Topical Retinoid / Topical Antibacterial
Reviews
3.7
579 Reviews
Topical Retinoid / Topical Antibacterial
Efficacy
67%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
A way of using benzoyl peroxide in combination with the topical retinoid, adapalene, that studies show works a bit better than benzoyl peroxide alone. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Adapalene / Benzoyl Peroxide (Epiduo®)
Compare To Other Treatments
5
38.2%
4
27.3%
3
11.1%
2
8.6%
1
14.9%

Used Adapalene / Benzoyl Peroxide (Epiduo®)? Rate It:

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April 27, 2015
Life Saver
I have suffered from acne on and off since I was a teen and have tried lots of antibiotic treatments which worked and then stopped working, retin-a gel, benzoyl peroxide, salicylic acid etc. to the point where my Doctor said there was nothing more he could do as he had tried everything, I am now 39, and had a horrendous outbreak after having a few years of beautiful clear skin. I really thought I had grown out of acne, so was horrified when this happened. I ordered Epiduo from an online UK registered pharmacy at a cost of £38 delivered after filling out a form, they have a doctor review before dispensing. I had not heard of this treatment before, and it was like a miracle cure. I had no irritation, redness nothing. Infact it was like putting a skin rejuvenation treatment on my skin. I must add, this might be due to the fact that before using this I had been using Benzoyl peroxide 10% cream, which I now realise was far too strong, this had probably toughened my skin up, so now Epiduo was like a walk in the park. I applied it once a night, and no more than that, following with Eucerin dry skin moisturiser 15 minutes afterwards, which is for really sensitive skin, I did not apply it more often, I was very disciplined, less is more. My skin is now back to normal, and the spots cleared up within a week of starting to use it, I now have totally clear skin, lets hope it lasts. I would encourage everyone to give it a go. Update: **Just thought I would add, it's now August 2015 and the Epiduo is still working well, my skin still tolerates it and I am still very happy. Update: Unfortunately it stopped working in February 2016, acne came back.
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July 5, 2017
what are you doing for your acne now?
March 1, 2015
AMAZING!!
I am 27 and have been suffering from acne for over 10 years. I have tried over the counter treatments and prescribed treaments and nothing has helped like EPIDUO and ORACEA. I used to apply heavy makeup to hide the acne and now I barely apply makeup and feel GREAT. It's been 12 weeks and I would say this has cleared up my skin about 95%. It takes a few weeks but it does help! Amazing!!
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February 23, 2015
Adult Acne after Quitting the Pill
I had great skin while on Yasmin, then stopped taking it and had the worst acne of my life. I tried everything- 10% benzoyl, tons of different medicated face wash, witch hazel, etc. I was prescribed retin A which cleared some forehead bumps but developed severe cystic acne on both cheeks. I regret listening to people who said stick with it because it was the WORST time for me- I used it religiously according to directions and still no luck. I was feeling so miserable and frustrated. After almost 2 months using Retin A, I begged my derm for alternate treatment and started Epiduo combined with Cetaphil regular face wash. Honestly----- the best thing that has happened for my acne! Saw results after 2 weeks. Lots of dryness at first but if you moisturize it will do wonders! I honestly am so thankful and hope you see the same results as I did. I am 24 and finally starting to see my normal skin return, while the scars are fading. It's been 4 weeks and my face is smooth and clear. It does make you a bit red, but nothing worse than acne. Reccomend to anyone who didn't have luck with Retin-A/Trentinoin alone.
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July 1, 2014
Love it!!!
I have suffered with mild acne since I was a young teen. I have tried all sorts of topical treatments and nothing seemed to work for me. Finally, I tried a sample of epidou and I really liked it! I have been using it for probably 3 years now and follow my schedule with it religiously. My skin has completely cleared up besides the pimple or two I get around my period. This was a drastic change to when I used to completely break out during that time. I will say it can be a little drying sometimes so I use a moisturizer as well. This is the only thing that has ever worked for me and I highly recommend giving it a try, and give it time. Your breakouts won't go away after a day! A few months my skin was clear and STAYED CLEAR!
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June 28, 2014
Absolutely recommend!
