29 minutes ago, guitarman01 said:

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.1982.tb00410.x/abstract
Accutanes effect on bacteria. there is an effect. how far reaching, meaning the gut. not sure. but looking in this direction now love you btw

Awwww back at ya my friend! I do believe that Accutane makes us more susceptible to bacteria, yeast, autoimmune and viral issues. Whether it be the gut, or some who have developed sarcoidosis which effects the lungs and is thought to be caused by bacteria/immune response. I know that I have had some success with a probiotic saccharomyces boulardii. Not sure for those who live out of the country.
As for dryness I started recently aloe vera gel (not juice) either plain  or adding into my morning smoothie or juice from juicing, has helped with some dryness and we will see how it works elsewhere  

Are there any people who have used Accutane and had side effects from it but their skin was in good shape? Such as it was moist and not bone dry. I am curious if everyone who takes Accutane has permanent dry skin or if some people regain skin and hair moisture.

Try this it's cheap. Vitamin b2 and nothing else. Take it with food. At least 100 to 400mg per day. Let me know if your skin/face get softer along with lips and hair and vision/eyes feel a little better. You will notice fairly quickly in the first couple days. I'm trying to figure something out and it might be related to b2

55 minutes ago, JustSayinn said:

Are there any people who have used Accutane and had side effects from it but their skin was in good shape? Such as it was moist and not bone dry. I am curious if everyone who takes Accutane has permanent dry skin or if some people regain skin and hair moisture.

http://www.ncbi.nlm.nih.gov/pubmed/18981221
very close relationship between riboflavin and vitamin a

Just to clarify.... everything im reading says 13-cis retinoic acid upregulates ATP7A and rids the body of copper. copper is needed for cell proliferation. If you read about copper deficiency symptoms... a lot of them match.

The role of copper in biological phenomena that involve signal transduction is poorly understood. A cellular model of neuronal differentiation has been utilised to examine the requirement for copper during nerve growth factor (NGF) signal transduction that leads to neurite outgrowth (Birkaya and Aletta, 2005). NGF increases cellular copper content within 3 days, whereas copper chelators reduce the effects of NGF on neurite outgrowth and copper accumulation (Birkaya and Aletta, 2005). Our data supports a model of malignant neural cells requiring higher intracellular copper levels for viability, and that retinoid-induced neuritic differentiation of neuroblastoma cells causes intracellular copper depletion. In non-neuronal cells ATP7A regulates copper homeostasis by translocating copper from thetrans-Golgi network to the plasma membrane, in response to an increased copper load. In Menkes disease a defect in the ATP7A protein leads to a reduced transport of copper from the intestine into the circulation and central nervous system, as well as reduced transport of copper into the Golgi apparatus. In our studies, a significant increase in copper efflux, and decrease in copper uptake occurred over 8 days of retinoid treatment. Thus, reduction in cellular copper levels directly contributes to the retinoid therapeutic effect.

In summary, our results indicate that ATP7A is an important component of the RARanticancer effect. Most importantly, copper chelators reduce viability and proliferation of neuroblastoma cells. ATP7A and copper are novel potential drug targets that may be exploited in the treatment of neuroblastoma.
[Edited link out]

On 2/5/2016 at 9:06 AM, tryingtohelp2014 said:

Just to clarify.... everything im reading says 13-cis retinoic acid upregulates ATP7A and rids the body of copper. copper is needed for cell proliferation. If you read about copper deficiency symptoms... a lot of them match.

The role of copper in biological phenomena that involve signal transduction is poorly understood. A cellular model of neuronal differentiation has been utilised to examine the requirement for copper during nerve growth factor (NGF) signal transduction that leads to neurite outgrowth (Birkaya and Aletta, 2005). NGF increases cellular copper content within 3 days, whereas copper chelators reduce the effects of NGF on neurite outgrowth and copper accumulation (Birkaya and Aletta, 2005). Our data supports a model of malignant neural cells requiring higher intracellular copper levels for viability, and that retinoid-induced neuritic differentiation of neuroblastoma cells causes intracellular copper depletion. In non-neuronal cells ATP7A regulates copper homeostasis by translocating copper from thetrans-Golgi network to the plasma membrane, in response to an increased copper load. In Menkes disease a defect in the ATP7A protein leads to a reduced transport of copper from the intestine into the circulation and central nervous system, as well as reduced transport of copper into the Golgi apparatus. In our studies, a significant increase in copper efflux, and decrease in copper uptake occurred over 8 days of retinoid treatment. Thus, reduction in cellular copper levels directly contributes to the retinoid therapeutic effect.

