Acne.org Products
Im also including positive results of accutane.
Influence ofisotretinoinon hippocampal-based learning in human subjects.
CONCLUSION:
Isotretinoindoes not reduce learning and memory and our study suggests that it may instead lead to a dose-related improvement in specific aspects of hippocampal learning and memory. Retinoic acid functions in the hippocampus as the active metabolite of vitamin A, suggesting that this may be a limiting factor in the human hippocampus and addition of exogenous retinoic acid brings levels closer to an optimal state.
Effect of different doses ofisotretinointreatment on the levels of serum homocysteine, vitamin B 12 and folic acid in patients with acne vulgaris: A prospective controlled study.
Homocysteine levels were significantly increased in both groups taking 0.5 mg/kg/day and 1.0 mg/kg/dayisotretinoin(p<0.05). There were no statistically significant differences in the levels of vitamin B12, folate and liver function tests (p>0.05 each). Total cholesterol level increased significantly in the group using 1.0 mg/kg/day (p<0.05). In the triglyceride levels, significant increases were seen in both groups (p<0.05).
Decreased vitamin B12 and folic Acid concentrations in acne patients afterisotretinointherapy: a controlled study.
RESULTS:
In total, 120 patients with moderate and severe acne vulgaris who completed 6 monthsisotretinointherapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B12 and folic acid levels (P < 0.05).
CONCLUSION:
Vitamin B12/folic acid treatment should be given under medical surveillance before and duringisotretinointherapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases.
Severe generalised rhabdomyolysis with fatal outcome associated withisotretinoin.
We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.
(couldnt acess the last one without paying a lot for it)
Isotretinoin-induced arthritis mimicking both rheumatoid arthritis and axial spondyloarthritis.
Effects ofisotretinoinon the inflammatory markers and the platelet counts in patients with acne vulgaris.
RESULTS:
A statistically meaningful increase was observed in the platelet density, hemoglobin levels. And a statistically significant decrease has been determined in the red-blood-cell distribution width level while no meaningful differences were detected in the mean platelet volume, neutrophil lymphocyte rate, platelet lymphocyte rate, and white blood cell count.
CONCLUSIONS:
The oralisotretinointreatment has been demonstrated as having increased the platelet density, hemoglobin levels and having decreased red-blood-cell distribution width level significantly.
The effect of oralisotretinoin(13-cis retinoic acid) on hearing systems in patients with acne vulgaris: a prospective study.
Our results suggest that the oralisotretinoin(13-cis retinoic acid), which is a derivative of retinol (vitamin A), improved the hearing level of the patients in all audiometric frequencies in a short-period follow-up.
Doesisotretinoinhave effect on vitamin D physiology and bone metabolism in acne patients?
The 25 hydroxy vitamin D and serum calcium levels decreased significantly (p < 0.0001, p < 0.05, respectively), whereas 1,25 dihydroxy vitamin D, parathormone, and bone alkaline phosphatase levels increased significantly after 3 months ofisotretinointreatment (p < 0.005, p < 0.005, p < 0.0001, respectively). Aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels also increased significantly afterisotretinointreatment. This prospective clinical study showed thatisotretinoinhas an effect on vitamin D metabolism.
6 hours ago, lolaccutane said:+1 for oysters. Supps work, if you know what you're doing. Certain nutrients like dha have been protected by certain nutrients like iodine for millionsof years. These nutrients usually come together in nature this food makes sense most of the time. Sometimes we need super physiological doses of certain supps to reverse something. I think you should take ubiquinol, magnesium (orotate specifically, but anything really), and d ribose if you're taking taurine for the full mitochondrial stack. Someone told me Accutane shuts down the sod2 pathway and we need to focus on mitochondrial efficiency in order to gain control of our bodies again (and realistically, revers want disease. What's more fundamental than fixing energy centers in our cells? That's my next experiment. Ithink water (I've been drinking exclusively acqua panna for a couple months) is the MOST important thing. No fluoride or chlorine which are dielectric blockers that block semiconduction in collagen. Iodine is important, to promote semiconduction and to build the brain up. Realistically, I'm tryna be healthy and getting by on food and suppsuntil I got enough money to figure everything out. I'm a musician and I'm getting closer and closer to my goals thanks to food and supps and positivity. Positivity helps you do shit, it's not an end all. Keep knocking down your goals, guys. Anyone smoking/vaping weed? Psychedelics? Anything? I wanna hear some crazy next level stuff lol. I'm bored of vitamins and minerals...