This worked wonders for me! I once had moderate acne, which was greatly helped by a 5% Benzoyl Peroxide cream and a change in my skincare. However, soon it didn't work so well anymore and I was left with mild yet persistent and extremely stubborn acne and red marks from old acne. I tried many home remedies, shop-bought creams, washes, masks, I tried changing my diet but that didn't work for me - and then my Doctor prescribed me Epiduo. The first time I used it, I made the huge mistake of treating it like my old BP cream which my skin could handle quite well. My skin burned so bad I nearly cried! I gave it a miss for a night and tried it again - this time I used literally a pea sized amount for my entire face. It still burned a lot but a little more bearable. I used it every other night whilst my skin built up a tolerance, and then used a moisturiser in the morning. I actually saw results pretty quick...within a couple of weeks I was getting compliments from friends and colleagues on how well I looked. Now I've been using it for 3 months and I only get the odd spot here and there (usually during that time of the month), which are quickly dealt with with Epiduo. It has helped fade red marks a little too which is a bonus. I do still have a few little bumps that it doesn't seem to be helping, but I'm the only person who can notice them. The only drawback I can think of is that after 3 months my skin seems to be getting oily, whilst I usually have normal/dry skin - the only change I can think of is the Epiduo. That said, I have changed my contraceptive pill, though haven't done any research into whether this can cause oily skin. Overall, I would recommend giving this a go. I was reluctant to at first, thinking - if BP didn't fix my skin why would this be any different? - but I'm so glad I tried it. I can now sit in board room meetings without feeling like the token acne-ridden teenager! It's important to understand that everyone's skin is different though, so what works for one person may not work for another.
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June 21, 2014
50%
I'm 17, female, have mild to cystic acne, depending on the season. My experience with Epiduo was good, I'd say. I began using it last summer. At first, I was horrified at my skin. I could not believe that a doctor would prescribe it to someone. What I was also doing was slathering it on, twice a day. More than usual. So of course, because I wasn't using it as prescribed, my skin was dry, irritated, itchy, and I was breaking out more. I kept at it for about two weeks and then put the product away in my medicine cabinet. A few months later, at the end of August, I was fed up with spending money on neutrogena and clearisil products that don't work. I decided to be patient, and give it a try again. I also read the package insert this time. It stated that acne may worsen during the first stages of treatment because it is treating all the acne you can't see. Which actually makes sense. A drug can't stop a blemish in the middle of it's cycle. The pimple has to become a pimple and get rid of the clogged pore, or it will just remain a bump under the skin, which makes the texture of the skin awful. So I stuck it out again for a few weeks. I would use it at night as directed, and not use too much. Using more product doesn't increase absorption. The only was to increase absorption is rubbing in, increasing the surface area that you apply the product, and applying to clean skin. I used it on my back and chest as well. I used a st. Ives lotion on my back and chest after I took a shower the next day to replenish the moisture I lost from using Epiduo. As far as face lotions go, I recommend clean and clear dual action. It has a very small amount of salicylic acid, not enough to overdry your skin. I also recommend yes to grapefruit moisturizer. It works great but it's a little expensive. My back cleared up with no scarring, the same for my chest. It was amazing. The texture of my skin improved immensely. My face cleared too, except I would occasionally get acne on my nose, which I attribute to my large pores in that area. What you have to realize is that acne is ongoing and you're always going to have acne prone skin. The best thing you can do is find a treatment that takes care of the main symptoms of acne: bacteria, oil, and clogged pores. If you don't treat the other symptoms your skin is experiencing, then the treatment won't work. Moisturize! It doesn't matter if your face feels greasy or gross. Do not skip a day of moisturizing or it will upset your skin's balance. Cleanse and exfoliate! Try using pink grapefruit daily scrub or a st. Ives scrub. Even use a gentle cleanser like cetaphil. Although you're not supposed to use salicyclic acid with Epiduo, my skin was clear using neutrogena's pink grapefruit scrub, clean and clear moisturizer, and Epiduo. The other thing that helped was patience. I wasn't looking in the mirror every day looking for results. I wasn't popping my acne, I was just letting it run its course and eventually it stopped showing up. Also, when using makeup, MAKE SURE IT IS NON COMEDOGENIC. I suggest physicians formula mineral wear, the most minimal coverage you're comfortable with, and apply it with a foam beauty round. They come in like 12 packs and are cheap to replace when the old one is nasty. Which is a good idea to minimize bacteria. Use your moisturizer 20 minutes before applying the powder. Use liquid foundation instead of concealer if you need more coverage. Also non comedogenic. Do all of what I just said, make it a routine, and don't watch for results. It will take a while but I promise this product works. The only reason I stopped using it was that my insurance changed and instead of 26$ a month, it was $240. No way I was paying that! Hope this helped.
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October 16, 2013
worth it!

