30 minutes ago, Jones4545 said:

 

I get so tired of hearing people complain about the side effects of Accutane. When you were in the midst of your acne, tell me you didnt stay up at night saying you would give anything for it to go away.

I'm not looking to start a debate, as whether or not accutane causes side effects is not up for debate. It does. End of.

Posts like yours are highly offensive to everyone sufferingfrom these severe and life-changing side effects who have to put up with this sort of mentality. I hope for your sake you never haveto experience what people are having to go through, but if you do you'll realise the side effects are very real, and links to the drug, and others with similar mechanisms like propecia and finasterideare undeniable.

Please don't drag this off-topic any further.

2 hours ago, tanedout said:

 

I'm not looking to start a debate, as whether or not accutane causes side effects is not up for debate. It does. End of.

Posts like yours are highly offensive to everyone sufferingfrom these severe and life-changing side effects who have to put up with this sort of mentality. I hope for your sake you never haveto experience what people are having to go through, but if you do you'll realise the side effects are very real, and links to the drug, and others with similar mechanisms like propecia and finasterideare undeniable.

 

Please don't drag this off-topic any further.

Everyone knows there are side effects, like the ones you mentioned. I'm talking about all the complaining of the normal things people deal with everyday that they blame on Accutane. Dry skin, dry eyes, depression etc.. These things are so common and most likely you would have had them accutane or not. Blaming the drug is just what stops others from wanting to use it, which is the real risk, someone not using accutane when they could/should. My only regret is not taking it sooner.

1 hour ago, Jones4545 said:

 

Everyone knows there are side effects, like the ones you mentioned. I'm talking about all the complaining of the normal things people deal with everyday that they blame on Accutane. Dry skin, dry eyes, depression etc.. These things are so common and most likely you would have had them accutane or not. Blaming the drug is just what stops others from wanting to use it, which is the real risk, someone not using accutane when they could/should. My only regret is not taking it sooner.

 

 

Yes, sure, they're common, but what isnt common is having to deal with all those all at once, both during and after your treatment. These things are clearly induced by accutane.If you have nothing to contribute to the thread, I think we'd all appreciate if you just didnt post.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/

you guys seen this article about fox01 protein gene transcription hypothesis? fairly new and very detailed study/hypothesis on all of accutanes effects. explains everything from bone loss to mental to physical changes and why they happen. also list Mitochondrial disease as a possible side effect. that i know is treated with high dose nicinamade, coq10 and b2 riboflavin. but its progressive, so great. says accutane up regulates fox01 causing all the side effects. towards end of article says milk hormones and whey down regulate fox01. so drink lots of milk and protein shakes? lol.

idk have you guys seen this article though?

1 hour ago, guitarman01 said:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/

you guys seen this article about fox01 protein gene transcription hypothesis? fairly new and very detailed study/hypothesis on all of accutanes effects. explains everything from bone loss to mental to physical changes and why they happen. also list  Mitochondrial disease as a possible side effect. that i know is treated with high dose nicinamade, coq10 and b2 riboflavin. but its progressive, so great. says accutane up regulates fox01 causing all the side effects. towards end of article says milk hormones and whey down regulate fox01. so drink lots of milk and protein shakes? lol.

idk have you guys seen this article though?

 

from your article:

 "Furthermore, the isotretinoin-induced decrease of IGF-1 serum levels may impair IGF-1/PI3K/Akt-mediated nuclear export of FoxO1. Moreover, IGF-1 is regarded as an androgen-dependent stimulator of 5±-reductase activity.³⁸ In fact, experimental evidence has been provided for decreased androgen 5±-reduction in skin and liver of men with severe acne after oral isotretnoin treatment.³⁹ The isotretinoin-induced decrease of IGF-1 may reduce the conversion of less potent testosterone to the more potent dihydrotestosterone (DHT)"

So here it states accutane causes all of the problems by:  upregulating FOXO1 ---> upregulated FOXO1 supresses IGF-1 and PI3K/AKT --->  drying out of the skin.   this also directly ties us with the finesteride people by reducing 5AR.

