Topical Retinoid / Topical Antibacterial
Reviews
3.7
579 Reviews
Topical Retinoid / Topical Antibacterial
Efficacy
67%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
A way of using benzoyl peroxide in combination with the topical retinoid, adapalene, that studies show works a bit better than benzoyl peroxide alone. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Adapalene / Benzoyl Peroxide (Epiduo®)
Compare To Other Treatments
5
38.2%
4
27.3%
3
11.1%
2
8.6%
1
14.9%

Used Adapalene / Benzoyl Peroxide (Epiduo®)? Rate It:

Choose from 1 to 5 stars
June 30, 2010

Pros:

-Clears pretty much all acne
-No smell/odor
-Actually even gets rid of a few scars

Cons:

None.

Before using Epiduo I used Differin. It worked for like a month and stopped working. So I asked my mom to make an appointment with my dermatologist. She said I didn't have the worst case of acne around, but I felt like a pepperoni pizza face :| so she prescribed me Epiduo and Clindamycin Phosphate. I didn't think it'd work, but after one day, I saw huuuge results! It got rid of about 35% of my acne already! And after a month I got rid of a bunch of scars. I totally recommend this. If it doesn't work for you, I suggest you ask for a different medication. Don't choose Proactiv. It's just soap in a fancy bottle that's expensive. PS: Ive had this for about 2 months and I just need to get rid of a few more pimples; remember, I had a lot. USE FACIAL SUNSCREEN DAILY.
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March 9, 2010

Pros:

Drys out the acne you have.

Cons:

Redness, Burning when you put anything on with it, Mild Peeling, Doesn't stop new acne.

It has helped with my cystic acne & it speeds the amount of time i have a zit on my face. Except it does not stop new ones from appearing & your red for a week if you set foot in the sun without sunscreen- even for 15 minutes and Im pretty tan naturally.
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December 17, 2009

Pros:

I helped clear most of my existing acne and blemishes

Cons:

Didn't help keep it away for good

This really cleared me up for about 2 weeks but then my acne returned as it has before. I think my skin built a resistance to it because its only 2.5 % bp.
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December 1, 2009

Pros:

seems to help heal acne, although its acne that appeared after i started using epiduo.

Cons:

burned my skin, intensely! still not clearing my acne up and ive been using it for a month and a half.

give it a try. i use it twice daily now, and only for spot treatment. it is to severe for the entire face. at first it made me break out terribly and then my skin cleared up for a good 2 weeks. now i am back to another break out cycle. when is the relief coming!?
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September 29, 2009

Pros:

Worked very well in beginning. My skin never felt so good.

Cons:

Dry, irritated skin. After 1-2 months it seemed to lose its function and I'm worse than ever.

