Dapsone (Aczone)

Topical Anti-inflammatory

The following side effects are expected to occur with the use of dapsone. Contact your doctor if these symptoms are severe and/or do not go away with continued use:

How Common (based on clinical studies)

Increased skin oilinessUp to 11.1% of all users
Burning, stinging, or tingling sensationUp to 24.1% of all users
Redness and/or warmth in the areaUp to 13.8% of all users
Dryness of skinUp to 20% of all users
Skin peeling or scalingUp to 11.1% of all users
ItchingUp to 4% of all users 
Increased sensitivity of skin to UV rays / sunburnUp to 3.4% of all users

If you experience any of the following side effects, stop using dapsone immediately and contact your doctor or get emergency medical care right away:

  • Difficulty breathing or shortness of breath
  • Burning, numbness, or tingling sensations over hands and feet
  • Unexplained tiredness or weakness
  • Back pain
  • Bluish discoloration of the lips, nails, and/or the inner parts of the mouth
  • Dark-colored urine
  • Fever
  • Pale or yellow discoloration of skin
  • Muscle weakness

Dapsone may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using dapsone.

References
  1. UpToDate. Dapsone (topical): Drug information. Available from: https://www.uptodate.com/contents/dapsone-topical-drug-information?source=preview&anchor=F9745883#F9745883. Cited 14 November 2016.
  2. Dailymed- U.S. National Library of Medicine. Dapsone, gel. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e3426f2f-4d2b-40b4-ac26-e7d873c30f78. Cited 2 November 2016.
  3. Prendiville, J.S., Logan, R.A., & Russell-Jones, R. A comparison of dapsone with 13-cis retinoic acid in the treatment of nodular cystic acne. Clin. Exp. Dermatol. 13, 67-71 (1988).
  4. Draelos, Z.D., et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J. Am. Acad. Dermatol. 56, 439.e1-10 (2007).
  5. Lucky, A.W., et al. Dapsone gel 5% for the treatment of acne vulgaris: safety and efficacy of long-term (1 year) treatment. J. Drugs Dermatol. 6, 981-987 (2007).
  6. Fleisher, A.B., et al. Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study. J. Drugs Dermatol.  9, 33-40.
  7. Tanghetti, A., et al. Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene 0.1% in patients with acne vulgaris. J. Drugs Dermatol. 10, 783-792 (2011).
  8. Faghihi, G., Rakhshanpour, M., Abtahi-Naeimi, B., & Nilforoushzadeh, M.A. The efficacy of 5% dapsone gel plus oral isotretinoin versus oral isotretinoin alone in acne vulgaris: a randomized double-blind study. Adv. Biomed. Res.  3, 177 (2014).
  9. Stein, L.F., et al. Efficacy and safety of once-daily dapsone gel, 7.5% for treatment of adolescents and adults with acne vulgaris: first of two identically designed, large, multicenter, randomized, vehicle-controlled trials. J. Drugs Dermatol. 15, 553-561 (2016).
  10. Eichenfield, L.F., et al. Efficacy and safety of once-daily dapsone gel, 7.5% for treatment of adolescents and adults with acne vulgaris: second of two identically designed, large, multicenter, randomized, vehicle-controlled trials. J. Drugs Dermatol. 15, 962-969 (2016).
  11. Alexis, A.F., et al. The efficacy and safety of topical dapsone gel, 5% for the treatment of acne vulgaris in adult females with skin of color. J. Drugs Dermatol. 15, 197-204 (2016).
  12. Del Rosso, J.Q., Kircik, L., & Gallagher, C.J. Comparative efficacy and tolerability of dapsone 5% gel in adult versus adolescent females with acne vulgaris. J. Clin. Aesthet. Dermatol. 8, 31-37 (2015).
  13. DailyMed. Dapsone. Available from: https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=dapsone&pagesize=20&page=1. Cited 10 January 2019.