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Everyone has tried zinc. How about zinc carnosine?
Oral zinc therapy for zinc deficiency-related telogen effluvium.
Abstract
Zinc is crucial for maintaining human body homeostasis and is one of the major components of hormones, signal molecules, and enzymes. Zinc deficiency is caused by insufficient uptake of zinc from food, or caused by malabsorption syndromes, increased gastrointestinal and urinary losses, and administration of various medications. In order to test whether oral zinc administration can successfully improve zinc deficiency-related alopecia, we treated five patients with zinc deficiency-related telogen effluvium with oral zinc administration in the form of polaprezinc (Promac). In all patients, hair loss was cured or improved. The administration of zinc for zinc deficiency-related alopecia may recover appropriate activities of metalloenzymes, hedgehog signaling, and immunomodulation, all of which are required for normal control of hair growth cycle.
11 hours ago, tanedout said:Anyone ever tried a high dose of methylfolate?! (i.e. the active form, specifically not regular 'folate' like the type found in many cheap supplements. I'm starting on 'Freddds' Active B12 protocol currently (only a week into slowly starting the sups), but I've tended to in the past have brief periods of improvements when taking thing like 'Now Choline & Inositol', but the improvements are never consistent, and it almost feels like I'm running out of something that's important for a process involved. Reading the Active B12 protocol here would seem to potentially tie in a few things, which is why I'm giving it a go. It's also yielded good results for CFS suffers whose condition appears related to ours in terms of underlying mechanisms and some side effects (methylation is without doubt affected).
This got me reading some interesting stuff on PhoenixRising from the late Rich Van K, whose probably one of the cleverest and best qualified people to give their take on accutanes mechanism and side effects. Regarding asking if anyone has a tried a high dose of methylfolate, see below;
Has anyone tried Boron?
Googlepropecia, boron!
There is lots of information coming out this thread. Thanks everyone. I will have to take a look when I have a chance.
But I recently got a blood test result that shocked me. Has anyone got their cholesterol checked?!
As I'm sure this has been brought up before, cholesterol assists in converting Vitamin D, keeping brain cells healthy, and producing hormones. My total cholesterol was UNDETECTABLE, meaning it was under 100. My LDL ("bad cholesterol") was also UNDETECTABLE, which is problematic because the body needs a certain level of this as well.
I already eat organic eggs, coconut oil, and whole milk (kefir) daily, so this was very odd. Many experts are now saying that it is permissible for total cholesterol to hover around 200 (previously seen as dangerous) because it is the ratio of HDL and LDL that matters most. But being as low as I am is associated with depression, cognitive impairments, and violence. (I do NOT have violent tendencies, but I have severe apathy and cognitive problems.)
Any recommendations on where to go from here? Personal experiences? I think the best thing I can do is see an endocrinologist and request more testing. My testosterone has always been on the low side too.
Hey guys, quick question: anybody get a fungal rash under their armpits after being on antibiotics? What's the best OTC cream and should I get flagyl from a doctor? I'm going to take garlic tabs do I need a prescription?
25 minutes ago, ACCUiTy_drANE said:There is lots of information coming out this thread. Thanks everyone. I will have to take a look when I have a chance.
But I recently got a blood test result that shocked me. Has anyone got their cholesterol checked?!
As I'm sure this has been brought up before, cholesterol assists in converting Vitamin D, keeping brain cells healthy, and producing hormones. My total cholesterol was UNDETECTABLE, meaning it was under 100. My LDL ("bad cholesterol") was also UNDETECTABLE, which is problematic because the body needs a certain level of this as well.
I already eat organic eggs, coconut oil, and whole milk (kefir) daily, so this was very odd. Many experts are now saying that it is permissible for total cholesterol to hover around 200 (previously seen as dangerous) because it is the ratio of HDL and LDL that matters most. But being as low as I am is associated with depression, cognitive impairments, and violence. (I do NOT have violent tendencies, but I have severe apathy and cognitive problems.)
Any recommendations on where to go from here? Personal experiences? I think the best thing I can do is see an endocrinologist and request more testing. My testosterone has always been on the low side too.
no. Honestly, I don't even wanna know...
On 7/24/2016 at 9:31 PM, snarkygirl said:and, that a lot of people taking it are kids (12-18). Kids cannot possibly comprehend weighing the potential side effects, though you could argue a well informed adult might.
Ha! Well-informed adult? impossible. If you go to any dermatologist or doctor that prescribes this drug, you cannot be well-informed about the side effects. If you were, they would not sell a single pill.