In summary, our results indicate that ATP7A is an important component of the RARanticancer effect. Most importantly, copper chelators reduce viability and proliferation of neuroblastoma cells. ATP7A and copper are novel potential drug targets that may be exploited in the treatment of neuroblastoma.
[Edited link out]

believe it or not I think I have a copper only supplement laying around. if its not expired. man i'd sure like to know the total dollar amount i've spent on supplements since day one.

On 2/5/2016 at 9:06 AM, tryingtohelp2014 said:

Just to clarify.... everything im reading says 13-cis retinoic acid upregulates ATP7A and rids the body of copper. copper is needed for cell proliferation. If you read about copper deficiency symptoms... a lot of them match.

The role of copper in biological phenomena that involve signal transduction is poorly understood. A cellular model of neuronal differentiation has been utilised to examine the requirement for copper during nerve growth factor (NGF) signal transduction that leads to neurite outgrowth (Birkaya and Aletta, 2005). NGF increases cellular copper content within 3 days, whereas copper chelators reduce the effects of NGF on neurite outgrowth and copper accumulation (Birkaya and Aletta, 2005). Our data supports a model of malignant neural cells requiring higher intracellular copper levels for viability, and that retinoid-induced neuritic differentiation of neuroblastoma cells causes intracellular copper depletion. In non-neuronal cells ATP7A regulates copper homeostasis by translocating copper from thetrans-Golgi network to the plasma membrane, in response to an increased copper load. In Menkes disease a defect in the ATP7A protein leads to a reduced transport of copper from the intestine into the circulation and central nervous system, as well as reduced transport of copper into the Golgi apparatus. In our studies, a significant increase in copper efflux, and decrease in copper uptake occurred over 8 days of retinoid treatment. Thus, reduction in cellular copper levels directly contributes to the retinoid therapeutic effect.

In summary, our results indicate that ATP7A is an important component of the RARanticancer effect. Most importantly, copper chelators reduce viability and proliferation of neuroblastoma cells. ATP7A and copper are novel potential drug targets that may be exploited in the treatment of neuroblastoma.
[Edited link out]

Sorry im confused. It's excess copper that I had diagnosed not a deficiency in copper??

if you guys lack energy you should try vitamin b2. I still feel good about this vitamin but I have overdone it from time to time. It might jump start your heart with higher doses(meaning you feel palpitations or notice your heart but after awhile/ your body gets used to it, it calms down. I did 1200 mgs the past couple days and it kept me up all night. I mean i would only get a couple hours of sleep and wake up and be up the rest of the night. this happened 2 nights in a row. but the crazy thing is I wasnt tired at all during the day time and was in a good mood and had tons of energy. I stayed pretty sharp, Im a delivery driver downtown in a big city. So i know if im slipping. this vitamin seems to make my hair feel softer and blonder and makes my hair lay more naturally, it makes my skin softer my lips softer my eyes look more healthy. I can drink alot of beer and it dosent even phase me the next day.
Its something about our mucous membranes being inflammed maybe, you got that constant over production of mucus that can effect our vision, our throat, our face, our gut, our jumpy heart, over excited nerves, brain fog. 400 mgs per day is used to treat migraines and they say it can take a couple months to even take effect. I just wonder with such a close relationship to vitamin a.
has anyone else tried high dose b2? meaning at least 400mgs? I think i feel some moisture in my sinuses as well.
this is just a rambling thought bubble for me, this whole forum. And was just wondering why is it mostly dudes that seem to have the side effects or have been on this forum?

