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Repairing the long-term damage from Accutane

 
MemberMember
16
(@bobby-digital-2)

Posted : 02/28/2016 11:41 pm

8 minutes ago, guitarman01 said:
yes. ive basically said this exact same thing. for me the excess mucus gets so bad i get dizzy. its in my ears. used to be just my left now its moved to my right as well. i do have allergies. im taking montelukast atm just started this but i think it is helping. diff nasal steroids seem to help or make things worse. to give a funny example. when the mucus is bad i can drink just a couple beers and feel drunk. when ive been on Nasonex for awhile, I can drink like 6 beers and still feel pretty normal. there is def something going on here. whether its inhaled or brought on by gut problems/deficiencies. antihistamines have also helped but they are all either drying or sedating.

I have chronic ear and nose congestion. Anytime I swallow I can feel the stickyness in my ears. Recently I discovered that pulling and holding the hair on my head for 5-10 seconds causes a bit of drainage and relief.

I've been tested for allergies which I tested positively for dust and ragweed. I only reacted once the serum was injected into my blood and even then I only got a bit of swelling but bad fatigue. So I've been getting allergy shots for the past year which hasn't made that much of a difference. Seems like our immune systems are hyper active. I developed ALOT of food intolerances a couple years after accutane. It's ridiculous I can pretty much can only eat chicken, vegetables and fruit. Most other foods cause me excess mucus production, worsening brain fog, and extreme fatigue.

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MemberMember
1803
(@guitarman01)

Posted : 02/28/2016 11:46 pm

2 minutes ago, Bobby.Digital said:
I have chronic ear and nose congestion. Anytime I swallow I can feel the stickyness in my ears. Recently I discovered that pulling and holding the hair on my head for 5-10 seconds causes a bit of drainage and relief.

I've been tested for allergies which I tested positively for dust and ragweed. I only reacted once the serum was injected into my blood and even then I only got a bit of swelling but bad fatigue. So I've been getting allergy shots for the past year which hasn't made that much of a difference. Seems like our immune systems are hyper active. I developed ALOT of food intolerances a couple years after accutane. It's ridiculous I can pretty much can only eat chicken, vegetables and fruit. Most other foods cause me excess mucus production, worsening brain fog, and extreme fatigue.

i feel like shit after i eat of ice cream.horrible brain fog/depression. i wonder if this goes back to pancreatic health? they say to have a low or no fat diet if you have pancreatic enzyme secretion problems.

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MemberMember
16
(@bobby-digital-2)

Posted : 02/28/2016 11:52 pm

On 2/29/2016 at 12:46 PM, guitarman01 said:
On 2/29/2016 at 12:41 PM, Bobby.Digital said:
I have chronic ear and nose congestion. Anytime I swallow I can feel the stickyness in my ears. Recently I discovered that pulling and holding the hair on my head for 5-10 seconds causes a bit of drainage and relief.

I've been tested for allergies which I tested positively for dust and ragweed. I only reacted once the serum was injected into my blood and even then I only got a bit of swelling but bad fatigue. So I've been getting allergy shots for the past year which hasn't made that much of a difference. Seems like our immune systems are hyper active. I developed ALOT of food intolerances a couple years after accutane. It's ridiculous I can pretty much can only eat chicken, vegetables and fruit. Most other foods cause me excess mucus production, worsening brain fog, and extreme fatigue.

i feel like shit after i eat of ice cream.horrible brain fog/depression. i wonder if this goes back to pancreatic health? they say to have a low or no fat diet if you have pancreatic enzyme secretion problems.

You might be on to something. I just finished treating Sibo and one of the causes for it is pancreatic insufficiency:

[Edited link out]

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1803
(@guitarman01)

Posted : 02/28/2016 11:57 pm

On 2/29/2016 at 12:52 PM, Bobby.Digital said:

You might be on to something. I just finished treating Sibo and one of the causes for it is pancreatic insufficiency:

[Edited link out]

you had sibo too? did this get diagnosed by a doctor?

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MemberMember
16
(@bobby-digital-2)

Posted : 02/28/2016 11:58 pm

On 2/29/2016 at 12:57 PM, guitarman01 said:
On 2/29/2016 at 12:52 PM, Bobby.Digital said:
You might be on to something. I just finished treating Sibo and one of the causes for it is pancreatic insufficiency:

[Edited link out]

you had sibo too? did this get diagnosed by a doctor?

