The following side effects are expected to occur in the first 2-4 weeks of treatment, and resolve with continued use of adapalene / benzoyl peroxide. Contact your doctor if these symptoms are severe and/or do not go away after 4 weeks of treatment:
Adapalene / Benzoyl Peroxide may cause some side effects that are serious. If you experience any of the following, get in touch with your doctor immediately or seek emergency medical treatment. Data on side-effects consists of a combination of government data as well as acne.org’s compilation of side-effect data from existing clinical studies:
|Burning, stinging, or tingling sensation||Up to 84.9% of users|
|Dryness of skin||Up to 75.3% of users|
|Skin irritation||Up to 68.8% of users|
|Skin peeling or scaling||Up to 64.4% of users|
|Redness and/or warmth in the area||Upto 64.4% of users|
|Itching||Up to 20.8% of users|
If you experience any of the following side effects, stop using adapalene / benzoyl peroxide immediately and contact your doctor or get emergency medical care right away:
|Burning of the skin with |
blistering, swelling, and redness
in the treated area
|Up to 3% of users|
|Intense skin irritation or rash||Up to 3% of users|
- A sudden appearance of swelling and rash (known as hives)
- Swelling of the eyes, lips, tongue, or entire face
- Severe itching
- Trouble with breathing
- Feeling dizzy or faint
Adapalene / Benzoyl peroxide may also cause other side effects that are not mentioned here. Contact your doctor if you experience any other troublesome symptoms when using adapalene / benzoyl peroxide.
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- Eichenfield LF, Draelos Z, Lucky AW, Hebert AA, Sugarman J, Stein Gold L, Rudisill D, Liu H, Manna V. Preadolescent moderate acne vulgaris: a randomized trial of the efficacy and safety of topical adapalene-benzoyl peroxides. J Drugs Dermatol. 12(6), 611-8 (2013).
- Stein Gold L, Weiss J, Rueda MJ, Liu H, Tanghetti E. Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3 %/Benzoyl Peroxide 2.5 % Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study. Am J Clin Dermatol. 17(3), 293-303 (2016).
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