Topical Retinoid
Reviews
3.2
1910 Reviews
Topical Retinoid
Efficacy
54%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Prescription and over-the-counter adapalene share the same efficacy percentage due to non-specific research, but prescription strength likely performs better.
Topical Retinoid
Side Effects
Low
Topical Retinoid
Acne.org’s Real World Take
This topical retinoid medication provides partial relief at higher prescription dosages, but don’t look for complete clearing, especially at over-the-counter strength. Relatively affordable and comes with less side effects than tretinoin, the other affordable topical retinoid. As a bonus, it improves the look of skin and reduces fine lines and wrinkles a bit too.
Topical Retinoid
How to Get It
This is an over-the-counter treatment. Here are some places you can find it online.
Read All About Adapalene (Non-prescription)
Compare To Other Treatments
5
17.5%
4
30.4%
3
22.6%
2
17.1%
1
12.4%

Used Adapalene (Non-prescription)? Rate It:

Choose from 1 to 5 stars
March 21, 2011

Pros:

Not Sure Yet

Cons:

Broke me out hella bad after the 1st week

I hope that this will heal my skin my acne is not very bad and the fact that i am breaking out is horrifing to me... definitely try it but i hope that its one of those things where it gets worse before it gets better ... i have also changed my diet beacuse of the break outs im hoping to like make milder the initial bad effects of the um adapalene or differin
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January 10, 2011

Pros:

Clears Skin
Doesnt crust on your face
Actually works

Cons:

Initial break out is bad

This prescription works guys. The reason why most people say it doesnt work because they get so sick and tired or the initial break out, so they quit using it. Over the first month of using .01% concentration, my forehead broke out like a little 14 old boy hitting puberty again. I have found the optimal solution to cure your acne for good. I am 25 years old and I tried it on my little brother as well and he is 13. Here it is: 1) Never miss one night of using your differin solution. 2) It is going to get bad after the first couple of weeks but it will go away after a month of using it. 3) Go to you nearest Trader Joes or order online, a small bottle of 100% pure tea tree oil. 4) Buy 100% pure aloe vera gel, it has to be 100%. (they sell it at walmart) 5) In the morning after you wash your face and at night after you put differin on, place a quarter size of aloe vera in your hand along with 1 or 2 drops of tea tree oil. -Tea Tree Oil is using for bacterial and fungi infections which will help you fight the acne on the surface. Differin will help eliminate the acne that is very very deep down. It make your skin thiner. I am also a victum of painful acne on my cheeks and chin area after I shave. Tea Tree Oil and aloe vera has completely eliminated this problem along with other few things. Hope this helps you guys as much as it changed my life.
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July 31, 2010

Pros:

-it had a nice consistancy, I guess

Cons:

-it was VERY drying, and I am almost never dry, even while treating my acne
-it didn't do anything to clear my acne

Basically, I tried differin for 2 months as a topical gel treatment. The dermatologist told me to put it on every night. What happened was my skin was completely dried out and flaking but all of my acne was still there, so in an attempt to reduce the dryness I had to try several kinds of moisturizers that ended up clogging my pores and my acne got worse. So I had awful acne and a very, very dry face.
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September 3, 2015
Fantastic stuff
Having done accutane TWICE and having acne re occur every time I seriously felt like there was no hope for my skin until I finally had the balls to start Differin after hearing all the horror storis. Yeah I had a bit of an initial breakout in hindsight. But the main word here is hindsight - I didn't even feel like I was having one as it really wasn't that bad. I am on my 9th week of treatment and will continue this forever. Since week 6 I have had only 4 or 5 tiny pimples that have disappeared quicker than they appeared! After a couple of weeks of flaking my skin really adjusted to it and it no longer makes me go red or flake at all. As long as this keeps working I will give it 5 stars!
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August 14, 2014
Wonderful
I'm not one for writing reviews so bare with me; this might be long. I have suffered with acne since the end of my freshman year of high school. I went to the derm. right away because I did not want to go through having severe acne for years. Right away he prescribed Epiduo. That wrecked my skin and made it dry, itchy, RED, and bumpy. It was horrible. So he the prescribed Ziana. This was not aggressive enough and made my skin oily and pores huge. Next he prescribed Aczone and Solodyn (the pill). I had such high hopes and unfortunately this treatment didnt work either. I then took birth control for personal reasons and I knew people whose skin cleared up from taking it. Unfortunately this made my hormones crazy and my acne worse. By this time I was a junior in high school still struggling with mild/moderate acne and I felt like nothing would work for me. I decided that the derm. couldnt prescribe anything that would get rid of my acne so I was going to make my own treatment. I started eating better and using only organic face products. I realized that the problem was likely hormonal/genetic so i would either have to use some type of prescribed treatment or just wait it out until I grew out of my acne. I was feeling so insecure and I absolutely hated my skin. My whole high school experience was plagued with this embarrassing thing I had on my face. I felt like no one would want to talk to me because of it. Of course now I realize that acne doesn't make a person. Often times we see our flaws as much worse and if you are struggling with acne you need to understand that your acne should not control you. The summer before my senior year I made a goal for myself: clear my acne! I went to the derm and he said that Differin Adapalene would benefit my skin. So I believed him and began using that every night on my face as well as taking the pill Doxycycline. Let me tell everyone, the first month for me was very rough. I struggled a lot with even leaving the house. My acne was the worst that it ever had been but since it was summer I didn't have many obligations. The hardest part for me was not the acne itself but it was my confidence. I had zero confidence and I didn't want anyone to see me. Luckily, after that first month my acne began improving! This happened slowly. The acne marks and scars started to fade and any bumps I would get were very small and would heal quickly. I am still dealing with some scars but I am happy with the results and I truly believe that it will clear my skin all the way. Be patient with this product! Don't give up on it because if Differin is right for you it will all be worth it! Hang in there.
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March 7, 2012