Yeah I took the lactoluse breathe test. I'm working with a functional medicine doctor.

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MemberMember
1803
(@guitarman01)

Posted : 02/29/2016 12:05 am

3 minutes ago, Bobby.Digital said:
Yeah I took the lactoluse breathe test. I'm working with a functional medicine doctor.

good info. was just looking at this. http://www.gidoctor.net/lactose-breath-test.php

they recommend align post antibiotic treatment

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MemberMember
16
(@bobby-digital-2)

Posted : 02/29/2016 12:11 am

5 minutes ago, guitarman01 said:
good info. was just looking at this. http://www.gidoctor.net/lactose-breath-test.php

they recommend align post antibiotic treatment

Im taking low doseErythromycin as my prokinetik agent. I'm staying away from probitocs for a couple months just to assure the Sibo won't come back. But I've already ordered vsl #3 to start taking as soon as my doc gives me the go ahead. Have you been tested for SIBO? Or had a comprehensive stool test done?

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299
(@macleod)

Posted : 02/29/2016 3:50 am

Man, someone needs to create a well regulated forum. An entire page back and forth on SIBO...really?

Even if it was an issue, it's not the source of your problems. You would have to periodically treat it for the rest of your life, and it would arise every time you stopped. The same with copper. Yes, our immune system is shot, which allows for bacteria overgrowth, but what does that mean? It means that our body is not producingsomething that it should.

Think guys. What was accutane designed to do? Shrink sebaceous glands underneath the epidermis. What is a sebaceous gland? It is an exocrine gland. How many other types of exocrine glands are there in the body? Where are they located? How many types of endocrine glands are in the body. Where are they located? What if they were all affected during treatment of isotretinoin?

Have issues with red eyes? Look to the lacrimal gland.
Have issues with ED? Look to the Hypothalamus gland and its production of Vasopressin.
Depression? Also look to the Hypothalums.
Digestive issues? Also exocrine glands.
Testosterone? Endocrine glands.

Now, delve into glands a little. Read on the cells that make up organs and glands. Epilitheal cells.

Allglandsare made up of epithelial cells. Functions of epithelial cells includesecretion, selectiveabsorption, protection,transcellular transport, andsensing

http://wberesford.hsc.wvu.edu/histolch31.htm

"3Organization of the differentiating cells to repair an organ

lCoordination of regenerationsof more than one tissue is needed, e.g., (a) glandular cells"

"4Requirements for regeneration

2Communicationbetween the participating cells by means of cytokine and other agents.
3 Adequate hormone levels, e.g., thyroid.
4 Adequatestoresorintakeof amino acids, vitamins, etc., for the synthesis of new protein and other materials.
5 Freedom from infection."

so, while you guys aren't completely off. there is a much bigger picture. and we need solutions to the entirety of the issue.

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MemberMember
16
(@bobby-digital-2)

Posted : 02/29/2016 5:17 am

1 hour ago, macleod said:

Man, someone needs to create a well regulated forum. An entire page back and forth on SIBO...really?

Even if it was an issue, it's not the source of your problems. You would have to periodically treat it for the rest of your life, and it would arise every time you stopped. The same with copper. Yes, our immune system is shot, which allows for bacteria overgrowth, but what does that mean? It means that our body is not producingsomething that it should.

Think guys. What was accutane designed to do? Shrink sebaceous glands underneath the epidermis. What is a sebaceous gland? It is an exocrine gland. How many other types of exocrine glands are there in the body? Where are they located? How many types of endocrine glands are in the body. Where are they located? What if they were all affected during treatment of isotretinoin?

Have issues with red eyes? Look to the lacrimal gland.
Have issues with ED? Look to the Hypothalamus gland and its production of Vasopressin.
Depression? Also look to the Hypothalums.
Digestive issues? Also exocrine glands.
Testosterone? Endocrine glands.

Now, delve into glands a little. Read on the cells that make up organs and glands. Epilitheal cells.