Thanks for your insight. I focus a lot on mitochondria but i need to step back and fix my gut first, its severely damaged.
Have used psychedelics and weed..(LSD, shrooms and 2C-B)I had a period of wanting to explore that stuff as well. None of it helps accutane sides but im curious to all things like that. Also done MDMA. Never touch alcohol. Been completely sober for 1,5 years from all substances. (I didnt have substance abuse lol, just wanted to try stuff once)
None of this has any healing ability except possibly mental health (outside of neurochemistry, like your perspective and self image may improve etc)
Dont recommend anyone here tries it. I only did so because of the severe depression i ended up in after accutane and all my classmates started doing it so it was partially a social thing as well. Not worth it.
Been through 600 studies now. Ive gone over a lot of the FoxOstudies indepth and the effects accutane has on it shows up as beneficial for a lot of things in some cases. I am confused..
Chronic low-doseisotretinointreatment limits renal damage in subtotally nephrectomized rats.
Retinoids are anti-proliferative and anti-inflammatory compounds. We had previously shown that retinoids alleviate kidney damage in acute models of renal disease.
The influence of 13-cis retinoic acid on human meibomian gland epithelial cells.
RESULTS:
We found that 13-cis RA inhibited cell proliferation, induced cell death, and significantly altered the expression of 6726 genes, including those involved in cell proliferation, cell death, differentiation, keratinization, and inflammation, in human meibomian gland epithelial cells. Further, 13-cis RA also reduced the phosphorylation of Akt and increased the generation of interleukin-1 and matrix metallopeptidase 9.
CONCLUSIONS:
Exposure to 13-cis RA inhibits cell proliferation, increases cell death, alters gene expression, changes signaling pathways, and promotes inflammatory mediator and protease expression in meibomian gland epithelial cells. These effects may be responsible, at least in part, for the 13-cis RA-related induction of MGD.
Functional brain imaging alterations in acne patients treated withisotretinoin.
RESULTS:
Isotretinoinbut not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between theisotretinoinand antibiotic treatment groups before or after treatment.
CONCLUSIONS:
This study suggests thatisotretinointreatment is associated with changes in brain functioning.
Isotretinoindoes not induce insulin resistance in patients with acne.
CONCLUSIONS:
Three months ofisotretinointreatment did not change insulin sensitivity in patients with AV. Further studies with insulin resistance models may even reveal an improvement in insulin resistance, as experimental animal studies have previously shown.
Short-termisotretinointreatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: doesisotretinoinaffect growth hormone physiology?
RESULTS:
IGF-1 and IGFBP3 levels decreased significantly after treatment (P < 0.01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P < 0.0001) while high-density lipoprotein cholesterol levels were significantly decreased (P < 0.0001).
CONCLUSIONS:
Isotretinointherapy may have an effect on GH physiology, and further studies are needed to understand this association.
Is nuclear deficiency of FoxO1 due to increased growth factor/PI3K/Akt-signalling in acne vulgaris reversed by isotretinoin treatment?
Cardiac remodeling induced by 13-cis retinoic acid treatment in acne patients.
RESULTS:
Patients showed reductions in right atrium vertical diameter, left atrium longitudinal diameter, left atrium volume and left ventricular diastolic diameter over the course of treatment. Significant increases in interventricular septum diastolic thickness, posterior wall diastolic thickness, relative wall relative thickness and left ventricle (LV) mass were observed. The LV mass index showed an increase in ventricular mass and a decrease in the cavity size. Examining LV systolic function, a decrease was observed for the cardiac index.
CONCLUSION:
In this study, 10 weeks of 13-cis-RA therapy at a dose of 0.5 mg/kg/d was found to promote concentric-type heart remodeling due to the occurrence of two associated events: heart hypertrophy and hypovolemia.
I stopped going over studies, i made it to around the first 1000 and all the next ones are dated 1980-1995 and they are somewhat useless mostly..
