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19 hours ago, hatetane said:Just posting this again as so many Vit D defficient.
Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.) Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.
I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.
So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.
On 1/6/2017 at 4:28 PM, MrErdem said:After checking my testicles by other urologist and everything seems fine, my endocrinologist said I dont need hormone replacement therapy. After I insisted that I had the all side effects of high estrogen, she gave me Nebido Testo Injection (single injection for 3 months). Anybody has any experience with Nebido? I doubt that this will help, as Testo will be aromatised to estrogen.
I found it interesting your TSH is .75 which here in the U.S. the standard from the American College of Endo would consider you either hyper or borderline hyper thyroid. There standard for a normal thyroid is between 2.0-3.0. However, labs are not mandated to update their values here. Go figure. It wouldn't surprise me though I can't remember all your symptoms if this might be the reason too for high Estrogen, Low T and a few other issues. I developed Graves/Hyper shortly after my course. My values were in the .52 and I was recently at .75 and they did some adjustments.
3 hours ago, ACCUiTy_drANE said:Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.) Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.
So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.
Do you attribute low Vit D due to Accutane or are you just someone who genetically has issues with D levels?
I know no one knows but why are we potentially deficient in Vit D post tane??
Too much Vit A in liver/body correct??
4 hours ago, TrueJustice said:Do you attribute low Vit D due to Accutane or are you just someone who genetically has issues with D levels?I know no one knows but why are we potentially deficient in Vit D post tane??
Too much Vit A in liver/body correct??
5AR inhibition is linked with low VD3 very often.
On 1/11/2017 at 12:47 PM, ACCUiTy_drANE said:Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.) Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.
I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.
So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.
All you just wrote is absolutely correct. For the best diet to control inflammation, my best suggestion is to buy the Bulletproof Diet book. Dave Asprey is absolutely anal on avoiding inflammation at all cost. Alternatively, most content is available in posts on his website for free. If you seek the perfect diet for inflammation, that would be it. It discusses vit D, how to properly cook meat and veggies to avoid inflammation, cancerous components and degradation of nutrients, and adresses mercury in fish (and fish oil). Take Krill oil. For ALA, don't even look at it. Non-animal o3 is poorly converted and likely rancid by the time you eat it.
I wouldn't worry about genes affecting your diet this much. I've looked it all up and maybe you deal with fats a little bit less well than some people, but the benefits from eating fat beat the cons, no matter your genes. In my case, I supposedly handle sulfur and ammonia poorly, but if I try to avoid that.. I'll eat nothing healthy.
If you do take 10k IU vit D a day, which is fine temporarily, just make sure you get your levels tested after ~3 months to see where you're at. You don't want to overdo it.
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https://blog.bulletproof.com/bulletproof-your-sleep-with-vitamin-d/
http://www.marksdailyapple.com/is-it-primal-chia-seeds-black-rice-refined-avocado-oil-and-other-foods-scrutinized/
On 1/9/2017 at 8:28 PM, Weltschmerz47 said:hey man, effexor is many many times more likely to cause suicidal tendencies than accutane. and if you're worried about anhedonia, why are you taking something that causes it?are you sure accutane caused your issues?
no disrespect intended, i genuinely would like an explanation
i was on cymbalta a few years ago, which is almost exactly like effexor, and i would almost rather take a very low dose of accutane again than go on cymbalta/effexor. makes u depressed, apathetic, suicidal, and has horrible withdrawal. i wouldnt touch that stuff if i were u
how the hell do I get off of it then? I'm stuck in a spot where I'm kinda forced on it right now. Do I lie my way out? BTW, I feel more suicidal OFF the medicine than on.
3 hours ago, ehohel said:I'm taking an AI which is a lot more powerful PCT treatment to restart HPTA.
Usually AIs arent used for restart? Which AI are you taking?
My issue is normal E, but low-normal T and low-normal cortisol. Ive been on TRT with gel (minor response) , hcg (moderate response) but never clomid. Still a bit scared to take it...its like jumping into another world of unknown.