This is what these dermatologists are telling their patients about the drug, and it needs to stop.
[Edited link out]
PS. Don't waste your time leaving a comment on this blogbecause it will not be posted.
6 hours ago, ACCUiTy_drANE said:There is lots of information coming out this thread. Thanks everyone. I will have to take a look when I have a chance.
But I recently got a blood test result that shocked me. Has anyone got their cholesterol checked?!
As I'm sure this has been brought up before, cholesterol assists in converting Vitamin D, keeping brain cells healthy, and producing hormones. My total cholesterol was UNDETECTABLE, meaning it was under 100. My LDL ("bad cholesterol") was also UNDETECTABLE, which is problematic because the body needs a certain level of this as well.
I already eat organic eggs, coconut oil, and whole milk (kefir) daily, so this was very odd. Many experts are now saying that it is permissible for total cholesterol to hover around 200 (previously seen as dangerous) because it is the ratio of HDL and LDL that matters most. But being as low as I am is associated with depression, cognitive impairments, and violence. (I do NOT have violent tendencies, but I have severe apathy and cognitive problems.)
Any recommendations on where to go from here? Personal experiences? I think the best thing I can do is see an endocrinologist and request more testing. My testosterone has always been on the low side too.
My cholesterol is also 'undetectable', I also thought this was unusual, and according to the test notes it says "Non-elevated levels indicate adequate fat absorption or a lack of dietary cholesterol".Triglycerides were also undetectable on the same test, which again seems odd. This was from a Genova Diagnostics gastrointestinal test.
Vitamin D is one of the few things I really notice if I stop taking, always take 10,000ui D3 every 2 days.
@ HateTane yes boron has been tried by quite a few people, I've never really noticed much from it and I've taken loads. Some testosterone boosting herbs do clearly work to increase T, but after a while it seems to just raise estrogen and you start getting symptoms of high e. I've also tried estrogen inhibitors (erase pro works well and is herbal), but it only improves things to an extent and isn't a long term option really.
Someone really needs to see if they can get acne.org to sort a sub-form here as this thread just goes in circles as clearly not everyone can spend days reading the whole thing to see if topics have already been covered.
The extract I posted further above from Rich Van K is probably the most interesting thing I've read in a while though.
50 minutes ago, Gladiatoro said:I call these derms COMPLETE liars.
Accutane is gone from the body in 10 days , moreB.S.
I'd probably say that's correct, it's clearly the epigenetic changes that the drug induces which are what causes the persistent side effects.
More here from Rich Van K
You mentioned Roaccutane. I've probably heard from four PWMEs now who had this in their history. In the U.S., it's just called Accutane. I don't know if this is relevant to your case, but it is known that one of the effects of Roaccutane (also called isotretinoin or 13cis-retinoic acid) is to raise the expression of the gene that codes for glycine N-methyltransferase. This enzyme is the "safety valve" that normally prevents the SAMe to SAH ratio from going too high, and it works by taking methyl groups from SAMe and putting them on glycine to form sarcosine. The sarcosine then gives the methyl groups to tetrahydrofolate to form 5,10 methylene tetrahydrofolate, which can then be used to make thymidine for DNA production, or can be used to make methylfolate to drive the methionine synthase reaction.
When Roaccutane raises the activity of glycine N-methyl transferase, the result is that the ratio of SAMe to SAH goes too low, and the person's methylation capacity drops. This affects a large number of reactions in the cells that require methyl groups, and in particular, it affects the methylation of DNA. Methylation in general silences the expression of genes, so if the methylation capacity drops, I think we should expect higher gene expression to occur, which could cause many changes in the biochemistry as more copies of various enzymes and other proteins would be made.
In most people, when treatment with Roaccutane is stopped, the methylation apparently returns to normal. However, I suspect that in some cases, the methylation gets "stuck" in a positive feedback loop, i.e. a vicious circle mechanism, so that the expression of the glycine N-methyl transferase stays high, and the lowered methylation capacity prevents methylation and silencing of the gene expression for this enzyme.
Since methylfolate has the additional property that it downregulates glycine N-methyl transferase at the biochemical level, treatment with high dose methylfolate may be able to break this vicious circle. So far, this is just a hypothesis.
Methylfolate can be purchased over the counter in small doses like this, but you can also get Delpin which is 15mg of methyfolate per capsule.
On 7/30/2016 at 3:40 AM, Gladiatoro said:It says accutane is a naturally occurring body chemical hmmm , I'm pretty sure chemotherapy is NOT a naturally occurring body chemical lol.