Will go over all studies with the tags "accutane" and "roaccutane"
I went over all the pubmed studies by searching for isotretinoin, these are the ones I found relevant. I stopped once the studies started dating in the 90s, you might find something relevant in the studies from 80s up to 1999 but I didnt bother going through that many thousand studies, even tho scrolling through pubmed is relatively fast. I feel like older studies only focused on how well it treated acne, not what it does to the body. I might be wrong.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
http://www.ncbi.nlm.nih.gov/pubmed/24697846
http://www.ncbi.nlm.nih.gov/pubmed/24966012
http://www.ncbi.nlm.nih.gov/pubmed/25573071
http://www.ncbi.nlm.nih.gov/pubmed/25219729
http://www.ncbi.nlm.nih.gov/pubmed/26110123
http://www.ncbi.nlm.nih.gov/pubmed/22517509
http://www.ncbi.nlm.nih.gov/pubmed/23135667
http://www.ncbi.nlm.nih.gov/pubmed/25597375
http://www.ncbi.nlm.nih.gov/pubmed/26338739
http://www.ncbi.nlm.nih.gov/pubmed/22714752
http://www.ncbi.nlm.nih.gov/pubmed/25484410
http://www.ncbi.nlm.nih.gov/pubmed/25294249
http://www.ncbi.nlm.nih.gov/pubmed/25853176
http://www.ncbi.nlm.nih.gov/pubmed/21410620
http://www.ncbi.nlm.nih.gov/pubmed/23722388
http://www.ncbi.nlm.nih.gov/pubmed/15863802
http://www.ncbi.nlm.nih.gov/pubmed/10859533
http://www.ncbi.nlm.nih.gov/pubmed/26154692
http://www.ncbi.nlm.nih.gov/pubmed/21720662
http://www.ncbi.nlm.nih.gov/pubmed/24683393
http://www.ncbi.nlm.nih.gov/pubmed/21860167
http://www.ncbi.nlm.nih.gov/pubmed/20941944
http://www.ncbi.nlm.nih.gov/pubmed/20930691
http://www.ncbi.nlm.nih.gov/pubmed/26034688
http://www.ncbi.nlm.nih.gov/pubmed/25721216
http://www.ncbi.nlm.nih.gov/pubmed/20059367
http://www.ncbi.nlm.nih.gov/pubmed/20128787
http://www.ncbi.nlm.nih.gov/pubmed/25625453
http://www.ncbi.nlm.nih.gov/pubmed/22813063
http://www.ncbi.nlm.nih.gov/pubmed/25354039
http://www.ncbi.nlm.nih.gov/pubmed/22110774
http://www.ncbi.nlm.nih.gov/pubmed/20465675
http://www.ncbi.nlm.nih.gov/pubmed/20465621
http://www.ncbi.nlm.nih.gov/pubmed/20394627
http://www.ncbi.nlm.nih.gov/pubmed/21663986
all the links are individual studies, I didnt think of adding the title to each link so you have to open each one.
Here are some more showing intestinal damage, mechanism of why it causes night blindness etc
http://www.ncbi.nlm.nih.gov/pubmed/7669643
http://www.ncbi.nlm.nih.gov/pubmed/7858417
http://www.ncbi.nlm.nih.gov/pubmed/19492487
http://www.ncbi.nlm.nih.gov/pubmed/16517990
http://www.ncbi.nlm.nih.gov/pubmed/15177980
http://www.ncbi.nlm.nih.gov/pubmed/11675849
http://www.ncbi.nlm.nih.gov/pubmed/11172037
http://www.ncbi.nlm.nih.gov/pubmed/25008440
On 12/7/2015, 8:24:03, Mike San said:He fasted for a few days, ate, and feels better...kids onto something....
Increases in ATP also increase NAD+ (in liver cellular fluid) (R).
Blood sugar dose dependently worsens (increases) your NADH/NAD+ ratio in the same way as low oxygen. When you combine excess carbs/sugar and low oxygen, you start getting fatigued and have low energy.
This is one of the most significant reasons why sugar/carbs makes people with healthissues feel worse.
In fact, you might feel worse after eating anything because eating decreases NAD+ levels and fasting increases it. This is especially true in a high fat+/high sugar diet (R).
Fasting, calorie restriction and interval exercise help peoplebecause they all raise NAD+ levels (R). There are other reasons why these help, but increasing NAD+ is perhaps the most significant reason.
On the other hand, some people do worse in the short term from fasting because skipping meals causes hypoglycemia and when I was in a bad state, Id feel like crap if I skipped meals. And then Id eat a meal and crash, becausethere wasnt enough energy related molecules (ATP levels) in my lateral hypothalamus from fasting, which shuts orexin down.
tryingtohelp2014, can you please reply to the PM I sent you?
Thanks.
15 hours ago, trantran83333 said:
So you're saying I should continue with taurine even tho I experienced the crash? I felt so tired 30 minutes after taking it. It lasted for about 4 hours. Horrible
Yes take it before youre going to bed. Its a popular supplement for sleep improvement.
Thats why you feel a "crash" its just the taurine slowing your brain down.
