Intralesional Corticosteroids

What Is It?

Intralesional corticosteroids, usually triamcinolone acetonide, are injected directly into the scar in order to reduce the size and thickness of the scar. It is thought that intralesional corticosteroids are effective in the treatment of hypertrophic (raised) scars because they decrease the proliferation of cells that produce collagen, decrease the production of collagen, promote the degradation of collagen, and reduce immune-mediated inflammation.

Scar Height Reduction

Strength of Evidence
1
2
3
4
5
Average 54% reduction in scarring

Scar Volume Reduction

Strength of Evidence
1
2
3
4
5
Average 71% reduction in scarring

Success Rate

Strength of Evidence
1
2
3
4
5
Average 60% reduction in scarring

Mean improvement in VSS total score

Strength of Evidence
1
2
3
4
5
Average 62% reduction in scarring

Mean improvement in VSS pigmentation score

Strength of Evidence
1
2
3
4
5
Average 40% reduction in scarring

Mean improvement in VSS height score

Strength of Evidence
1
2
3
4
5
Average 64% reduction in scarring

Mean improvement in VSS pliability score

Strength of Evidence
1
2
3
4
5
Average 81% reduction in scarring

Mean improvement in VSS vascularity score

Strength of Evidence
1
2
3
4
5
Average 66% reduction in scarring
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  43. Ahuja, R. B. & Chatterjee, P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns 40, 583–588 (2014).
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  52. Berman, B. et al. Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids. J Drugs Dermatol 7, 757–761 (2008).
  53. Asilian, A., Darougheh, A. & Shariati, F. New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 32, 907–915 (2006).
  54. Manuskiatti, W. & Fitzpatrick, R. E. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138, 1149–1155 (2002).
  55. Yosipovitch, G., Widijanti Sugeng, M., Goon, A., Chan, Y. H. & Goh, C. L. A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study. J Dermatolog Treat 12, 87–90 (2001).
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Side Effects

Medium-High
Medium-high side effects and adverse reactions

Reviews

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