1 hour ago, Mike San said:Usually AIs arent used for restart? Which AI are you taking?
My issue is normal E, but low-normal T and low-normal cortisol. Ive been on TRT with gel (minor response) , hcg (moderate response) but never clomid. Still a bit scared to take it...its like jumping into another world of unknown.
https://forums.t-nation.com/t/hpta-restart-protocol/196904
its debated on what to use for hpta protocols depending on your certain blood levels. I'm also in the same boat as you my e was only 37 so perhaps nuking it with anastrozole isn't the best idea and i should've done clomid. But I'm having pretty great results right now. I'm going to get off anastrozole next week and see how things go.
ehhhh.. don't compare AIs to SERMs... their only similarity it that both relate to estrogen.. be careful
Sustain Alpha resulted in a 100% recoveryfor me. However, it was not permanent. About 3 weeks into using 1 pump a day I developed gyno, and ed came back, as well as fatigue, weird bowel movements, etc. This is absurd - there's an AI in sustain alpha. my reaction to sustain alpha speaks VOLUMES about how it issurely our hormones that are messed up.
obviously our hormones are messed up because retinoic acid etc plays a huge role in fertility and such. however, approaching that angle will never fix us.
instead, we must restore our bodies to hormonal homeostasis (i.e., homeostasis PRIOR to taking accutane).
My next step is to try proviron. many guys have taken this and feel completely better. this is true for both accutane and propecia. however, it obviously isn't a permanent solution. i figure i do need to get some dht into my penile tissue, though, (been deprived so long) so a few days of proviron is probably good for me, if anything. who knows in long term. cannot hurt - i made sure
HOWEVER, and MORE IMPORTANTLY, if i react to proviron like i did to the first couple weeks of sustain alpha (i.e., complete remission of this syndrome), then I can absolutely confirm that only a hormonal approach will work.
my plan after that will be similar to cdnuts. I will additionally take a large amount of an indica-based edible every night before bed, and continue weight training 3 hours a day, and continue not drinking more than 8 drinks or so on any one night.
*keep in mind that bpsnutrition epidrone is the same as the androhard that propecia recoverers used in their protocol.
here it is (not determined dosages and such.. just doing the science)
3 weeks clomid (doing this to get rid of gyno.. i already had developed some like a year ago when i finished accutane too, so i figure this may help with that too as its fairly recent onset).
1 week break
1 month proviron cycle
2 week nolva pct (20/10) + sustain alpha
1 month cycling 7 cdnuts top herbs
1 week nolva pct (10) -- to reset HPTA
1 month androhard
2 week nolva pct (20/10) + sustain alpha
1 month cycling 7 cdnuts top herbs
1 week nolva pct (10) -- to reset HPTA
repeat after clomid
i think that as long as we continue shocking the dht, but not causing any permanent loss of natural production via proper PCT and timing, it will eventually return to where it should be. HOWEVER, EVEN IF IT DOES NOT, THIS CYCLE WILL WORK FOR SURE. it will completely alleviate symptoms as long as it is continued, in my opinion. ive spent this entire week doing research and i just wanted to show u guys what i came up with.
So I tried the Anastrazole for some day and it made me aggressive as fuck.
Very short temper and a bit angry. Normally at my work I was the mediator in HR problems and those days I was the initiator of HR problems, holy shit.
I'm currently on I3C and DIM, both give me less brain fog and more energy so i'll continue those.
Also still doing some VIT D shots once every other day. Its the only thing that makes my nails and hair grow.
I'm interested in Anastrazole but it also makes me more tired and edgy so'll see if I react better on clomid.
Proviron
/topic/313556-accutane-side-effects-cured/?do=embed">
11 minutes ago, Walden Rev said:So I tried the Anastrazole for some day and it made me aggressive as fuck.
Very short temper and a bit angry. Normally at my work I was the mediator in HR problems and those days I was the initiator of HR problems, holy shit.I'm currently on I3C and DIM, both give me less brain fog and more energy so i'll continue those.
