Adapalene / Benzoyl Peroxide (Epiduo®)

Topical Retinoid / Topical Antibacterial
Compare To Other Treatments

The following side effects are expected to occur in the first 2-4 weeks of treatment, and resolve with continued use of adapalene / benzoyl peroxide. Contact your doctor if these symptoms are severe and/or do not go away after 4 weeks of treatment:

Adapalene / Benzoyl Peroxide may cause some side effects. Data on side-effects consists of a combination of government data as well as’s compilation of side-effect data from existing clinical studies:

How Common (based on clinical studies)

Burning, stinging, or tingling sensationUp to 84.9% of all users
Dryness of skinUp to 75.3% of all users
Skin irritationUp to 68.8% of all users
Skin peeling or scalingUp to 64.4% of all users
Redness and/or warmth in the areaUpto 64.4% of all users
ItchingUp to 20.8% of all users
Burning of the skin with blistering, swelling, and redness in the treated areaUp to 3% of all users
Intense skin irritation or rashUp to 3% of all users

If you experience any of the following side effects, stop using adapalene / benzoyl peroxide immediately and contact your doctor or get emergency medical care right away:

  • A sudden appearance of swelling and rash (known as hives)
  • Swelling of the eyes, lips, tongue, or entire face
  • Severe itching
  • Trouble with breathing
  • Feeling dizzy or faint

Adapalene / Benzoyl peroxide may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using adapalene / benzoyl peroxide.

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