On 03/01/2017 at 0:47 PM, TrueJustice said:

Thx MoreTwine but I need more detail pls, post the links to those who've had success using the 2 antibiotics you mentioned on treating the gut specifically!!

Also, if you know how a doctor/specialist knows how to look in detail at ones specific gut health pls let me know????

Sure enough they can do a castroscopy to check for disease etc which I had done back in June - nothing sinister BUT tell me how the can test your flora and gut lining???? To my knowledge they can't be that specific!?

I do know that with "Iridology" they can tell if your gut health is good or bad but again they can't conclude what/if you need antibiotics and which ones!!??

So if you know of any "Gut Health" test that we're unaware of pls let us know.....

cheers.

Hi TrueJustice, that link I pasted is the only info I came across on supposed antibiotic cure stories. I don't know of any tests specifically for the gut, I just thought that the topic seemed valid based on the link I had read. If I do end up trying antibiotics I will let the forum know; likewise if anyone else has a result it would be great to know.

On 1/6/2017 at 3:01 AM, Kynarr said:

I had never looked up the propheciahelp website as I thought it may not give me accurate information seeing as I didn't take Finasteride, but reading this right now today.. this is exactly in line with my conclusions from 6 months of experiment. I'm going to keep working on this.

[Edited link out]

I am always cautious about any recoveries I hear about - only because they seem so rare.
However this guy English says he recovered by mostly diet, exercise, some supplements and positive thinking.
It was good to hear he had a child on the way.
curious how when a guy on the propecia forum claims a recovery he gets told by some others that he probably didn't have PFS!!!
Anyway, I though I would give you the link - let me know what you think.
http://www.propeciahelp.com/forum/viewtopic.php?f=3&t=9684&sid=403275aef2e0aa8964c9b07e7ba13ff3&start=60

1 hour ago, ACCUiTy_drANE said:

Yeah, I think the mind-gut connection is incredibly interesting. You have probably already read the article themselves, but we have literally cured devastating diseases in mice (e.g,., Parkinson's) by transplanting certain gut bacteria from diseased mice to healthy mice. We can make a mouse obese by transplanting gut bacteria from an overweight mouse a to healthy mouse, even if diet remains the same. If you Google "gut flora, mouse, depression" you'll see similar studies with depression. Depression and cognition are dictated by biological forces just like any other disease, and the role of the microbiome cannot be overstated. The problem is that we don't have equally precise methods of altering microbiome in humans as we do mice. Anything that enhances the immune system probably positively influences the microbiome in some way, and vice versa. That's why I wouldn't immediately write-off anything that ISN'T probiotics/prebiotics/dietary. And that's why LDN appeals to me.

That being said, if you want the best shot of healing of your gut, I think it would be smart to eliminate all of the following: Grains, processed sugars, nightshades, and lectin. Furthermore, total carbohydrate intake should probably be no higher than 100-150 grams, regardless of the source. I recently read many studies that suggest all of the aforementioned foods can increase inflammation. Even non-gluten grains can aggravate inflammation/allergies, because the immune system sucks at differentiating similar-looking proteins once the sensitivity is acquired! Unfortunately, I haven't yet mustered the willpower to implement such a strict diet.

All good info that I agree with but it's the long way of working on a cure via diet when we could possibly benefit from taking the correct antibiotic yeah??

Im willing to push the gut issue again this year. It just screams "foundation" to me and whilst other supplements/drugs are providing relief including LDN I'm of the opinion that the gut still needs to be cleaned up for lasting quality of health!!!

I had my hopes on the DHT theory...all the science/reasoning was there, but my DHT came back smack in the middle of the range. Sometimes knowing where not to invest time can be just as helpful I guess.

1 hour ago, mikez said:

I had my hopes on the DHT theory...all the science/reasoning was there, but my DHT came back smack in the middle of the range. Sometimes knowing where not to invest time can be just as helpful I guess.

I'll settle the DHT debate for myself. I've been loading Creatine for the past week and will keep at it for at least a month. I've also received my Butea (finally) yesterday and just started taking some. All that'd be left is to order some Boron. I'll be shooting up my DHT (In theory) and see how I feel. As of today, nothing feels different, but I definitely don't feel worse. I'm not placing much hope on this though.