4 hours ago, TrueJustice said:

Sorry im confused. It's excess copper that I had diagnosed not a deficiency in copper??
 

How were you diagnosed?  plasma copper isnt a good test.  hair tests not good, if anything contradictory? high copper excretion?  A defect in the gene that makes ATP7A chaperone protein is responsible for causing Menkes syndrome and a defect in the gene responsible for ATP7B chaperone protein causes Wilson™s syndrome.   If you had Wilsons disease... you wouldve known it loooooong ago.  there is no mild version?  you either have the gene defect, or you dont.

RBC copper test results?

ceruloplasmin test results?

i had both of these tests done as part of a bigger nutrient panel a few days ago... awaiting results.  should be informative.  In any case, being copper toxic or deficient... getting the bile to flow is paramount.  

This shows why retinoids are a chemotherapy tool.   

13-cis retinoic acid ----> upregulates RAR2-----> upregulated RAR2 stimulates ATP7A -----> reducing intracellular copper-----> causing cell death.

what this paper talks about is the added effect of depleting copper to the tumors even more with a copper chelator to stop cells from surviving.  thats great for a cancer patient... its death for us! for our gut lining, for our skin, for our joints. etc etc.   WE WANT CELL PROLIFERATION, NOT AUTOPHAGY

http://www.ingentaconnect.com/content/ben/ccdt/2011/00000011/00000007/art00005?crawler=true

1. The observation that RAR2 was upregulated in patients after treatment with 13-cis-RA, and that increased expression of RAR2 correlated with clinical response, suggest that RAR2 has an important role in suppressing carcinogenesis [

2. This study demonstrated that prolonged copper starvation in these replicating cells leads to mitochondrial damage, oxidative stress and ultimately, apoptosis in neuroblastoma [99]. Our data support a role for ATP7A in neuroblastoma. In contrast to findings in other cancers, ATP7A has been identified as a retinoid-responsive gene and was up-regulated by ectopic overexpression of RAR2 

Forced downregulation of ATP7A reduced copper efflux and increased viability of retinoid-treated neuroblastoma cells. Copper supplementation enhanced cell growth and reduced retinoidresponsiveness, whereas copper chelation reduced viability and proliferative capacity (Fig. 2). These data demonstrate ATP7A expression is regulated by RAR2 and has effects on intracellular copper levels, revealing a link between the anticancer action of retinoids and copper metabolism in neuroblastoma
 

key takeaway at the very bottom of this chart  .... "Copper supplementation enhanced cell growth, and reduced retinoid responsiveness."  ??????

Holy shit... after all of this reading about methylation.. i didnt even realize methionine synthase is a COPPER dependent enzyme!!!  could this be the other way accutane messes with our methyl groups?!

plus ive read on this thread a lot of people have a hard time tanning after accutane... guess whats needed for that?  copper dependent melanin!!!!

Methionine synthase also known as MS, MeSe, MetH is responsible for the regeneration of methionine fromhomocysteine. In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase).^[1][2] Methionine synthase forms part of the S-adenosylmethionine (SAMe) biosynthesis andregeneration cycle.^[3] In animals this enzyme requires Vitamin B12 (cobalamin) as a cofactor, whereas the form found in plants is cobalamin-independent.^[4] Microorganisms express both cobalamin-dependent and cobalamin-independent forms.^[4]

1 hour ago, tryingtohelp2014 said:

How were you diagnosed?  plasma copper isnt a good test.  hair tests not good, if anything contradictory? high copper excretion?  A defect in the gene that makes ATP7A chaperone protein is responsible for causing Menkes syndrome and a defect in the gene responsible for ATP7B chaperone protein causes Wilson™s syndrome.   If you had Wilsons disease... you wouldve known it loooooong ago.  there is no mild version?  you either have the gene defect, or you dont.

RBC copper test results?

ceruloplasmin test results?

i had both of these tests done as part of a bigger nutrient panel a few days ago... awaiting results.  should be informative.  In any case, being copper toxic or deficient... getting the bile to flow is paramount.  

This shows why retinoids are a chemotherapy tool.   