So now how to fix this in  the exact reverse?   stimulate or upregulate the PI3K/AKT ---> leading to increased IGF1 ----> leading to a nuclear mediated/ suppressed FOXO1

FoxO1 is an important metabolically regulated AR corepressor and binds to the TAD, where it disrupts p160 coactivator binding and suppresses N-terminal/C-terminal-interaction, which is most important for AR transcriptional activity (Fig. 2A).³² The AR repressive function of FoxO1 is attenuated by increased growth factor signaling with activation of the PI3K/Akt cascade.^33,34

cross reference this with PI3K/AKT IGF1 promoters and i find this!:

http://onlinelibrary.wiley.com/doi/10.1002/eji.201242450/full

also mitochondrial dysfunction chart

ALL very exciting!!!

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/

you guys seen this article about fox01 protein gene transcription hypothesis? fairly new and very detailed study/hypothesis on all of accutanes effects. explains everything from bone loss to mental to physical changes and why they happen. also list Mitochondrial disease as a possible side effect. that i know is treated with high dose nicinamade, coq10 and b2 riboflavin. but its progressive, so great. says accutane up regulates fox01 causing all the side effects. towards end of article says milk hormones and whey down regulate fox01. so drink lots of milk and protein shakes? lol.

idk have you guys seen this article though?

pops more taurine. again...

i think the problem with taurine that you can buy is that its all sourced from china and who knows what your getting. maybe there needs to be a more bioavailable source.

if redbulls werent so damn expensive and had like 5 grams oftaurine in them.

these are some of the tightest theories i've seen in awhile though.

39 minutes ago, guitarman01 said:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/

you guys seen this article about fox01 protein gene transcription hypothesis? fairly new and very detailed study/hypothesis on all of accutanes effects. explains everything from bone loss to mental to physical changes and why they happen. also list  Mitochondrial disease as a possible side effect. that i know is treated with high dose nicinamade, coq10 and b2 riboflavin. but its progressive, so great. says accutane up regulates fox01 causing all the side effects. towards end of article says milk hormones and whey down regulate fox01. so drink lots of milk and protein shakes? lol.

idk have you guys seen this article though?

 

pops more taurine. again... 

 

i think the problem with taurine that you can buy is that its all sourced from china and who knows what your getting. maybe there needs to be a more bioavailable source. 

if redbulls werent so damn expensive and had like 5 grams of taurine in them.

these are some of the tightest theories i've seen in awhile though.

more IGF  PI3K/AKT  promoters!! reads like a who's who in supplements  Taurine TMG TUDCA !  thats why whey protein is mentioned.

http://www.cvasps.com/wp-content/uploads/2014/04/Nutritional-Ergogenics-for-Athletes-BRUNNER.pdf

Relentless: Did you by any chance know of any other studies about NAC and BBB? Not doubting just curious? NAC was a staple but if its likely it screws with BBB I wont touch it.

Also RE: dangers of R-ALA and redistributing mercury ...wouldn't that only be an issue if you have mercury or heavy metal toxicity to begin with?

On 12/9/2015 at 2:32 AM, tanedout said:

One thing I've just got hold of is NADH which I plan to introduce some time (NAD seems difficult to find - 'NOW' have discontinued it too, so settled for NADH (the reduced form of NAD).

 

I'm thinking along these lines too, doing whatever you can to lessen side-effects while looking/waiting for a permanent solution, which will almost certainly be found once the accutanes mechanisms are fully understood. The effect of some supplements can be as powerful as pharmaceuticals drugs, and many are prescribed as such, look at NAC for example.

NAD is sold as nicotinamide riboside (patent name NIAGEN)
Look at [removed] post about NAD+, it made me think taking NADH might be bad due to screwing over the ratios. NADH increases by eating carbs and all kinds of stuff but NAD+ is hard to increase. But im not educated enough on this to make any statement.

Dr's best and Life Extension sells NAD, and if you can buy from amazon theres more that sell it.
Search for NIAGEN ornad+ cell regenerator

On 12/9/2015 at 5:06 AM, Jones4545 said:

 

Sorry for the rant, im just sick of reading all of these normal issues people deal with everyday blamed on Accutane.