At this point I dont have any hair loss. Its fucking great, when I wake up there are zero hairs on my bed.
Also my tinnitus is down a bit. At least I'm not focussing anymore on it. I think its due to the TUDCA - Taurine combination.
I supplement Vitamin A Retinyl Palmitate 5000ui in the morning so it can utilize Vitamin A throughout the day.
Also started a week ago with HIIT Hill sprints and energy-wise they are a hit or miss but for mood they are great.
Keep up the good work, this looks promising.
Wald,
On 12/7/2015, 8:24:03, Mike San said:Relentless1k: Posting function bugged lol i can only write stuff by quoting people and editing it.
What is the reasoning for TUDCA except to digest fat? Ive used UDCA (pharma version) and ox bile (has tudca) and both aid in fat digestion but what else. I have seen the post about protein folding and ER stress but that does seem somewhat inconclusive
Hope you dont mind that i used you for typing this, Mike San
On 12/10/2015 at 2:37 AM, sam1w2e said:
But are you certain it's vitamin A deficiency and not toxicity? Because the symptoms seem very similar for both, and I wouldn't want to go taking more vitamin A if I don't need it.
You are toxic in synthetic vit A (accutane) and deficient in real vit A.
[Edited link out]
Also, for the people believing the studies that show accutane positively impacts the body, just know that LOADS of peer reviewed, published studies are being manipulated. The whole system is messed up. The authors behind most studies are actually in the pharmaceutical industry. It's crazy. They don't want drugs to appear harmful.
Even the British Journal of Medicine recently declared that evidence-based medicine is dead. Evidence is cherry-picked. Loads of studies done are just thrown away and not published (hiding the truth).Some studies are even manipulated. One of the biggest crimes in history is the story of Dr. Nicholas Gonzalez and his cancer treatment trials being manipulated in favor of conventional "treatments" (chemo & radiation).
Here's an audio clip of the great Dr. Gonzalez detailing what goes on behind the scenes.
This was just DAYS before he died under very suspicious circumstances.
http://fearlessparent.org/radio-blog-toxicity-hydration-and-healing-episode-75/
Hehas a book on the topictitled, What Went Wrong.
I suggest everyone here listen to more interviews with him to become more informed about how corrupt the world is today.
By the way, he's a big proponent of liver flushes, coffee enemas, and other detoxification methods such as juice fasting.
Don't believe the studies that attempt to disprove the effectiveness & safety of such methods.Always follow the $$$. Open your eyes.
On coffee enemas: (I believe this will speed up our recovery by eliminating the toxic accutane residues from our livers).
If anyone jumps on board with me, let me know. I want to see the effects others get from trying these ancient healing methods.
link3- detailed overview
link4- how to perform them
--
Even very smart scientific oriented bloggers are being misinformed by these biased studies:
Here's an article of someone who doesn't believe in them due to the studies.
..But, if you scroll down to thecitations and take a look at the studies, you'll see what I'm talking about above.
Let's take this study as an example:
Cassileth B.Gerson regimen.Oncology. 2010;24(2):p. 201.
Looks legit but look at the journal it's posted in. The journal of Oncology (cancer research).
Hmm.. interesting. Look at the author information: "Sloan-Kettering Cancer Center" (one of the most conventional cancer treatment centers around). Also, if you take a look at other studies done by Cassileth B. you will find articles such as " http://www.ncbi.nlm.nih.gov/pubmed/22957409 " where they discuss the uselessness of alternative therapies and they try to reinforce views of vaccinations being safe, etc..Be aware that things like this go on. One last example is the infamous lancet study on liver flushing popularized by quackwatch. Do not fall for the trap. Become informed.
My 0.02..
1 hour ago, VanceAstro said:Anyone else is having problems with fat digestion after Accutane?
Yep. Still working on that. It could be just that accutane did damge to the digestion (fat digestion is the first one to fail because its the most difficult macronutrient to break down)
Or its a gall bladder issue, but i dont know that for certain. I used to believe that because this thread has been filled with theories on that.
Just stick to 50-70g fat per day, you should at least be able to digest 50. Add ox bile and digestive enzymes to meals. Bile salts work as well
Accutane sucks. been 5 years. joints are always painful. skins yellow. depressed is like, staring at a wall, alone. instead of having a normal conversation with people now i just go blank minded, or try to pretend (cocoleaves help?). i was on 80mg a day for 6 months. all above posters about side effects speak to my heart. i didn't know or expect this to happen this way or even know it was possible. i still work, i still appear normal and stuff, but you guys, the ones with bad side effects especially, we need to consider each other family.
