Oral Antibiotic
Reviews
3.4
1734 Reviews
Oral Antibiotic
Efficacy
56%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Should never be used on its own and for a maximum of 3 months.
Oral Antibiotic
Side Effects
Medium-High
Oral Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show doxycycline can reduce severe acne in the short term, and as far as oral antibiotics are concerned, it’s usually the go-to, but approach with caution and stay your own advocate.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Doxycycline
Compare To Other Treatments
5
20.7%
4
32.9%
3
22.1%
2
12.7%
1
11.5%

Used Doxycycline? Rate It:

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January 20, 2012

Pros:

Works!!

Cons:

Expensive

Not sure what type the other reviews received but the title on my bottle was doryx & it was $100 for one bottle. Thats 30 pills & I take 1 every morning--- BUT combined with spironolactone this stuff worked miracles. I would pay $200/month for it if I had to... Clear skin is important.. Gives you more confidence and a brighter complexion!!! Two thumbs way UPPPPP!!
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December 5, 2011

Pros:

No Side Effects
Cheap

Cons:

Takes a while to work

So I've been taking this for a couple days and I haven't really noticed any results yet (my acne is moderately bad) But I havent had any side effects. I take it every night right before I go to bed and I have no nausea or anything
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September 9, 2014
Definitely helpful with reducing acne
My journey has been quite different than most I know. I've never had bad acne in my life. I've never had perfect skin though. It's more on the dry side which complicates things when it comes to acne. I've had rashes, dry patches and occasional pimples throughout my life. Nothing major or too bad. I am now 37 and for the first time in my life, have full on acne. Had big pimples on my cheek bone area, jaw, chin, a little on my neck. I know antibiotics can be controversial and some of the posts written about antibiotics just sound plain scary! Fortunate enough for me, I am surrounded by individuals with an extreme amount of intelligence and information about our body and how it functions. (my father's a physician and sister is a dietitian!) There is nothing scary about antibiotic if used correctly. I wouldn't rely on antibiotics solely to help with your acne. My acne has improved drastically because I am undergoing an elimination diet and exploring what is causing this issue. The most asked question - The antibiotics really started helping after 3-4 weeks. I started seeing an improvement within 2 weeks but nothing too significant. But you can not stay on these antibiotics forever. I was taking 2 - 100 mg pills a day, for 2 months. Now I am taking 1 pill - 100mg a day. That will be reduced to 50mg next month and then my treatment will be over. But I do notice that when I eat certain foods, I will get a pimple. (dairy for sure, some meats) So I make a conscious effort to not eat those foods and I take probiotics to regulate my 'good' bacteria. It's a huge learning lesson and I have so much research and lessons learned that I am starting a blog/community for adults that may share my concerns, challenges, and just want to share stories and methods. Good luck to everyone! Do try doxy, it's worth it.
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January 22, 2010

Pros:

Working very well, Started seeing very good improvements after one month, No side effects

Cons:

Nothing

coming up the 8th week (using differen at night to) 80-90% of my acne has cleared up, only alot of scarring left over which is clearing to... Being about 2 weeks since a noticeble breakout (which means it must be working i used to break out every few days) Only the odd new head here and there, still a little bit of cystic acne under the jawline
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January 25, 2011

Pros:

It does fight acne

Cons:

stops working as soon as you take it
not for everyone (made me puke no matter what I did)

Although this did clear my acne when I took it, my stomache cannot handle it. At first I could eat and no worry about it making me sick... but over time my body just rejects this medicine and it made me puke at random. One day I would take it and be fine the next I'd throw up again. Personally I wouldn't suggest people use this medication unless you think your acne is simply due to a bacterial infection. It stops working as soon as you go off of it. & you cannot use antibiotics for long peroids of time because it interupts the good bacteria in your digestive tract which could lead to c-diff (a very nasty intestional infection). Not that this happened to me but it can very well happen. If anything i'd suggest this as a temporary solution to clear your sebacious glands of bacteria... but then you have to search for a more perminate solution.
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December 4, 2011

Pros:

Acne is cleared fast
No side effects

Cons:

Doesn't really work for cystic acne
Leaves red/brown marks

Didn't really experience any side effects because I took precautions after reading this page. Overall, it worked effectively for me in less than a week maybe because I have only light-moderate acne.
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July 8, 2011

Pros:

- Removed cysts
- Reduced inflammation, pain, swelling, etc.
- Reduced number of regular "zits"

Cons:

- Nausea if taken on an empty stomach
- Complete cure for my cysts, but not for all other acne lesions