I went from a healthy 18 year old who could exercise for 15 hours a day (i was a competing level skateboarder + weight lifting and cycling) and had top grades in school + a really active social life. Post accutane i ended up with so many issues i wont even start listing them and ive been 70% bedridden for 2,5 years and 30min of weight lifting will make me completely broken for several days. Ive lost 30kg (i had abs before losing weight i just lost a lot of muscle and all my fat so now im super ripeed but its unhealthy.)

I gained 10+ food allergies and im also unable to work/study and i receive money from the government to pay for food/housing (health care perks.) I have 5+ diagnoses that qualify me for money for life if i dont get better. But i would much rather work. And if i dont get better my dream of being a doctor and personal trainer wont happen no matter how hard i try.

None of my family members are sick. I have always lived really healthy and drank alcohol less than 30 times in my life. Now i cant tolerate 1 beer.

Maybe it wasnt accutane but then why did all this start while on it, and why has it not gotten better considering i eat healthier than anyone ive ever met and i also have taken nearly all supps on the market with no help. Theres no medication to help me and nothing wrong with tests to explain this.

Regardless im just here to discuss with people who seem to suffer the same problems as me that also took accutane. I also discuss with people that has not taken accutane, and i explore every possible other thing that could have made me sick. Im saving up money to test for everthing there is to test that i cant get for free through doc.

Thinning hair and anxiety are the least of my worries, those dont ruin my life.

On 12/9/2015 at 12:34 PM, Mike San said:

Relentless: Did you by any chance know of any other studies about NAC and BBB? Not doubting just curious? NAC was a staple but if its likely it screws with BBB I wont touch it.

 

Also RE: dangers of R-ALA and redistributing mercury ...wouldn't that only be an issue if you have mercury or heavy metal toxicity to begin with?

I dont know. I would still take NAC but with reasonable doses and for max 6 weeks at a time with an equal break. If you get brain fog or notice strong decline in cognitive function then its probably worthwhile to stop it.

R-ALA, i again dont know. If you feel positive effects then it probably is good for you, but i cant tell. Here its classified a diabetes medication and i cant get it cuz i dont have diabetes. Ordering it online is illegal..

By the way i personally know 3 females who have taken accutane without side effects (or they lack awareness of it and manage to live life cuz they are not serious enough like mine is)

I feel like accutane screws over males way more due to all the negative impact on androgens?

I might pay [removed] to research accutane as he is far smarter than i will ever be, and smarter than any doc i currently know of. He will interpret studies and figure what supplements / how to eat / how to live far better than we can.

We should also get our 23andme data and get all the raw genetic data so we can see what our genes are like, as that might possibly show what accutane has altered. Unless it doesnt alter those kind of genes, i have no clue. But it will show a lot of useful stuff regardless..

19 hours ago, sam1w2e said:

Ordered some taurine, looks promising from what I've read in this thread.

Finished my course of accutane in Feb of this year. Symptoms are (currently): moderate upper abdominal bloating, difficulty getting a deep breath (likely due to bloating), chronic dry skin (present before but exacerbated by accutane), keratosis pilaris (probably linked to the dry skin in some way), fatty stools (likely bile related),brain fog, poor sleep, fatigue, pain in left wrist andhot flushes with subsequent skin itchiness and redness.

The symptoms you present are caused by a deficiency in vitamin A.

Vitamin A deficiency symptoms: link

A dead obvious giveaway is having keratosis pilaris, which is absolutely caused by vitamin A deficiency (which accutane exacerbates). I suggest eating healthy liver from a pasture raised animal weekly.

Fatty stools arebile related. Get plenty of taurine, glycine, and vitamin C to increase bile flow. If you have congestion, liver flushing is the way to go. Andreas Moritz has a book on it.

For those wanting advice on which supplement companies to choose: link

For those talking about ALA causing toxicants to enter brain tissue: Here's a good video: link

53 minutes ago, yetanotheraccutanevictim said:

The symptoms you present are caused by a deficiency in vitamin A.

Vitamin A deficiency symptoms: link

A dead obvious giveaway is having keratosis pilaris, which is absolutely caused by vitamin A deficiency (which accutane exacerbates). I suggest eating healthy liver from a pasture raised animal weekly.