@ACCUiTy_drANEI've been following a very strict Paleo/Bulletproof diet. I definitely feel better the stricter I am, and I feel the pain from excess sugar, grains and polyunsaturated/rancid oils very quickly. In spite of this, this has not been the solution for me. It helps me not feel completely miserable, but it does not solve anything.

@hatetaneI wish I could recover this way, but I think it would have happened by now. Might sound weird, but I too would be skeptic of anyone claiming all their tane sides were cured by simply living healthily. Then again, everyon's body is different, but this feels far too grave to be fixed this *easily*. I wish. I really do, but the tremendous amounts of efforts that I put into diet, workouts, low-stress, supplements... the hours, the money, the energy spent.. all that for not much. I acquire knowledge, I get smarter, but am I physically better than 3 years back? A bit, but barely so. Certainly not sufficiently.

@TrueJusticeI agree that gut health plays a big part in this. This is a very significant issue for me. I feel bloated as I'm typing this, yet I haven't had food in over 12 hours. It's odd, and never goes away. What I've yet to grasp is how might hormones affect gut health, assuming it's all hormone related.

On 29.12.2016 at 9:59 PM, MrErdem said:

Ok these are my results. Estradiol is high and explains most of my problems. 

Summary after 3 years: Low testo, high estrogen..
 

After checking my testicles by other urologist and everything seems fine, my endocrinologist said I dont need hormone replacement therapy. After I insisted that I had the all side effects of high estrogen, she gave me Nebido Testo Injection (single injection for 3 months). Anybody has any experience with Nebido? I doubt that this will help, as Testo will be aromatised to estrogen. 

Abstract Recent investigations have shown that bacterial overgrowth of the small intestine is associated with a number of functional somatic disorders, including irritable bowel syndrome (IBS), fibromyalgia, and chronic fatigue syndrome

Expansion of colonic bacteria into the small intestine is often due to intestinal stasis and/ or hypochlorhydria.7 The elderly, in particular, can be susceptible to SIBO due to both a lack of gastric acid8 and the consumption of a disproportionately large number of drugs that can cause hypomotility.9 Symptoms of SIBO can resemble those of irritable bowel syndrome (IBS) and functional dyspepsia (such as bloating, diarrhea, abdominal pain, and constipation),10 and symptoms commonly observed in chronic fatigue syndrome (CFS)11 and fibromyalgia (FM).12 Patients with SIBO can have difficulty with proper absorption of proteins, fats, carbohydrates, and B vitamins and other micronutrients due to bacterial interference.13-16 Excess bacteria can successfully compete for nutrients, produce toxic metabolites, and cause direct injury to enterocytes in the small intestine.2

SIBO may be accompanied by both maldigestion and malabsorption. Bacteria in SIBO might significantly interfere with enzymatic, absorptive and metabolic actions of a macro-organism. Due to injury of the brush-border of enterocytes, the activity of disaccharideses may be decreased. If bacteria simultaneously metabolise fructose, lactose and sorbitol, malabsorption of saccharides may occur. Injured small intestinal mucosa can have undesirable consequences in increased intestinal permeability and/or protein-losing enteropathy. Bacteria may also utilise intraluminal protein in the small bowel, this may lead to protein deficiency for the macro-organism and excessive production of ammonia by bacteria. Deconjugation of bile acids by bacteria results in malabsorption of fat and liposoluble vitamins. Extensively formed lithocholic acid is poorly absorbable and acts enterotoxically

This could be why alot of people mention bloating. alot of people mention acid reflux.The aspirations from the reflux can also create pressure and fullness in the ears, nose and sinuses due to the reflux. and might be what triggers facial flushing due to the inflammation.and possibly cph.(chronic persistent headache)this could also be why alot of people feel better not eating or eating a very restricted diet. or feel better when they take things like magnesium or miralax to help move things along and not stagnate.

Prevalence of Small Intestinal Bacterial Overgrowth in Multiple Sclerosis

Is Rheumatoid Arthritis Caused by Alterations in Gut Bacteria?

Small intestinal bacterial overgrowth in Parkinson's disease.

