Antiandrogen
Reviews
4.1
1326 Reviews
Antiandrogen
Efficacy
68%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Antiandrogen
Side Effects
High
Antiandrogen
Acne.org’s Real World Take
“Spiro” has been shown to work in a real and noticeable way most of the time. However, messing with hormones is messing with hormones and it’s best to proceed with caution.
Antiandrogen
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Spironolactone
Compare To Other Treatments
5
51.1%
4
28%
3
10.1%
2
4.9%
1
5.9%

Used Spironolactone? Rate It:

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July 11, 2016
Wish I was pleased as everybody else...
I have extremely oily skin with mild-to-moderate acne that fluctuates. I was put on Spironolactone to try and help regulate my breakouts and it really only made me break out in places that are considered to be "hormonal breakout areas" like my jawline, neck and shoulders. It helped mildly with the smoothness of my face but I would still get breakouts around my period. Since I stopped taking it, my jaw and neck don't have any breakouts and the condition of my face remains as it was. I haven't seen enough of a miracle with this product that would make me keep using it.
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July 8, 2016
Tiredness as a Side Effect?
Hi, I'm 21 and just a few months ago had break outs all over my chin and neck. I'm so confused as to why this is happening given that I never struggled with acne to this level before. In high school I had crystal clear skin. Does anyone know why hormones change like this? Also, I just uped my dosage to 100mg three days ago and have been very sleepy and sluggish. Yesterday I took a three hour nap. I haven't seen much about this side effect and don't know if it will go away or if it's serious. Any feedback would be fantastic!!
July 16, 2016
I feel for you. I'm currently 25 and I started getting really terrible acne when I turned 20. Like you, I had perfect skin all throughout high school. It started out as deep painful cysts on my face and I made the mistake of trying to pop them (trust me, don't) because acne was so new to me. I just wanted them gone. I found a dermatologist who prescribed me a few different types of antibiotics, one which worked well for a few months until I became immune. Birth control made it worse for me and I really didn't want to deal with side effects of accutane so I gave up and tried a holistic approach which included a complicated mix of vitamin supplements morning and night. For a while my acne got better, though it didn’t completely clear up. Then when I was 23 it came back with a vengeance. I began getting cysts on my upper AND lower back, my shoulders, and my hairline. I saw several dermatologists and none of them suggested anything new – until I saw my current dermatologist for the first time and she suggested spironolactone which I had never heard of before. She told me that it appeared as though my acne was caused by a hormonal imbalance. I started taking 200 mg a day for 2 months but stopped because nothing changed other than my periods becoming irregular. Once again, I gave up. A year later I went back to see her out of desperation. She put me back on spiro and told me to give it more time. I'm SO glad that I listened to her advice and gave it more time. I've been on spiro for about a year and a half now and my skin looks just as good as it did in high school. I have to tell you that it takes a while for your body to get used to it but DON’T GIVE UP ON IT! It took 2-3 months before my skin cleared up completely and 4-5 months before my period became regular again. Like some other users I also experienced light-headedness and occasional dizzy spells, but I soon found that dehydration was behind those symptoms. Spiro is a diuretic so it is extremely important to stay hydrated while you’re taking it if you want to avoid symptoms of basic dehydration. I’m not a doctor, but from years of similar personal experience and hours of my own research it sounds to me like your tiredness may be hormone related. Fatigue is a symptom of adrenal imbalance. The adrenal gland is where hormones including testosterone are produced. Since spironolactone is prescribed to counter the overproduction of testosterone (aka the hormone behind your acne) both your tiredness and your acne are probably signs that you’re dealing with a hormonal imbalance. If that is the case then the spironolactone should actually help with both as long as you give it time. I would still tell your doctor about the tiredness next time you see them though, because there’s always the chance that it’s from something totally unrelated. Hope this helps! Good luck!