Allglandsare made up of epithelial cells. Functions of epithelial cells includesecretion, selectiveabsorption, protection,transcellular transport, andsensing

http://wberesford.hsc.wvu.edu/histolch31.htm

"3Organization of the differentiating cells to repair an organ

lCoordination of regenerationsof more than one tissue is needed, e.g., (a) glandular cells"

"4Requirements for regeneration

2Communicationbetween the participating cells by means of cytokine and other agents.
3 Adequate hormone levels, e.g., thyroid.
4 Adequatestoresorintakeof amino acids, vitamins, etc., for the synthesis of new protein and other materials.
5 Freedom from infection."

so, while you guys aren't completely off. there is a much bigger picture. and we need solutions to the entirety of the issue.

Re read our posts. We know sibo isn't the cause. However even though it isn't it's still something you want to treat if you have. It can cause a whole host of other problems which can severely undermine you ability to heal.

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MemberMember
13
(@dakiramir)

Posted : 02/29/2016 7:57 am

3 hours ago, macleod said:

Man, someone needs to create a well regulated forum. An entire page back and forth on SIBO...really?

Even if it was an issue, it's not the source of your problems. You would have to periodically treat it for the rest of your life, and it would arise every time you stopped. The same with copper. Yes, our immune system is shot, which allows for bacteria overgrowth, but what does that mean? It means that our body is not producingsomething that it should.

Think guys. What was accutane designed to do? Shrink sebaceous glands underneath the epidermis. What is a sebaceous gland? It is an exocrine gland. How many other types of exocrine glands are there in the body? Where are they located? How many types of endocrine glands are in the body. Where are they located? What if they were all affected during treatment of isotretinoin?

Have issues with red eyes? Look to the lacrimal gland.
Have issues with ED? Look to the Hypothalamus gland and its production of Vasopressin.
Depression? Also look to the Hypothalums.
Digestive issues? Also exocrine glands.
Testosterone? Endocrine glands.

Now, delve into glands a little. Read on the cells that make up organs and glands. Epilitheal cells.

Allglandsare made up of epithelial cells. Functions of epithelial cells includesecretion, selectiveabsorption, protection,transcellular transport, andsensing

http://wberesford.hsc.wvu.edu/histolch31.htm

"3Organization of the differentiating cells to repair an organ

lCoordination of regenerationsof more than one tissue is needed, e.g., (a) glandular cells"

"4Requirements for regeneration

2Communicationbetween the participating cells by means of cytokine and other agents.
3 Adequate hormone levels, e.g., thyroid.
4 Adequatestoresorintakeof amino acids, vitamins, etc., for the synthesis of new protein and other materials.
5 Freedom from infection."

so, while you guys aren't completely off. there is a much bigger picture. and we need solutions to the entirety of the issue.

I agree on needing a solution that applies to the whole picture. Everyone's pictures are different though. You're right in us requiring some serious organisation here. I actually sometimes envy the pfs guys because the symptoms don't seem as broad. We have links to all sorts of autimmune stuff going on which makes everything very confusing when a solution to ED is put forward next to details regarding fibromyalgia or flushing. What I will say, is that when I research what's going on with me personally, and I research the symptoms individually, a lot of people find solutions by addressing what is going on in their gut. (dry eyes cured by diet, joint pain cured by diet, brain fog cleared by diet,) I say cured loosely, because avoiding certain triggers isn't a cure as far as I'm concerned, but being symptom free is what I'm aiming for in the short term, and unfortunately, addressing the whole picture might unearth a seriously big picture, requiring battles on multiple fronts. If we can narrow it down to what those battles are, we'll be heading in the right direction. If accutane has messed up the cells in my gut, research like this could help: http://www.scielo.br/scielo.php?pid=S0102-86502007000700014&script=sci_arttext

I'm dealing with burning joint pain in most of my joints at the moment, along with morning stiffness. If a bacterial infection can damage the stomach enough to cause reactive arthritis, I have no doubt that accutane could damage the stomach to a similar extent. It makes things a little difficult on here that we're all looking for answers to different symptoms. Some people's issues could be as simple as supplementing B12 for instance. I've read countless accounts of people who had joint pain during/after accutane and they cured it by taking omega 3's and MSM/Chondroitin etc. The bigger picture is unfortunately that we're dealing with a lot of much smaller pictures, and they probably all need addressing individually. Would be great if we could start breaking those pictures down a bit.

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MemberMember
1803
(@guitarman01)

Posted : 02/29/2016 11:48 am

has anyone looked intoselenomethionine in the past? and lol dont tell me about its not the big picture or that we need to be looking at copper. just a straight up yea we tried selenomethinoine for awhile and it didnt do shit. or no, we havent looked at it much. thanks.

