Pregnancy
Human and animal reproduction studies have not been conducted with dapsone.
Extensive, but uncontrolled experience and two published surveys on the use of dapsone in pregnant women have not shown that dapsone increases the risk of fetal abnormalities if administered during pregnancy (any trimester), nor has it been shown to affect reproduction capacity.
Because of the lack of animal studies or controlled human experience, dapsone should be given to a pregnant woman only if clearly needed.
Breastfeeding
Dapsone is excreted in breast milk. Hemolytic (blood) reactions can occur in breastfed infants.
Because of the potential for tumorgenicity (tumor promoting) shown with oral (not topical) dapsone in animal studies, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug use to the mother.
References
- Medlineplus.gov. (2024). Dapsone: MedlinePlus Drug Information. [online] Available at: https://medlineplus.gov/druginfo/meds/a616045.html [Accessed 20 Oct. 2024].
- PubChem.ncbi.nlm.nih.gov (2024). Dapsone. [online] Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Dapsone [Accessed 20 Oct. 2024]
- Uptodate.com. (2024). Dapsone. [online] Available at: https://www.uptodate.com/contents/dapsone-topical-drug-information?search=dapsone&source=search_result&selectedTitle=1~146&usage_type=default&display_rank=1. [Accessed 20 Oct. 2024].
- Epocrates.com. (2024). Dapsone. [online] Available at: https://online.epocrates.com/drugs/4168/dapsone-topical. [Accessed 20 Oct. 2024].
- DailyMed.nlm.nih.gov. (2024). Dapsone, gel. [online] Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e3426f2f-4d2b-40b4-ac26-e7d873c30f78. [Accessed 20 Oct. 2024].