I call these derms COMPLETE liars.
Accutane is gone from the body in 10 days , moreB.S.
Hate to play the devil's advocate, but isotretinoin/13-cis-retinoic acid does occur naturally in very small concentrations. (around 1.5ng/dL)
It is produced as a by-product of retinoid metabolism.
On a side-note, I tried leaving a comment refuting some of the one-sided misinformation about the safety profile of Accutane on that dermatologist's blog:
[Edited link out]
and it was blocked.
On 7/25/2016 at 1:59 PM, QuietSoldier said:I stopped taking after about a week. It began to make sexual side effects worse. I'd notice a slight rebound when I hadn't taken a pill in awhile so I just abandoned it.
Thanks for the feedback. Sorry to hear the saw palmetto didn't pan out. Might be for the best that you stopped though. Who knows.
On 7/30/2016 at 5:14 AM, Dubya_B said:On a side-note, I tried leaving a comment refuting some of the one-sided misinformation about the safety profile of Accutane on that dermatologist's blog:
[Edited link out]
and it was blocked.
I tried too. Pretty long and articulate paragraph if I may say so myself. Says 'it will be reviewed'. What a joke of a medical professional.
On 7/30/2016 at 5:14 AM, Dubya_B said:Hate to play the devil's advocate, but isotretinoin/13-cis-retinoic acid does occur naturally in very small concentrations. (around 1.5ng/dL)
[Edited link out]
It is produced as a by-product of retinoid metabolism.
On a side-note, I tried leaving a comment refuting some of the one-sided misinformation about the safety profile of Accutane on that dermatologist's blog:
[Edited link out]
and it was blocked.
If its naturally occurring then what's with all the side effects?
5 hours ago, tanedout said:Someone really needs to see if they can get acne.org to sort a sub-form here as this thread just goes in circles as clearly not everyone can spend days reading the whole thing to see if topics have already been covered.
Sry I still disagree. A new forum would just divide us and balloon into the same thing. You cant control what people are going to say. This is "the" source for long term damage from accutane. The main take away would be that its still a fluid situation and there isnt much reason to look at the back pages. Unless you want to be amused by some of the people and infighting that has appeared on here over the years. Remember that real creepy dude that talked like hannibal lector some years back? What a trip...
5 hours ago, tanedout said:The extract I posted further above from Rich Van K is probably the most interesting thing I've read in a while though.
Thought you were around. I was taking about this for awhile and this person. I thought he was a dr at first. he's not. he's an engineer if i remember.
I tried high dose folate for a bit. hell i prob got 3 different types of folate sitting somewhere right now. I also mentioned Delpin. This is prob one of those circle jerks you mentioned. Your right, it is good to know what people have tried so people dont waste time or money on the same supps or theories. (not to say this is a completely closed book)
On 7/30/2016 at 7:17 AM, Gladiatoro said:On 7/30/2016 at 5:14 AM, Dubya_B said:Hate to play the devil's advocate, but isotretinoin/13-cis-retinoic acid does occur naturally in very small concentrations. (around 1.5ng/dL)[Edited link out]It is produced as a by-product of retinoid metabolism.
On a side-note, I tried leaving a comment refuting some of the one-sided misinformation about the safety profile of Accutane on that dermatologist's blog:
[Edited link out]
and it was blocked.If its naturally occurring then what's with all the side effects?
Not sure if that is a rhetorical question or if you are being serious. Toxic amounts of substances that are naturally produced by the body are still toxic.
As is the case with alcohol, cortisol, adrenaline, insulin, GHB (yes, a small amount of GHB occurs naturally too). Too much of any of these substances can cause serious health problems or even kill.
.
On 7/30/2016 at 12:12 AM, Trapt said:Ha! Well-informed adult? impossible. If you go to any dermatologist or doctor that prescribes this drug, you cannot be well-informed about the side effects. If you were, they would not sell a single pill.
This is what these dermatologists are telling their patients about the drug, and it needs to stop.
[Edited link out]
PS. Don't waste your time leaving a comment on this blogbecause it will not be posted.
hey I agree I was just giving them a tiny bit of leeway. The truth is, nobody researches these drugs until we have major problems from them. I took antibiotics non and off for years but only learned in the past month of the potential long term and serious issues.
If detms were honest, they would say " accutane is pretty much a deal with the devil". Because we all know the devil finds ways to completely screw you in the deal.