Also still doing some VIT D shots once every other day. Its the only thing that makes my nails and hair grow.I'm interested in Anastrazole but it also makes me more tired and edgy so'll see if I react better on clomid.
Proviron
/topic/313556-accutane-side-effects-cured/?do=embed">
Cool, what dose were you taking? I received nothing but positive results from anastrozole. (Except joint pain after I nuked estrogen for the first 2 weeks at 1mg ED). Best of luck on clomid.
I truly think that 99% of our problems will go away if we could have success with a HTPA restart. Our bodies just really love our CURRENT homeostasis, not our old one.
I've been experimenting with DHT with Creatine for the past 3 weeks. No effect whatsoever. I finally received Butea and took doses up to 1200mg a day. Increased libido and strength I believe, but my face skin is more dry than ever before. I thought more DHT would increase sebum production. In any case, I'll continue experimenting with DHT.. but I don't think it's the cure.
I'm still debating which AI/SERM to try.
1 hour ago, Kynarr said:I've been experimenting with DHT with Creatine for the past 3 weeks. No effect whatsoever. I finally received Butea and took doses up to 1200mg a day. Increased libido and strength I believe, but my face skin is more dry than ever before. I thought more DHT would increase sebum production. In any case, I'll continue experimenting with DHT.. but I don't think it's the cure.
I'm still debating which AI/SERM to try.
With anastrozole I've gotten extremely oily/greasy and acne is coming back full force. 
7 hours ago, ehohel said:Cool, what dose were you taking? I received nothing but positive results from anastrozole. (Except joint pain after I nuked estrogen for the first 2 weeks at 1mg ED). Best of luck on clomid.I truly think that 99% of our problems will go away if we could have success with a HTPA restart. Our bodies just really love our CURRENT homeostasis, not our old one.
Might be worth supplementing with the suggested things in the phase 2 section of this restart (seeing as you're basically finishing phase 1) when you come off the Anastrozole
http://increasemyt.com/hpta-restart/
Active B vit complex, active B12, D3, vit E, DHEA, pregnenolone etc
I tried 5g Creatine for a month or so as well, no effect at all, but in combination with my binge drinking on weekends ended up severely damaging my pancreas. My creatinine levels are already at the veryupper scale (12-14.5) so supplementing makes little sense. And I re-iterate that for everything, if you have a proven deficiency, address it, if not, then good luck trying to convince a doctor why one should take the time totreat it.
2 hours ago, tanedout said:Might be worth supplementing with the suggested things in the phase 2 section of this restart (seeing as you're basically finishing phase 1) when you come off the Anastrozolehttp://increasemyt.com/hpta-restart/
Active B vit complex, active B12, D3, vit E, DHEA, pregnenolone etc
I take all of that except the DHEA andPregnenolone. I've tried the preg, but never noticed it do anything so I tossed it. I might give DHEA a try, that could be good for me. Probably good in the testes department, this whole entire week my balls have been non stop tingling (the good kind of tingling) throughout the day(s).
17 hours ago, Weltschmerz47 said:ehhhh.. don't compare AIs to SERMs... their only similarity it that both relate to estrogen.. be careful
Not really comparing them to each other, just that they are both puzzle pieces to PCT. I chose anastrozole based on someones success with it for PFS. Glad sustain alpha did good for you, I talked to someone through PM who also tried it and had no luck with it unfortunately.
Hello, new here but have struggled with accutane side effects for a long time. Im 23.. i want out of the situation and my personality back but its unrealistic to think i will be able to get back those teenage years (took it at 16)and by the way i took 60 mgs a day for 6 months..... there is no doubt this stuff shuts down more than sebaceous glands.
