Topical Retinoid
Reviews
3.2
1910 Reviews
Topical Retinoid
Efficacy
54%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Topical Retinoid
Side Effects
Low
Topical Retinoid
Acne.org’s Real World Take
This topical retinoid medication provides partial relief at higher prescription dosages, but don’t look for complete clearing. Relatively affordable and comes with less side effects than tretinoin, the other affordable topical retinoid. As a bonus, it improves the look of skin and reduces fine lines and wrinkles a bit too.
Topical Retinoid
How to Get It
Adapalene is available in strengths up to 0.3% by prescription. Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one. Adapalene is also available over-the-counter in 0.1% strength. Here are some places you can find it online.
Read All About Adapalene
Compare To Other Treatments
5
17.5%
4
30.4%
3
22.6%
2
17.1%
1
12.4%

Used Adapalene? Rate It:

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February 24, 2017
Finally! Something that really works!
I'm a 37 year old African-American woman. I have struggled with adult hormone-induced acne for nearly 15 years. Over the years, I have watched large areas of my flawless chocolate skin become overcome by dark stubborn scars around my jawline and on my cheeks. I have tried bleaching, exfoliants, proactiv, etc. But, nothing worked to remove them. Nothing. I saw a differin gel .1 commercial on BET. I immediately picked up a tube at Walmart. And I tell you, I saw results after only 2 days. No lie! Now, I'm 3 weeks in and my jawline (which had a dark spot about 5 inches wide), is 50% clear! My family and co-workers noticed without me saying anything. I feel like I'm alive again. I don't have to cover up as much. I highly recommend this product. Don't hesitate. Go get it!
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April 7, 2017
Why would you use bleaching on your "flawless chocolate skin"? Isn't bleaching to lighten one's skin? In my case, my flawless pure milky white complexion benefited marvelously from the medication.
April 27, 2017
She meant that she "bleached" her skin to get rid of the unwanted dark scars left over from acne, not that she wanted to lighten her "flawless chocolate skin" to a lighter skin color.
January 16, 2017
good product!
My skin is sensitive and combination/oily. I have never had horrible or cystic acne, just a few pimples on my forehead all the time. About a month ago, the acne spread to all over my forehead. I knew the problem wasn't my diet or a product because i tried eliminating these things. My dermatologist prescribed me .1% differin gel a few weeks ago. There was no difference the first two days but on the third day, I had no new pimples and it's been that way since! I did experience slightly drier skin than usual, but no redness or flaking. I believe the key is to use as little product as possible and moisturize as soon as the product sinks into the skin. Also, it's important to exfoliate daily to help the product remove waste from your face. One thing i did notice though was that i have a couple clogged pores still on my forehead. Do i wait them out? Will they turn into pimples?
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March 22, 2017
I have the same skin combination but after using differin, my skin becomes irritable , dry and has constant tingling feeling. I had my skin peeling off and I wonder how do I exfoliate these dead skin without worsening my skin ?
March 22, 2017
I have the same skin combination but after using differin, my skin becomes irritable , dry and has constant tingling feeling. I had my skin peeling off and I wonder how do I exfoliate these dead skin without worsening my skin ?
September 23, 2016
A MIRACLE WORKER!!!!