- I took 100 mg in the morning, and 100 mg at night. - I also washed my face twice a day with 2.5% BP wash, then followed with 5 or 10% BP gel and a moisturizer if needed. If you have acne characterized by large, painful cysts, I highly suggest taking this medicine (or another antibiotic). Persistent picking caused an infection in both of my cheeks, and numerous cysts under the skin. This medicine cleared it up without fail. Before this, my acne was always sore and bleeding, and would open up at very awful moments, like in public or when I was sleeping. I haven't had anything awful -- no large painful bumps or terrible red bleeding messes -- since taking this medicine. While it definitely cleared my cysts it also cleared some of my regular zits, but not all. I still have a few zits left, but these are slowly going away. They aren't NEARLY as bad as my cysts! Overall I'm thankful, and the doxy did a wonderful job but didn't clear me 100%, so it gets a 4/5. Overall: If you have BAD acne, take this or another antibiotic! You'll be happy you did. (Notes: Some people experience a reduction in gut flora when taking this long-term, resulting in intestinal issues. I haven't had this problem. Others also experience yeast infections. I also did not have this problem.)
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April 14, 2011

Pros:

Works relatively fast
Cleared up existing pimples
Kept skin very clear during duration
Evened out skin tone
Less redness

Cons:

None really, but if you have a very sensitive stomach I HIGHLY recommend you take something like acidopholus which restores the pH balance in your stomach

I have had pretty bad acne for about 3-4 years now. I have gone to soooo many different dermatologists and they have all just done the same thing...prescribe cream after cream after cream. The same thing would happen. At first, I would be so excited because it seemed to be working so well and then after a while my skin would get super dried out and then would go back to normal. You name it, I have most likely tried it. Epiduo, Duac, Sulfur treatments-the list goes on. I even tried some supposed "homeopathic"treatment that had "homeopathic" pills along with a benzoyl peroxide cream and salicyclc acid toner, which like before, worked and then eventually my skin was back to normal. So I heard a lot of people talking about Isolaz and decided to look into it and even ask my new dermatologist. After discovering the price ($3000 per treatment!!) and that it is not recomended, it was a no go. I was so ready to just give up and wait until I grow out of puberty to get rid of this acne. I finally went to a new dermatologist just to give it one more try. She explained to me that I have all different types of acne- huge pores, pimples under the skin, and then inflammatory acne, and that Doxycycline would only treat the pimples under the skin and partly the inflammatory acne. I was at first scared to try it but I am only taking 100 mg so the side effects are minimal. I CANNOT BELIEVE THE AMAZING RESULTS!! I am so suprised because I never thought such a low dose could possibly work, but it has!! I notice that my skin has stayed relatively clear, except for the occasional pimple here and there and somewhat enlarged pores, that my skin is less red, and that the tone of my skin has improved-mind you I have only been taking this for about 2 weeks. I hope that the same thing will not happen again, but I am trying to stay hopeful :)
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August 29, 2010

Pros:

Clears up acne
reduces redness and inflamation
kills bad bacteria

Cons:

kills good bacteria too
causes yeast infection
makes stomach feel quezzy

It's not worth getting it if your a women because it can cause yeast infections and there are better pills out there!
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March 16, 2015
Definitely works...depending on what kind of acne you have
I've struggled for decades now with acne on and off, mostly of the mild-moderate variety with the occasional hormonal cystic pimple that usually would never come to the surface. Starting a few months ago, I went through a series of extremely stressful life events (relationship, work, family health issues, etc.) It was honestly the most horrible time of my life, and my skin suffered. Badly. I broke out -- oddly almost entirely on the left side of my face -- with sort of cystic looking pimples. Think bright red, super raised from the surface of my skin, like frozen peas underneath the skin. The worst part was that I'd get a cluster of a few that would basically merge together into a pulsing, throbbing mess. These "cysts" actually came to the surface. The top layer of skin would dry out and start to peel, which looked bad enough, but then I'd actually get green/yellow pus oozing from them. So horrible. I felt like I could barely leave the house! I mean, people would stare. Let me also mention that at the same time, I always had my more normal variety of very small spots, mostly around my jawline. No big deal at all with these -- easy to cover up with makeup and would usually go away on their own in a few days. Anyway, I also wound up hurting my hand taking a fall and got a scrape that became infected. My doctor basically looked at it and my face and was like, you need an oral antibiotic right now. He gave me Doxy, 2x100 mg a day. In less than 24 hours, not only did my hand scab over, turn a normal color again and stop hurting, but nearly 100% of the raised acne went down and also became way less red. They're all in a healing process right now -- and no new cystic bumps whatsoever. The improvement is dramatic. It will definitely take a few more weeks for everything to heal and start to fade, and unfortunately, I do think there is some scarring that I'll need to get a peel/laser for, but I can't recommend this antibiotic enough. BUT, I want to mention that the minor acne I always had is basically exactly the same. It seems like this should be reserved for severe infections. I obviously have had some stress-related immune suppressing things going on, and this is the backup artillery my immune system needed to fight off the bacteria that were running rampant. I'm planning on weaning off of it in a few weeks and also focusing on stress reduction in my life right now.
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.