Worst breakout of my life at the moment. The acnes are large, painful and many. I have no reason why this suddenly happened. Have used Epiduo for 3-4 months. Worked very well in the beginning, but no lasting effect. Is it possible to become immune? Talked with my doctor today and he suggested combining Epiduo (at night) with Dalacin (in the morning). Hope that works!
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August 19, 2017
so far so good!
my doctor prescribed me epiduo three days ago and it works like magic! i have mild/moderate acne, which really flared up a year ago (age 15) and it's been difficult trying to keep it away. i get cysts and nodules. there would be 3-5 in one area which can be painful. i don't get a lot of spots but i do get larger pimples. my acne is hormonal so i never know what it will do next. sometimes it goes down completely and one day i'll wake up with 2 cysts on my cheeks. i've tried doxycycline which didn't work for me at all. 2 and a half months in and i was still getting cysts frequently. i thought it would work because i was taking the fight inside out but it was a big fail. i was hesitant to try the epiduo as it is a topical treatment and i've heard many times that it is inside that you need to take care of (to control the hormones), hence taking prescription pills. personally i have had no bad side effects, it would VERY slightly itch/tingle on the side at a small area but goes right away. i haven't had any burning sensations, as i've read many people experienced on here at the first couple of weeks, but i'll have to wait and see. i saw a big difference the morning after my first night with it on and it has completely removed my cysts and nodules since, at least on the surface. i've also seen scars fading a little but i'm not sure if it is the epiduo. in the morning i would rinse it off with just water and use the olay complete spf 15 moisture lotion. my skin hasn't purged, i'm not sure if it will or if i'll get minor side effects later. i have only been on it for three days so i'll have to check back on here in two-three months. hopefully, i won't have to take pills with the epiduo or be disappointed yet again :)
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July 22, 2017
my ride or die
epiduo dries out pimples and if you breakout epiduo is there to save the day. However after using this epiduo for months and months and years and years relying on it, it irritated my skin and made specific places where i applied the epiduo very red, sensitive and irritated (maybe because i did not apply a pea size amount). HOWEVER, i still think this is one of the best topical pimple treatments out there, and definitely by far the best one ive tried out of duac, clindamycin toner, etc.
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March 9, 2017
Moisturize, moisturize, moisturize
This is the only product that worked as well as accutane did for me. I've been using it for 2 years. There seems to be a lot of people giving up on Epiduo/Tactuo/Tactupump way too soon. You guys gotta push through the first month of stingy/raw/sunburned feeling skin. Just Use it at night before going to bed..... then MOISTURIZE during the day.
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April 23, 2017
Which moistirizer did you use ?
April 23, 2017
Murad Oil-Control Mattifier SPF 15
April 25, 2017
UPDATE: This product still works for me. check my profile to see what else I use to keep my skin clear.
March 3, 2017
Less oil but still loads of acne
I went to the dermatologist and got prescribed this for my cystic acne which started almost overnight about 6 months ago. I had really high hopes that it would work because all the OTC stuff that used to work on my non-cystic acne didn't have any affect at all on this new development. Long story short, I will give it 2 stars because it did manage to cut down oil production on my face which was really positive at first. I thought it would lead to less acne and less cysts. But the opposite happened. My skin got so dry and irritated at first. After 3 weeks, the dryness turned to just red and inflamed - like my entire face! It was itchy and painful to the touch. I talked to my dermatologist and they told me to soldier on. I did until I went to my primary care doctor (for something unrelated) and while I was there I just mentioned my face. I mean, it was obvious, kind of the elephant in the room. She said she could't help me but recommended that I call a lady named Pamela at Ninja Skincare and that she could help me. That she had a lot of patients who used that product with a lot of luck. So I called and sure enough this lady knew her stuff when it came to acne. I learned so much about skin, my skin and what I had been doing wrong. Firstly, I learned that I was likely sensitive to benzoyl which is pretty interesting since even when I talked to my dermatologist that never came up as a possibility. Then she told me about stress and how bad it was for acne prone skin (I am going through a divorce so this made so much sense) and gave me a few lifestyle things that I could work on to lower my breakouts. Oh and that epiduo didn't work most likely because it has a bunch of oils in it that end up clogging the pores. And I got the Ninja product which within 1 week I could tell a difference and within 3 weeks, my acne was almost completely gone with the exception of one huge cyst that I had had for about a month. Now I am at about 5 weeks and couldn't be happier. I was with epiduo for 6 weeks and saw almost no changes at all and now 5 weeks with Ninja and everything is completely healed. I know a lot of people have had luck with Epiduo but at this point, I am not sure why or how it works for other people. I had much more luck with other products.
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September 30, 2016
Works amazingly well for me
Prior to Epiduo I used Differin for about a year, with fairly good results, but I had to use it morning and evening, and a bit more heavily than is recommended, for it to be effective. But there were too many occasions where I would still develop a few red acne lumps for seemingly no reason, and if I ever went a night without using it, within a few days there would again be a few red lumps developing. In the last month I have switched to Epiduo, and whilst it contains the same 0.1% Adapalene as Differin, it also contains Benzoyl Peroxide which appears to have made a huge difference. My skin has been completely clear since I started using it, I have also had the odd night or two where I have not used it (came home late and fell asleep!) and my skin has remained clear. I think this works for me because the cause of my acne seems to be excessive oil rather than any kind of bacterial problem. I honestly would compare the results to that of taking a course of roaccutane (which I have done in the past) - it's that effective for me. The dryness is minor and whilst there is a bit of redness to my skin, it's nothing particularly noticeable. I also find the consistency of the cream easier to use that the Differin gel.
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.