This is not a sob story, this is just where I'm at right now. Its a thursday night and there is no love in my heart, because I am not able to connect with love in a way i know how.
Accutane sucks. been 5 years. joints are always painful. skins yellow. depressed is like, staring at a wall, alone. instead of having a normal conversation with people now i just go blank minded, or try to pretend (cocoleaves help?). i was on 80mg a day for 7months. all above posters about side effects speak to my heart. i didn't know or expect this to happen this way or even know it was possible. i still work, i still appear normal and stuff, but you guys, the ones with bad side effects especially, we need to consider each other family.
This is not a sob story, this is just where I'm at right now. Its a thursday night and there is no love in my heart, because I am not able to connect with love in a way i know how.
When a song comes on i know and like, i can still enjoy it a bit! Time will tell?
I DON'T KNOW.
PS: Just bought the new 27 inch iMac! Its sweeeeeeet. but wow expensive. I guess I don't have buyers remorse though because it is really nice and hopefully lasts a long time!
If the forum user "Trapt" is still out there, please message me. I have important information for you.
@AlanTookAccutaneWowIf your skin is yellow, it is most likely due to liver congestion. You probably need to flush out your biliary system.
Hello All!
I'm back. Nothing astounding to report.
I've been taking high dose iodine (helps complexion, sleep, joints, lubrication in eyes), digestive enzymes, ox bile, and HCL betaine for improved digestion, and my naturopathic doctor started me on a methylation program with glutathione, methylfolate, and methylb12. Cannot really say if the methylation is working and I am not sure how long it will take.
Still have "alleged" chronic candida, food sensitivities, and bacterial infections/pseudo UTI's which I believe is genuinely interstitial cystitis triggered by different foods, etc. as well as bacteria. Horrible bowel congestion which improves with acacia fiber, magnesium (natural calm), and I take high dose glutamine on the daily which helps with keeping on muscle mass, helps some with joint pain, and THICKER hair thank god. Also helps the bowels repair some. Also, helps retain the follicle.
I've also been doing 10 minute scalp massages a day the past year, yes YEAR, in the shower, and my hair is much better than it used to be. I am going on 12 years after accutane. I cannot say things are necessarily better, but I know my body more, have had some relief from liver flushes, but got lazy and worried that it may not cure it/help if I keep doing it/ wasn't sure if it contributed to the candida...or if I'm in some state of mid-flushing where I didn't clear it yet. Who knows. Skeptical, but all the same hopeful. I made it to 8 flushes...the most amazing thing was the different size of "Stones", whether they are genuine stones or not, my body felt better for weeks and it wasn't any placebo effect. I am not looking for naysayers to liver cleansing against my post, I won't listen anyways. So don't even try 
Yoga helps with digestion and overall blood flow. Still have all the symptoms of diabetes including neuropathy and tingling in extremities, but don't cut it when the tests come. I also know candida an mimic that, but I honestly feel it's just a symptom of all of the thinning and side effects. I picture all of my epithelial layers, including the digestive tract as being thinner, as well at the skin on the outside. My gums are "thin" as well. It was interesting though, when my naturopathic doctor gave me progesterone micronized cream to put on in between my periods (due to painful, hemorrhaging and clots), my skin THICKENED some, but then I got outbreaks which I didn't like, but I was happy with the thicker skin, which seems odd. Don't know if anyone can explain the hormonal reasoning for that??
If 70% of serotonin is made in the gut, I have been thinking like some others on here, and wondering if SSRI's could help at some level. I understand that they can definitely be harmful, but I still have severe psychiatric effects including severe anxiety and depression. Can anyone speak to an SSRI or SNRI that they have tried that didn't harm them and helped them? Normally I'd be SO against it, but I think the pros might outweigh the cons in terms of the effect on my mental health.
Keep on keeping on everyone. I'm very impressed by all the posts and research going on on here. It's hard to keep track of everything at times and I'm so busy working! Bleh!
So I did some searching on Alan up there ^ and he seemingly checks out. He's on the Westcoast in the U.S. and probably akin to what you would picture when you read his posts. Even his ebay reviews are mixed with several negative feedbacks. So, I jumped the gun a little bit and am gonna try to cut him some slack more, even though he is borderline cray and makes us look bad, I actually believe him.