Eradication of small intestinal bacterial overgrowth decreases symptoms in chronic fatigue syndrome: A double blind, randomized study

READ THIS CHECKLIST> SOUND FAMILIAR? This is what some strange hard to diagnose infection is capable of. They have a very similar story. hundreds of doctors. 1000$s in supplements . until finally they are just told to see a physciatrist . anyone guess what it is?

Head, Face, Neck

• Unexplained hair loss
• Headache, mild or severe, seizures
• Pressure in head, white matter lesions in brain (MRI)
• Twitching of facial or other muscles
• Facial paralysis (Bells Palsy, Horners syndrome)
• Tingling of nose, (tip of) tongue, cheek or facial flushing
• Stiff or painful neck
• Jaw pain or stiffness
• Dental problems
• 10. Sore throat, clearing throat a lot, phlegm (flem), hoarseness, runny nose

Eyes/Vision[Edited link out]

• Double or blurry vision
• Increased floating spots
• Pain in eyes, or swelling around eyes
• Oversensitivity to light
• Flashing lights, peripheral waves or phantom images in corner of eyes

Ears/Hearing

• Decreased hearing in one or both ears, plugged ears
• Buzzing in ears
• Pain in ears, oversensitivity to sounds
• Ringing in one or both ears

Digestive and Excretory Systems

• Diarrhea
• Constipation
• Irritable bladder (trouble starting, stopping) or interstitial cystitis
• Upset stomach (nausea or pain) or GERD (gastroesophageal reflux disease)

Musculoskeletal System

• Bone pain, joint pain or swelling, carpal tunnel syndrome
• Stiffness of joints, back, neck, tennis elbow
• Muscle pain or cramps, (Fibromyalgia)

Respiratory and Circulatory Systems

• Shortness of breath, cant get full/satisfying breath, cough
• Chest pain or rib soreness
• Night sweats or unexplained chills
• Heart palpitations or extra beats
• Endocarditis, heart blockage

Neurologic System

• Tremors or unexplained shaking
• Burning or stabbing sensations in the body
• Fatigue, Chronic Fatigue Syndrome, weakness, peripheral neuropathy or partial paralysis
• Pressure in the head
• Numbness in body, tingling, pinpricks
• Poor balance, dizziness, difficulty walking
• Increased motion sickness
• Light-headedness, wooziness

Psychological Well-being

• Mood swings, irritability, bi-polar disorder
• Unusual depression
• Disorientation (getting or feeling lost)
• Feeling as if you are losing your mind
• Over-emotional reactions, crying easily
• Too much sleep, or insomnia
• Difficulty falling or staying asleep
• Narcolepsy, sleep apnea
• Panic attacks, anxiety

Mental Capability

• Memory loss (short or long term)
• Confusion, difficulty thinking
• Difficulty with concentration or reading
• Going to the wrong place
• Speech difficulty (slurred or slow)
• Difficulty finding commonly used words
• Stammering speech
• Forgetting how to perform simple tasks

Reproduction and Sexuality

• Loss of sex drive
• Sexual dysfunction
• Unexplained menstrual pain, irregularity
• Unexplained breast pain, discharge
• Testicular or pelvic pain

General Well-being

• Phantom smells
• Unexplained weight gain or loss
• Extreme fatigue
• Swollen glands or lymph nodes
• Unexplained fevers (high or low grade)
• Continual infections (sinus, kidney, eye, etc.)
• Symptoms seem to change, come and go
• Pain migrates (moves) to different body parts
• Early on, experienced a flu-like illness, after which you have not since felt well
• Low body temperature
• Allergies or chemical sensitivities
• Increased effect from alcohol and possible worse hangover

3 hours ago, MrErdem said:

After checking my testicles by other urologist and everything seems fine, my endocrinologist said I dont need hormone replacement therapy. After I insisted that I had the all side effects of high estrogen, she gave me Nebido Testo Injection (single injection for 3 months). Anybody has any experience with Nebido? I doubt that this will help, as Testo will be aromatised to estrogen.

Please let me know how you get on - you definitely don't want your E to go higher. Best between 10-30pg/ml
You might want to follow this thread - Legendary
http://www.propeciahelp.com/forum/viewtopic.php?f=3&t=7548&start=160
He had some good results and suggests trying Letrozole if E is high.
He was on clomid as well but is recommending just Letrozole to begin with.

