Topical Retinoid / Topical Antibacterial
Reviews
3.7
579 Reviews
Topical Retinoid / Topical Antibacterial
Efficacy
67%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
A way of using benzoyl peroxide in combination with the topical retinoid, adapalene, that studies show works a bit better than benzoyl peroxide alone. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Adapalene / Benzoyl Peroxide (Epiduo®)
Compare To Other Treatments
5
38.2%
4
27.3%
3
11.1%
2
8.6%
1
14.9%

Used Adapalene / Benzoyl Peroxide (Epiduo®)? Rate It:

Choose from 1 to 5 stars
December 20, 2011

Pros:

It works! No more pimples, smaller pores, evens tone.

Cons:

I bleached my pillow and sheets :(

My acne was mild.. I would have about about 2-3 small blemishes at a time and maybe 1 larger one. I have large pores on my t-zone. I have been using the product for about 4 weeks. When I started I used it for four nights in a row. Face got very dry and a little red and burned when I moisturized. Stopped using for 4-5 nights to let it get back to normal. Then started using 3 nights in a row, one night break. I have no more drying or redness. I have not had one blemish since I started using this. Even my pores are getting small and my tone is more even. I love it!
This Was Helpful

10 user(s) found this helpful

Report
September 10, 2011

Pros:

clears up acne
controls oil and shine
evens out skin tone

Cons:

dries out skin and occasional flakiness can occur

The only con is the fact this product dries out my skin...alot. but this doesnt seem to be a problem for most users so its probably just my skin. as for clearing acne this is pretty much perfect because it controls the oil production hence the shine control. I also have acne scarring and this helped to clear it and even my skin out.i have light skin so the scarring was very prominant. i dont use epiduo consistantly as it dires out my skin too much and causes it to flake so i give it a rest. As i live in the UK, medication is free of cost so i dont have any comments about the price. Overall this product does what it says. *im 14 years old :)
This Was Helpful

10 user(s) found this helpful

Report
July 24, 2011

Pros:

seems to help reduce size and redness of existing acne; also seems to prevent certain spots of area from breaking out

Cons:

dryness, little stinging sensation when first using but goes away after using for awhile;

been using epiduo for about a year and a half now. I can honestly say that this has been the most effective topical medicine ive tried. Pro-activ is crap and only works for people with HARDLY any acne and are just whiners. I've tried clindamycin and a bunch of other topical lotions/gels but they all seem to make my skin very oily. Epiduo will dry out your skin and make it flaky but that is how it works, so your oil doesn't excrete as much and clog the pores causing acne. I tried antibiotics and i had bad experiences with that. It made me have diarrhea, light-headedness and now i seem to have shakyness in my hands from anxiety or whatever after using anti-biotics. Epiduo helps but its not the best. I can honestly say my acne would probably be worst if i didnt use this. Will use this until i can find something else worth trying without as many terrible side effects.
This Was Helpful

10 user(s) found this helpful

Report
May 16, 2016
Works great
Ive been using Epiduo for about 6 months... For the first few weeks it was really irritating to the skin, dried it out and gave it a odd texture. ( Mind you i have very sensitive skin) After the first month that went away and my acne significantly improved. I was having large pustules, pimples and lots of black heads. Now 6 months into use I havnt had a pimple in what seems like forever or the pustules on rare occasions. I still have black heads but those are reduced by at home masks and etc, but not to much of a bother. That first few weeks filled me with doubt honestly on how it seemed to just be causing more issues, but after that month everything settled out and is good now. My advice is to NOT use to much to soon, it will make the skin very dry... even now i lightly... very lightly cover my skin in it before bed and once a day, even now if i use way to much i need to make up with moisturizer because it can still dry you out. I am so thankful i decided to test run it !!
This Was Helpful

9 user(s) found this helpful

Report
April 10, 2016
Day One
I am a 28 year old female who has suffered from cystic acne on the cheeks , nose, mouth and chin as well as white heads, black heads and sore rash like spots, since I was 17. I have been on and off Lymecycline my entire acne career, and in between I have tried every expensive, cheap, medicated and herbal remedy that I have researched to work. Every path I have tested has been carried out for three months minimum to have certain results; some worked for a while then stopped (eg Lymecycline, witch hazel and aloe Vera) and some have been a disaster! I have wanted to come off Lymecycline for a while now because the idea of taking a pill every day for the rest of my life is not appealing, for both the reasons of waste and undoubted eventual resistance to the drug. Yesterday, For the first time in my life, I saw a dermatologist to discuss my options. I asked for roacutane but past depression and continued social anxiety has ruled me out of that option. I cannot have birth control as I have migraine with aura that rules it out, and I have taken the choice aside from acne to not take chemical birth control (personal choice). The dermatologist believes that I am breaking out occasionally, despite being on Lymecycline, because my body is building an immunity so she prescribed Epiduo to use alongside Lymecycline, until the breakouts stop; then I will stop Lymecycline and switch to Epiduo for the long term. I have been cautioned to expected some initial dryness, as I would with many acne lotions, I have read many reviews of people having adverse effects to Epiduo within their first week. I wonder if this is to do with their application? My dermatologist directed me to apply just TWICE A WEEK for the first THEEE WEEKS to allow my skin to adjust to the ointment. This is in stark contrast to some users who appear to be applying EVERY DAY in their first weeks of usage; no wonder they are reporting burning, redness and excessive flaking. After the interim two to three weeks I will increase application to three times a week, as directed, for a further two weeks and then to every day. My first application was not uncomfortable and did not burn, hence four stars. I will update with my progress!
This Was Helpful