22 hours ago, Relentless1k said:
http://examine.com/supplements/tauroursodeoxycholic-acid/#ref7
Beyond TUDCA's primary treatment purpose (Cholestasis, next section) TUDCA also appears to have beneficial modulation of cells in the liver, promoting regeneration and reducing cell death. May not be relevant in an already health liver (due to high regeneration rates already), but nice for unhealthy livers
Cholestasis is a condition in which bile flow from the liver is distrupted in some manner. UDCA and TUDCA are currently one of the first lines of treatment for a variety of cholestatic syndromes.[2]
Accumulation of bile acids in the liver during periods of impeded intestinal secretion (cholestasis) can cause cell death in hepatocytes secondary to the bile acid's detergent-like effects,[20][21][22]and UDCA/TUDCA confer protective effects in this scenario. The detergent-like effects are related to bile acid's hydrophobicity and lipid solubilizing actions, yet UDCA/TUDCA are highly hydrophilic and unlikely to possess the same toxicity.[23][24]
55 minutes ago, Walden Rev said:
http://examine.com/supplements/tauroursodeoxycholic-acid/#ref7
Beyond TUDCA's primary treatment purpose (Cholestasis, next section) TUDCA also appears to have beneficial modulation of cells in the liver, promoting regeneration and reducing cell death. May not be relevant in an already health liver (due to high regeneration rates already), but nice for unhealthy livers
Cholestasis is a condition in which bile flow from the liver is distrupted in some manner. UDCA and TUDCA are currently one of the first lines of treatment for a variety of cholestatic syndromes.[2]
Accumulation of bile acids in the liver during periods of impeded intestinal secretion (cholestasis) can cause cell death in hepatocytes secondary to the bile acid's detergent-like effects,[20][21][22] and UDCA/TUDCA confer protective effects in this scenario. The detergent-like effects are related to bile acid's hydrophobicity and lipid solubilizing actions, yet UDCA/TUDCA are highly hydrophilic and unlikely to possess the same toxicity.[23][24]
Thanks 
Now to source it... I have used UDCA like 2 years ago and ordered it from a research chemical company lol, idk how it made it through customs.
--
Regarding NAC: (from Dr. Ben Lynch)
if one has high levels of oxidative stress, taking sulfur (NAC is a sulfur amino) can really backfire. Also “ if one™s sulfur levels are elevated, it pushes them to become cysteine and then sulfites. This pathway can get clogged which is why I make the recommendations above. Stop the sulfur-containing foods and supplements for a few days, take the B1 and molybdenum. Then introduce the glutathione slowly “ not the NAC.
Fat malabsorption can be related to MTHFR or just by itself “ both. If methylation or sulfur is low, then making phosphatidylcholine is low and so is taurine. Taking Lipsomal Glutathione along with PC and/or Taurine may be useful “ with meals. If there are pathogens present, they push out taurine (not directly “ indirectly) and this can cause fat malabsorption.
It™s all connected.
From personal experience i can say i did not do well with NAC (it unclogs my nose but causes brain fog and more fatigue)
Glutathione also did nothing or made me more foggy, i dont know.
Will retry both in the future once i feel like my fundamental systems are balanced.
Taurine has been really good to me, i must have been deficient seeing as how the 3 and 5g doses did so well. I now take 1-3g daily. Its not a cure, just a piece of the giant puzzle of the body.
Idk how many times i need to repeat the fact that NOT ONE SINGLE SUPPLEMENT WILL BE A CURE, ITS A BIG PUZZLE AND WE NEED TO FIX THE BIOLOGY WHICH IS 100000 THINGS AT ONCE. THIS WILL TAKE TIME.
Accutane obviously screwed over a lot of systems and or caused issues that eventually lead to more stuff being off balance, alltho that is not accutanes fault directly it still needs fixing.
I feel like accutane might have pushed a few systems into the wrong state, which eventually created a domino effect to fuck over all of it.
Personally i feel like the gut, brain and liver was fucked up most. I managed to get rid of libido and hormone issues, joint and muscle pain is also gone 🙂
This seems like a decent alternative to tudca? iherb.com/Jarrow-Formulas-Bile-Acid-Factors-90-Capsules/172
I also believe that ox bile has tudca in it, if im not remembering wrong.
33 minutes ago, Relentless1k said:Thanks
--
Regarding NAC: (from Dr. Ben Lynch)
if one has high levels of oxidative stress, taking sulfur (NAC is a sulfur amino) can really backfire. Also “ if one™s sulfur levels are elevated, it pushes them to become cysteine and then sulfites. This pathway can get clogged which is why I make the recommendations above. Stop the sulfur-containing foods and supplements for a few days, take the B1 and molybdenum. Then introduce the glutathione slowly “ not the NAC.