On 1/7/2017 at 9:26 AM, guitarman01 said:

Abstract Recent investigations have shown that bacterial overgrowth of the small intestine is associated with a number of functional somatic disorders, including irritable bowel syndrome (IBS), fibromyalgia, and chronic fatigue syndrome

Expansion of colonic bacteria into the small intestine is often due to intestinal stasis and/ or hypochlorhydria.7 The elderly, in particular, can be susceptible to SIBO due to both a lack of gastric acid8 and the consumption of a disproportionately large number of drugs that can cause hypomotility.9 Symptoms of SIBO can resemble those of irritable bowel syndrome (IBS) and functional dyspepsia (such as bloating, diarrhea, abdominal pain, and constipation),10 and symptoms commonly observed in chronic fatigue syndrome (CFS)11 and fibromyalgia (FM).12 Patients with SIBO can have difficulty with proper absorption of proteins, fats, carbohydrates, and B vitamins and other micronutrients due to bacterial interference.13-16 Excess bacteria can successfully compete for nutrients, produce toxic metabolites, and cause direct injury to enterocytes in the small intestine.2

SIBO may be accompanied by both maldigestion and malabsorption. Bacteria in SIBO might significantly interfere with enzymatic, absorptive and metabolic actions of a macro-organism. Due to injury of the brush-border of enterocytes, the activity of disaccharideses may be decreased. If bacteria simultaneously metabolise fructose, lactose and sorbitol, malabsorption of saccharides may occur. Injured small intestinal mucosa can have undesirable consequences in increased intestinal permeability and/or protein-losing enteropathy. Bacteria may also utilise intraluminal protein in the small bowel, this may lead to protein deficiency for the macro-organism and excessive production of ammonia by bacteria. Deconjugation of bile acids by bacteria results in malabsorption of fat and liposoluble vitamins. Extensively formed lithocholic acid is poorly absorbable and acts enterotoxically

This could be why alot of people mention bloating. alot of people mention acid reflux.The aspirations from the reflux can also create pressure and fullness in the ears, nose and sinuses due to the reflux. and might be what triggers facial flushing due to the inflammation.and possibly cph.(chronic persistent headache)this could also be why alot of people feel better not eating or eating a very restricted diet. or feel better when they take things like magnesium or miralax to help move things along and not stagnate.

Prevalence of Small Intestinal Bacterial Overgrowth in Multiple Sclerosis

Is Rheumatoid Arthritis Caused by Alterations in Gut Bacteria?

Small intestinal bacterial overgrowth in Parkinson's disease.

Eradication of small intestinal bacterial overgrowth decreases symptoms in chronic fatigue syndrome: A double blind, randomized study

READ THIS CHECKLIST> SOUND FAMILIAR? This is what some strange hard to diagnose infection is capable of. They have a very similar story. hundreds of doctors. 1000$s in supplements . until finally they are just told to see a physciatrist . anyone guess what it is?

Head, Face, Neck

• Unexplained hair loss
• Headache, mild or severe, seizures
• Pressure in head, white matter lesions in brain (MRI)
• Twitching of facial or other muscles
• Facial paralysis (Bells Palsy, Horners syndrome)
• Tingling of nose, (tip of) tongue, cheek or facial flushing
• Stiff or painful neck
• Jaw pain or stiffness
• Dental problems
• 10. Sore throat, clearing throat a lot, phlegm (flem), hoarseness, runny nose

Eyes/Vision[Edited link out]

• Double or blurry vision
• Increased floating spots
• Pain in eyes, or swelling around eyes
• Oversensitivity to light
• Flashing lights, peripheral waves or phantom images in corner of eyes

Ears/Hearing

• Decreased hearing in one or both ears, plugged ears
• Buzzing in ears
• Pain in ears, oversensitivity to sounds
• Ringing in one or both ears

Digestive and Excretory Systems

• Diarrhea
• Constipation
• Irritable bladder (trouble starting, stopping) or interstitial cystitis
• Upset stomach (nausea or pain) or GERD (gastroesophageal reflux disease)

Musculoskeletal System

• Bone pain, joint pain or swelling, carpal tunnel syndrome
• Stiffness of joints, back, neck, tennis elbow
• Muscle pain or cramps, (Fibromyalgia)