9 user(s) found this helpful

Report
December 7, 2015
Day 3 of Epiduo on Mild/Moderate Acne
So basically I have started using my Epiduo cream three days ago and I have mild to moderate acne, and it has been clearing it up, but also I have been getting some of the burning, redness and dryness. However, it does look like something that should work, so I am going to persist.
This Was Helpful

9 user(s) found this helpful

Report
December 18, 2013
It takes awhile, but it's worth it!
My experience with Epiduo has been some what of a roller coaster. I just hit the three month mark using the product. First off, let me say that I am vigilant in washing my face every night and using the cream before I go to bed. However, when I first started using the cream, I was mortified. Like many other reviews, my face felt like it was on fire in the beginning. My skin was extremely sensitive around my eyes and mouth. It was also very blotchy. After that pain subsided, my face began to break out. And I mean really breakout. These breakouts were 100X worse than my original breakouts. Not only did I have new pimples, blackheads and blemishes appearing every hour (literally), but my face was also EXTREMELY greasy and dry at the same time. It was gross. I got to the point where I called my dermatologist ready to fight her. Okay, not really, but I was pissed! After my derm talked me down and I stuck with the product for a few more weeks, I am finally starting to see results! It took close to two and half months for me to get there, but my skin is finally leveling out. My break-outs have almost completely stopped. And when I do get a new blemish, they are very small and go away very quickly. My complexion is much brighter and more consistent. I'm finally starting see the results I was originally seeking. I know results vary for each individual, but hopefully people who are going through the same experience will find some hope in this review. Things most certainly got worse, way worse, before they got better. So far though the results have been worth it.
This Was Helpful

9 user(s) found this helpful

Report
January 26, 2013

Pros:

It works like nothing else I've ever tried.
Doesn't burn or dry skin.

Cons:

VERY VERY EXPENSIVE WITHOUT INSURANCE

I broke out very bad on March of 2012. We're talking about acne and some cysts on my face, neck, back, chest, shoulders, and even my arms. I had never felt so helpless and sad for myself in my whole life (I'm twenty 23). Depression hit me like a ton of bricks. Even my younger sisters mocked and laughed at my face. The last thing a person dealing with severe acne needs is mockery about their skin condition. After trying OTC products for two months I decided to see my old dermatologist. When he first saw me he asked me if I was using anabolic steroids And of course i wasn't (but I do workout a couple times a week). He then prescribed me Epiduo along with 80 mg of Solodyn. He told me that a combination of antibiotics and a topical cream works best together for my condition. At the time I had little money and in desperate hope this medication would work because I was unable to pay for another dermatologist appointment After researching for a couple hours I decide to stick with a simple, time-efficient, but effective routine. Here is my routine: Wash face using Neutrogena Daily Scrub (Benzoyl Peroxide 2.5%) in lukewarm water. Take my A.M.dose of Solodyn Wear Aveeno Non-comedogenic (DOESNT CLOG PORES) Moisturizer before going outside. Take my P.M. dose of Solodyn at night Wash face again with Neutrogena Daily Scrub (Benzoyl Peroxide 2.5%) before bed. Wait 15-20 mins after washing face to put on Epiduo all over the affected areas. Then watch the magic happen. I guarantee you will get the results you've dreamed about. I promise! JUST MAKE IT A DAILY HABIT!
This Was Helpful

9 user(s) found this helpful

Report
September 5, 2012

Pros:

Gets rid of acne!
Use one time a day, huge time saver

Cons:

Redness
Burning
Drying
Peeling
Takes a bit of time

Epiduo works very well. I have been suffering from acne for 2 years. It was only on my forehead, but when it started showing up on my cheeks is when I went to the doctor for Epiduo. I have tried EVERY product for my acne. NOTHING worked except for Epiduo. The acne on my forehead cleared completely in under a week, my cheeks however have not cleared completely. I do however see massive improvements in it. When I first started using it, it burned and itched horribly. After a bout a week the burning stopped, but it stills leaves my face a little dry. But it has worked for me better than anything else, and I would recommend it to everyone!
This Was Helpful

9 user(s) found this helpful

Report
June 29, 2012

Pros:

-Improved the number of pimples I got
-No greasy feeling when applying
-Made my acne not as red the next morning
-Made my skin look clearer

Cons:

-Initial breakouts
-Dried my skin out a lot
-Burned
-Didn't clear my skin completely.

I am so glad i used epiduo! I've been using it for almost a year now and my acne was REALLY bad. I have cystic acne so I would always get these massive bumps all over my face- even my nose! Epiduo made my acne better by not getting so many pimples. The downfall was the initial breakouts. I would breakout more at first but after a few weeks it got a little better and then I started seeing major improvements by about 3 months. I still use it now though. However, I had to use a lot of moisturizer because my skin would peel and fall off, and it really burned when i put it on the next day. I still do get huge bumps on my face, just not as many, but IT DOES NOT CLEAR YOUR ACNE COMPLETELY! One great thing I noticed is that it helps prevent breakouts when your stressed- and I have had a lot of stress after my aunt passed away of Ovarian Cancer and my mom getting breast cancer. When I used Epiduo, I didn't break out at all during those difficult times. I used cetaphil soap and moisturizer and it did my skin good. I would also get some sun during the summertime because thats the time my skin was the best, but I live in Florida so I guess that's normal. Overall, If you just want an improvement on the number of pimples you are getting, epiduo isn't a bad thing to ask your dermatologist about. But don't expect it to clear your acne all the way, i still get some zits but I am much happier than i was before!
This Was Helpful

9 user(s) found this helpful

Report

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.