On 7/30/2016 at 10:15 PM, snarkygirl said:hey I agree I was just giving them a tiny bit of leeway. The truth is, nobody researches these drugs until we have major problems from them. I took antibiotics non and off for years but only learned in the past month of the potential long term and serious issues.
If detms were honest, they would say " accutane is pretty much a deal with the devil". Because we all know the devil finds ways to completely screw you in the deal.
Read this about anti-life-biotics.
Antibiotics severely disable the immune system
The immune system, when working at maximum efficiency, is a miracle of nature, with the ability to prevent and heal virtually any disease, including cancer.
What doctors call "diseases" are now known to be the experiential externalized symptoms of a condition arising from a compromised, ineffective immune system. All modern medicine ever attempts to do is mask the experiential symptoms of a disease without ever holistically healing the origin of the condition itself, and thereby without healing the disease, often causing even more harm to the patient through chemical medicines and invasive surgical procedures.
In most people today, the immune system is often already highly compromised through a poor diet and lifestyle, environmental toxins and other factors, including medicines.
The immune system[Edited link out] is highly complex, at least 80% being located in the digestive system and regulated by the "gut flora," microbes, that live there in vast numbers. At least 15% of the weight of the entire body can be attributed to trillions of microbes [Edited link out]and other organisms, living mostly in the digestive tract.
The ratio of "good" or "beneficial" microbes to "bad" or "pathogenic" microbes is absolutely critical to the efficient functioning of the immune system, being broadly 85% "good microbes" to 15% "bad microbes" in the gut. In most people, due to the previously mentioned factors, this ratio is severely skewed in favor of bad microbes, which in turn has the effect of seriously weakening the immune system.
This imbalance in the ratio of good to bad microbes is known as "dysbiosis."
When antibiotics [Edited link out]are consumed, not only are the "bad microbes" killed off, so too are the good microbes, leaving the gut almost completely depleted of beneficial, immune response-regulating gut flora, and consequently a seriously compromised immune system as a whole.
Taking antibiotics is therefore bad for health, because it effectively destroys the very natural [Edited link out] bodily mechanism that protects us against all disease in the first place - the immune system - which may never fully recover by itself.
On 7/30/2016 at 10:53 PM, Gladiatoro said:Read this about anti-life-biotics.
Antibiotics severely disable the immune system
The immune system, when working at maximum efficiency, is a miracle of nature, with the ability to prevent and heal virtually any disease, including cancer.
What doctors call "diseases" are now known to be the experiential externalized symptoms of a condition arising from a compromised, ineffective immune system. All modern medicine ever attempts to do is mask the experiential symptoms of a disease without ever holistically healing the origin of the condition itself, and thereby without healing the disease, often causing even more harm to the patient through chemical medicines and invasive surgical procedures.
In most people today, the immune system is often already highly compromised through a poor diet and lifestyle, environmental toxins and other factors, including medicines.
The immune system [Edited link out]is highly complex, at least 80% being located in the digestive system and regulated by the "gut flora," microbes, that live there in vast numbers. At least 15% of the weight of the entire body can be attributed to trillions of microbes [Edited link out] and other organisms, living mostly in the digestive tract.
The ratio of "good" or "beneficial" microbes to "bad" or "pathogenic" microbes is absolutely critical to the efficient functioning of the immune system, being broadly 85% "good microbes" to 15% "bad microbes" in the gut. In most people, due to the previously mentioned factors, this ratio is severely skewed in favor of bad microbes, which in turn has the effect of seriously weakening the immune system.
This imbalance in the ratio of good to bad microbes is known as "dysbiosis."
When antibiotics [Edited link out] are consumed, not only are the "bad microbes" killed off, so too are the good microbes, leaving the gut almost completely depleted of beneficial, immune response-regulating gut flora, and consequently a seriously compromised immune system as a whole.
Taking antibiotics is therefore bad for health, because it effectively destroys the very natural [Edited link out]bodily mechanism that protects us against all disease in the first place - the immune system - which may never fully recover by itself.
ugh yeah. I wish I'd known that years ago.
On 7/30/2016 at 11:50 PM, snarkygirl said:On 7/30/2016 at 10:53 PM, Gladiatoro said:Read this about anti-life-biotics.Antibiotics severely disable the immune system
The immune system, when working at maximum efficiency, is a miracle of nature, with the ability to prevent and heal virtually any disease, including cancer.