Pros:

clears skin
controls oil

Cons:

VERY DRY SKIN, AND FLAKY PATCHES
takes a while to work (a month for my skin)
expensive

I have been using epiduo (tactuo) for about 5 weeks. i am 21 years old. I used to have mild to moderate acne and i have been on birth control since i was 16 so i know my acne probably isnt hormonal. my skin was pretty clear when i was 18 but was never consistently clear. I had always used benzoyl peroxide every night because i always had at least 1-2 blemishs. Then last year at age 20 my skin completley went crazy and broke out all over in big red cyst like acne and whiteheads. i had at least 10 pimples all the time and i hated it . i tried everything from salicylic acid to different brands of benzyl peroxide to prescription antibiotic topical treatments to 1% tretinoin. finally tried epiduo as last step before i was going to beg for accutane. Epiduo made my skin WORSE for the first month and sooo dry litterly my face stung like acid was being thrown on it (and i have quite oily skin normally) i am using epiduo EVERY NIGHT even though my face felt like it was on fire. Now in week 5 my skin is finally clearing up magically all at once all my pimples are shrunken to flat red smooth scars.. (better then acne) and i hope it will just continue to get better and better. I still have dry flakes around my mouth and cheeks (i probabaly used too much epiduo becuase i just wanted the pimples to go away) But this treatment IS WORTH IT even though there are more cons then pros, in the end we all just want clear skin right? and in my opinion, no one should use antibiotics for acne if your dr. tries to give you them do your research, it does more harm then good, especially oral antibiotics.
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May 21, 2013

Cons:

burned, stings, redness
very drying (my skin is crazy oily!!)
breakouts continued

My doctor gave me this for my cystic acne........should have never purchased this!!! I used it like he said for 6 months and my skin had awful cysts and big pimples that didn't go away until a month after I stopped. I finally looked at the ingredients in it to see what was causing this and I found sorbitan oleate. This ingredient is known for causing big acne problems. It also stung my face after every apllication and made it crazy red. People asked me if I had been out in the sun lately. I have very oily, greasy skin and this caused my skin to flake up and peel which was annoying. I do NOT recommend this at all!! Especialy for acne-prone people!!
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March 28, 2013

Pros:

Actually works!
Easy to apply.
Doesn't burn /dry out face.
Works within a week!

Cons:

It doesn't work over night.

I absolutely love this. I went to my dermatologist 2 years ago around this time and he recommended i be on solyden (oral treatment) and epiduo. At first i had severe acne it was just awful. Then I started using the solyden and epiduo and my skin got 10 clearer i have acne but its very very light now you have to be rally close to even tell I have any. I LOVE THIS PRODUCT!
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October 27, 2012

Pros:

This product works great. I was starting to think there was no way to clear my skin but the my doctor suggested this topical cream. It starts to work within a week and by 2 weeks my skin was completely clear with just a couple acne scars left.

Cons:

There is no downside to this topical acne treatment except that it makes your face incredibly dry, which can be treating with a tiny bit of moisturizer. Also the price of the cream is really expensive

I would recommend this product to anyone. After years of suffering acne I finally found a product that has cleared up my skin. Even though the price is quite high here in Canada it is defiantly worth the results.
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.