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Zinc and Acne Overview

How Zinc Can Help with Your Acne Treatment

By: Dan Kern, Acne.org Founder & CSO
Last updated: April 27, 2020

The Essential Information

Inadequate levels of zinc in the body may be linked to acne. Bringing levels of zinc up to adequate levels may reduce the severity of acne by:

Oral Zinc: Taking up to 30 mg of zinc gluconate per day appears to work as well or almost as well as oral antibiotics for acne. Zinc gluconate is proven to work and easy to find at any drugstore.

Topical Zinc: Topical zinc appears to work as well as topical antibiotics for acne.

All of this sounds fantastic, especially since zinc is natural and relatively safe, but keep in mind that antibiotics, whether topical or oral, do not provide dramatic clearing of acne. So while research shows us that zinc works about equally as well as antibiotics, just like antibiotics, zinc is unlikely to produce dramatic results on its own and should be used in conjunction with other treatments.

From Dan: Since there is compelling evidence regarding zinc, I keep some zinc gluconate around and take a 30 mg pill whenever I remember, which is usually a few times a week. If I had a bigger problem with acne, I would be sure to take it every day. Like most people, I have to take it with food or it makes me nauseous. 

The Science

Possible Effects of Zinc on Acne

Zinc is found throughout the human body where it provides essential support to the immune system, central nervous system, skeletal system, digestive system, and reproductive system. When it comes to the skin, and particularly acne, zinc may help reduce acne by suppressing inflammation, reducing bacteria, and balancing hormone levels.1

Scientists have studied zinc deficiency in acne patients since the 1970s. The evidence at this point leads the dermatology community to believe that low levels of zinc is in fact associated with acne.

However, there is still controversy over whether zinc deficiency is correlated more with (1) incidence, or (2) severity of acne. This is an interesting distinction when we start to look at the science behind zinc and acne.

  • Incidence refers to the mere occurrence of the condition.
  • Severity refers to how severe the condition is

Some reports state that zinc deficiency correlates with acne incidence. In other words, if a person does not have adequate levels of zinc, they are more likely to have acne. However, a recent study suggests that zinc deficiency may correlate more strongly with acne severity.2 In other words, if a person who already has acne does not have adequate levels of zinc, their acne will become more severe.

Zinc Deficiency Symptoms

Zinc Deficiency and Acne Incidence

Let's take a look first at the evidence that inadequate levels of zinc makes a person more likely to have acne. The first report of zinc levels in acne patients was published in the 1970s. Studies have since shown that zinc levels are lower in acne patients.

Levels of Zinc in Acne Patients Lower Than Normal

For example, one scientific article published in 2006 described research showing that people with acne tend to have lower than normal levels of zinc.3

Expand to read details of research

Journal of Dermatological Treatment

The authors of a 2006 review published in The Journal of Dermatological Treatment reported, "Serum levels of zinc surveyed in patients suffering from acne vulgaris were found to be significantly lower than normal."3 In other words, people with acne tend to have lower blood levels of zinc than people without acne.

Zinc Deficiency and Acne Severity

However, as is often the case in science, conflicting results can surface. In a more recent 2014 study published in BioMed Research International, researchers found no correlation between zinc levels and acne incidence. Instead, they found a correlation between zinc levels and the severity of acne.2

Expand to read details of study

BioMed Research International

The researchers looked at one group of 100 participants who had acne and another group of 100 who did not and measured serum zinc-levels in each group. They found that zinc levels in the group of people who had acne were not significantly lower than those present in the acne-free group. However, there was a significant correlation between zinc levels and the severity of acne lesions.2

Treating Acne with Zinc

Both topical zinc treatment and oral zinc supplementation may help reduce acne symptoms.

Topical Zinc

Topical Zinc Treatment

Topical zinc formulations used for treating acne are at least as effective as topical antibiotics. However, as with topical antibiotics, reduction in acne is usually not dramatic, so experts suggest that topical zinc is best used in conjunction with other treatments. It is also important to use a topical zinc that reduces side effects like skin irritation.3

Zinc may help topical antibiotics work better

While there is serious controversy over using topical antibiotics for acne due to their incomplete and temporary results, and ability to create lifelong resistant strains of bacteria in people who use them, they do work to some degree in at least some people. And zinc may help them work a bit better.

