The following side effects are expected to occur with the use of spironolactone. Contact your doctor if these symptoms are severe and/or do not go away:
How Common (based on clinical studies)
|Irregular menstrual periods and other menstrual disturbances||Up to 80% of all users|
|Breast pain or tenderness||Up to 38.95% of all users|
|Dry skin||Up to 38.9% of all users|
|Increased urination||Up to 29% of all users|
|Breast enlargement||Up to 24.1% of all users|
|Nausea and/or vomiting||Up to 20.4% of all users|
|Tiredness or drowsiness||Up to 15% of all users|
|Changes in sex drive||Up to 15% of all users|
|Increase in blood potassium levels||Up to 13.7% of all users|
|Headache||Up to 13% of all users|
|Skin pigmentation||Up to 3.7% of users|
|Swelling in lower legs and feet due to fluid collection||Up to 2.2% of all users|
|Abdominal pain, discomfort, or cramps||Unknown|
|Postmenopausal vaginal bleeding||Unknown|
|Difficulty with sexual performance in men||Unknown|
|Voice changes (usually deepening)||Unknown|
|Increased unwanted hair growth||Unknown|
|Feelings of restlessness||Unknown|
|Diarrhea or watery stools||Unknown|
Spironolactone may cause some side effects that are serious. If you experience any of the following, get in touch with your doctor immediately or seek emergency medical treatment:
- Cold or flu-like symptoms
- A sudden appearance of swelling and rash (known as hives)
- Severe itching
- Trouble breathing or swallowing
- Fainting episodes
- Vomiting blood
- Extreme tiredness or low energy levels
- Pain, cramps, or weakness in muscles
- Abnormal heartbeat
- Loss of appetite
- Blood in stools
- Rash on any part of the body
- Sudden inability to move the arms and legs
- Severe nausea
- Abnormal bruising or bleeding
- Yellow discoloration of eyes or skin
- Numbness, pain, tingling, or burning sensations in the hands or feet
- Signs of dehydration: persistent headache, dizziness, feeling unsteady, dry mouth, and increased thirst
- Pain in the upper right part of the abdomen
- Decrease in urination
Spironolactone may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using spironolactone.
- Uptodate; spironolactone. Available from: https://www.uptodate.com/contents/spironolactone-drug-information?source=search_result&search=spironolactone&selectedTitle=1~150. Last cited 9 December, 2016
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