Isotrexin : Erythromycin (2%) and Tretinoin (.05%) Gel

140 Reviews

Active ingredients:
Erythromycin (2%) and Isotretinoin (0.05%).

Inactive Ingredients:
Hydroxypropylcellulose, butylated hydroxytoluene and ethanol.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.


Used Isotrexin : Erythromycin (2%) and Tretinoin (.05%) Gel? Rate It:

Choose from 1 to 5 stars
November 17, 2018
I've used this product .. And there's no pimples at all should try it if you are suffering from moderate acne really effective but the only side effect it has it'll dry your skin completely along with a good moisturizer it'll really works wonder. And yes have patience for about 2 months may be u dont really see any results at first but after a month you'll see noticeable difference .. Hope it will help u :)
November 1, 2017
used this after panoxyl face wash being discontinued- its the worse thing ever- applied only at night it coats your skin with a plastic layer and makes it so tight its impossible to move your face. I feel because of its gel-like consistency it never really soaks in it just sits on your skin? not nice! would not reccomend!
September 2, 2018
What an ignorant amd close-minded review. You rate it 2 stars and "horrible" based on its consistency only, but not on whether it actually works or not. And how tf do you know whether or not it actually soaks into the skin? Are you a chemist to know the interactions it has with your skin when applied, beyond a superficial level when initially applied? Maybe if you would have had the sense to wait it out and study how it works for you, aside from its "consistency"(because of course, you only bought it for how it "feels"
October 23, 2016
Awful !
Been using this gel for nearly 3 month, due to a manafacturing problem with duac gel i had now been perscribed this gel , didnt have many spots before hand and orginally only got bad spots on my chin area, after using this gel my skin became extremely red and especially my chin and although the spots i have arnt painful as they once were they are now all over my face ! I have had to stop with this gel completely due to my chin being extremely red, dry to the point its so tight it hurt when i move my mouth in a large way, stopped thus gel for around 5 days and bought some E45 which seems to be slowly taking the stubbord dryness away. After reading many good reviews i was still skeptical to start it but i did start it and cannot say how much i regret this, anyone waring of starting this gel i reccomnded you not to as my experience as a 15 year old girl who once only got larger spots at that time of the month now has them all over her face, and a very painful, dry skin complexion All in all i would not reccomend starting this gel i once had spots only on my chin and rarely anywere else and now my chin and cheeks are very inflammed, hopefully i can now try to recover my skin
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2 user(s) found this helpful

November 10, 2016
Isotrexin gel should not be used in Areas of skin affected by eczema. Sunburnt skin. Acne rosacea. Inflammatory rash around the mouth (perioral dermatitis). Women who are pregnant or trying to conceive. Breastfeeding. So be careful guys
October 29, 2017
Where to buy this gel? Please share.
July 29, 2016
Best retinoid for me
Out of all the topical retinoids offered to me through my 12 years with acne this has been the most effective. My acne is extremely resistant to treatment and I've been on Accutane twice but this kept it at manageable levels. If starting out with this, only use it a few nights a week. It's drying and irritating. Each time I've gone back to using it I've had an extreme initial breakout / purge which is so difficult to deal with but overall it's my favourite topical I go back to again and again.
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2 user(s) found this helpful

September 6, 2016
Hi, I am 21 male. My doctor prescribed me Isotrexin. I have been using it for two months now. Can you tell me how long does it take before the medication actually starts working? Furthermore, how good is this medicine when it comes to dealing with scars. Thank you.
October 29, 2017
Please advise where to buy isotrexin gel?
June 12, 2016
It's definitely worth sticking it out!
I began having bad ance break outs on my forehead and chin about a year ago, after about 6 months I'd had enough and headed to the doctors, that's when he prescribed me with isotrexin gel. For the first 4-5 weeks my ance got a lot worse! I was having a lot more break outs and my skin was left very sore and dry. After reading lots of reviews I decided to stick it out. I've now been using it for several months and my skin is perfect!! I never have break outs and my scars are fading! I was using it everyday to begin with but I've not cut down to every other day and that works perfect for me. I would really recommend isotrexin! It gets worse before it gets better but it's definitely worth sticking it out!!
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8 user(s) found this helpful

September 6, 2016
Hi, I am 21 male. My doctor prescribed me Isotrexin. I have been using it for two months now. Can you tell me how long does it take before the medication actually starts working? Furthermore, how good is this medicine when it comes to dealing with scars. Thank you.
October 29, 2017
May I ask where do you buy the isotrexin gel?
May 12, 2016
Solution for me
Suffered from moderate acne since teens. Various contraceptive pills, topical treatments (Duac, Differin), and one course of antibiotics only partially helped. Following a recent breakout I decided to tackle it from all angles, and I think Isotrexin was the key. Also went back on a combined oral contraceptive and took 5-month course of oxytetracycline. Skin cleared up after around 2 months. Having finished the course of oral antibiotics 2 moths ago, skin is still basically spot-free, better than it ever has been. Initially drying but quickly skin gets used to it. I only apply a very thin layer, once daily, at night.
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6 user(s) found this helpful