13-cis retinoic acid ----> upregulates RAR2-----> upregulated RAR2 stimulates ATP7A -----> reducing intracellular copper-----> causing cell death.

what this paper talks about is the added effect of depleting copper to the tumors even more with a copper chelator to stop cells from surviving.  thats great for a cancer patient... its death for us! for our gut lining, for our skin, for our joints. etc etc.   WE WANT CELL PROLIFERATION, NOT AUTOPHAGY

http://www.ingentaconnect.com/content/ben/ccdt/2011/00000011/00000007/art00005?crawler=true

1. The observation that RAR2 was upregulated in patients after treatment with 13-cis-RA, and that increased expression of RAR2 correlated with clinical response, suggest that RAR2 has an important role in suppressing carcinogenesis [

2. This study demonstrated that prolonged copper starvation in these replicating cells leads to mitochondrial damage, oxidative stress and ultimately, apoptosis in neuroblastoma [99]. Our data support a role for ATP7A in neuroblastoma. In contrast to findings in other cancers, ATP7A has been identified as a retinoid-responsive gene and was up-regulated by ectopic overexpression of RAR2 

Forced downregulation of ATP7A reduced copper efflux and increased viability of retinoid-treated neuroblastoma cells. Copper supplementation enhanced cell growth and reduced retinoidresponsiveness, whereas copper chelation reduced viability and proliferative capacity (Fig. 2). These data demonstrate ATP7A expression is regulated by RAR2 and has effects on intracellular copper levels, revealing a link between the anticancer action of retinoids and copper metabolism in neuroblastoma
 

key takeaway at the very bottom of this chart  .... "Copper supplementation enhanced cell growth, and reduced retinoid responsiveness."  ??????

That's a very interesting find!!!

When I did a hair mineral analysis about 5 years ago, that's when I was found to have a high Copper content. Interesting that you say the hair analysis is inconclusive, you could be right, I can only trust what my doctor says. Never thought about actually supplementing Copper - I'll wait to see what others think about this as well - thanks for providing the info!
 

1 hour ago, tryingtohelp2014 said:

How were you diagnosed?  plasma copper isnt a good test.  hair tests not good, if anything contradictory? high copper excretion?  A defect in the gene that makes ATP7A chaperone protein is responsible for causing Menkes syndrome and a defect in the gene responsible for ATP7B chaperone protein causes Wilson™s syndrome.   If you had Wilsons disease... you wouldve known it loooooong ago.  there is no mild version?  you either have the gene defect, or you dont.

RBC copper test results?

ceruloplasmin test results?

i had both of these tests done as part of a bigger nutrient panel a few days ago... awaiting results.  should be informative.  In any case, being copper toxic or deficient... getting the bile to flow is paramount.  

This shows why retinoids are a chemotherapy tool.   

13-cis retinoic acid ----> upregulates RAR2-----> upregulated RAR2 stimulates ATP7A -----> reducing intracellular copper-----> causing cell death.

what this paper talks about is the added effect of depleting copper to the tumors even more with a copper chelator to stop cells from surviving.  thats great for a cancer patient... its death for us! for our gut lining, for our skin, for our joints. etc etc.   WE WANT CELL PROLIFERATION, NOT AUTOPHAGY

http://www.ingentaconnect.com/content/ben/ccdt/2011/00000011/00000007/art00005?crawler=true

1. The observation that RAR2 was upregulated in patients after treatment with 13-cis-RA, and that increased expression of RAR2 correlated with clinical response, suggest that RAR2 has an important role in suppressing carcinogenesis [

2. This study demonstrated that prolonged copper starvation in these replicating cells leads to mitochondrial damage, oxidative stress and ultimately, apoptosis in neuroblastoma [99]. Our data support a role for ATP7A in neuroblastoma. In contrast to findings in other cancers, ATP7A has been identified as a retinoid-responsive gene and was up-regulated by ectopic overexpression of RAR2 

Forced downregulation of ATP7A reduced copper efflux and increased viability of retinoid-treated neuroblastoma cells. Copper supplementation enhanced cell growth and reduced retinoidresponsiveness, whereas copper chelation reduced viability and proliferative capacity (Fig. 2). These data demonstrate ATP7A expression is regulated by RAR2 and has effects on intracellular copper levels, revealing a link between the anticancer action of retinoids and copper metabolism in neuroblastoma
 

key takeaway at the very bottom of this chart  .... "Copper supplementation enhanced cell growth, and reduced retinoid responsiveness."  ??????