Fat malabsorption can be related to MTHFR or just by itself “ both. If methylation or sulfur is low, then making phosphatidylcholine is low and so is taurine. Taking Lipsomal Glutathione along with PC and/or Taurine may be useful “ with meals. If there are pathogens present, they push out taurine (not directly “ indirectly) and this can cause fat malabsorption.
It™s all connected.
From personal experience i can say i did not do well with NAC (it unclogs my nose but causes brain fog and more fatigue)
Glutathione also did nothing or made me more foggy, i dont know.
Will retry both in the future once i feel like my fundamental systems are balanced.
Taurine has been really good to me, i must have been deficient seeing as how the 3 and 5g doses did so well. I now take 1-3g daily. Its not a cure, just a piece of the giant puzzle of the body.
Idk how many times i need to repeat the fact that NOT ONE SINGLE SUPPLEMENT WILL BE A CURE, ITS A BIG PUZZLE AND WE NEED TO FIX THE BIOLOGY WHICH IS 100000 THINGS AT ONCE. THIS WILL TAKE TIME.
Accutane obviously screwed over a lot of systems and or caused issues that eventually lead to more stuff being off balance, alltho that is not accutanes fault directly it still needs fixing.
I feel like accutane might have pushed a few systems into the wrong state, which eventually created a domino effect to fuck over all of it.
Personally i feel like the gut, brain and liver was fucked up most. I managed to get rid of libido and hormone issues, joint and muscle pain is also gone 🙂
This seems like a decent alternative to tudca? iherb.com/Jarrow-Formulas-Bile-Acid-Factors-90-Capsules/172
I also believe that ox bile has tudca in it, if im not remembering wrong.
Mentioned before
http://www.powdercity.com/products/tudca-tauroursodeoxycholic-acid .
They have a great collection of supplements
7 hours ago, Walden Rev said:
Mentioned before
http://www.powdercity.com/products/tudca-tauroursodeoxycholic-acid .
They have a great collection of supplements
Didnt know they shipped to europe, great.
But then again is tudca really different from ox bile?
----
To everyone who wants to try something:
I have tried most supps and foods + a lot of pharma on the market, ask me anything
16 hours ago, macleod said:So I did some searching on Alan up there ^ and he seemingly checks out. He's on the Westcoast in the U.S. and probably akin to what you would picture when you read his posts. Even his ebay reviews are mixed with several negative feedbacks. So, I jumped the gun a little bit and am gonna try to cut him some slack more, even though he is borderline cray and makes us look bad, I actually believe him.
Thanks officer Dangus
Glad to have Macleods approval for posting freely on the internet. You're so cool dude!
21 hours ago, MovingOnMusicGal said:Still have "alleged" chronic candida, food sensitivities, and bacterial infections/pseudo UTI's which I believe is genuinely interstitial cystitis triggered by different foods, etc. as well as bacteria.
I cannot say things are necessarily better, but I know my body more, have had some relief from liver flushes, but got lazy and worried that it may not cure it/help if I keep doing it/ wasn't sure if it contributed to the candida...or if I'm in some state of mid-flushing where I didn't clear it yet. Who knows. Skeptical, but all the same hopeful. I made it to 8 flushes...the most amazing thing was the different size of "Stones", whether they are genuine stones or not, my body felt better for weeks and it wasn't any placebo effect. I am not looking for naysayers to liver cleansing against my post, I won't listen anyways. So don't even try
l-glutamine is a fantastic food for yeasts just so ya know. Mainly the beneficial yeasts. However, if there is an undesirable overgrowth, it could prolong their survival.
Infections can be caused by poor bile flow. Bowel congestion/sluggishness can also be caused by it. If you have chronic candida, it may not be the root cause. There are many things like heavy metal toxicity which can exacerbate the problem.
..Yet another person who benefited from liver flushing. I've seen over 10 people now who have had positive changes through cleansing the biliary tree.
For those brave enough to do liver flushing and coffee enemas, it's WAY more effective if you take a binding agent 30-60min before the gallbladder squeezes out all the junk to prevent reabsorption
- Activated charcoal works to mechanically adsorb toxicants
- Cholestyramine works as a chemical binder (However, it's a folate antagonist and may cause constipation)
- 1tbsp chia seeds with a chlorella pellet to bind toxicants
---- Anyone here going to be doing liver flushing or coffee enemas? I want you to post your experiences to convince others to try it. I believe it's a great way for people like us to recover. My digestion gets better with each flush.