September 6, 2016
Hi, I am 21 male. My doctor prescribed me Isotrexin. I have been using it for two months now. Can you tell me how long does it take before the medication actually starts working? Furthermore, how good is this medicine when it comes to dealing with scars. Thank you.
October 29, 2017
Please advise where to buy the isotrexin gel.
January 29, 2016
2 weeks in
I am a 26 year old female suffering from mild normal acne on my chin and jawline area. I have always had clear skin up until a year ago when I started getting breakouts around my mouth and chin. In the last year I've tried benzoyl peroxide gel which didn't do anything other than make my skin red and sore and flakey. I then tried a topical liquid antibiotic to apply to the affected area ( I can't remember the name of it). This also didn't work. I then tried lymecycline and took these antibiotics for 3 months - leaving me with clear skin. The doctor wanted me to stop taking them due to effects on my liver. After just a few weeks of stopping them my spots came back. I went to see a dermatologist and was prescribed isotrexin. I've been told to put a thin layer of the gel over the affected areas at night time after washing my face but before moisturising, so that the product can sink in. I don't find this product sore or difficult to use. I don't feel any stinging when putting it on like other reviews mention. It dries and goes a little crusty. I have however (like all the reviews say) had a big breakout. I've gone from just a couple of manageable spots to several at once which I find difficult to hide with make up. I've been using the gel for two weeks and my skin has definitely got worse. My dermatologist has told me to use it for two months then to go back and see him to review the progress. I will persevere with it until then. Interestingly he also told me the best face moisturiser to use was aqueous cream which you can buy in huge tubs for only a few pounds. I s water based and oil free and fragrance free etc. I will add another review once I am at the end no of my two months to let you know how it goes.
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12 user(s) found this helpful

April 22, 2016
Please do let me know what happens next. I only applied it for a week now, and my acne got worst too. It gets me sick.
August 13, 2017
same !!!!! can you also detail if you are sleeping with the gel on only or if you're waiting for it to dry then adding moisturiser over the top while you sleep?
October 29, 2017
Please share where to get this gel? Which clinic to buy? Thanks.
September 28, 2015
Make sure you stick it out!
Since I hit my twenties (2 years ago) I have been battling with my skin, something I never thought I would be worrying about having normal skin throughout my teens! I have tried different anti biotics, the pill, etc and all of them only offer a short term fix. I would say my acne is moderate which can verge on severe after a flare up but the scars/hyperpigmentation which it leaves behind makes me the most self conscious. I went to the doctors about a month ago after a really bad flare up and she gave me a combination on isotrex gel, lymecycline and the pill. So far it has got better than it was and I've gone from about 12 active spots down to about 2. All the reviews are right, it does break you out so bad the first couple of weeks but if you persevere it does get better! When I apply it it kind of stings and makes my eyes water but within seconds that passes, it also does leave a residue of your face in the morning due to the peeling effect but this can easily be washed off. It does dry out your skin, but so do many acne cream/gels! After a super bad break out I am finally seeing my skin sort it's self out! I am currently using this before bed after cleansing my face, then using an exfoliator (St ives apricot scrub) some mornings, effeclar duo and lymecycline and the pill. I am going to carry on with this product for another 4 weeks and see if my skin improves further but so far so good (after the initial breakout) Hope this helps! :)
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9 user(s) found this helpful

March 4, 2016
scrubbing particles can remove your skin's protective outer layer and make acne worse! My dermatologist has told me. only use Isotrexin in the night and effecter duo+ in the daytime that all.
September 22, 2015
patience required
For this to have any positive outcome you need patience. If you don't have patience then don't bother using it. It will take longer if you have severe acne. I have moderate Anne around the frame of my face inc. Jawline and forehead line plus around the sides of my chin and upper lip. I've been using it for 3 weeks and i can see that my pores are opening up and blackheads coming out more easily. Whiteheads also are coming to the forefront and ironically im also left with a radiant glow. The idea of this gel is to draw out impurities and that's what it does hence the increase in spots at first. The erythromycin is the anti bacterial element which fights the bacteria from living and attacking the sub glands. Small cysts have cleared in a week. I am still getting new smaller spots but i know the gel is drawing out the bugs that having been sitting under my skin. Persevere for minimum 3 months at least before you decide to give up. Good luck
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10 user(s) found this helpful

October 1, 2016
im using Isotretinion & Erythromycin and completed my first week.. my acne is dry now.. but m having dark spots where i applied the cream.. is it acne burn? what did you experience in first week of this gel?
October 23, 2016
Fms, begin using moisturizer my face become so dry it was painful to move and extremely tight
September 18, 2015
Pain pain pain.
Ok so most of you might not agree with my results or time period using this product but for me it hasn't done any favours. I have NEVER sufferd with acne as bad this year as I have in the past. A few years a ago I got prescribed "lymacycline" and it did the trick to clear up (or so I think) but this month when I started to develop different signs and more spots than usual I went to the docters for something stronger and he prescribed me this gel "isotrexin". After reading reviews and not finding many good ones I was willing to give it a go and hope that it would work for me. He did specify that it might take a few weeks to work and now I'm three weeks in I refuse to use this gel anymore. After reading reviews I took into consideration that my skin may get worse before it for better, skeptical about using it I had a go for the benefit of my face. However, it has made my face red, sore, dry and uncomfortable. The skin doesn't look healthy and looks inflammed and irritated. I have tried to put moisturiser on to stop the flakiness/dry patches under my makeup but my skin would flake and you can still see the scars. Each day I would wake up with a new painful spot or even a boil under the skin. No matter how much makeup I tried to use it didn't cover or help the situation. I might not have given it long enough to work but during the 3weeks I used it I was in constant pain and discomfort hence why I decided to stop. Everyone is different and will react in different ways. At the moment I'm back using my dermologica products and staying clear of any gels or creams prescribed medically. I hope this don't put you off using it if you do have it, I was just expressing my time whilst using it. Please feel free to ask me any questions x Charlotte 21 :)
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4 user(s) found this helpful

August 17, 2016
I experienced the same as you. However i used i first started using it October 2015-january 2016 and at first it made my skin dry and cleared my face a little bit. After 8weeks i decided to stop using it amd my acne came back much worse. I started using it again last month and have only been using it for 6.5 weeks and my skin is clear now and my acne scars are starting to fade. But when trying for the second time i had worse reactions. My skin burnt like i had been in the sun for too long and went bright red. But after using it for a few weeks the symptoms went and now its all clear.