Respiratory and Circulatory Systems

• Shortness of breath, cant get full/satisfying breath, cough
• Chest pain or rib soreness
• Night sweats or unexplained chills
• Heart palpitations or extra beats
• Endocarditis, heart blockage

Neurologic System

• Tremors or unexplained shaking
• Burning or stabbing sensations in the body
• Fatigue, Chronic Fatigue Syndrome, weakness, peripheral neuropathy or partial paralysis
• Pressure in the head
• Numbness in body, tingling, pinpricks
• Poor balance, dizziness, difficulty walking
• Increased motion sickness
• Light-headedness, wooziness

Psychological Well-being

• Mood swings, irritability, bi-polar disorder
• Unusual depression
• Disorientation (getting or feeling lost)
• Feeling as if you are losing your mind
• Over-emotional reactions, crying easily
• Too much sleep, or insomnia
• Difficulty falling or staying asleep
• Narcolepsy, sleep apnea
• Panic attacks, anxiety

Mental Capability

• Memory loss (short or long term)
• Confusion, difficulty thinking
• Difficulty with concentration or reading
• Going to the wrong place
• Speech difficulty (slurred or slow)
• Difficulty finding commonly used words
• Stammering speech
• Forgetting how to perform simple tasks

Reproduction and Sexuality

• Loss of sex drive
• Sexual dysfunction
• Unexplained menstrual pain, irregularity
• Unexplained breast pain, discharge
• Testicular or pelvic pain

General Well-being

• Phantom smells
• Unexplained weight gain or loss
• Extreme fatigue
• Swollen glands or lymph nodes
• Unexplained fevers (high or low grade)
• Continual infections (sinus, kidney, eye, etc.)
• Symptoms seem to change, come and go
• Pain migrates (moves) to different body parts
• Early on, experienced a flu-like illness, after which you have not since felt well
• Low body temperature
• Allergies or chemical sensitivities
• Increased effect from alcohol and possible worse hangover

 

 

 

 

Ok good post but what's next??

Pariot works for reflux

Rifaximin & Vancomycin don't work

Pribiotics although good arent a cure

Eliminating sugar although good is no cure

Eating fermented foods good

Where to next??

56 minutes ago, hatetane said:

Please let me know how you get on - you definitely don't want your E to go higher. Best between 10-30pg/ml
You might want to follow this thread - Legendary
http://www.propeciahelp.com/forum/viewtopic.php?f=3&t=7548&start=160
He had some good results and suggests trying Letrozole if E is high.
He was on clomid as well but is recommending just Letrozole to begin with.

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

1 hour ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

"Why did calcium d glucarate not work as well as hoped"??

well perhaps like me ( I hoped for more on CDG although I'm still currently taking it ) your gut health is poor!!?

Your thoughts on gut health?

49 minutes ago, TrueJustice said:

Pariot works for reflux

Rifaximin & Vancomycin don't work

Pribiotics although good arent a cure

Eliminating sugar although good is no cure

Eating fermented foods good

Where to next??

I have a few thoughts. some conflicting. first is the acid reflux.excess bloating can be a sign of a few different things ibs, gastritis, sibo. if bloating is causing food to build up and stagnate this would eventually cause a buildup of gas that is going out one way or the other, like burping. the bloating is prob putting alot of pressure on the les valve and that's what could be causing the reflux. if this is happening constantly and severe enough you prob need to be on a ppi to prevent damage to the esophagus. But ppis are a double edged sword because they can contribute to sibo and further slow down digestion. i've mentioned this a few times about that teenage girl that had surgery and lost most of her pancreas due to a high dose of accutane. I wonder if there was any sort of minor pancreatic insufficiency caused by accutane that became chronic in us. pancreatic enzymes along with gastric acid , and motility and are the main things that keep sibo in check. from everything i read, if there was a bacterial overgrowth, probiotics are generally not recommended(more fuel for the fire).

Rifaximin is more for sibo that feature chronic watery stools. i Think most of us have the opposite problem. there is another antibiotic used mainly for constipation. starts with a N. there is sibo that could be resistant to both of these antibiotics btw. and alot of times they say sibo can come back shortly after a course of antibiotics.