Started 13/8 and its been 8 weeksish (2 MONTHS) now. I'll write a detailed n thorough review + tips. Differin 0.1 gel is amazing! History : normal/dry and clear healthy glowing beautiful skin until cue worst stress ever (college)+wrong products (i used two simultaneously and did not patch test ;_;) I got a clusterf**k of closed comedones (flesh coloured bumps) littered allll over my forehead. Worst sh*t ever then. I didnt even bother with ahas/bhas as they were hardly accessible+extortionate where im from. Differin is available otc&dirt cheap here. About $12/30g tube. Usage : i started out with applying once every 3rd day for 2 weeks (12 days), then every other day for 10 days then every day at night. Application : I put it on after my toner+moisturizer (wait 30 mins) then differin. Its called buffering. Im nt a f**king med pro but a lot of people myself included buffer and it still works. Use after t+m for about 3 weeks and then use it after toner for another 3 weeks and see if ur bare skin cn tolerate it, if nt, dial down to applying after toner. Just give it like at least 20-30 minutes for each product to absorb. I use big globs (about 4) for my whole face but you should start out with only 1 big dollop/pea-sized for ur entire face (i built my usage up only after 1 month) just dot on ur face n smear evenly on entire skin & not just affected areas. Differin works by increasing cell turnover rate for ur acne on affected areas & as a preventative measure for the clear parts of ur skin. "As close to bare skin as possible" my f**king ass. A lot of people dont even have a basic QUALITY skincare routine on lock-down. Accounting that fact + harsh, drying cleansers and you'd be lucky if you get away with just a slight stinging sensation. (Trans:most ppl burn their faces off and experience gruesome peeling,flaking,stinging,burning and sensitivity if they apply on bare skin when just starting off.) I experienced very minimal if none irritation. Honestly most of the douchebags that gave bad reviews just didnt stick with it long enough. Hear me out Week 1: broke out in a few tiny red pimples, maybe 3-4 on forehead. I freaked out at first bt that just means that differin is working and its pushing all the gunk in ur pores unto the surface, thus causing pimples to rear their ugly heads. Its called purging. Ur fine. Dont freak out. Btw differin worked right off the bat for me but you should experience purge/break out/worsening of acne within the first 8 weeks. It varies frm one person to the other how long ur purge would be. Some people purge for 2-3 months. Sone experience cycles of purge. Week 2: more tiny red pimples on forehead. 5 more.Ur still fine dont freak out. Right cheek appeared 2 tiny red pimples. Week 3-5: got a papule, its sooo red and inflamed and it hurtss to touch it. 7 tiny red inflamed pimples, whiteheads, blackheads. Later that night 2 more papules popped up. 1 on forehead and another on on right cheek (my forehead & right cheek had ccs and were congested) thiz is where it got the absolute f**king worse. My forehead was sooooo inflamed and ANGRY and RED. It HURTS to touch my forehead and it wasnt just bumpy it HURTS coz of active acne. I remember thinking "id rather live with the fleshy bumps bcuz this is so much worse than when I started" Needless to say my self esteem took a huge toll, everyone used to comment and praise me on how beautiful my skin is on a daily basis and now I get comments + snides like "what happened?" "Your skin used to be sooo clear and pretty!" Or just the plain STAREEEEEEEE. F**k. I had school and it was EXCRUCIATING. I wanted to hide until i got my clear skin back. Im proud of myself for powering through. Because... Week 6: (FIRST HALF) breakouts stopped. Pimples got smaller. Tiny red ones r still appearing but theyre gone real quick. A lot are disappearing. A patch on my forehead is smooth and bump-free. I had a healthy glow on. Things improved by leaps and bounds. I am so happy. I see light at the end of the tunnel. (SECOND HALF) I swear some pimples just appeared outta nowhere like within a few days.... Week 7 - Okay so I still have leftover cc's and some active tiny pimpz and they're purging (the fleshy bumps called closed comedones are turning into red pimples that have whiteheads on them!) I feel like Differin takes a lot of patience because it the mildest retinoid product (in comparison to tretinoin and tarozatene{ ¿} ) so it takes a lot longer to work but pose the least irritation compared to tretinoin! Its improving and the right side of my forehead is clearing up nicely. Left with lots of PIH on skin! :) tldr skin is improving bt still purging bt fear not its nt nearly as bad as the first purge this is really really mild and nothing to worry about! :) Week 8 - My skin has A SH*TTON OF PIH (Dark marks) and active acne and still some closed comedones...I can them using 2 hands, isn't that nice? lol ahhaha...I can see that things are steadily improving...Remember