesize=20&page=1. Cited 23 October, 2024.
- Kozan A, Guner RY, Akyol M. A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. Dermatol Ther. 33(4), e13534 (2020).