That's a very interesting find!!!

When I did a hair mineral analysis about 5 years ago, that's when I was found to have a high Copper content. Interesting that you say the hair analysis is inconclusive, you could be right, I can only trust what my doctor says. Never thought about actually supplementing Copper - I'll wait to see what others think about this as well - thanks for providing the info!
 

I was shown to be low / normal in copper in blood tests, and also low normal in zinc. Ill be taking zinc with copper for balance.

[Edited link out]

This guy took accutane when he was 15, still fine and very muscular (he uses hormone injections but still)
He did have some sort of stomach surgery because he had GI symptoms, but he is not suffering from the fatigue and all that seeing how succesful he is as an entrepreneur. Lucky bastard

Point being, accutane doesnt screw up everyone

Marc lobliner, lol. Yea, he is a pretty successful supplement mogul. Amped up jacked up body builder. I'd be surprised if he makes it past 55 with the staples in his chest and various cardiovascular issues that might arise after his competing days...

And of course it doesn't affect everyone, this drug has been prescribed to millions. I have friends who have had nary a side effect after Accutane. I have friends who have developed IBS. I myself have a wide range of side effects incl. muscular, neurological...Dan Kern, the founder of this site only has systemic joint pain after Accutane.

We can't quantify this drug at the moment, and I think that is what doctors and people need to realize. It is by definition "controlled" toxicity for humans. It should be reserved for the most severe forms of acne because its too unpredictable. May be genetic, who knows?

confirmation of a theory? how ironic a day after reading about this copper, and posting a possible link, all due to koikoi's post about methylation and copper.

methylmalonic acid and b-12 within normal range. .. homocysteine normal after weeks of methionine.  no problems there. i can definably rule out b-12 as a limiting factor

But low copper of all things could be the methylation block? this is needed for methionine synthase.
ceruloplasmin normal, ferritin normal.   

If any of you could get tested for this... it would help.   you can order these online from walkin labs.  or goto your doctor and ask.   make sure you get RBC copper 

3 hours ago, tryingtohelp2014 said:

confirmation of a theory? how ironic a day after reading about this copper, and posting a possible link, all due to koikoi's post about methylation and copper.

that copper deficiency appears to be very borderline did the doctor mention any concern? it could still mean something though.

Association of Copper to Riboflavin Binding Protein

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662589/ look at this connection between riboflavin and copper
These results suggest the possibility of a previously unknown function of riboflavin binding protein in the storage or transport of copper.

there is also an active form of riboflavin that you can buy, just like active folate, that is directly used in the body without need for conversion. used in the methylation cycle. and I see on amazon is sold in a methyl formula containing active folate active ribo and b12 and tmg.

I still feel good about ribo but i dont think my body could handle these 400mg capsules as opposed to 100mg tablets split up throughout the day with foodDeficiency of Vitamin B2

Clinical signs and symptoms may appear 3-8 months after deficiency. These include sores at the corners of the mouth, sore tongue, dermatitis numbness of the hands or decreased sensitivity to touch, temperature and vibration and visual changes. There may be the tiredness and fatigue associated with anaemia. Alcohol decreases the bioavailability and absorption of riboflavin.
Decreased sensitivity to touch, you know what that means gentlemen.And look at the timeframe for deficiency

tryingtohelp - how long after tane was that test, just curious. Also, did you ever get zinc tested?

doctor wants to put me on HCG monotherapy in lieu of TRT bc of age. anyone know anything positive about this? Would my muscles respond well, but more importantly the depression? Again, my t levels were so beyond low. I knew they were low but not this low. I may just opt for trt. i don't want to waste anymore time.
and i have been taking taurine for the last 2 months so don't suggest that.

a copper containing enzyme is the 3rd most upreglated on the accutane list
 

2 hours ago, Mike San said:

tryingtohelp - how long after tane was that test, just curious. Also, did you ever get zinc tested?

i just had the test done last week. 20 years post accutane.