it won't work overnight, be realistic about this :) I can actually go out and feel confident about it..just avoid mirrors guys..exp when ur washing ur face other than that plz avoid it , it wud just make u feel like sh*t, but remember that u r not sh*t, u r a GEM and that people are vain and they care more about themselves (we are our own worst critic, i keep saying this but its true so dont worry about it and just be patient and LOOK FOR THE SILVER LINING!) Week 9 - im purging a bit bt its nt that bad, the cc's turned into red pimples... but sokay cause Its never as worst as the initial purge!!! Also clean ur glasses (i got pimples coz of greasy glasses TT) all is well! The dark marks n red marks r fading Week 9 (end) - huhuhuhu I felt sore bumps on my right cheek and then the next day a hugeeee cyst appeared and little pimples cropped up around the cyst....GOD its terrifying Im STILL purging and its almost 2 months 2 weeks TT ughhh POSITIVE! IT'LL ALL BE WORTH IT!! Tips: 1) give it 3 months. At least. Im 6 weeks in and i see significant improvements! Its improving slowly but surely! 2) pick up a gentle products:cerave hydrating cleanser, cerave am+pm cream with ceramides, garnier micellar water in pink r good drugstore options. Avoid alcohol in products. 3) cleanse ur face morning or night but i only splash with water during mornings coz dry skin. You can cleanse twice if you are oily-skinned. Use garnier micellar water(pink) to remove ur sunscreen or makeup at night. Pour adequate amount on cotton pad and do GENTLE, CIRCULAR MOTIONS to evenly distribute on skin. Then cleanse with cerave hydrating cleanser (do not for the love of God use cetaphil's oily cleanser. those sh*ts are very very stripping and they will f**k ur skin up) 4) for the love of God (or whatever the f**k u believe in) WEAR F**KING SUN PROTECTION. La roche posay n elta md uv clear 46 are options bcz i knw the americanas have gross goeey sunscreens (majority). Apply 1/4tsp or APPLY a lot, two layers, 15 minutes wait time in between. 5) reapply sunscreen every 40 minutes if ur sweating vigorously and avoid going out in the sun during peak hours (10-4pm) 6) wear wide brimmed hats and sunglasses. 7) differin strips the outermost layer of ur skin so plz wear sunscreen unless u want to get a sunburn and have ur dark spots/hyperpigmentation/acne scars darken and take 2 eternities to fade. 8) no waxing threading no aha no bha no harsh scrubs/exfoliation for the 1st month, slowly incorportate afterwards. Btr safe than sorry. 9) apply around eyes n below eyes but not on the browbone or eyelids or creases of ur nose unless u wanna burn ur skin off. Around the lips where pimples r are fine but not on the lips (duh) and dont get too close to it it will burn. Laugh lines are fine 10) ur skin will look bad one week and then btr/good the next this is normal & cn continue well into 3 months, if u
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August 4, 2016
AMAZING
Below is a detailed look at my journey. If you don't feel like reading it, here are the 2 major points: 1. Adapelene worked great for me, however it took much patience; about 8 weeks to get my desired results. 2. Adapelene makes you VERY sensitive to the sun. I got second degree burns & sun poisoning on my face by going out unprotected for a few hours. Wear lots of sunscreen & avoid the sun if possible. If you do end up getting a burn, discontinue the Adapelene until the sunburn is COMPLETELY healed. Start date: May 9, 2016 So here's my story: I started going to the dermatologist almost a year ago. I had, what I considered to be, horrible acne. Not cystic or anything, but very bad hormonal acne along my cheeks. I believe I made it much worse by all the DIY acne treatments I used before going to the derm: Oil pulling, raw honey, every OTC facewash imaginable, steaming my face every day, any product I could find off Amazon, Proactiv, etc. I finally gave up and went to the derm. I was prescribed 200 mg of Doryx (Doxycycline) and instructed to wash my face twice a day with Cetaphil, exfoliate 3x a week with NEO cleanser (which I bought directly from my dermatologist) and put on Aczone cream twice a day. Over the course of 7 months, I gradually decreased the antibiotic until I completely stopped. Also during this period, I had 3 chemical peels done, as well as 4 sessions of micro needling (for my acne scars) The difference was amazing. I had almost no acne and finally felt confident in my skin. I had pimples every now and then, but they were few and far between. When I went back for a check-up in May, my dermatologist said that I still have a lot of clogged pores and that is where my current acne was coming from. She prescribed me 0.1% Adapelene gel and instructed me to put it on every night after I put on my Aczone. She told me to make sure to put on moisturizer afterwards as well, because this product would dry my skin. I am still on the same exact routine as when I first started, minus