Topical Retinoid / Topical Antibacterial
Reviews
3.7
579 Reviews
Topical Retinoid / Topical Antibacterial
Efficacy
67%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
A way of using benzoyl peroxide in combination with the topical retinoid, adapalene, that studies show works a bit better than benzoyl peroxide alone. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Adapalene / Benzoyl Peroxide (Epiduo®)
Compare To Other Treatments
5
38.2%
4
27.3%
3
11.1%
2
8.6%
1
14.9%

Used Adapalene / Benzoyl Peroxide (Epiduo®)? Rate It:

Choose from 1 to 5 stars
May 23, 2012

Pros:

Cleared up almost ALL my acne! (only have a few small pimples)
Work immediately (within 2-3 nights)
Skin looks clean and fresh
Gave back my confidence! Haven't been happier with my face

Cons:

Burns like CRAZY after putting it on
Skin is very very dry (esp. around the nose.)
Bleaches things
Skin is very sensitive but its worth it..

I know some people have had bad results with this, but I was out of options and wanted to give this a last shot...I could not be happier! I've been using it for about a month and my skin looks wonderful...even though the acne is hormonal it took it all away! I would choose this over Retin-A any day! It also seems less harsh.
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February 26, 2012

Pros:

Within 2-3 days you can see spots reduced in size.
Within a few weeks (3-4) your acne scars and spots are REDUCED
After the first week or so, the burning and other side effects go away.

Cons:

1st Week or so, side effects: Maybe a breakout(short)
Burning
Stinging
Dry Skin
But are quite minor effects and disappear quickly.

I have been using Epiduo for 3 weeks after it was prescribed to me by a doctor and it has worked wonders o my skin, however it still hasn't completely cleared up my skin, the leaflet says it should do so within the first 8 weeks max. By the way things are going, I think it should be gone by next week! I TOTALLY RECOMEND this product, it is AMAZING! It also moisturizes really nicely after the first week!
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January 25, 2012

Pros:

CLEARS UP ACNE
WORKS AMAZINGLY
easy to apply

Cons:

it burns for the first few uses
takes a while to kick in

this WORKS. trust me, i was doubtful. the first few weeks... it was rough. i was ashamed of my face. but foundation and powder and concealer helped me through it. it does take a little while (maybe over a month) but it WORKS i promise. this will change your life. i'm no longer ashamed to show my face after i've washed it at overnight events or sleepovers. it will change my sleepaway camp experience :) not having to put make up on after my shower... i am so excited. THANK YOU EPIDUO <3
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June 7, 2017
In the process, Week 4
I've been on epiduo for 4 weeks now and I have had moderate acne for about a year, when it started i didn't really see much of a difference it got a little better. At week 3-4 I have started experiencing the purge stage on my chin and it is pretty rough, but everywhere else has no acne just fading scars. Just got to stick it out. Hopefully it will be done purging in a couple weeks. During this purging stage I have probably had about 5 new pimples a day on my chin. I will post again at 8 weeks and then at 12 weeks. Thinking long term helps a lot and getting the epiduo app as well.
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April 16, 2016
Epiduo Forte worked wonders for me
I am a 21 year old girl with mild acne. My main issues are closed comedones and the occasional large, blind pimple. When I began treatment on this topical, I was given Bactrim as well. I noticed improvement immediately after starting Epiduo Forte. My skin has always responded very well to BP, so I knew that was part of my success. But the adapelene really lightened my post acne marks and made my skin really smooth. I did experience an intense burning sensation at times, along with peeling, but I now buffer it with a light moisturizer and have had much less redness and irritation. It purged all my comedones and made getting a pimple way less frequent, and best of all no more close comedones occur. Also I haven't had any "deep" pimples since using this topical. It is definitely something I recommend when people ask me about my skin!
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March 15, 2016
Worked great for a while but....
When I was 12 years old I started getting acne on my forehead. When I went to my dermatologist, he prescribed me Epiduo. I was on Epiduo for almost 3 years and my skin improved tremendously. All of the sudden I started breaking out everywhere; my cheeks, forehead, chin, back, chest. My doctor told me that I had been on Epiduo for too long that my skin was getting use to it and pretty much rejecting the medicine. I'm 16 now and have tried soooooo many medicines. I'm about to start accutane and I couldn't be more excited. All in all, Epiduo is great. Although, it doesn't help keep acne away forever. Don't we all wish we could find a miracle medicine to do just that?
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January 5, 2016
Epiduo it really works..
So i started using Epiduo after being recommended by my dermatologist in August 2015, last i had acne was back in 2010 while i was in college and now after 5 years..I am not sure of the reason behind sudden breakout but it is really scary to start seeing sports and little bumps appearing on your pretty face..So my dermatologist ask me to use Epiduo + Doxycyline (2 tabs a day ) and asked me to visit him in 2 months, initially i thought 2 months is a long time but as the day started to pass my acne started to get worse and more and more breakout is all i could see. I was depressed, shattered and sad and all i wanted to do is lock myself in a room and not to go anywhere. But by the time it was about 2 months and was time to see my doctor again my acne was looking way better than they use to be, there were no more new Acne or breakouts any more, my skin started to feel smooth and it has a shine in it, but still i had the spots and blemishes left from the acne. I visited my doctor after 2 months, and briefed him with the entire story of my journey on acne.. he graded my acne 4 this time, i was not sure what does that mean. He advised me to change the Epiduo to its advanced version Epiduo Forte, with insurance it will cost you no more than $25 ..and asked me to visit him again in 3 months..and today i am about to complete my 3rd month and i have zero acne, very light blemishes, my skin has brightened 2 times what it use to be and i feel so confident like never before.. My advise is please stick to it and u will see the results..Thank you Epiduo
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October 4, 2015
Amazing, however doesn't work forever.
I'm a 17 year old male, with combination skin. I've been suffering from acne ever since I first hit puberty when I was around 12 years old. It's been up and down for me, but it got especially bad in Grade 10 and onwards. I tried everything on the market that I possibly could get my hands on, including proactiv, but nothing seemed to really work. Frustrated, I went to see my local walk in clinic to see if they could help, and they prescribed me Clindoxyl. It was a great product, as it helped reduce my acne greatly, but it caused me to get a huge zit once in awhile. When my prescription for it ran out, and I stopped using it, I slowly started breaking out again. Before things got out of hand, I went to see the doctor again, and this time they prescribed me Tactupump. It's definitely a lot more expensive than Clindoxyl, but it worked quite well for me, so it was kinda worth it. I've noticed many other reviews mention how Tactupump is drying, can burn and causes redness, and also how it can cause you to break out when you first use it. I think because I've used other strong products in the past, that now my skin is tough to this kind of stuff. I never had the "breakout" while using this, and it never burned, but apparently, it caused my face to be more red than normal. Tactupump definitely caused my skin to dry out, but if you apply moisturizer the morning after, it's all good. I used about a pea sized amount every night before I go to bed, and wake up the next day feeling a lot cleaner. I've used this product for about 2 months now, and I've noticed quite a difference. The first couple of days, I noticed it got rid of a group of zits that I've had for forever that I just couldn't get rid of, but this got rid of it in like 2-3 days. It took about 1-2 weeks to start seeing real results, but now I'm very pleased. I'm not perfect quite yet, but compared to what I used to be, it's better. I started feeling confident and happy again. I still remember being so scared to try this because I was very skeptical if it would work, but I'm glad I took the risk. However, at the end of the 2 months, it stopped being as effective, and I've had a big breakout on the side of me face and a bit on my forehead. I went to see the doctor again, and this time she prescribed me oral medication and Clindoxyl again. Hopefully this works... I think the problem with users who rated this product negatively is that they overused it or used it wrongly. You're only supposed to use it once a night before you sleep, and use a pea sized amount and put it all over your face. If you use it more than once a night or if you use too much at once, I think it would wreck your skin, so be careful. In short, Pros: Clears up your acne effectively Can help with scars/marks Prevents further breakouts Cons: Can be quite drying Causes redness/burning Expensive ($130 in Canada if not covered by insurance) Doesn't work forever (at least for me) Good luck to everyone trying this out! Hopefully it will for you as well!
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September 4, 2015
Weekly Epiduo Review! 4 YEARS LATER UPDATE

