Certain/Likely Side Effects
|SHORT TERM Limited skin redness (erythema)||incidence not known|
|SHORT TERM Swelling (edema)||incidence not known|
Possible/Rare Side Effects
|SHORT TERM Blister formation||up to 6.3%|
|SHORT TERM Infection||incidence not known|
One study has looked at the side effects of treatment with non-ablative non-fractional lasers.
- Study 1:
- Authors: Bhatia et al.6
- Total # of patients: 16
- # of female patients: (not reported)
- # of male patients: (not reported)
- Age of patients: Average: 42
- Laser type: Nd:YAG laser
- Laser settings: 10 mm spot size, 18-20 J/cm2
- Duration of treatment and follow-up: 6 treatments, follow-up at 3-12 months
- Side effects: Blister formation: 6.3%
Study 1: In a study published in 2006 in the journal Dermatologic Surgery, Bhatia and colleagues treated 16 patients with acne scarring with a 1,320-nm Nd:YAG laser. Patients received 6 treatments at intervals of 1 month and were interviewed sometime between 3 and 12 months after treatment to discuss side effects. One patient reported a transient blister that developed after one of the treatment sessions and later healed without leaving a scar.6
- Sobanko JF, and Alster TS. Management of acne scarring, part I: a comparative review of laser surgical approaches. Am J Clin Dermatol. 13(5), 319-30 (2012)
- Preissig J, Hamilton K, and Markus R. Current laser resurfacing technologies: A review that delves beneath the surface. Semin Plast Surg. 26(3), 109–116 (2012).
- Uptodate.com. Management of acne scars. Available from: https://www.uptodate.com/contents/management-of-acne-scars?source=search_result&search=subcision&selectedTitle=1~4. Last retrieved on 30 June, 2017.
- Alexis AF, et al. Nonablative Fractional Laser Resurfacing for Acne Scarring in Patients With Fitzpatrick Skin Phototypes IV-VI. Dermatol Surg. 42(3), 392-402 (2016).
- Alster TS, and West TB. Resurfacing of atrophic facial acne scars with a high-energy, pulsed carbon dioxide laser. Dermatol Surg. 22(2), 151-4 (1996).
- Bhatia AC, Dover JS, Arndt KA, Stewart B, and Alam M. Patient satisfaction and reported long-term therapeutic efficacy associated with 1,320 nm Nd:YAG laser treatment of acne scarring and photoaging. Dermatol Surg. 32(3), 346-52 (2006).
- Chae WS, et al. Comparative study on efficacy and safety of 1550 nm Er:Glass fractional laser and fractional radiofrequency microneedle device for facial atrophic acne scar. J Cosmet Dermatol. 14(2), 100-6 (2015).
- Ahmed R, Mohammed G, Ismail N, and Elakhras A. Randomized clinical trial of CO₂ LASER pinpoint irradiation technique versus chemical reconstruction of skin scars (CROSS) in treating ice pick acne scars. J Cosmet Laser Ther. 16(1), 8-13 (2014).
- Engın B, et al. Evaluation of effectiveness of erbium:yttrium-aluminum-garnet laser on atrophic facial acne scars with 22-MHz digital ultrasonography in a Turkish population. J Dermatol. 39(12), 982-8 (2012).
- Jeong JT, and Kye YC. Resurfacing of pitted facial acne scars with a long-pulsed Er:YAG laser. Dermatol Surg. 27(2), 107-10 (2001).
- Lee SJ, Kang JM, Chung WS, Kim YK, and Kim HS. Ablative non-fractional lasers for atrophic facial acne scars: a new modality of erbium:YAG laser resurfacing in Asians. Lasers Med Sci. 29(2), 615-9 (2014).
- Wanitphakdeedecha R, Manuskiatti W, Siriphukpong S, and Chen TM. Treatment of punched-out atrophic and rolling acne scars in skin phototypes III, IV, and V with variable square pulse erbium:yttrium-aluminum-garnet laser resurfacing. Dermatol Surg. 35(9), 1376-83 (2009).
- Tanzi EL, and Alster TS. Treatment of atrophic facial acne scars with a dual-mode Er:YAG laser. Dermatol Surg. 28(7), 551-5 (2002).
- Bjørn M, Stausbøl-Grøn B, Braae Olesen A, and Hedelund L. Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: an intra-individual randomized controlled trial. Lasers Surg Med. 46(2), 89-93 (2014).
- Cho SB, Lee SJ, Kang JM, Kim YK, Chung WS, and Oh SH. The efficacy and safety of 10,600-nm carbon dioxide fractional laser for acne scars in Asian patients. Dermatol Surg. 35(12),1955-61 (2009).
- Hedelund L, Haak CS, Togsverd-Bo K, Bogh MK, Bjerring P, and Haedersdal M. Fractional CO2 laser resurfacing for atrophic acne scars: a randomized controlled trial with blinded response evaluation. Lasers Surg Med. 44(6), 447-52 (2012).
- Majid I, and Imran S. Fractional CO2 Laser Resurfacing as Monotherapy in the Treatment of Atrophic Facial Acne Scars. J Cutan Aesthet Surg. 7(2), 87-92 (2014).
- Manuskiatti W, Triwongwaranat D, Varothai S, Eimpunth S, and Wanitphakdeedecha R. Efficacy and safety of a carbon-dioxide ablative fractional resurfacing device for treatment of atrophic acne scars in Asians. J Am Acad Dermatol. 63(2), 274-83 (2010).
- Manuskiatti W, Iamphonrat T, Wanitphakdeedecha R, Eimpunth S. Comparison of fractional erbium-doped yttrium aluminum garnet and carbon dioxide lasers in resurfacing of atrophic acne scars in Asians. Dermatol Surg. 39(1 Pt 1), 111-20 (2013).
- Nirmal B, et al. Efficacy and safety of erbium-doped yttrium aluminium garnet fractional resurfacing laser for treatment of facial acne scars. Indian J Dermatol Venereol Leprol. 79(2), 193-8 (2013).
- Wang YS, Tay YK, and Kwok C. Fractional ablative carbon dioxide laser in the treatment of atrophic acne scarring in Asian patients: a pilot study. J Cosmet Laser Ther. 12(2), 61-4. (2010).
- Yuan XH, Zhong SX, and Li SS. Comparison study of fractional carbon dioxide laser resurfacing using different fluences and densities for acne scars in Asians: a randomized split-face trial. Dermatol Surg. 40(5), 545-52 (2014).
- Zhang Z, Fei Y, Chen X, Lu W, and Chen J. Comparison of a fractional microplasma radio frequency technology and carbon dioxide fractional laser for the treatment of atrophic acne scars: a randomized split-face clinical study. Dermatol Surg. 39(4), 559-66 (2013)
- Cachafeiro T, Escobar G, Maldonado G, Cestari T, and Corleta O. Comparison of Nonablative Fractional Erbium Laser 1,340 nm and Microneedling for the Treatment of Atrophic Acne Scars: A Randomized Clinical Trial. Dermatol Surg. 42(2), 232-41 (2016).
- Isarría MJ1, Cornejo P, Muñoz E, Royo de la Torre J, and Moraga JM. Evaluation of clinical improvement in acne scars and active acne in patients treated with the 1540-nm non-ablative fractional laser. J Drugs Dermatol.10(8), 907-12 (2011).