1 hour ago, Modeaa said:
on the next if you have any wornings or benefits or any other input:
chanca piedra- i heard it is good for kidneys and gallbladder stones and also wonderd if for liver stones, also generally if herbs can break liver stones (yetanotheraccutanevictim-?)
pancreas glandular
venous support formulas or herbs- like horse chestnut ,butcher's broom ,gotu kola,diosmin ,hesperidin.
now candida support, candex, sangre de grado (dragon's blood), colostrum, l-glutamine.
I also agree with your way of thinking that it might take fixing several things at the same time.
To start off, even a perfectly "healthy" person will not have all their bodily systems fully optimized. Having a perfect diet and supplement regimen + other enhancing tools will also make their life better and increase their chances of achieving whatever they may want in life. So it doesnt only apply to "sick people"
I have not really delved into herbs beyond cognitive enhancement/aiding mental illness as herbs do not serve a function in our biology. Im going to study it but ive been focusing on the stuff that actually has a bigger role. But herbs can at least be great for liver health, alltho i dont know about stones. Only results for gallstones in the database i look a lot of things up was TUDCA.
Candex is just biofilm enzymes i believe, colostrum is good if u get a proper brand, glutamine is good but it can fuck up your neurotransmitters. It did for me, its what started my panic attack disorder. It worked fine for a week or two then every time i took it i would think i was dying and even after quitting i still have that, likely due to excess glutamate. (I quit it 1,5 years ago, and alltho i only get like 1 panic attack every 2-3 months its still weird cuz i never had that, not even post accutane) Used to have several ones daily for no reason when i took glutamine.
Gotu kola and hesperidin are good. Grape seed extract is also good for venous support. Garlic as well (eating garlic beats any current supplement)
Dont know about the others yet, ill become a "herbalist" expert in the future.. Now its a low hanging fruit compared to other things
10 hours ago, AlanTookAccutaneWow said:
Thanks officer Dangus
Glad to have Macleods approval for posting freely on the internet. You're so cool dude!
You should seriously evaluate your behavior in this thread if you are actually desiring to improve your life. So far you've just made people think you are a troll or borderline crazy.
Either positively contribute to the road towards a semi or full solution or quietly observe us who actually try...
That's wonderful. You keep taking your supplements and studying how you think the body works fictionally. *facepalm* What is all of this horse shit seriously it drives me up the WALL reading what you guys think should or could be a good idea. This stuff is not good ideas, brother. For your OWN sake throw out ALL of your supplements.I took Accutane too.If you want to feel better and improve you need to listen.Maybe you can try taurine. What next? I am "trying to help" and it's not helping because of you and macleods cool cardsbeing stuck to wanting to argue and pickabout it. Do you think? I am really sick of hearing it bud! Take in some sunshine. Skip eating your meals for a day please here and remember how good real hunger feels. You WILL feel better. Leave me out of this quoting crap unless it's something even real.
Amazing!
On 19 November 2015 7:52:25 pm, Modeaa said:http://www.ncbi.nlm.nih.gov/pubmed/2227153
''Taurine failed to protect against the embryotoxic effects of isotretinoin in the rat.
Abstract
Experimental evidence exists to indicate that retinoids may act as detergents to disrupt biological membranes. Taurine, an amino sulfonic acid, has been shown to possess membrane-stabilizing and cytoprotective properties. This study was undertaken to test whether taurine coadministered with isotretinoin might be able to protect against the teratogenic effects of the retinoid. Our study failed to find any support for this speculation. Whether challenged against a 75 (mildly teratogenic) or 150 (very teratogenic) mg/kg/day dose of isotretinoin, taurine for the most part worsened the retinoid embryotoxicity. While in a few combinations taurine decreased the resorption or malformation rate associated with isotretinoin, the decrease was, at best, marginal. In no case was taurine able to decrease these rates to those noted in the controls''
maybe they didn't used enogh taurine? maybe there's a diffrence between embryo effect vs adult effect. but i thoght it worth mentioning this study because it talks about taurine and isotretinoin and not regular vitamin A.
It is because Taurine improves the regulation of retinoids, and may help alleviate the effect of imbalances,(eg.Too muchIsotretinoin imbalance,) whereas high levels of consumption of Vitamin A will have teratogenic effects, no matter how your body tried to process it. I believe that taurine helps determine the best ratios ofretinol, retinyl esters or Retinoic Acids, and in this case what was good for the health of the mother wasn't in the babies interest
Thanks Modeaa!