But are you certain it's vitamin A deficiency and not toxicity? Because the symptoms seem very similar for both, and I wouldn't want to go taking more vitamin A if I don't need it.

1 hour ago, sam1w2e said:

 

But are you certain it's vitamin A deficiency and not toxicity? Because the symptoms seem very similar for both, and I wouldn't want to go taking more vitamin A if I don't need it.

 

Hey just stop totaking that poison ! how are you still taking it while you have breathing problems ??? how any person can do this to his body !

5 minutes ago, SaffronAide said:

Hey just stop totaking that poison ! how are you still taking it while you have breathing problems ??? how any person can do this to his body !

Huh? Are you talking about accutane? I stopped taking it in February.

5 minutes ago, sam1w2e said:

 

Huh? Are you talking about accutane? I stopped taking it in February.

Oh sorry then , i thought you are still using it. Do you have ant sexual symptoms ? or any other ones ?

17 minutes ago, SaffronAide said:

Oh sorry then , i thought you are still using it. Do you have ant sexual symptoms ? or any other ones ?

No worries. Well I have lowered libido; but I'm not sure whether that's an issue all by itself or it's related to the fatigue, poor sleep etc.

taurine gave me such a bad break out in acne...it is the taurine no doubt. Only thing I changed.I'm not saying that its a bad thing...it obviously had an effect on something. I'm just scared to continue. any advice? I take zinc etc.

Hi guys,

some really interesting posts happening but can we be clear on supplements being discussed,

On one hand someone's discussing NAD - what is it??

The next post someone's talkingabout NAC - what is the full name of this supplementplease??

I want to be sure I'm following correctly and that's it not a typo from someone - don't want to be mislead!!

thankyou

On 8 December 2015 at 3:54:23 PM, tryingtohelp2014 said:

It is the purpose of this review to demonstrate that oral isotretinoin treatment restores all major pathogenetic factors of acne vulgaris by upregulation of the nuclear transcription factor FoxO1, which will be shown to be the major target of retinoid action. Nuclear FoxO1 deficiency is the result of increased growth factor signaling with activated phosphoinositol-3-kinase (PI3K) and Akt kinase during growth hormone signaling of puberty and increased insulin/IGF-1 signaling due to consumption of insulinotropic milk/dairy products as well as hyperglycemic carbohydrates of Western diet.

http://www.ncbi.nlm.nih.gov/pubmed/20930691

 

 

In addition, insulin downregulates FOXO1 activity by augmenting ubiquitination of FOXO1 and enhancing FOXO1 degradation (Matsuzaki et al. 2003).

 

Taurine Mimics Effects of Insulin

Even administered on its own (without insulin) theanorexic effect of taurine had a "similar magnitude to the effect produced by either insulin or leptin"

http://suppversity.blogspot.com/2011/08/taurine-mimics-effects-of-insulin.html

injection of an acute dose of taurinereduces food intakeand locomotor activity, andactivates signal transduction through the Akt/FOXO1, JAK2/STAT3 and mTOR/AMPK/ACCsignaling pathways. These effects are accompanied by the modulation of expression of NPY. In addition,taurine can enhance the anorexigenic action of insulin.

http://www.ncbi.nlm.nih.gov/pubmed/22130357

 

 

ACCUTANE upregulates FOXO1 = Insulin downregulates FOXO1 thru PI3K and AKT = TAURINE acts like insulin downregulatingFOXO1 thru AKT AMPK

 

Listen, to all of the people posting about eating right and thinking this away... thats great. Its not the answer, but do what you guys have to. Accutane(excess retinoid) is only removed from the body in one of two ways ... by glucuronidation and taurine conjugation. We need to focus on that. To the people that are crashing, i dont know... it could be second or third derivativeof the problem, i.e. accutane got rid of the methionine, which caused copper to accumulate in the liver, by taking taurine , you could be causing a copper dump and crashing... but you need to keep going!!! when youre going thru hell, dont stop.