Me personally im looking at allicin from garlic, a sweetener called stevia, eccentric coded pancreatic enzymes .this supplement called dysbiocide.
what some of these here have in common is they work where antibiotics have failed. stevia has been compared to triple antibiotic therapy. Allicin has worked on some MRSA resistant supper bugs, and is very broad spectrum and gets into the blood stream.

the reflux though. this could be big as well. hard to tell when its happening. might even happen in your sleep and you not know it. this could put your body in a constant stress/anxiety state. and if its reaching your throat nose and sinuses, this could effect your quality of sleep and energy level the following day. and all that inflammation could def mess with your concentration/brain fog. how they treat that is a daily ppi and 150 zantac or pepcid complete at night. sometimes even a ppi twice daily. have to wait up to 6 months for results. healing takes much longer past the esophagus. ramble ramble ramble. I should have been a doctor. i mEAN IN MY DO OVER LIFE.

41 minutes ago, guitarman01 said:

I have a few thoughts. some conflicting. first is the acid reflux.excess bloating can be a sign of a few different things ibs, gastritis, sibo. if bloating is causing food to build up and stagnate this would eventually cause a buildup of gas that is going out one way or the other, like burping. the bloating is prob putting alot of pressure on the les valve and that's what could be causing the reflux. if this is happening constantly and severe enough you prob need to be on a ppi to prevent damage to the esophagus. But ppis are a double edged sword because they can contribute to sibo and further slow down digestion. i've mentioned this a few times about that teenage girl that had surgery and lost most of her pancreas due to a high dose of accutane. I wonder if there was any sort of minor pancreatic insufficiency caused by accutane that became chronic in us. pancreatic enzymes along with gastric acid , and motility and are the main things that keep sibo in check. from everything i read, if there was a bacterial overgrowth, probiotics are generally not recommended(more fuel for the fire).

Rifaximin is more for sibo that feature chronic watery stools. i Think most of us have the opposite problem. there is another antibiotic used mainly for constipation. starts with a N. there is sibo that could be resistant to both of these antibiotics btw. and alot of times they say sibo can come back shortly after a course of antibiotics.

Me personally im looking at allicin from garlic, a sweetener called stevia, eccentric coded pancreatic enzymes .this supplement called dysbiocide.
what some of these here have in common is they work where antibiotics have failed. stevia has been compared to triple antibiotic therapy. Allicin has worked on some MRSA resistant supper bugs, and is very broad spectrum and gets into the blood stream.

the reflux though. this could be big as well. hard to tell when its happening. might even happen in your sleep and you not know it. this could put your body in a constant stress/anxiety state. and if its reaching your throat nose and sinuses, this could effect your quality of sleep and energy level the following day. and all that inflammation could def mess with your concentration/brain fog. how they treat that is a daily ppi and 150 zantac or pepcid complete at night. sometimes even a ppi twice daily. have to wait up to 6 months for results. healing takes much longer past the esophagus. ramble ramble ramble. I should have been a doctor. i mEAN IN MY DO OVER LIFE.

My specialist put me on Paroit for my reflux- definitely does the trick but I must now watch magnesium lvls.

Still it's not the cure for great gut health, it only prevents my reflux. What about Metronizadole & Parmomycin??

Let me work backwards here and ask "why shouldn't we be taking these antibiotics"?

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

For mostEndos , it seems any discussion of the latest research on sexual hormones is 'complex' and foreign to them. Diabetes is their ticket. We would have little to zero luck going to them. We need to seek out 'Andrologists' or 'Anti ageing' general practitioners. Even with these, it can be frustrating as to the gross lack of some basic knowledge.

21 hours ago, mikez said:

I had my hopes on the DHT theory...all the science/reasoning was there, but my DHT came back smack in the middle of the range. Sometimes knowing where not to invest time can be just as helpful I guess.

I'm the same, my DHT is high. How do you respond to DHT inhibitors like zinc? I'm better for eating loads of pumpkin seeds which are a natural DHT inhibitor.

I've recently tried to lower E2 by using sustain alpha, but it doesn't help me at all. I just got progressively weaker morning glory, and started to feel low e2 sides like increasing anxiety, I was getting bad fatigue and was generally starting to feel pretty shit. I've stopped using it, and now those things are improving again. Others however are seeing good benefits from this stuff.

What were your other results from your hormone panel?