I've rated 3 for my current review. However as weeks progress on comments below my rating might change according to my experiences. Age: 20 Sex: Female Skin type: Olive skin, Oily, Medium Pores. Acne history: Never had acne, just a few spots here and there on my face. Acne: Hit me at 20 - moderate acne such as blackheads, white heads, lots of cysts around lower cheeks and jawline and a bit of spots on my back. Acne Treatment History: I undertook SGA at Clearskin Clinic Australia: FAIL - WORSENED acne by 3 x Current Acne Treatment: Finally went to a dermatologist. He prescribed me Epiduo and Doryx 50mg. Routine: Morning- 1. Wash with Cetaphil Foam Cleanser. 2. Dry with a anti-bacterial cloth and if I'm leaving the house: 3. Apply Cetaphil oil-free moisturiser spf 30 if I'm not leaving the house: 3. Apply Cetaphil oil-free moisturiser After i eat breakfast: I take 2 Doryx tablets with water. Night- 1. Wash with Cetaphil Foam Cleanser. 2. Dry with anti-bacterial cloth 3. Apply Epiduo (pea-sized amount) I put Epiduo every second night on my face as the dermatologist recommended (Always listen to what the dermatologist recommends as everyones skin is different). So on the nights i do not put it i put Cetaphil oil-free moisturiser. I will be writing a weekly review on this post. It will be UPDATED every week. The rest of the weeks will be posted as a comment on this post. Week 1. Skin: Very dry, flaky, itchy, red Acne: A few old pimples went but a lot of new ones appeared. Week 2. Skin: Slight Improvement - dry, flaky, red Acne: Its like a continued cycle of a few old ones leaving but a lot of new ones appearing and my back has gotten SO MUCH more pimples to which i have never had in my entire life. Week 3. Skin: My skin has gotten used to Epiduo. It's only a little dry but moisturising quickly fixes it. Still a little itchy and red. Acne: During this week i felt like some days my skin looked like wow its improving and other days i feel like a got stung by 20 bees. Its like a cycle. But i feel like the new ones that come quickly go and my back is still really bad. I will now be posting weekly reviews on the comments. If you would like to ask any questions go ahead.

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September 6, 2015
Week 4: Skin: Dry, Red and not as itchy Started off crazy at the start of the week. I nearly gave up but its very important to continue. My back has flared up again... im sure itll get better. But by the end of the week i had a great experience the left side of my face and forehead has not one active pimple just high red pigmentation which looks like pimples but they arent!!!! Wohoo but the right side is still crazy so fingers crossed for Week 5.
September 13, 2015
Week 5: Skin: Not as dry and not as red but still dry and red. Acne: My back is getting a little better. My face has slightly flared again on my forehead, upper lip and on lower cheeks and jawlines. I was so excited last week thinking yay its finally going but now that it flared again it made me feel really upset. But with all the reviews i read they have similar experiences and they only really see big improvements by 8 weeks to 12 weeks. So i have to be patient!!! Im going dermatologist by the end of Week 6 and ill update you on what happens.
September 14, 2015
Do not worry! It took my face 8 weeks to clear up, and it stayed super clear after, good luck!
September 20, 2015
Thankyou for the response!!! I hope so, patience is seriously so important with this treatment. So anyone reading this just stay patient... its a pain but nothing comes quick and anything that claims it does is a lie all they do is damage your skin or worsen it. So always go to a dermatologist.
September 20, 2015
Week 6: Skin: Not dry anymore, still red and a little itchy. Acne: My back is really soft again and it isnt flared anymore but i have alot of pigmentation. My skin is okay not that great a few pimples on my forehead and lower chin and a few under the skin cysts under my right cheek on the neck. Its very similar to week 5 not much differences. But with epiduo i feel like the pimples improve within three days even less. I went dermatologist end of week 6. He saw my face and said that it has improved and he said itll take upto 12 weeks and to be patient. So i am. He told me to put epiduo now every night rather than every second night like previously. He also told me to go on Yaz birth control pill once i start my periods and stay on the Doryx tablets also. Ill be seeing him in 5 weeks.
September 25, 2015
Week 7: Skin: not as dry, red pigmentation, no more itchy feels. Acne: Back has flared again ALOT but i guess part of the cycle? Face: my forehead has no active pimples , my left side cheek and jaw only has one active pimple, my right side cheek has one active pimple and under my right jaw i have like 3 under the skin cysts. So it has improved alot. The rest of my skin looks like it has alot of pimples but its all red pigmentation and its very very smooth to touch. Well see how next week goes. Patience!!!!
October 10, 2015
Sorry delayed. Week 8. Skin: No more dry skin, no more redness just LOTS of red pigmentation and not one bit itchy. Acne: As everyone has said by week 8 thats when you see results and thats exactly what happened to me Week 8 and not one active pimple not one not even a cyst or under the skin bumps ZERO but lots of pigmentation but if i run my hand across my face its perfectly smooth. Week9. Skin: No dryness No redness and No itchyness. Acne: For some odd reason i got 2 cysts on my lower right jaw and i got 4 active pimples on the middle of my cheeks and ive never had pimples on my cheeks before :( i was over the moon last week that i actually improved incredibly but this week i dont know what happened. I read other reviews and alot of people said by week 8 you see improvements but by week 12 it actually completely improves so now patience for another 3 weeks!!!!
October 18, 2015
Week 10: same as week 9
October 22, 2015
Week 11: same as week 10
November 4, 2015
Week 12. Skin: lots of red pigmentation. I asked the dermatologist how i can get rid of this red scar pigmented blotches. He said that its actually from the Doryx oral antibiotics which causes redness and as soon as i stop the pills i will have no redness. So bonus! The dermatologist also now does glycolic peels every 4 week visits. Ive had one and he said its for blackheads and for any brown pigmentation from previous pimples. He also gave me a 10percent glycolic acid lotion for my back to reduce brown pigmentation. Acne: I dont have much active pimples just 2 or 3. The rest of my skin is sooooo smooth especially beneath my left jaw which used to be extra bump with large cysts. My skin isnt perfect but its improved by 70 percent. Just a reminder to what im on. Morning: 2 × 50mg Doryx antibacterial tablets Yaz Birth control pill Both Morning and Nights i wash with Cetaphil Cleanser Night: Epiduo cream on my face
November 8, 2015
Week 13. Same as week 12 . . . Still getting pimpled here and there. Lots of pigmentation
November 13, 2015
Week 14: Skin is very hyperpigmented. Few active pimples. Has improved incredibly. The pigmentation is putting me off. Not sure how long that will take.
November 30, 2015
Hi, did you wear any makeup during the treatment process?
January 28, 2016
Yes i wore oil free makeup everyday
May 4, 2016
FINAL review after exactly 8 months and 2 weeks. My skin is completely clear of pimples! I get the occasional pimple when I am on my monthlys but other than that not one single pimple! Hyperpigmentation slowly goes every single day. I am currently on 1 Doryx tablet every morning and Epiduo cream every night. Still rated a four as it takes a lot of patience to see results. Its no quick fix that's for sure. PATIENCE is key to this treatment! Do no start if you are not willing to pass 5 months of it as stopping mid-way only makes it worse for you. Goodluck to anyone who begins this treatment. You will only be disappointed if you are not patient and expect fast results. Stick with it and you will see wonders happen. Also take photos every 2 weeks and you will see how it gets worse and worse and worse than by 3 months better and better!
June 3, 2019

