Spironolactone

Antiandrogen

Spironolactone works through the following mechanism:

Antihormonal

Spironolactone helps to regulate hormones that cause acne. 

Although this is how it works for acne, spironolactone is primarily a diuretic (water pill), which means that it makes the kidneys excrete water and sodium from the body into the urine. Spironolactone is a potassium-sparing diuretic which means that when it is used, potassium is retained in the body. For these reasons, spironolactone is most commonly used in the treatment of the following conditions:

  • Heart failure
  • Fluid retention (edema)
  • High blood pressure
  • Hyperaldosteronism (a condition in which the body produces too much aldosterone) 
  • Low potassium levels