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2
(@matt2399)

Posted : 02/29/2016 3:25 pm

Just to add in here, following accutane i had ED at 19 years old. I am now 27 years old. Testosterone injections of 500mg per week, testosterone level of around 3000, range was around 300-1200, works for only the first 3 months then like any supplement...Tolerance. Although i had libido its useless without the use of high doses of viagra which i also got hold off. I will also add i did weight training during this time and after the initial couple months i made no gains after, if i did it was very little i did not notice, no matter how much i ate, just fat accumulation.

I was on for 4 years straight. Now i been off for year and half, libido is shot and erections i would have to be dreaming.

My input for anyone thinking of going this route.

EDIT: Guiterman01 you got me to edit this post as i just read your post where you took a huge dose of probiotic how come you have not followed up or stopped, oil production is a good sign.

For everything i have tried over the years the health of the gut is what has made the most difference, day and night difference

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MemberMember
1803
(@guitarman01)

Posted : 02/29/2016 6:39 pm

3 hours ago, MATT2399 said:

Just to add in here, following accutane i had ED at 19 years old. I am now 27 years old. Testosterone injections of 500mg per week, testosterone level of around 3000, range was around 300-1200, works for only the first 3 months then like any supplement...Tolerance. Although i had libido its useless without the use of high doses of viagra which i also got hold off. I will also add i did weight training during this time and after the initial couple months i made no gains after, if i did it was very little i did not notice, no matter how much i ate, just fat accumulation.

I was on for 4 years straight. Now i been off for year and half, libido is shot and erections i would have to be dreaming.

My input for anyone thinking of going this route.

EDIT: Guiterman01 you got me to edit this post as i just read your post where you took a huge dose of probiotic how come you have not followed up or stopped, oil production is a good sign.

For everything i have tried over the years the health of the gut is what has made the most difference, day and night difference

well i ran out of culturelle. I have some align left over that im going to be taking 1 a day at night now. it seems like alot of gastro drs recommend this after treating sibo to keep it from hopefully coming back. it also seems after doing a little research bifi strain might be the better all around probiotic to take. it is the most important from birth and has numerous effects on the body. i know something is fd up in my gut ive had a yellow tongue for years now. i might get that breath test soon at a gastro dr to see if i have sibo. for now i will take align and see if it helps.

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MemberMember
299
(@macleod)

Posted : 03/01/2016 4:13 am

We are all in the same boat. But, we will prevail. Humanity and science always does.Don't let it get youdown. We will utilize this forum and the internet to communicate and find solutions to these problems.I expect nothing less than the truth and science should prevail when its all said and done, in this lifetimeor the next. We are, in a sense, just complex systems. No different from a computer or an automobile. It's all within reach and I feel that we are very close to finding at least what went wrong and where. And even still, as medicine progresses, we move closer to at the very least understanding if not curing.

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MemberMember
6
(@vicecaz)

Posted : 03/01/2016 4:24 am

7 hours ago, oldschoolplz said:

Hi. My side effecfs are the same as everyone on here dry eyes a shell of a person, no connection to life or girls. Use to be a flirt man and cuddler now feel like a robot. Doesn't satisfy much.Fatigue stomach pains and maldigestion, bone pain joint pain and general depression each day as we think how much better we were off before rhe posion. Obviously it shrinks something in our brains. They won't do anything about it and no one is willing to help because we appear completely normal. No lawyer can help a situation like this, unless you were diagnosed with chrones disease shortly after taking the actual Accutane brand, your screwed.

Yes no ability to grow and gain muscle! And full on Ed. Forgot those two.

Lifes real fair huh. Suprised mlre people haven't gone the suicide route after this drug. 80mg was a lot.

What can we do!
-sick of living this trapped

Hello, that is not permanent. It takes time and requiers a lot of motivation but your side effects will disappear over time if you're helping your body to heal. Or at least dramaically improve.

This is just based on recovery stories and my understanding of how works our body ( basically Dr Morse's knowledge if you know him )

_ Clean Diet with a lot of fresh vegetable's/fruit's juice, olive, avocado, coconut butter, sometimes brazil nuts for example, leafy greens..

_ Kidney/Liver flush

_ clean your gut with the way you want. Whatever. Add also probiotics , Kombucha , chlorophylle , herbs ..