 

 

http://gutenberg.us/articles/hypervitaminosis_a

TREATMENT

Toxicity has been shown to be mitigated throughvitamin E(tocopherol),cholesterol,zinc,taurine, andcalcium.^[8]

Cholesterol has been shown to prevent retinol inducedgolgifragmentation.^[9]

Retinoids can be conjugated by taurine and other substances. Significant amounts of retinotaurine are excreted in the bile,^[10]and it is believed this retinol conjugate is an excretory form as it has little biological activity.^[11]In rats, the toxic effects of vitamin A were significantly reduced when diets were supplemented with taurine,^[12]and also Cholestin.^[13]

So you're saying I should continue with taurine even tho I experienced the crash? I felt so tired 30 minutes after taking it. It lasted for about 4 hours. Horrible

On 12/9/2015 at 7:21 PM, Relentless1k said:

NAD is sold as nicotinamide riboside (patent name NIAGEN)
Look at [removed] post about NAD+, it made me think taking NADH might be bad due to screwing over the ratios. NADH increases by eating carbs and all kinds of stuff but NAD+ is hard to increase. But im not educated enough on this to make any statement.

Dr's best and Life Extension sells NAD, and if you can buy from amazon theres more that sell it.
Search for NIAGEN ornad+ cell regenerator

I went from a healthy 18 year old who could exercise for 15 hours a day (i was a competing level skateboarder + weight lifting and cycling) and had top grades in school + a really active social life. Post accutane i ended up with so many issues i wont even start listing them and ive been 70% bedridden for 2,5 years and 30min of weight lifting will make me completely broken for several days. Ive lost 30kg (i had abs before losing weight i just lost a lot of muscle and all my fat so now im super ripeed but its unhealthy.)

I gained 10+ food allergies and im also unable to work/study and i receive money from the government to pay for food/housing (health care perks.) I have 5+ diagnoses that qualify me for money for life if i dont get better. But i would much rather work. And if i dont get better my dream of being a doctor and personal trainer wont happen no matter how hard i try.

None of my family members are sick. I have always lived really healthy and drank alcohol less than 30 times in my life. Now i cant tolerate 1 beer.

 

Maybe it wasnt accutane but then why did all this start while on it, and why has it not gotten better considering i eat healthier than anyone ive ever met and i also have taken nearly all supps on the market with no help. Theres no medication to help me and nothing wrong with tests to explain this.

Regardless im just here to discuss with people who seem to suffer the same problems as me that also took accutane. I also discuss with people that has not taken accutane, and i explore every possible other thing that could have made me sick. Im saving up money to test for everthing there is to test that i cant get for free through doc.

Thinning hair and anxiety are the least of my worries, those dont ruin my life.

I dont know. I would still take NAC but with reasonable doses and for max 6 weeks at a time with an equal break. If you get brain fog or notice strong decline in cognitive function then its probably worthwhile to stop it.

R-ALA, i again dont know. If you feel positive effects then it probably is good for you, but i cant tell. Here its classified a diabetes medication and i cant get it cuz i dont have diabetes. Ordering it online is illegal..

By the way i personally know 3 females who have taken accutane without side effects (or they lack awareness of it and manage to live life cuz they are not serious enough like mine is)

I feel like accutane screws over males way more due to all the negative impact on androgens?

I might pay selfhacked to research accutane as he is far smarter than i will ever be, and smarter than any doc i currently know of. He will interpret studies and figure what supplements / how to eat / how to live far better than we can.

We should also get our 23andme data and get all the raw genetic data so we can see what our genes are like, as that might possibly show what accutane has altered. Unless it doesnt alter those kind of genes, i have no clue. But it will show a lot of useful stuff regardless..

I was was fine on it for 3 courses until I added birth control,acontraceptive device, to my 4th course. That was when everything went down hill

2 hours ago, trantran83333 said:

 

So you're saying I should continue with taurine even tho I experienced the crash? I felt so tired 30 minutes after taking it. It lasted for about 4 hours. Horrible

take it before you goto bed then. a lot of people take it with magnesium before bed in order to sleep well.

