What Is It?
Intralesional corticosteroids, usually triamcinolone acetonide, are injected directly into the scar in order to reduce the size and thickness of the scar. It is thought that intralesional corticosteroids are effective in the treatment of hypertrophic (raised) scars because they decrease the proliferation of cells that produce collagen, decrease the production of collagen, promote the degradation of collagen, and reduce immune-mediated inflammation.
Scar Height Reduction
Strength of Evidence
1
2
3
4
5
Average 54% reduction in scarring
Scar Volume Reduction
Strength of Evidence
1
2
3
4
5
Average 71% reduction in scarring
Success Rate
Strength of Evidence
1
2
3
4
5
Average 60% reduction in scarring
Mean improvement in VSS total score
Strength of Evidence
1
2
3
4
5
Average 62% reduction in scarring
Mean improvement in VSS pigmentation score
Strength of Evidence
1
2
3
4
5
Average 40% reduction in scarring
Mean improvement in VSS height score
Strength of Evidence
1
2
3
4
5
Average 64% reduction in scarring
Mean improvement in VSS pliability score
Strength of Evidence
1
2
3
4
5
Average 81% reduction in scarring
Mean improvement in VSS vascularity score
Strength of Evidence
1
2
3
4
5
Average 66% reduction in scarring
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- Khalid, F. A. et al. Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: randomised control trial. Burns 45, 69–75 (2019).
- Hietanen, K. E. et al. Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial. J Plast Reconstr Aesthet Surg 72, 4–11 (2019).
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- Srivastava, S., Patil, A., Prakash, C. & Kumari, H. intralesional triamcinolone acetonide, 5-fluorouracil, and their combination in treatment of keloids. World J Plast Surg 7, 212–219 (2018).
- Garg, A. M. et al. The efficacy of intralesional triamcinolone acetonide (20mg/ml) in the treatment of keloid. International Surgery Journal 5, 868–872 (2018).
- Azimi Alamdari, H., Davarnia, G., Herizchi Ghadim, H. & Asal, S. Intralesional cryotherapy versus intralesional corticosteroid and 5-fluorouracil in the treatment of hypertrophic scars and keloids: a clinical trial. Crescent Journal of Medical and Biological Sciences 5, 215–221 (2018).
- Ahsan, M. Q., Sikder, M. A. U. & Khondker, L. Efficacy of combination of intralesional corticosteroid injection and cryotherapy versus intralesional corticosteroid injection alone in patients of keloid. J Pak Assoc Dermatol 28, 474–481 (2018).
- Aggarwal, A., Ravikumar, B. C., Vinay, K. N., Raghukumar, S. & Yashovardhana, D. P. A comparative study of various modalities in the treatment of keloids. Int J Dermatol 57, 1192–1200 (2018).
- Abedini, R. et al. Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: a randomized controlled trial. Burns 44, 1482–1488 (2018).
- Zamanian, A., Nokandeh, M., Behrangi, E., Fazel, Z. & Zahra, A. Comparing efficacy and tolerability of triamcinolone and verapamil in treatment of hypertrophic scars and keloids. Journal of Skin and Stem Cell 4, 1–4 (2017).
- Saleem, F. et al. Comparison of efficacy of intralesional 5-fluorouracil plus triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of keloids. J Pak Assoc Dermatol 27, 114–119 (2017).
- Nor, N. M., Ismail, R., Jamil, A., Shah, S. A. & Imran, F. H. A randomized, single-blind trial of clobetasol propionate 0.05% cream under silicone dressing occlusion versus intra-lesional triamcinolone for treatment of keloid. Clin Drug Investig 37, 295–301 (2017).
- Chen, X.-E. et al. Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars. Exp Ther Med 13, 3607–3612 (2017).
- Acosta, S. et al. Effectiveness of intralesional triamcinolone in the treatment of keloids in children. Pediatr Dermatol 33, 75–79 (2016).
- Uzair, M., Butt, G., Khurshid, K. & Pal, S. S. Comparison of intralesional triamcinolone and intralesional verapamil in the treatment of keloids. Our Dermatol Online 6, 280–284 (2015).
- Shaarawy, E., Hegazy, R. A. & Abdel Hay, R. M. Intralesional botulinum toxin type A equally effective and better tolerated than intralesional steroid in the treatment of keloids: a randomized controlled trial. J Cosmet Dermatol 14, 161–166 (2015).
- Payapvipapong, K., Niumpradit, N., Piriyanand, C., Buranaphalin, S. & Nakakes, A. The treatment of keloids and hypertrophic scars with intralesional bleomycin in skin of color. J Cosmet Dermatol 14, 83–90 (2015).
- Khan, M. A., Bashir, M. M. & Khan, F. A. Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. J Pak Med Assoc 64, 1003–1007 (2014).
- Aluko-Olokun, B., Olaitan, A. A., Ladeinde, A. L. & Oginni, F. O. The facial keloid: a comparison of treatment outcome between intralesional steroid injection and excision combined with radiotherapy. Eur J Plast Surg 37, 361–366 (2014).
- Ahuja, R. B. & Chatterjee, P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns 40, 583–588 (2014).
- Rossi, A. et al. The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids. J Drugs Dermatol 12, 1256–1262 (2013).
- Saha, A. K. & Mukhopadhyay, M. A comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloids. Indian J Surg 74, 326–329 (2012).
- Sadeghinia, A. & Sadeghinia, S. Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg 38, 104–109 (2012).
- Prabhu, A., Sreekar, H., Powar, R. & Uppin, V. M. A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. Journal of the Scientific Society 39, 19 (2012).
- Darougheh, A., Asilian, A. & Shariati, F. Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 34, 219–223 (2009).
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- Koc, E., Arca, E., Surucu, B. & Kurumlu, Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg 34, 1507–1514 (2008).
- Berman, B. et al. Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids. J Drugs Dermatol 7, 757–761 (2008).
- Asilian, A., Darougheh, A. & Shariati, F. New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 32, 907–915 (2006).
- Manuskiatti, W. & Fitzpatrick, R. E. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138, 1149–1155 (2002).
- Yosipovitch, G., Widijanti Sugeng, M., Goon, A., Chan, Y. H. & Goh, C. L. A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study. J Dermatolog Treat 12, 87–90 (2001).
- Tan, E., Chua, S. & Lim, J. Topical silicone gel sheet versus intralesional injections of triamcinolone acetonide in the treatment of keloids — a patient-controlled comparative clinical trial. Journal of Dermatological Treatment 10, 251–254 (1999).
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Side Effects
Medium-High
Medium-high side effects and adverse reactions
Reviews
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