_ Sun exposure , sauna,lymphatic brushing, sweat as much as you can, 30/40min jogging for example.

_ Cannabis oil ( at least over a period of six months, made with high quality Indica strains, following by Rick Simpson instructions )

_ Try Herbs known to be good for liver, kidney.. Glandular has been effective for some also.

_ Isotherapy

_ hyaluronic Acid and red ice skate liver oil has been also effective

Do not waste time with " magic pills ", it has never cured anyone, and it is only a short term solutions.

I m not cured yet, but i'm feeling a lot better than it was on October for example . I have so far only made the change in my diet, and tried some herbs/red skate liver oil. I can solidly say that my chronic fatigue has improved a lot, almost gone. My eyes are less dry, the pain in my back disappeared , depression has also improved.. I still have lack of libido/emotions , ED, dry eyes, skin unable to sweat.. That is huge issue but i'm sure that I will be healed after having done all that.

good luck

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MemberMember
0
(@matt23988)

Posted : 03/01/2016 8:05 am

ViceCaz are you anonnyy?

Even 9 years post accutane if I eat sweet potato or carrots I get dry lips, dry eyes joints ect. The only time I have been able to eat them is when on antibiotics no side effects. I know recently I read a post not sure if it was on here or not. That they found he had a certain bacteria in his gut that would turn vitamin a that he consumed into 13 cis retonic acid maybe we are deficient in vitamin a. Just throwing it out there

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MemberMember
6
(@vicecaz)

Posted : 03/01/2016 11:06 am

2 hours ago, MATT23988 said:
ViceCaz are you anonnyy?

Even 9 years post accutane if I eat sweet potato or carrots I get dry lips, dry eyes joints ect. The only time I have been able to eat them is when on antibiotics no side effects. I know recently I read a post not sure if it was on here or not. That they found he had a certain bacteria in his gut that would turn vitamin a that he consumed into 13 cis retonic acid maybe we are deficient in vitamin a. Just throwing it out there

Nop I'm not. I saw his previous posts though. I have never heard about such bacterias. But after a accutane there is no doubt that we are deficient in vitamin A, this is maybe why. " bad " bacterias will disappear over time after cleaning your gut ( water fasting should help a lot if so ) But I think issue with vitamin A are rather linked with the liver. That is probably why some has really really improved after performing liver flush. Our body is smart and do have the ability to recover. Accutane damaged it a lot , and obviously damaged also its ability to heal. But once again it is not permanent . It takes time, maybe more for some though, but this is possible to be Healed.

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/01/2016 11:33 am

7 hours ago, MATT23988 said:
ViceCaz are you anonnyy?

Even 9 years post accutane if I eat sweet potato or carrots I get dry lips, dry eyes joints ect. The only time I have been able to eat them is when on antibiotics no side effects. I know recently I read a post not sure if it was on here or not. That they found he had a certain bacteria in his gut that would turn vitamin a that he consumed into 13 cis retonic acid maybe we are deficient in vitamin a. Just throwing it out there

anonnyy is back!!!!

i just posted this... i believe without a doubt we have a backup of retinoic acid. a few possibilities. the depression people feel could be the accutane version of postpartum depression?!

1. accutane destoyed our normal gut flora, leaving only the bacteria that can handle retinoic acid/or more importantly somehow messed up or promoted the bacteria that convert vitamin A into retinoic acid. seeing how there was a huge amount of retinoic acid in our bodies for months... they couldve been trained to keep this level of retinoic acid as a new homeostasis?!
2.accutane depleted something that controls this bacteria and or parasites naturally, allowing the bacteria that produce retinoic acid to flourish
3. something is backed up in the liver controlling everything.
4. a combination of all 4.

anecdotes:

1. people cure nightblindess due to accutane with iodine possible reason: iodine destroys bad bacteria/parasites causing excess retinoic acid production
2. ketogenic diet cures man from accutane sides: he avoids all sugar and eats scallops (very high in iodine and copper) killing bad parasites
3. guitarmann takes 30bil probiotics and skin temporarily gets oily possible reason: bad gut flora causing retinoic acid backup, gets shocked/crowded out but not killed
4. finasteride people report cure from taking antibiotics and then VSL#3 possible reason: eliminated bad bacteria, and reset flora
5. poster on this board says the only thing that has helped him is tyrosine. possible reason: tyrosine(to form topaquinone) along with copper, are the two cofactors needed to form the copper anime oxidase that accutane upregulates 3.21x this is a detoxification response. tyrosine also needed for dopamine and thyroid production
6. poster on this board mention in his only post that tocotrienols (the other 4 sides to vitamin E) would help with detoxification by stimulating the PXR and CYP34 pathways. I mentioned PXR and CYP34 with st johns wort.