2 hours ago, marlin15 said:

taurine gave me such a bad break out in acne...it is the taurine no doubt. Only thing I changed.I'm not saying that its a bad thing...it obviously had an effect on something. I'm just scared to continue. any advice? I take zinc etc.

that would mean its starting to work in my mind!! its what i was looknig for by taking this. your oil glands are turning on for the first time in years. i would absolutely murder for oily skin again!!!you remember when you took accutane, and they said that it will get worse brfore it gets better? that was your oil glands turning off, and things getting stuck. i would continue with it for six weeks minimum.

On 12/8/2015, 9:01:57, Jones4545 said:

 

Everyone knows there are side effects, like the ones you mentioned. I'm talking about all the complaining of the normal things people deal with everyday that they blame on Accutane. Dry skin, dry eyes, depression etc.. These things are so common and most likely you would have had them accutane or not. Blaming the drug is just what stops others from wanting to use it, which is the real risk, someone not using accutane when they could/should. My only regret is not taking it sooner.

 

 

Don't you think we are adept enough to know which problems were derived from Accutane or not? From all of the posts that you have read, do you not think some of us are intelligent enough to discern whether or not an issue is Accutane related? While some of us are not doctors, we are educatedin other fields of science, mine being computers.

You have your firsthand experience, and I have mine, that's great, but there isevidenceto suggest what we are "blaming" on Accutane is plausible. Frankly, I don't want to be here. Even if we remove ourselves from the equation, you with your positive experience, me with my negative, you have a drug that doctors are divided on when it comes to prescribing and when it comes to side effects.

A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances.

^ But, studies like that above isn't an end all tell all. It's just one study. There are plenty. Some for. Some against. These are just a handful of doctors on the front line interacting with patients of whom have their own opinion, likely from their firsthand experience practicing medicine, such as your doctor. They aren't the scientists in the lab that understand isotretinoin inherently. Or victims like us who spend countless of hours pouring through medical literature.

A lot of us believe that isotretinoin can be an effective treatment for some. Like in your case. But, it would be foolish to doubt the validity of our claims. Tendonitis is very common within a population. Yet sitting here with throbbing rotator cuffs without even doing any form of exercise recently, I can very well attribute it to my post Accutane side effects. It correlates with the pancreatitis that I have as well. It seemsas if my body is in a constant state of inflammation. This is just one example of many issues we have to deal with. The changes in our bodies were sudden and systematic and seemingly progressing with time (which is understandable with age).You wouldn't understand it unless you yourself are going through it.I'm completely convinced the state of my health would be totally different right now and I could age normally like I was meant tohad I nottaken Accutane.

I am confident so much so in my opinionthat I WANT more people to take Accutane. Because, inevitably, more people are gonna end up like us, which brings me closer to a cure (selfish, i know. indifference, you have no idea).

The percentages of people affected by this drug are askew. I think the numbers are a lot higher, and Roche knows this, so they removed the drug from sale. But, they probably could still get away with it in the USA, because of our free market, and the FDA, which would probably tolerate a bell curve of people affected adversely by a drug maybe even up to 10% (kinda messed up).

Point is: take Accutane. Recommend it to your family and friends.

We are going to continue gathering information, researching, and collaborating. For the sake of science and the future.

+1 for oysters. Supps work, if you know what you're doing. Certain nutrients like dha have been protected by certain nutrients like iodine for millionsof years. These nutrients usually come together in nature this food makes sense most of the time. Sometimes we need super physiological doses of certain supps to reverse something. I think you should take ubiquinol, magnesium (orotate specifically, but anything really), and d ribose if you're taking taurine for the full mitochondrial stack. Someone told me Accutane shuts down the sod2 pathway and we need to focus on mitochondrial efficiency in order to gain control of our bodies again (and realistically, revers want disease. What's more fundamental than fixing energy centers in our cells? That's my next experiment. Ithink water (I've been drinking exclusively acqua panna for a couple months) is the MOST important thing. No fluoride or chlorine which are dielectric blockers that block semiconduction in collagen. Iodine is important, to promote semiconduction and to build the brain up. Realistically, I'm tryna be healthy and getting by on food and suppsuntil I got enough money to figure everything out. I'm a musician and I'm getting closer and closer to my goals thanks to food and supps and positivity. Positivity helps you do shit, it's not an end all. Keep knocking down your goals, guys. Anyone smoking/vaping weed? Psychedelics? Anything? I wanna hear some crazy next level stuff lol. I'm bored of vitamins and minerals...