On 1/5/2017 at 9:45 PM, TrueJustice said:

All good info that I agree with but it's the long way of working on a cure via diet when we could possibly benefit from taking the correct antibiotic yeah??

I'm of the opinion that the gut still needs to be cleaned up for lasting quality of health!!!

My final point on the gut issue is this: We know antibiotics destroy microbiome diversity. All of us here were on Accutane from the start, and likely preceded that medication with an antibiotic(s). Therefore, throwing a third or fourth microbiome-destroying agent in the mix seems like a high-risk idea. It's one thing if you are doing so under the supervision of a medical professional who knows of some protocol for building gut flora back up, but as far as I know, we know of no ironclad methods in humans. Antibiotics are associated with all sorts of issues, so unless something substantial is in place following the antibiotics, I wouldn't take any (assuming no apparent infection or other proven gut issue). We can't reverse autoimmune/mental/degenerative conditions by manipulating bacteria like we can in animals. Fecal transplants are a great step, but they aren't even a guarantee. The best we can do is eat fermented foods, probiotics, avoid grains, limit carbs, and eat a balanced diet. I'm not saying it will cure you, but it's the best we got. Feel free to prove me wrong on the risk of antibiotics.

@Kynarr, I certainly wouldn't be surprised if it took more than diet to recover from this mess, even if you were strict 100% of the time. But if one wanted to focus on gut health, I think that diet is a great start.

All good info ACCUiTy - you always provide good info.

I know antibiotics can destroy gut flora - the very thing we're trying to fix. I would hate to find out though one day that Accutane smashed our gut flora and led to some type of infection and all we had to do was take the right antibiotic to fix it, that's my concern!!

I will say this in regard to diet, to those who've worked hard at eliminating this and that only to feel little improvement, when diet is really poor ie too much sugar and crap food I feel like absolute hell so I would say that a good diet would at the very least boost ones self esteem and psychologically give you a lift, that's a lot when you're trying work and compete in this world so don't beat yourself up too much with trying to work on diet.

A good diet, exercise and reasonable amount of sleep can sustain one for a long time while we chip away at all these other problems!!

Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug. I nearly committed suicide over this in September and was in a psych ward for 5 weeks (I might have mentioned that here) and things have only gotten worse. I probably would have killed myself if it wasn't for the high dose of Effexor I am on now, but that only lessens suicidal urges by making you feel good and probably messes with my head even more. I've tried nsi 189 but I doubt that's done anything at all.

5 hours ago, cnb30 said:

Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug.

That aside, you can always get creative with conventional treatments. Personally, I stay far away from SSRIs, as sustained use can limit burst activity and overall firing rate of dopamine. In my experience, SSRIs can make emotional blunting worse. You can combine an SSRI with another drug (5HT2c antagonist/inverse agonist) to diminish the anti-dopaminergic effect of the SSRIs (e.g., Sertraline/Zoloft + Nortriptyline), but it's obviously a risk. Consult a doctor.

I spoke to highly respected psychiatrist on this matter, named Dr. Gillman. I like him because he is blatantly honest that 1) many doctors have no ****ing idea how to treat depression 2) the market is littered with ineffective drugs due to corporate games 3) the measures studies use to determine the so-called "anti-depressant" potency of a compound are inherently flawed, because are largely based on irrelevant properties like the anti-anxiety or hypnotic properties of a drug! WHAT?! Point number 3 explains why many mainstream antidepressants SUCK at treating anhedonia. Many antidepressants are actually sleep-aids, anti-anxiety meds, or even antihistamines, lol. A faulty model breeds faulty medications, never mind the issue of feigned/concealed clinical trials. That being said, Dr. Gillman is a big proponent of irreversible MAOIs (e.g., Parnate, Nardil). They simply work well. If you want a fresh perspective on treating depression (in the context of pharmaceuticals), feel free to read his articles on Psychotropical.com.
 

5 hours ago, cnb30 said:

I probably would have killed myself if it wasn't for the high dose of Effexor I am on now,

I am happy to hear it has done you any good at all. According to Dr. Gillman, Clomipramine is a significantly more potent SNRI. He says many of his patients who have tried both Clomipramine and Effexor (Venlafaxine) prefer Clomipramine . Unfortunately, it isn't prescribed as much anymore because it is off-patent. Money rules.