  • "In preparation for lactation, expectant mothers store retinoids in the liver and breast. Breastfeeding allows the transfer of stored retinoids to infants for proper growth, immunity against pathogens, and sight in the world outside the womb. Thus, there is a natural process in place for reducing toxic accumulation of retinoids in mothers, averting hypervitaminosis A. It has been theorized that maternal hypervitaminosis Aprimarily caused by a backup of retinoic acidcauses postpartum depression, a condition that affects 1 in 8 mothers.
  • [0011]
    Malaria is the most significant public health problem in the world with nearly 3.5 billion (1 in 2) people at risk.The malaria parasite absorbs vitamin A and converts it to retinoic acid for its use to invade the red blood cells. Listlessness from anemia in patients is the hallmark symptom of the disease.It has been theorized that hypervitaminosis Afrom a backup of retinoic acid produced by the parasitecauses or exacerbates the symptoms in the person.
  • [0012]
    It is therefore understood that the oxidized form of vitamin A, retinoic acid, is detrimental. Furthermore, vitamin A in its reduced form (retinol) should be maintained for its essential functions in the body (FIG. 1C) "

    .....................................................................

    Other natural retinoic acid reducers: selenium and Vitamin E... more specifically tocotrienols (these induce CYP34A and PXR detoxification pathways)

    #1 transthyretin (this could be the reason iodine and selenium ameliorateaccutane side effects, by helping the thyroid)

    The thyroid gland works with the liver to produce a vitamin A binding protein called transthyretin. This keeps vitamin A bound in the blood and only releases it to the body when needed. When there is no thyroid gland, the lack of transthyretin makes high doses of vitamin A potentially toxic because there is no control mechanism to hold the vitamin A in a biologically unavailable form. Therefore, those with thyroid cancer should avoid vitamin A.

    How does T4 become metabolically active in the cell?
    The active form of thyroid hormone is T3 but the thyroid gland releases 14 times more T4 than T3. Thus in the cell, the T4 must be converted to T3 by type l 5"-deiodinase, a selenium-dependent enzyme.(Selenium deficiency in rats decreased enzyme activity by 90%).

    the T in thyroid = Tyrosine residues the number following i.e. T1 T2 T3 T4 = the number of iodine molecules attached to it.

    Therefore, vitamin E (tocopherol andtocotrienol) protects phytonutrients from oxidation and reduces phytonutrients into its active forms. This can be done endogenously (in vivo) as well as exogenously (ex vivo). The latter is one of the discoveries disclosed in the application.Additionally, vitamin E (tocotrienol and tocopherol) protects the oxidation of retinol to retinoic acid in situ, and furthermore, reduces retinoic acid to retinol in vivo.

    i believe we have a backup of retinoic acid... be it in the skin or fat or liver.

    selenium + tocotrienols (reduced side effects, reducing retinoic acid formation and or use in vivo)

    copper + tryosine ( to provide both co-factors in forming the copper anime oxidase for removal of any potential metabolite or stored vitamin A in liver)

    (potassium)iodine + tryosine (thyroid)

    supporting factors: b1,b2,b3, Mg, K, SAM-e (for GSH and intrahepatic cholestasis) , Taurine (to bind the aldehydes and for bile excretion?)

    http://perfecthealthdiet.com/2010/12/micronutrient-deficiencies-an-underappreciated-cause-of-hypothyroidism/

    Cu deficiency reduced serum total T(3) by 48%, serum total T(4) by 21%, and whole-brain T(3) by 10% at P12. Fe deficiency reduced serum total T(3) by 43%, serum total T(4) by 67%, and whole-brain T(3) by 25% at P12. [1]

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MemberMember
960
(@tryingtohelp2014)

Posted : 03/01/2016 12:23 pm

On 2/29/2016 at 6:57 AM, dakiramir said:
"4 Requirements for regeneration

2 Communication between the participating cells by means of cytokine and other agents.
3 Adequate hormone levels, e.g., thyroid.
4 Adequate stores or intake of amino acids, vitamins, etc., for the synthesis of new protein and other materials.
5 Freedom from infection. "

"You can trace every sickness, every disease, and every ailment to a mineral deficiency." - Dr. Linus Pauling, two-time Nobel Prize winner

macleod

2. norepinephrine and epinephrine and dopamine (what controls this? see #4)
3. what controls the thyroid? (see #4)
4. stores of which?
5  what controls the infection (see #4)

back to your epithelial cells...   here is another theory called "Oral tolerance"   by taking accutane, we couldve promoted an oral tolerance in our guts to produce retinoic acid ourselves?

