Topical Retinoid
Reviews
3.2
1910 Reviews
Topical Retinoid
Efficacy
54%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Prescription and over-the-counter adapalene share the same efficacy percentage due to non-specific research, but prescription strength likely performs better.
Topical Retinoid
Side Effects
Low
Topical Retinoid
Acne.org’s Real World Take
This topical retinoid medication provides partial relief at higher prescription dosages, but don’t look for complete clearing, especially at over-the-counter strength. Relatively affordable and comes with less side effects than tretinoin, the other affordable topical retinoid. As a bonus, it improves the look of skin and reduces fine lines and wrinkles a bit too.
Topical Retinoid
How to Get It
This is an over-the-counter treatment. Here are some places you can find it online.
Read All About Adapalene (Non-prescription)
Compare To Other Treatments
5
17.5%
4
30.4%
3
22.6%
2
17.1%
1
12.4%

Used Adapalene (Non-prescription)? Rate It:

Choose from 1 to 5 stars
July 10, 2008

Pros:

None at all

Cons:

Makes it worse. causes itching, burning and redness.

It doesn't do anything good. I got it hoping it would help and it just made it worse. don't use this product. it's horrible
July 8, 2008

Pros:

My Derm prescribed it to me

Cons:

Didnt clear acne; EXTREME dryness; Constant Burn; Hard to apply

Ive never cared much about dryness of skin but this was so intense even with moisturizer....i was like drying so much my face went from tan to pale within days wtf.............its burns everytime u touch ur face with water now...if u take a shower ur skin will proly fall off.....didnt help pimples either...KINDA helped scabs.....hard to apply pea amount to whole face y did my derm prescribe this???to make things worse so id be a longterm patient??? I told her my regime was workin but NOOOO i hadda use differin and kill myself
May 9, 2008

Pros:

Has stopped major breakouts, and acne I do get clears up a lot quicker.

Cons:

Is a bit pricey (I paid $35) but I use only a very small amount each day, so I think it will last a while. Dried my skin, but was able to balance the moisture in my skin with sorbelene cream.

Has been great, no longer gettin the large sore pimples I used to get. If I don't apply it everyday I do get small breakouts, but nothing like what I had. I still get blackheads, but I am just pleased that my skin has cleared. My skin did get worse before it got better with this product, but after a few weeks, it really made a difference. Moisturiser is essential when using this though.
April 10, 2008

Pros:

none really.

Cons:

it just didn't work at all. there was no change in my skin.

It didn't irritate or anything, but my skin was exactly the same and i stuck with it for months. i'm using retin-a now and it's amazing. my skin is pretty much clear.
April 4, 2008

Pros:

works for a while

Cons:

stops working after long term use
major redness and peeling
still get some pimples even when working

I have tried both differin .1% and .3% for my mild acne. Using the .1% it took about 2-3 months to see results. I never had any peeling, but even when I cleared up some I'd still get some acne. Once I went off antibiotics it went back to how it was before even though I was still using differin. I went back to the derm and got the .3%. It made me extremely dry. I was peeling bad, even with a lot of moisturizer. I'd still get zits. I've been on it for about 4 months now and my pimples are worse then ever, though the dryness subsided about a month ago. My acne is now very large, red, sore, and under the skin and it a pimple seems to last 2 or more months. My skin was not nearly this bad when I started using differin initially 2 years ago. I've been on it regularly since then and am going to quit using it because it has turned my skin into a nightmare and I'm in my mid-20s when acne should be clearing up! Going to try Clinique or Proactiv instead.
March 15, 2008

Pros:

Useless

Cons:

I have tried both Erythromycin and differin. Former has been much better and works from first day. Differin does not help anything

Ask your doctor if you can see him/her within two weeks if she happens to prescribe differin so that the medication gets changed before you have been affected beyond control
February 26, 2008

Pros:

I'm using Differin 0.3%.  I have cystic acne on my cheeks. It's day 20 and it's clearing up great.  No new pimples/zits have formed since I started using this.  Helps fade the red marks/scars. Non-irritating.

Cons:

None for me.

I've had pimples since I was 11 and I'm 30 now.   My acne seems to have gotten worse as I got older. I've tried everything: OTC meds, all prescription meds except accutane.   I've tried Differin 0.1% gel two years ago,it worked well but seemed to stop after a while. Recently I broke out on the right side of my cheek which left red marks/scars and I was so embarrassed and self-conscious that I went back to my Dermatologist and I was against using Accutne so she prescribed Differin 0.3% gel, Doryx, and Klaron.   My face is clearing up so well and my scars are fading.   No new pimples have surfaced since I've been on this regimen.   Differin does not irritate my skin at all.
January 18, 2008

Pros:

None yet

Cons:

Acne is getting worse ,really dry skin

Just started using, gonna stick it out for at least a month to see what happens
January 4, 2008

Pros:

cleared acne

Cons:

made my skin itch, dry, and acne got really REALLY bad before it worked

I hated the product at first that I actually stopped using it. Then after weeks of not using it, I went back and tried it again but this time I used it very VERY lightly every night(after 15 minutes of applying clindamycin gel. I still have dark spots but acne almost all gone! Don't use too much! Be patient and apply only little amount and it will actually work!!!
December 26, 2007

Pros:

Worked better than expected! Used differin at night (alternated with AHA 15 night cream) and duac in the morning. Now I just have to deal with the dark spots left by old acne.

Cons:

Initial breakout - about 2 cysts and a few smaller ones

After two months, no more cystic acne! Dramatic difference.

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.