May 18, 2016
Not for me
Spiro gave me awful breakouts until I hit 100mg which took 4 months. It spread to my cheeks and really took a toll on me. But after 100mg within a week I noticed i stopped breaking out. HOWEVER at the same time, side effects hit me. I told myself in the beginning I would handle the side effects but it was too much. I felt weak, I couldnt exercise, I couldnt hold a conversation. I felt so awful, my heart was beating so fast that I thought maybe my birth control (yaz, which im off now too) was giving me a blood clot. I went to the hospital and all they could find was that I was peeing out all my phosphates (spiro is a diruetic). They gave me an attivan and it turned out it was also really bad anxiety. So dumb. I got off my bc and still had the issues and it was getting worse, I couldnt do anything without crying. I finally made the choice to get off it and feel like myself again. Im still breaking out but I never want to feel like that again
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December 16, 2015
Results may vary even if taken for a long time
Overall: I do recommend giving this medication a shot, especially if you are suffering from acne that's caused from internal issues/hormonal/PCOS and you're down to your wits about getting results for a better/normal complexion. I will say, however, that I honestly don't want to depend on this medication for the rest of my life. The side affects are a big nuisance and hindrance at times and sometimes I still suffer from bad breakouts. I'm just okay with it at this point until I can find a different solution once and for all. Below I have attempted to compile a detailed review of my experience with this drug so far. I suffered with acne and cystic acne around chin, jawline, and partial neck area severely, sometimes forehead but not often and sometimes around nose area as well. I was also a bit more hairy on my upper lip and chin area. These issues started once I turned 19 back in late 2011. I was using ProActive for a few years prior, which helped tremendously during the time I was in high school, but stopped working and actually destroyed my face once starting college. I was prescribed various topical treatments including retinol and have also been given several types of antibiotics, all of which did not work. I have also been on 3-4 different brands of BC that really screwed me up emotionally and physically. I refuse to take any now. At that point I knew there was something deeper and internal causing my issues so I was sent to an Endocrinologist. 2012 ' Diagnosed with PCOS. Main issue was androgen levels too high (as of summer 2015 also found out I do get ovarian cysts). I also have a Vitamin D deficiency. 2012-2013 ' Began Spironolactone (started off with 50 mg and eventually bumped up to 100 mg) and generic Junel BC. 2013 (Towards the end of summer/sometime in fall) ' Stopped taking both, as my face was clear, and I was given the clear to stop. Over time my face began breaking out awfully in cysts again (also didn't help I was stressed at a new college I transferred to). Decided to begin both medications again, only to find that BC was causing me to break out awfully, ditched it and only remained on spironolactone. Seemed to be helping, but not by much at all. Stopped taking it altogether as well considering the side effects were greatly affecting me. 2014 Spring ' Suffering from awful, hormonal cystic acne with rarely a break, in between. Even if my face were mostly clear, would always have 1 or 2 or more cysts/acne present. Bore through it all just trying to finish my semester until I could see a specialist back in my state again. 2014 Summer ' Started back on spiro again, really made a difference once more. Maybe I needed those several months for it to be effective again. Today (12/16/15) - Still on 100 mg spironolactone, been on it for over a year, although I have noticed I am starting to break out still even while on it. Could possibly be due to stress from school, but I am on break now and relaxed but still breaking out. The cysts and acne go away within a matter of time, only to have one or two new ones pop up on the other side of my face. Right now they're slowly subsiding. - I do get blood work done at 1-2 times a year to make sure my potassium levels are fine, as well as other blood work to help make sure nothing goes wrong. My last blood work from over the summer states I'm still Vitamin D deficient and now I'm low on B12 as well (which I have been taking vitamins for). Side Effects I have and continue to experience while on this drug: - Please note that Spironolactone is a diuretic. It prevents you from retaining salt, which also prevents you from retaining water, which is why you're constantly drinking and using the bathroom. That also explains some of these side effects: - Constant, constant urination (the biggest culprit). I find myself visiting the restroom a lot, which I've become accustom to (though I don't like it), but it makes it really difficult if I'm at an important event and I'm constantly having to step out to relieve myself every 5 minutes it feels like. Even if I'm doing something as simple as drinking water, I will need to unload about 15 or so minutes later. There are times at work where I literally hold my pee in for about an hour before I use the restroom again or else I would be going constantly. This forces me to drink more as well because I'm losing fluids at the rate I'm drinking them, which is extremely annoying. - Constantly thirsty. This coincides with the dryness and constant urination. - Dry skin. My face at times, especially around my chin and jawline area, tend to get more dry now which is where most of my breakouts occur. It's also around my nose. - Weight fluctuation. I don't gain weight as badly, fortunately, but I don't lose it as easily either. It's really difficult. I will continue to monitor this once I start working out again later this month and next year. - Hair is not as thick as it used to be. Fortunately, I'm not experiencing hair loss to the point where I'm balding, but there is a significant difference in my hair than what it once was. I used to have a decent amount of thick hair and the texture of it felt a lot stronger and now it's more normalized and thinner. - Digestive problems. Sometimes I'll be excreting at least 3 times a day or more, others none at all. I've been suffering from constipation a lot lately as well. I never realized or noticed that spiro could cause this as well until I looked it up again. - Periods are odd. My period doesn't last as long while on this medication, however I occasionally have messed up cycles. Recently I had my period and not even a week or two later I had it again. :/ Things I plan on trying to see if they make a difference: - Eating habits, especially cutting dairy out of my diet - Exercising more I try and will update in the future.