Along these lines, we found that LP-DCs isolated from the proximal small bowel possess greater RA-synthesizing ability than their distal counterparts, correlating with the levels of RA found throughout the intestinal tract.7 Importantly, these properties are RA-dependent, since DCs from animals fed on vitamin A-deficient diet lose their capacity to synthesize RA or to induce gut tropism in T cells. Hence, LP-DCs sense local RA (presumably produced by intestinal epithelial cells), inducing their own RA synthesis in a positive feedback loop.7 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601169/
 

2016-03-01_1203.png

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MemberMember
157
(@tanedout)

Posted : 03/01/2016 1:35 pm

@tryingtohelp2014

Yeah Im pretty much thinking along the same lines as you regarding accutane destroying good bacteria strains in the gut, and as a result we get issues with massive yeast overgrowth (such as candidia, along with potentially also parasites and pathogens). We are unable to properly utilise nutrients in our diet, and this is essentially the root cause of our side effects.

Evidence? Well as mentioned previously, EVERYONE who has done a gut flora/parasite stool test over on SolvePFS/PropeciaHelp has NO GROWTH of the good bacteria strain Lactobacillus (along with various other issues, but this is the consistent factor amongst all test results)

Bit of a coincidence? What is one of things Lactobacillus does? Controls Candidia yeast. Symptoms of yeast overgrowth? Brain fog, chronic fatigue, joint pain etc..

Parasites are also likely to be another consequence, and most people (although not all) have been diagnosed with at least one over on the PFS threads (and the 1 guy on here who had the test). Some symptoms of people with parasites? Again brain fog/mental clarity issues, joint aches/pains, anxiety/depression, leaky gut, vitamin deficiencies, etc..

Ive recently noticed that I get quite a significant improvement in mental clarity the day after eating a dinner of stir fry (noodles, veg, chicken and loads of OLIVE OIL), followed by some cinnamon coated cranberries. Ive also recently been drinking coconut water instead of fruit juice.

Well turns out olive oil is an anti-fungal and supports removal of parasite and yeast waste, cinnamon and coconut oil are both anti-fungals..

From a quick google there are many other things that are shown to help with parasites and yeast overgrowth, some particularly effective measures look to be diatomaceous earth and apple cider vinegar, but many are very hard to get rid of, even following courses of antibiotics specifically to tackle that specific parasite.

http://wellnessmama.com/1969/bugs-in-your-belly/

My course of action?

- Complete a gut flora/parasitology test (done, and should get results anytime)
- Take specific action based on the findings (not the usual assume I have the same, and copy the protocol stab in the dark) - if I have parasites or yeast overgrowth I'll take action based on the recommendations of a specialist, and if I'm lacking in certain strains of good bacteria I'll take probiotics to replenish these strains.
- Reduce sugar and carbs from diet

From there Ill see how things go, but people over on the PFS threads seem to be making quite big gains from doing this, even a couple making full recoveries!

Also regarding probiotics, I've actually already been taking one daily for about 8 months, but only one capsule per day. Reading up, many people say if the bottle says take one capsule, then you probably want to work up to like 3 twice a day.

People need to find out what they need to target, then take action based on those findings. I.e. get tested!!

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MemberMember
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(@guitarman01)

Posted : 03/01/2016 3:56 pm

so one clue over the years is in alot of my photos im unusually pasty white like ghostly. ive had someone even comment on my pale skin. and i remember taking a multivitamin then going to work and one girl thought i went tanning. so there is something we are lacking that is one of the ingredients in a multi(but we cant take multivitamins because i believe their are also antagonistic vitamins/minerals that are not good for us). other note something was really not good for my hair i recently took and it might have been selenium. then i see a study that copper has a protective effect on selenium toxicity. and what the hell is maganese? i see this has a relationship with copper and actually comes in a much higher amount in this centrum that im looking at. they give you 2.3mg of maganese compared to 0.5 mg copper. i remember popping centrum awhile back and people would say i seemed happier at work. but again i need to isolate what is having these tanning/happy effects.
i can look at alot of ingredients and know what its not. what about the few im unsure of?