Hello to anyone who read on my journey.

Since my last post on May 4 2016 i was on Epiduo once a night till September 2018. On September 2018 i decided to stop using it as i no longer thought i needed it. I was WRONG!! As soon as i stopped my entire face purged again! It’s like i was starting again from square one. I immediately booked an appointment with my original dermatologist. He was on holiday so i only got the chance to see him April 16th 2019. He prescribed me doryx 50 mg and Epiduo. I honestly feel depressed!!!!!!!! I am not willing to go through 8 months of purging on and off. I read my review honestly 8 months to get clear face AGAIN? How could i even mentally survive that. Surely i can not. I have been on doryx for now a month and a half. By now i came to realisation that i will he slowly stopping doryx as it killed my digestive and immune system when i was on them for 8 long months. For this reason i have decided to stop. Can someone PLEASE give me any advice on what i can do? My skin should not have relied on EPIDUO for 2 YEARS!! And purge again once stopped. Clearly something within me is destroyed!! 

January 23, 2015
Wow.
I never take the time to write reviews on products but I felt the need to write about this. I'm 20 and I've been struggling with acne for about 5 years. It has never been severe, but definitely noticeable and ongoing. I've tried everything. Every drug store product, home remedies, popular acne systems. Nothing made a big difference. Acne has prevented me from having a lot of self confidence. It SUCKS. About two weeks ago I went to my general doctor to ask for a referral to a dermatologist because I had finally had enough. She prescribed me Epiduo so I would have something until I could actually visit the dermatologist. I started using the Epiduo twice daily - once in the morning and once at night. My pimples starting to go away but I quickly learned that twice a day is entirely too much. My face started burning and becoming dry (I have sensitive, dry skin as it is.) so I stopped using it for a day and then I continued to only use it at night. All of my existing pimples AND blackheads are becoming non existent. My skin hasn't been this clear in years. Along with Epiduo, I drink a lot of water daily, and I use Cetaphil as a moisturizer. You MUST moisturize with a lotion such as this so your pores don't get clogged. Yes, burning and dried out skin will occur because of how strong this product is. Do not over use it and if your skin burns too much and gets too red, stop using it for a day or so and then begin again but maybe use less. Don't forget moisturizing is so important, as well as exfoliating. I use an apricot scrub from CVS every 3 days. Thank you Epiduo!! And good luck to the rest of you users.
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.