Anyway i think that testosterone and HCG might be good for us and that you guys are onto something at this point! I mean testosterone (androgen) gets oil going again and seems to help with mental clarity and a healthy lifestyle. I wonder if by any chance it could stimulate our adrenalin and thyroid glands and stuff that have probably been shrunken up from Accutane. (I seriously almost envision how retinoic acid works at this point, just stopping production of any gland in the body) I mean ive been reading this thread for years now and tried everything basically from the original posts like taking garlic capsules, b complexes, and milk thistle. Nothing actually seems to fix the damage. So I figured after years of trying different small crap and still live in this CRAPPY state, and that there is nothing to lose I would try testosterone injections from a local clinic. Its been about 4 months now of TRT
- 200mg test cypionate injection once a week. If I had it my way I would do an even larger dose of Test Cypionate.
- .5mg anastrozole once a week (day after shot)
- HCG injection (to signal testicals not to shut down) I havent memorized the schedule of HCG shots, but its just a basic TRT treatment i think HCG shot isevery month or two,
- Since starting I have also tried taking novladex (SERM for breast cancer) but I dont want to add too much too the puzzle so I am not taking that unless I develop bad gyno (again).
- Working 50 hour weeks, waking up at 3am
- Eating almost perfectly with no soy, preservatives, or processing to foods, eating a lot of carrots, greens, and a TON of fruit for about 3 years now. Tried dairy (Raw milk though), cut it back out to no dairy.
- Using THC from time to time.
Ive been following this thread for a while, I took accutane 3x over span of about 4 years, if i remember correctly 60mg a day. Have long term effects such as dry lips and skin, made my hair go curly and recede faster (so i stupidly went on finasteride, which had ED side effects) and have long term back pain, of which I attribute some to accutane at least.
I also think its affected recovery ability as i had to have shoulder surgery and get too many injuries, which most people would recover easily but we dont.
I'm glad people are now finally talking about real drugs, as supplements wont really cut it to reverse something so strong as accutane. I went on peptides for a short time, and even though it wasn't a good batch, had the best sleep of my life, and i think helped, but cant be sure.
Has anyone tried the various peptides out there, or pure HGH, with any success? Theoretically it should be a winner, naturally getting your body to start repairing and looking after itself. I might try it again but I have to wait about 6m before i can do a good run at it.
For people with back pain (almost everyone now) they used test and HGH localized, plus therapy, to get good results in 12m time. https://www.ncbi.nlm.nih.gov/pubmed/26203272 this stuff causes miracles to happen, hopefully someone here has had some good effects too!
11 hours ago, ehohel said:I take all of that except the DHEA andPregnenolone. I've tried the preg, but never noticed it do anything so I tossed it. I might give DHEA a try, that could be good for me. Probably good in the testes department, this whole entire week my balls have been non stop tingling (the good kind of tingling) throughout the day(s). Not really comparing them to each other, just that they are both puzzle pieces to PCT. I chose anastrozole based on someones success with it for PFS. Glad sustain alpha did good for you, I talked to someone through PM who also tried it and had no luck with it unfortunately.
increasemy T looks good. Have they ever helped PFS.
estrogen is seriously affected by accutane. You should not mess with it unless you have medical supervision and bloods are scrutinised.
Can anyone explain very low E but Gyno - has anyone got anyliterature expaing low E?
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Anyone else had their appendix out?!..
QuoteThe appendix, notorious for its tendency to become inflamed or even rupture, has historically been viewed as a vestigial organ with no real function. But new research supports the idea that the appendix may indeed serve a purpose: to protect beneficial bacteria living in the gut.
Had mine removed when I was 7! Maybe a factor why my gut bacteria isn't in great shape (as confirmed by gastrointestinal tests), and could be a reason why I was susceptible to suffering persistent sides from tane. Gut health, hormone balance, methylation - all interlinked.
On 1/14/2017 at 9:44 PM, tanedout said:[Edited link out]
Anyone else had their appendix out?!..
Had mine removed when I was 7! Maybe a factor why my gut bacteria isn't in great shape (as confirmed by gastrointestinal tests), and could be a reason why I was susceptible to suffering persistent sides from tane. Gut health, hormone balance, methylation - all interlinked.
No but my gallbladder has been removed.