These are just thoughts I'm sharing since you asked. This is not medical advice.

So correct me if I'm wrong but the biggest side effect to look out for when taking Roaccutane is Depression right?? emotional blunting, lack of drive ect etc - It's all depression. So my question is, how does it cause this depression???

Is it due to wreaking havoc on the gut? thus interfering with serotonin production? Or does it disrupt receptors in brain that control dopamine & serotonin and have nothing to do with the gut?

No one has ever explained how accutane causes depression?? the jury's still out as far as I'm concerned as to whether it's a gut problem or brain receptor problem, I just don't know....

Similarly - how did I get all these eye floaters that I've now had for nearly 20 years? What the hell caused them?

On 26.8.2016 at 4:25 PM, john86 said:

The most obvious and intrusive physical sensations in my case are:
1) This constant feeling of muscular tension all over my body, and especially in my head, face, mouth, and throat...Overall, it feels like my muscles are always "locked up" and my body is never relaxed like it could be before Accutane.

[...]

Does anyone else have anything like this?

Hi to all.

My muscles are feeling tensed all the time too, especially my calfs hurt. I developed Plantar Fasciitis and my archilles tendons hurt, I can't walk without ache anymore.
I have been trying now for 4 years to fix the problem with lots of therapies and visited doctors but nobody could give me an answer why I have this problem. Then I found this post and made the possible connection to Roaccutan.

I took Roaccutan 15 years ago for about 11 months (30 mg/60 kg), together with cortison (5 months).

- what did Roa damage in my body? The muscles, tendons, nerves or something in my brain?
- is it reversible?
- which possibilities do I have to fix it?
- @john86 did you find something that helped you?

Thanks a lot for every reply.

Mat

Hello,

I finish a long consolidation within the framework of an acute promyelocytic leukemia , blood disease in which the retinoic acid plays a fundamental role with regard to not only remission but also cure (in conjunction with arsenic trioxide). Did I want simply to know if somebody in this forum could explain me if there exist differences between isotretinoin (molecule of the accutane) and tretinoin (molecule of the vesanoid)? Being given the scarcity of my leukemia one almost does not speak about this drug. I recognized myself in certain side-effects quoted here and others not. It is true that in my case, it is initially more urgent to fight to remain in life than to trouble about side-effects. Lastly, if somebody can provide me explanations or a link towards a particular site Thank you!

PS : sorry for my bad English 🙁

On 1/10/2017 at 6:05 AM, belgianboy1830 said:

Hello,

I finish a long consolidation within the framework of an acute promyelocytic leukemia , blood disease in which the retinoic acid plays a fundamental role with regard to not only remission but also cure (in conjunction with arsenic trioxide). Did I want simply to know if somebody in this forum could explain me if there exist differences between isotretinoin (molecule of the accutane) and tretinoin (molecule of the vesanoid)? Being given the scarcity of my leukemia one almost does not speak about this drug. I recognized myself in certain side-effects quoted here and others not. It is true that in my case, it is initially more urgent to fight to remain in life than to trouble about side-effects. Lastly, if somebody can provide me explanations or a link towards a particular site Thank you!

PS : sorry for my bad English 🙁

Sorry, unable to advise but good luck.

Increase T:

[Edited link out]

An interesting test.
[Edited link out]

On 1/8/2017 at 6:29 PM, cnb30 said:

Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug. I nearly committed suicide over this in September and was in a psych ward for 5 weeks (I might have mentioned that here) and things have only gotten worse. I probably would have killed myself if it wasn't for the high dose of Effexor I am on now, but that only lessens suicidal urges by making you feel good and probably messes with my head even more. I've tried nsi 189 but I doubt that's done anything at all.

hey man, effexor is many many times more likely to cause suicidal tendencies than accutane. and if you're worried about anhedonia, why are you taking something that causes it?

are you sure accutane caused your issues?

no disrespect intended, i genuinely would like an explanation

i was on cymbalta a few years ago, which is almost exactly like effexor, and i would almost rather take a very low dose of accutane again than go on cymbalta/effexor. makes u depressed, apathetic, suicidal, and has horrible withdrawal. i wouldnt touch that stuff if i were u

https://www.suicideforum.com/community/threads/effexor-highest-suicide-rate-medication-fda-says.28133/