43 minutes ago, tryingtohelp2014 said:

a copper containing enzyme is the 3rd most upreglated on the accutane list
 

nice list and find. have no idea what half that shit means. is any thing riboflavin related on there? lol. Seriously though.

Vitamin B2 or riboflavin is delivered to your cells to help improve cellular function and convert sugars to energy. It is essential to the production of red blood cells. Riboflavin (vitamin B2) is integral to the body™s antioxidant defense systems. It activates the liver™s Phase II enzymes, which neutralize and flush toxins from the body. It also helps in the regeneration of glutathione, an enzyme that rids the body of free radicals. Riboflavin (vitamin B2) is known to help support adrenal function, and to help calm and maintain a healthy nervous system.

Vitamin B2: Health benefits¦

• Vitamin B2 has many health benefits. B2 is an antioxidant. It aids in the elimination of free radicals; in doing so, it helps in the prevention of cancers and heart diseases.
• It repairs damaged tissue and helps wounds heal more quickly.
• Is useful in preventing acne, eczema, and aids in keeping skin clear
• Regulates thyroid activity
• It plays a key role in keeping the mouth, skin, hair, eyes, and nervous system in healthy condition.
• It helps produce energy and helps break down proteins, fats, and carbohydrates.
• B2 may help decrease the number of migraine headaches
• Helps the body produce red blood cells, allowing it to transport oxygen throughout the body.

Vitamin B2:  Deficiency¦

A vitamin B2 deficiency can occur at 0.5-0.6 mg a day, those more likely to have this deficiency are the elderly, the chronically ill and alcoholics. A B2 can cause throat soreness and swelling, a swollen tongue, weakness, cracking of the skin “ mainly around the corners of the mouth.

• Can cause eye issues such as blurred vision, soreness, as well as watering, itching and bloodshot eyes. Eyes may become light sensitive.
• Trouble digesting foods
• Frequent dizziness can occur from lack of red blood cells to carry oxygen throughout the body as a result of low B2.
• Hair loss and skin problems
• May cause slow mental responses
• Can cause anemia and nervous system problems
• Premature wrinkling on the arms and face, and causes split nails

Sorry Guys, time ago in this topic i read discussion about a hpothetical problem with androgen receptors, all my sides look like very low testosterone, but my testosteron test are normal.

There are new in this direction? anyone have tried TRT?

2 hours ago, Ruvik said:

Sorry Guys, time ago in this topic i read discussion about a hpothetical problem with androgen receptors, all my sides look like very low testosterone, but my testosteron test are normal.

There are new in this direction? anyone have tried TRT?

great question and from what it appears they will only continue to talk about methylation and zinc/copper imbalances. they are caught up on that. you won't get an answer....hence why this entire thread has gone no where in 5 years despite people thinking they have made progress. If anything you'll get a private message from someone telling you to "take taurine". It's an endless loop here.

It goes from Biotin, to eating weed brownies, to vaping weed, to SSRI's, to water fasts, back to pot, then it goes to manganese, back to weed, to eating a lot of vitamin a, to not eating any vitamin a, to copper toxicity, to taurine depletion, to methylation and SAM-e, and now were back at copper but this time it's too little copper!

Unlike you I have very low testosterone tests but my libido is fine. everything else though is fucked. Doc wants to put me on hcg therapy.

Hello fellow genetic mutants!

I am a scientific researcher (genetics) who also, unfortunately, has been damaged by 'Accutane'. I was very young and not mindful enough to process the potential dangers, and of course, wanted perfect skin. 

That was 7 years ago to the day, and still experiencing the same issues, post dosage. 

I believe 'reversing' the side effects will be very difficult, given the genetic alterations involved. The drug which reverses the effects, sadly, may be more damaging yet still. I have had some some success in managing the symptoms, which has allowed me to live a normal and happy life. 