the Doryx. I've documented my journey thus far below, week by week: Week 1: Nothing noticeable yet. Missed a few nights here and there (I had trouble remembering at first). The only thing to note is that I had a pretty big pimple on my chin, but it went away within my first 2 days of using this gel. Week 2: Some very small bumps forming on my cheek. I actually didn't notice until I looked at my reflection outside. It freaked me out a bit, but it's nothing compared to the acne I used to get. Also beginning to notice itchiness and dryness, I can't see the dryness of my face until I put on my foundation in the morning. (I found that exfoliating with NEO cleanser 3 times a week got rid of this problem) My only complaint is that I went to six flags while it was very hot outside and by face BURNED all day. I was prepared for this, since I had read reviews about sweat making your face itch and burn while on this product. I used moisturizer with sunscreen in it that day, so at least I didn't get a sunburn, just the itchiness. Week 3: All the small bumps on my cheek are basically gone. However, two huge whiteheads formed on my chin within 24 hours. I didn't want to pop them, so I just put the Adapelene on as usual and hoped it'd dry them out quickly. The next day they were even worse so I couldn't resist. I put on the gel right after I popped them and went to bed. The next morning the bumps were pretty much flat. They still had a little redness around them, but looked much better. Still having slight burning when I sweat and also starting to notice the exfoliating isn't helping the scaly look of my skin as much as it did at first. Week 4: Not as much burning on my face anymore, but I am getting more breakouts on my cheek and forehead. Other people are just now starting to notice that I'm getting breakouts again. Luckily, I have learned to stop giving a sh*t. Yay! Week 5: Still more breakouts coming up, especially in places I never got acne before. It's the worst on my chin, which I expected because I've always gotten bad breakouts there. But now I'm getting them on my nose, forehead, and between my eyebrows. Still experiencing some drying. I'm not sure if I accidently got some near the corners of my mouth & eyes, but those areas are drying badly. The corner of my mouth is so dry that it hurts to open my mouth just to brush my teeth. I've slept with makeup on once this week (a big no-no) and paid the price: A couple huge pimples on my jawline and forehead. I doubt that was Adapelene's doing as much as it was having makeup on for so long. This is the first week I've considered just stopping the product, because I'm terrified of destroying the face I've worked hard for (or should I say, 'The face I have paid a lot of money for'?) Regardless, I'm going to push through it. Week 6: Zero pimples came up this week. All side effects (Burning, itching, redness, etc.) have completely subsided. I'm seriously amazed, it really does get worse before it gets better. It's like my face changed overnight! Week 7: The first half was pimple free then suddenly 4 new pimples came up. I'm not sure it's from the Adapelene. I was on an antibiotic for an infection and those usually wreak havoc on my skin. Man are they STUBBORN though. Going to keep on pushing through. Weeks 8-12: Not one single breakout! My skin is heavenly! **WARNING** On week 11 I went on a trip to my lake house and was in the sun for a few hours with no sun screen on my face. HUGE mistake. My face was burnt to a crisp- literally. Eyes swollen for days, the peeling process took a week and was extremely painful. This was my own fault- I had read that Adapelene makes you sensitive to the sun but I did not heed the warnings. Consider yourself warned! If you do end up getting burned, discontinue the Adapelene until your sunburn is COMPLETELY healed.
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June 22, 2016
AMAZING!!!
I used this in combination with Clindoxyl gel, and the results have been incredible! I used to get horrible acne on my chin and around my mouth, but I can't even remember the last time I've had a single pimple, and I've been on the cream for about 8-9 months. When you first start, use the cream only twice a week, then gradually move to 3x, 4x, etc. until you are able to use it daily. Differin cream is so moisturizing, and makes my skin feel incredible. It noticeably diminishes the size of your pimples, and when they do come, they stay for much less time (coming from someone who used to get cystic acne that would last 2+ weeks, I now have 0 pimples, and when they do come, they last a day or two). I get compliments on my skin all the time now, and am totally in love with Differin. 10/10 would recommend. My only advice is to stick with it!! If at first it doesn't work, don't give up, just let it take its time. Took me 5-6 months to start seeing perfect results.
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June 17, 2016
WAIT for results!