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September 2, 2015
Skin looks great but losing hair
I have been on spiro 100 mg for about six months now and have seen great results; however about three months ago I noticed my hair hair really begun thinning. A little bit of history about myself. I am 47 years old and have suffered from cystic acne since a teenager. I have done several courses of accutane, which cleared my skin greatly only to go back to breaking out again. My new derm said I would love Spiro since my breakouts were hormonal. She was right. It reduced my oiliness and cleared up my skin. My skin never looked so good. I got so many compliments. However, then I started noticing the hair loss. So I do have some family history of hair thinning in women and had noticed that my crown had thinned in the last seven years or so. However this new hair loss has been pretty drastic. My scalp is really showing on the top of my head, and I seem to be shedding lots of hair when shampooing and throughout the day. I'm going back in to see my derm tomorrow hoping she may have some answers. I share this info in case anyone else has experienced similar symptoms. I've read up on it and can't really find that hair loss is a symptom rather quite the opposite as it's used for hair loss?? So if you don't experience the hair loss with it, I think it's great and would recommend trying it.
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September 2, 2015
I have been on spiro for three months and have noticed a drastic change in hair loss. My hair was very full and has thinned out dramatically. Very happy with skin though so far! Going to ask about the hair loss at my next appt....
June 22, 2015
It's ok, but...
So I have been on it for over 11 weeks and there have been improvement in my skin however I have been getting my period every other week, not exaggerating! Then after my last period it went 8 days and started up again! I stopped taking it for a few days and I have been getting really bad headaches, not sure if that's related. I see others comments but no one really stated about if they have had messed up cycles and if that went back to normal...
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June 7, 2015
Very good at clearing acne, but the side effects are terrible.
Well, sprionolactone did work well for clearing my acne. I've been on it for almost two months, and my face is completely clear and was completely clear towards the end of the first month. But I'm now having to get off of it because of the serious side effects I've had. The less serious side effects started as soon as I got on the medication, but I brushed them off in hopes that they would subside as I continued the medication. But as I started the second month, almost two weeks in, I got up one morning and my right leg was completely numb. Not asleep or tingly, completely numb. Hahaha. (It's really not funny, but it's making me laugh now because I was in a huge rush, so I JUMPED out of bed, and fell immediately to the ground. Several times hahaha.) Anyway, It's so easy to stay on meds for acne cause it sort of feels like a one stop shop. No need to change your diet, don't have to be too careful about what you wash your face with, at least that's how it was for me. I've always been a natural person, trying to cure anything I had with natural remedies, supplements, internal cleanses, all that good stuff. And it all worked until my skin decided to go absolutely crazy. I started breaking out like normal, probably something you could clear with a good cleanser, but then it started getting progressively worse. It started to be more cystic, and then really before I could even keep up with it, I had horrendous cystic pimples everywhere, and I mean everywhere. Shoulders, down my arms, all over my entire face, even sometimes on my thighs. It was ridiculous and I always felt gross. So I broke down and gave up my ideas for natural cures for a while, and got on the meds. They cleared me right up! About one month and almost everything was gone. But then of course I had the terrible side effects, which is why I'm now having to get off. My sister on the other hand had no side effects at all. Everyone is different. So, hopefully I can find a natural way to keep it clear from now on. Good luck to anyone trying:)
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June 5, 2015
Better but not perfect
I have moderate stubborn acne and even though it didn't clear me up, it did make my breakouts less frequent. At any given time I would have about 10 pimples on my face and while this I'd only have about 4 or 5. It's definitely for hormonal acne though. I did only take it for a month though before trying something else so maybe I just didn't give it enough time.
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May 12, 2015
Works, but at a cost
My derm put me on Spiro to get rid of the cysts on my chin after switching from birth control pills to an IUD. I hated it. It worked, after two months I had no cysts, but I was SO dehydrated. I could not keep enough water in me. Felt like I had to pee all the time, was constantly worried I had a UTI, etc. Went to my primary care physician twice because I was convinced I had a UTI, and both times it came out negative. I stopped taking it after 2 months and thankfully, the cysts were completely gone after that.
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April 26, 2015
Just starting out.
I cannot really give a full review, since I've only been on it for barely a week..but these reviews keep me hopeful. I'm a 25 year old female, and while I've always struggled with mild to moderate acne, my face recently broke out in the worst hormonal acne I have ever had. It started off as a few cysts on my chin, then went to my right side of my face, and then to my left. It was horrible. I'm still breaking out, but I feel like my skin may be starting to calm down. I was also out on a birth control for acne, called Estrostep. I've read a lot of mixed reviews for it, but I'm hoping it helps when paired with the spiro. Wish me luck!
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.