I am always interested in extending and sharing knowledge, so I am happy that I have stumbled across this forum. Until now, I have conducted my own research, with help from the NCBI server.

My gosh are some of these larger pharmaceutical companies arseholes! I'm sure in a few decades, a biomedical lecture will end with a slide of something like "can you believe they use to treat acne with THIS..."

My issues mainly relate to digestion. I am now lactose and gluten intolerant, of which I was not pre-dosage. I have symptoms relating to IBS -CD. I have arrived at similar conclusions stated on this thread, such as: 

- Liver cell damage and alternative expression due to teratogenic effects
- Cell line reproduction altered in specific cells, often found in the intestine. (logical considering the drugs mechanism of action)
- Alteration to neural cell function (this is hard to accept, but once again rational.)

Currently, as management: 

- minimise coffee and alcohol (this was hard, but worth it)
- Daily probiotics
- Smaller meal sizes 
- Daily exercise (May be more difficult now, but helps biotic function)
- Digestive enzymes (daily)
- No Dairy, Minimal red meat 
- Minimal Gluten
- Keep food log, and eliminate problem foods. 
- Stay hydrated 
- N-Acteyl glucosamine (lines gut) 
- Vit D before bed. 
- Set bathroom times 
- High water, low sugar foliage as regular part of diet. 

- Scooterman 

On 01/01/2016 at 9:52 AM, yetanotheraccutanevictim said:

@Modeaa Awesome info about the kidneys and accutane. Check out my previous post above. My urine test showed HIGHLY elevated albumin.

" I'd also be curious if you could test your microalbumin/creatinine ratio. Ref range is < 3.9 mg/g. Mine was 65.9! (indicating severe kidney damage). This was done as part of an inflammation profile. I know accutane damages the kidneys but I'm 3 yrs post-treatment."

Has anyone else tested this biomarker for kidney function and leakiness?

--

Copying my post from above:

 

@tryingtohelp2014Lastly, from the SAM-E & 13CRA thesis you posted, I found some really cool NUGGETS OF INFO:

" Importantly, Vitamin A is a fat soluble vitamin that can be stored in the body, primarily in the liver as retinyl ester. This is highly beneficial in cases of Vitamin A deficiency: a supplement containing 200,000 IU can meet the patient™s daily requirement for four to six months"

 

http://www.unscn.org/layout/modules/resources/files/Policy_paper_No_13.pdf

"Recently Stoltzfus et al. (1992,1993) reported that a single 300,000 IU vitamin A (equivalent of 90 mg retinol) supplement administered to mothers within a few weeks of birth was effective in raising milk vitamin A levels and in maintaining an improved level of vitamin A status in the infant for at least six months."

 

"Liver retinyl ester concentration can vary widely and still be considered to be in the normal range. In the rat, concentrations exceeding 5ˆ’10 µg retinol/g liver support a normal output of retinol on its transport protein, retinolˆ’binding protein (RBP) (Goodman, 1984; Harrison et al., 1987). If liver retinol falls below this level, RBP synthesis continues but secretion is impaired unless additional retinol is provided (Smith et al., 1973). Thus it appears that these last retinol œreserves are not readily mobilized for secretion into plasma. The retinol molecule is very well conserved: it is eliminated from the body only after several passages between liver and peripheral tissues (Green et al., 1985)."

 

We've already established that we are deficient in true vitamin A. Perhaps this causes RBP secretion to become impaired. This supports the idea that we get symptoms of accutane all over again when we ingest more vitamin A because once we hit a certain concentration of retinol in the liver, it starts secreting it again. Also, this is yet another study that shows that retinol is very hard to get rid of. It seems to recirculate in the body. One of my older posts links 5-10 studies that show this increasing the pharmacological profile of isotretinoin.

In other words, I'm going to continue eating my liver (high in vit A) and doing liver flushes. Even if we eliminated all the accutane from the body, it will take a few months to notice the difference. It won't be an instant "I'm healed!" moment. All the epigenetic switches will have to go back to how they were. This may take a while.

It switches on a pathway that the drug altered. The drug itself leaves the body after ingestion relatively quickly. Interesting articles though