Background: I'm twenty years old and I've never had a problem with acne leading up to this. I would get the occasional spot, with one nagging cluster on my forehead because I rub there when I'm stressed. Then I had a massive cystic acne breakout. In January 2016 I started a new medication, which worked great except for it started to cause acne. This medication is known for doing that. It saved my life, but over the course of several months cause me to have a moderate to severe cystic acne breakout. I'd never had a cyst before, and four months later this was all over my cheeks and chin, overlapping each other and bright red. I've never worn make up before, but had to start in order to feel ok leaving the house. When my doctor saw me in March, we switched to a new medication that wouldn't cause acne, but we still had to deal with the fall out. He prescribed minocycline and told me to stick with my sacylic acid face wash. This did nothing by mid-April, so I started doing my own research. I found out that Epsom salt is really helpful for some, and gave it a shot. It worked like magic and drew up and drained almost all my cysts, but they were still not completely healed and were always threatening to flare up, I also had a few persistent ones that refused to drain. When I saw my doctor earlier this month, June, he put me on doxycycline and Adapalene 0.1%. I saw results within a couple of days, it was amazing. My cysts have almost all gone completely flat, a lot of them are completely healed except for scarring and that is starting to fade. I've only been on it a week and a half, which isn't normal at all. I think the reason why it's so accelerated is because I was using the Epsom salt religiously and it drew out so much of the infection that my face was already very primed to heal. You have to give this medication time to kick in. My face is peeling a little but that's how this medication works, my scarred skin is peeling away. I'll post a follow-up in a couple of weeks, I hope it'll be cleared completely by then.
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June 12, 2016
Recommend it!
Been struggling with acne for a long time, and this stuff has been one of the few things that have worked. Highly recommend.
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May 16, 2016
Works great!
I was feeling depressed because of a very bad sudden breakout, especially on my forehead and left cheek. For a whole week, I avoided meeting people including friends and family members. I went to the doctor and got prescribed some antibiotics, BP to apply every morning and Differin to apply at night. Not sure if it was because I took all 3 prescriptions together or just because of the Differin, but within a week the red bumps on my forehead and left cheek really cleared up. There are only red little marks left but it is definitely fading as days goes by. The Differin works great for me and I hope that all of you will soon find something that will be able to help cure your acne problems!
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April 6, 2016
Whitehead & acne
Im 25 years old.. I dont have big problem on acne..only whitehead around forehead, cheek and chin.. Already use differin gel 0.1% about a month..But now I got big acne between my eyebrow, on forehead, nose, chin, some on cheek.. Whitehead still on my face..my skin still oily, when I clean my skin using cleanser my skin got burn.. I hope my skin get better because now my skin worse than before..
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June 8, 2016
After 3months My skin super great now. I use differing 0.1% gel. My whitehead gone. I dont remember how its gonez.lol. First 2-3months, breakout no breakout no breakout no. But now im satisfied with my skin even I still got 1-2 tiny acne or whitehead. My skin great I use combination of vitamin C + wild yam from Artistry (my friend suggest it) then put differin and my skin super glow nice.. Sorry my broken english.
June 8, 2016
Differin*
June 8, 2016
Differin*
January 20, 2016
Not a Fast result Product
I've been using differin for about 6 months now. This is my second trial of differin because I quit the a year before after about 2 months. Differin is literally a skin renewal product. Your skin will flake and it will burn a little and you might break out for the first month or so while getting used to it. BUT IT WORKS! The problem that most people have is dealing with the flaky skin, so they compensate with lotion or terrible choice of moisturizers after. Or for some people nothing after. Differin sucks the oil and kills a small layer of skin, so your skin compensates and produces too much oil but if you moisturize then it is more regulated. I found that differin has the best results when coupled with a oil free moisturizer in the morning. What I did was wash my face with Noexema at night, put a THIN film of differin on the problem areas, let it dry then went to bed. In the morning, I woke up washed my face again, then put UP and Up Dual Moisturizer Oil free, and went about my day. Repeat everyday. but only use differen every 2 days, switching to a moisturizer at night to give your face a break. Another important thing is that since your skin is flaking dead skin, you need to EXFOLIATE each week, with a gentle face sponge. However, if you have severe bumps DO NOT scrub them raw this will only make things worse. If you have white heads, use a sterile needle puncture a hole then gentle nudge some of the pus out and then put differin on it. It will crust the acne up and be gone in a few days. Hope this helps. I went from cluster bumps on my cheeks and forhead to fading brown scars and smoother skin. It is just a balancing act so don't give up so easily and MOISTURIZE for goodness sakes!
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Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.