What doctors call "diseases" are now known to be the experiential externalized symptoms of a condition arising from a compromised, ineffective immune system. All modern medicine ever attempts to do is mask the experiential symptoms of a disease without ever holistically healing the origin of the condition itself, and thereby without healing the disease, often causing even more harm to the patient through chemical medicines and invasive surgical procedures.
In most people today, the immune system is often already highly compromised through a poor diet and lifestyle, environmental toxins and other factors, including medicines.
The immune system [Edited link out]is highly complex, at least 80% being located in the digestive system and regulated by the "gut flora," microbes, that live there in vast numbers. At least 15% of the weight of the entire body can be attributed to trillions of microbes [Edited link out]and other organisms, living mostly in the digestive tract.
The ratio of "good" or "beneficial" microbes to "bad" or "pathogenic" microbes is absolutely critical to the efficient functioning of the immune system, being broadly 85% "good microbes" to 15% "bad microbes" in the gut. In most people, due to the previously mentioned factors, this ratio is severely skewed in favor of bad microbes, which in turn has the effect of seriously weakening the immune system.
This imbalance in the ratio of good to bad microbes is known as "dysbiosis."
When antibiotics [Edited link out]are consumed, not only are the "bad microbes" killed off, so too are the good microbes, leaving the gut almost completely depleted of beneficial, immune response-regulating gut flora, and consequently a seriously compromised immune system as a whole.
Taking antibiotics is therefore bad for health, because it effectively destroys the very natural [Edited link out]bodily mechanism that protects us against all disease in the first place - the immune system - which may never fully recover by itself.
ugh yeah. I wish I'd known that years ago.
Yeah me too , but remember knowledge is power the more you learn in life the better off you are,
Dr. Douglas Bremner discusses his fMRI study of Accutane patients, the death of Dr. David Cornbleet at the hands of Hans Peterson, and one of Roche's own scientists admitting a cover-up of Accutane-induced depression by Roche's marketing team.
http://beforeyoutakethatpill.com/blog/2016/07/27/accutane-made-me-do-it/
On July 30, 2016 at 1:46 PM, Dubya_B said:Dr. Douglas Bremner discusses his fMRI study of Accutane patients, the death of Dr. David Cornbleet at the hands of Hans Peterson, and one of Roche's own scientists admitting a cover-up of Accutane-induced depression by Roche's marketing team.http://beforeyoutakethatpill.com/blog/2016/07/27/accutane-made-me-do-it
Interesting stuff like I always say MRI's don't lie , isotretinoindoes affect the human brain does it cause depression not necessarily but it does cause brain damage , fact. After treatment that person will have to live the rest of his / her life with reduced brain function.
On 30 July 2016 at 2:58 AM, guitarman01 said:Thought you were around. I was taking about this for awhile and this person. I thought he was a dr at first. he's not. he's an engineer if i remember.
I tried high dose folate for a bit. hell i prob got 3 different types of folate sitting somewhere right now. I also mentioned Delpin. This is prob one of those circle jerks you mentioned. Your right, it is good to know what people have tried so people dont waste time or money on the same supps or theories. (not to say this is a completely closed book)
I'm aware he's not a doctor as he often points that out in his posts, but regardless he's clearly spent a vast amount of time studying CFS related issues, and no doubt has an excellent understanding of the biochemical processes behind this, and tane and PFS issues are clearly closely related, to CFS issues. Look at how many people have benefited from his methylation restart protocol for example, this guy is worth listening to.
If he says he believes tane sides could potentially be mitigated with a high dose of methylfolate then it's probably our best shot at a 'cure'. You can see his thinking regarding this, how this would in theory lower GNMT activity and break the vicious cycle we appear to be stuck in.
How much methylfolate were you taking, and for how long, was it an active form (i.e. listing L-methylfolate on the ingredients)? I'm guessing you hadn't worked up to say 30mg/day for a month or anything?
http://www.healthline.com/health/erectile-dysfunction/korean-red-ginseng
This may help some people on this board , I take it but not for erectile dysfunction I have no problem there but I take it for energy . http://www.naturalnews.com/044849_ginseng_health_benefits_asthma_treatment.html
13 hours ago, Gladiatoro said:
Not sure how you would go about reversing brain damage? I mean it's one thing to detox the body, clean up liver etc as it has the capacity to repair itself, as for the brain - can't do much about that as far as I know.
On a different subject I've been reading up on Ayurvedic medicine - I'm a Pitta type. Might start looking at all the things I should be doing to balance pitta. When out of balance pitta types can be prone to acid reflux, sore joints, light sensitivity, infections etc - basically all the things I suffer from.