Dermatology Research and Practice

According to an article in Dermatology Research and Practice, using zinc acetate or zinc octoate at the same time as topical antibiotics may increase the antibiotics' effectiveness.4

Zinc Gluconate

Oral Supplementation

The Recommended Dietary Allowance (RDA) of zinc in adults (19 years and above) is 11mg per day. When we take a zinc supplement, only a certain percentage of it is zinc, which varies according to the type of supplement. We refer to this percentage as elemental zinc. For example, zinc gluconate contains 14% of elemental zinc, so in a 30mg tablet, there is 4.2mg of elemental zinc. Another type of zinc supplement, zinc acetate, contains 30% of elemental zinc, so a 30mg tablet would contain 9mg of elemental zinc. Studies show that supplementing with up to 30mg of oral zinc gluconate per day is mildly effective when it comes to acne. It is equally or less effective compared to tetracyclines (oral antibiotics), which are also only moderately effective in acne treatment.4 This is why it is normally recommended to supplement with zinc alongside other therapies. Remember that we also get zinc through the food we eat, so we shouldn't take the entire RDA of zinc only through our oral supplement. Since zinc can become toxic when taken at high levels, it is wise to keep your daily supplementation to one 30mg pill, preferably zinc gluconate.

Several oral zinc supplements are available over-the-counter in drugstores, though some are better absorbed in the intestines than others, resulting in fewer side effects. A commonly-found and well-absorbed choice that can often be purchased in 30mg tablets is zinc gluconate. Other zinc supplements include:

  • zinc ascorbate
  • zinc acetate
  • zinc citrate
  • zinc octoate
  • zinc picolinate
  • methionine-bound zinc5
International Journal of Dermatology

The author of an article published in the International Journal of Dermatology states that "oral zinc gluconate or methionine-based zinc could be a novel anti-acne approach, which could […] enhance the efficacy of the existing therapies."5

Moderate zinc supplementation is safe, comes with only minor and/or temporary side effects, and does not increase sensitivity to the sun.

How Zinc Works to Reduce Acne

Zinc may reduce acne by several processes, including:

  • Reducing inflammation: This is important since acne is an inflammatory disease.6,7
  • Inhibiting acne bacteria (C. acnes): This is important since C. acnes bacteria can lead to the redness and soreness found in pimples.
  • Acting as an anti-androgen (a medication that reduces the levels of male hormones, which are present in men and women): This is important since both males and females who have acne tend to have elevated levels of androgens.
  • Increasing effectiveness of topical antibiotics

These effects and their mechanisms of action are described in the table below:

Zinc's Effects and Mechanisms of Action


Zinc seems to be significant when it comes to acne. Its effects include anti-inflammatory activity, reduction of C. acnes bacteria, and anti-androgen action.

If you suffer from acne, especially severe acne, you might be deficient in zinc. You can ask your doctor to run a blood test. If deficiency is detected, supplementing with zinc may prove to be another weapon in your arsenal against acne.

Blood Test for Zinc Levels


  1. Tapiero, H. & Tew, K. D. Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed. Pharmacother. 57, 399 - 411 (2003). https://www.ncbi.nlm.nih.gov/pubmed/14652165
  2. Rostami Mogaddam, M., Safavi Ardabili, N., Maleki, N. & Soflaee, M. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed. Res. Int. 2014, 474108 (2014). https://www.ncbi.nlm.nih.gov/pubmed/25157359
  3. Bibi Nitzan, Y. & Cohen, A. D. Zinc in skin pathology and care. J. Dermatol. Treat. 17, 205 - 210 (2006). https://www.ncbi.nlm.nih.gov/pubmed/16971312
  4. Gupta, M. Mahajan, V. K., Mehta, K. S. & Chauchan, P. S. Zinc therapy in dermatology: a review. Dermatol. Res. Pract. 2014, 709152 (2014). https://www.ncbi.nlm.nih.gov/pubmed/25120566
  5. Sardana, K., Chugh, S. & Garg, V. K. The role of zinc in acne and prevention of resistance: have we missed the "base" effect? Int. J. Dermatol. 53, 125 - 127 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24350859
  6. Yamaoka, J. Kume, T., Akaike, A. & Miyachi, Y. Suppressive effect of zinc ion on iNOS expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocytes. J. Dermatol. Sci. 23, 27 - 35 (2000). https://www.ncbi.nlm.nih.gov/pubmed/10699762
  7. Prasad, A. S. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr. Opin. Clin. Nutr. Metab. Care. 12, 646 - 652 (2009). https://www.ncbi.nlm.nih.gov/pubmed/19710611

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