Adapalene / Benzoyl Peroxide (Epiduo®)

Topical Retinoid / Topical Antibacterial
Compare To Other Treatments

The following side effects are expected to occur in the first 2-4 weeks of treatment, and resolve with continued use of adapalene / benzoyl peroxide. Contact your doctor if these symptoms are severe and/or do not go away after 4 weeks of treatment:

Adapalene / Benzoyl Peroxide may cause some side effects that are serious. If you experience any of the following, get in touch with your doctor immediately or seek emergency medical treatment. Data on side-effects consists of a combination of government data as well as’s compilation of side-effect data from existing clinical studies:

Burning, stinging, or tingling sensationUp to 84.9% of users
Dryness of skinUp to 75.3% of users
Skin irritationUp to 68.8% of users
Skin peeling or scalingUp to 64.4% of users
Redness and/or warmth in the areaUpto 64.4% of users
ItchingUp to 20.8% of users

If you experience any of the following side effects, stop using adapalene / benzoyl peroxide immediately and contact your doctor or get emergency medical care right away:

Burning of the skin with
blistering, swelling, and redness
in the treated area
Up to 3% of users
Intense skin irritation or rashUp to 3% of users
  • A sudden appearance of swelling and rash (known as hives)
  • Swelling of the eyes, lips, tongue, or entire face
  • Severe itching
  • Trouble with breathing
  • Feeling dizzy or faint

Adapalene / Benzoyl peroxide may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using adapalene / benzoyl peroxide.

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