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MemberMember
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(@guitarman01)

Posted : 03/01/2016 6:59 pm

guys i had to tell you this as soon as i got home. something moisturized the hell out of my eyes.(and im wearing some old ass contacts too)my nose is running too and not dry. ive only been taking a few things, but I think it might be the fkn copper. i took 4mgs in the morning on empty stomach and 4mg in afternoon on an empty stomach. moisturized eyes equals sharp vision and good night vison i think its as simple as that. i say it might be the copper because the effect it has on my nose to run is unreal.(it actually hurt my nose when i first started taking it, it doesn't anymore).what this is doing is thining the mucus how it should be to maybe protect everything and flush out bacteria. this moisturizing effect on my eyes will also equal less light sensitivity. now im not 100percent sure its the copper, but i think it is. ive also taken montelukast the past couple days. and 800mcg of selenium yesterday(yea I know) and align the past couple nights and thats it. so to narrow it down i will just stay on copper alone the next few days and continue to take it on an empty stomach.
also my left ear has been full for years. one ent called it tinnitus and said there is nothing much i can do. now the right ear is starting to fill up. if copper or what ever it is keeps the mucus thin( copper has had me blowing out yellow,green and bloody mucus.) i image eventually the ear fullness might go away and with it brain fog too i bet. if so this would be a game changer for me.
or its the montelukast or a combination of the two(this would be related to allergies then). i dont think its the selenium or align. this wont be hard to narrow down though.

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299
(@macleod)

Posted : 03/01/2016 8:10 pm

7 hours ago, tryingtohelp2014 said:
"You can trace every sickness, every disease, and every ailment to a mineral deficiency." - Dr. Linus Pauling, two-time Nobel Prize winner

macleod

2.norepinephrine and epinephrine and dopamine (what controls this? see #4)
3. what controls the thyroid? (see #4)
4. stores of which?
5 what controls the infection (see #4)

You are completely missing an entire step. #3.

Well, back to supplements and sauerkraut. There is hope...

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MemberMember
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(@guitarman01)

Posted : 03/01/2016 10:28 pm

21 minutes ago, oldschoolplz said:

I'm confused on how any of this relates to solving the problem I do not think that as other members have said "taking magic pills" is a good solution... I meant more lifestyle changes or signs of hope

ill tell you how it fixes the problem. you fix one thing just one thing, this could be part of the cause of the rest of the problems.and i dont mean a bandaid i mean an actual fix. fox example my sideburn hair as short as it is, grows broken and curls out. this is one of the signs i first noticed post accutane. hairloss throughout my entire body followed. i fix this one thing as minor as my broken side burn hair, i would feel pretty confident that the rest would follow. and really all we can do is take pills. thats what we did in the first place.

while im thinking about it. did anyone look into higher dosed pancreatic enzymes? especially coupled with say a protein shake? i cant put on any fat it seems and high fat meals like ice cream make me feel like shit. lack of utilizing protein properly could have a serious effect on our muscles and hair. and when i say muscles this is a very far reaching thing. throat muscle, heart muscle, blood circulation. muscle twitching, weakness, numbness.

hell muscle problems could be causing my ear fullness, facial flushing, throat reflux problems, nasal congestion.

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MemberMember
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(@guitarman01)

Posted : 03/01/2016 11:13 pm

well would you look at that.

here is some serious connections
. http://www.vitaminstuff.com/superoxide-dismutase.html Superoxide Dismutase (SOD) is an enzyme that repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body. SOD is found in both the dermis and the epidermis, and is key to the production of healthy fibroblasts (skin-building cells).
There are two types of SOD: copper/zinc (Cu/Zn) SOD and manganese (Mn) SOD.

[Edited link out]

Vitamin A and Retinoids as Mitochondrial Toxicants

http://lpi.oregonstate.edu/mic/minerals/manganese
Manganese superoxide dismutase (MnSOD) is the principalantioxidantenzyme in themitochondria.

All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.

http://www.ncbi.nlm.nih.gov/pubmed/18280257

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