10 hours ago, sam1w2e said:

 

No worries. Well I have lowered libido; but I'm not sure whether that's an issue all by itself or it's related to the fatigue, poor sleep etc.

Last day i noticed my penis is shrinked a bit. It scares me out , i just have low semen volume but now. I can see another problems. I dont know what to do know , it seems like really little hourglass shape both when erect and flaccid.

Also i can feel a shrinkage at the end of my penis ; Front side of The Dorsal A. point of the penis. (the point that piss and semen goes , the big vein of the penis)

Please someone help me !

11 hours ago, trantran83333 said:

 

I was was fine on it for 3 courses until I added birth control,acontraceptive device, to my 4th course. That was when everything went down hill

Meanwhile i was fked over with one course lasting maybe 3 months @ 40-60mg daily

11 hours ago, TrueJustice said:

Hi guys,

some really interesting posts happening but can we be clear on supplements being discussed,

On one hand someone's discussing NAD - what is it??

The next post someone's talkingabout NAC - what is the full name of this supplementplease??

I want to be sure I'm following correctly and that's it not a typo from someone - don't want to be mislead!!

 

thankyou

NAD isnt a supplement per se, its one of the most important things in the body. We are discussing how to increase it via supplementation.
ATP and NAD+ are the energy sources of all the cells in the body. Low ATP is to be suspected post tane because i believe it negatively impacts mitochondria. And considering the importance of NAD+ its something to pursue regardless of being healthy or not. Its one of the most promising ways to increase longevity and quality of life, even for perfectly healthy people.

NAC is N-Acetyl L-cysteine / N-acetyl cysteine

I am going to go through all pubmed studies on accutane that might be of relevance. I wont do that many studies per day and there is roughly 4000 studies about it so it will take some time..

1#

Presumed Isotretinoin-Induced, Concomitant Autoimmune Thyroid Disease and Ocular Myasthenia Gravis

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531957/

A case is reported of possible association between isotretinoin intake and autoimmune disorders. Autoimmune reactions may be triggered by oral isotretinoin treatment. Patients with acne should be assessed for autoimmune disorders or any predisposition to their development prior to treatment.

Oralisotretinointherapy of acne patients decreases serum paraoxonase-1 activity through increasing oxidative stress.

RESULTS:

Dramatically decreased PON1 activity (p<0.001), increased TOS level and OSI value (p<0.001 and p<0.001; respectively) as well as slightly diminished TAC level were noted in posttreatment stage. Moreover significant increases were observed in lactate dehydrogenase and gamma glutamyl transpeptidase activities and levels of total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, triglycerides, low density lipoprotein cholesterol/high density lipoprotein cholesterol ratio respectively (p<0.05, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001 and p<0.001) while marked decrease was seen in high density lipoprotein cholesterol (p<0.01).

CONCLUSION:

This study revealed that decreased PON1 activity and increased oxidative stress may have a crucial role in the pathogenesis ofisotretinoin's side effects. Further studies on a large number of patients are needed to verify these results.

Isotretinoinexposure and risk of inflammatory bowel disease.

Our study did not show an increased risk of IBD with priorisotretinoinuse. If anything, the risk seemed to be decreased. Although these results may be due to chance given the small number of IBD cases, the anti-inflammatory and immune-modulating effects ofisotretinoinmay be worth exploring.

This is ironic considering it caused extreme gut issues in me.. I now cannot eat any grains, beans/legumes, nuts, eggs, many fish, and many fruits/vegs are also off the list of things i tolerate. + My digestion has been messed up ever since and ive yet to heal it.

Isotretinoineffect on the repair of bone defects - a study in rat calvaria.

CONCLUSION:

These results enabled us to conclude thatisotretinoinpromoted acceleration in the process of new bone formation in rat calvaria, although this increase was not statistically significant.

Selenium amelioratesisotretinoin-induced liver injury and dyslipidemia via antioxidant effect in rats.