Pros:

Cleared up acne after a month and a half.

Cons:

I'm giving it time, but my acne scars still show. Bad breakout when I started.

I started using Differin at the end of last December because my dermatologist recommended it and I was sick and tired of having moderately severe breakouts. When I first started, I had bad breakouts for about the first three to four weeks. It also created a stinging feeling on my skin when I washed my face. However, those are only temporary side effects and they eventually die down. The most important thing about this product is DON'T GIVE UP and BE PATIENT. It takes around two months before any real results start showing, so just give it time. If by three months there is no improvement, then you could inquire about it. For me, luckily, my acne has made such a drastic clearing that I only get a few new pimples every week (compared to when I used to get a few breakouts everyday). The only thing I'm still waiting for is for the Differin to fade my acne scars, because they still show on my face. Nonetheless, I have faith that it will do the job eventually.
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October 9, 2011

Pros:

Made a great improvement on my acne and continues to do so.

Made my skin glowy and the nicest it's been for years.

Cleared my skin up, also evened my skin tone.

Cons:

First few weeks:
-You have to wear suncream every day, or your skin will feel very sunburnt.
-Skin went super red.
-Made my skin peel so much.
-Stings when you use certain creams/makeup over it

This product did what it was supposed to, but it took a while for my skin to get used to it; the first few weeks were a nightmare, though I saw results quickly. It's been 2 months now and my skin is great, I haven't had any new acne and my old acne is nearly gone. My skin is soooo good now! I had the gel version and applied it every night. It dries out your skin. If you're patient this will pay off. The only thing is it doesn't take away all of the redness, I also found it doesn't fix blackheads. It's great with everything else though I had light/mild acne
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August 10, 2011

Pros:

-It got rid of the tiny oil bumps

Cons:

-Didn't get rid of the pustules and papules I had on my chin and cheeks.

When I began using this product I immediately saw results. Unfortunately, this lasted only for about one week. My skin soon returned back to normal. It did get rid of the tiny oil bumps I had on my forehead which was great but didn't get rid of my big pimples. This product didn't work well for me but I still recommend this product because it vanished my tiny pimples.
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June 25, 2011

Pros:

-helped with fine lines on forehead
-cleared small pimples

Cons:

-acne appeard in places where I was clear
-created cystic acne after 3 months use

I used the 0.1 cream based differin and I had a horrible breakout when I started it. I thought it would end, but it kept gettng worse and worse and now I have many cysts on my face becasue of it. Not strong enough for very oily skin.
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May 20, 2011

Pros:

Unclear whether it helped with renewing skin.

It's unclear whether my red marks healed more with or without this product.

The cream helped non-inflamed, non-red acne on my forehead.

Cons:

My skin rejected this cream. I put it on and it formed disgusting white inflamed pimples. I have never had white pimples before so I am the white sh*t is from this cream.

Definitely do not use on existing inflamed pimples, it will make them bigger and then they will fall off and make your face bleed and mark.

It's not worth it to use on post inflammatory pigmentation even if it increases cell proliferation because new pimples will form as a result of this cream.

I should have read the reviews. I have been through 5 months of misery with this sh*t. Use a very little amount on non-inflamed acne. Otherwise, stay away from this sh*t!
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.