Selenium administration produced a significant protection against the hepatotoxic effects of Iso and markedly alleviated alterations in these parameters. The results obtained herein clearly indicate that Iso causes induction of oxidative stress and the co-administration of Iso and Se provides protection against Iso-induced liver injury.

The effect ofisotretinoinon retinol-binding protein 4, leptin, adiponectin and insulin resistance in acne vulgaris patients.

RESULTS:

In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment.

CONCLUSION:

ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.

Spurious elevation of aspartate aminotransferase in a patient onisotretinoin.

Does exposure toisotretinoinincrease the risk for the development of inflammatory bowel disease? A meta-analysis.

CONCLUSION:

Isotretinoinexposure is not associated with an increased risk of developing both ulcerative colitis and Crohn's disease.

Again i feel this is bullshit

DO YOU GUYS HAVE GUT ISSUES POST ACCUTANE? MINE ARE SEVERE. They started on accutane and i never had them before. I used to live on gluten and whatever other normal crap people eat. Now i dont even have good digestion eating mostly veggies

Im also going to go through all the pages of this thread to summarize any findings by members here to see what has worked and what has not. And any good theories that may have been presented earlier.

Inter-relationships betweenisotretinointreatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks.

Several studies showed that patients with bipolar disorder had an increased risk for a clinical exacerbation of symptoms undergoing treatment withisotretinoin. A few studies also seem to suggest a possible link betweenisotretinoinand psychosis. Nonetheless, studies point out a link between retinoid dysregulation and schizophrenia through modulation of dopamine receptors. From this review, we propose guidelines forisotretinoinprescription to healthcare professionals.

Isotretinointreatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study.

Because the effects ofisotretinoinon oxidant and antioxidant systems have not yet been clarified, we investigated plasma and erythrocyte antioxidant vitamins, lipid peroxidation (LP), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) values in patients with acne vulgaris before and afterisotretinointreatment. The study was performed on the blood plasma and erythrocytes of 31 acne vulgaris patients. Blood samples were taken from the patients before treatment and afterisotretinoin(oral and 05-07 mgkg(-1)) treatment for 2 months. Plasma amtioxidant vitamins, erythrocyte malondialdehyde, GSH and GSH-Px levels were measured. Plasma vitamin E (p < 0001), lipid peroxidation (LP) and serum high-density lipoprotein cholesterol (p < 0001) values were significantly lower in the treatment group than in the pre-treatment group, although erythrocyte LP (p < 0001), GSH (p < 001) and GSH-Px (p < 0001), aspartate aminotransferase (p < 005), alanine aminotransferase (p < 005), density lipoprotein cholesterol (p < 0001) and total cholesterol (p < 001) levels were significantly higher in the treatment group than in the pre-treatment group. Vitamins A, C and -carotene concentrations did not change significantly between the two groups. In conclusion, the results of the current study indicate thatisotretinointreatment induces oxidative stress and liver damage by decreasing plasma vitamin E and increasing erythrocytes GSH-Px, GSH and liver enzyme values.

Effects of oralisotretinoinon serum folic acid levels. (do not supplement this guys, take methylfolate or folinic acid instead. Folic acid is synthetic garbage and most people cant use it. It will cause paradoxical folate deficiency)

RESULTS:

Mean levels of folic acid were 26.75 9.42 nmol/L at baseline, and and 23.6 8.42 nmol/L after 30 days ofisotretinoinsupplementation. This showed a significant decrease in the serum level of folic acid (P=.008).

CONCLUSION:

Given the significant decrease in the serum level of folic acid following a 30-day use of oralisotretinoinin acne patients, and considering the important role of folic acid in metabolic functions, we recommend further studies to assess the effect of longer periods ofisotretinointreatment, in addition to studies including other relevant factors in folic acid metabolism (e.g., serum homocysteine levels). Moreover, folic acid supplementation in acne patients usingisotretinoinis recommended.

Reduced central corneal thickness in patients withisotretinointreatment.

CONCLUSION:

Isotretinointreatment causes higher MGD scores. A statistically significant decrease in CCT due to MGD was detected at 6th month of treatment.