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I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012!
Non denatured ECM, or decorin at 200nm = Scar Free Healing, not scar less healing.
I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012!
Non denatured ECM, or decorin at 200nm = Scar Free Healing, not scar less healing.
A cited fact is a cited fact.
Heh, heh.
I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012!
Non denatured ECM, or decorin at 200nm = Scar Free Healing, not scar less healing.
A cited fact is a cited fact.
Heh, heh.
Though 117 pages and no one has removed any scars yet. 
I don't think we are going anywhere soon
I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012!
Indeed! I agree. 
@Lapis:
They do not need 2 efficacy trials. They are only doing it because of other indications for juvista and their phase 2 results.
The most laser devices have an fda approval for something else than acne scarring but they are also used for this indication. What I want to tell you is, that the they do only need one trial for the approval not two.
Another important aspect is, that the approval in europe will be sooner than the fda approval.
Shire has the promotion rights only for America. Renovo has the rights for distribution in Europe.
In my opinion we will see the results in the 1 quarter of 2011. This is not the distant future. And maybe in the middle of the next year we can use Juvista for our well-being.
I hope Ferguson is right with his mean 60% improvement statement. This would be awesome.
I will test it immediately when on sale.
From this point on, everything will only get better. Interesting times. I believe in this product because Ferguson said in an interview that he is using every medical drug they sell on himself first and so nobody has to fear that it won't work.
NEO
Yeah, I heard that too about him having used Juvista on himself. haha It's pretty cool. Anyway, let's keep our fingers crossed then that it comes around sooner than I thought it would... It's true what you say about the fact that it should become availabe sooner in Europe...so we'll see what happens.
http://www.pipelinereview.com/index.php/20...in-H1-2011.html
"Renovo reconfirms that when the first Juvista EU Phase III trial reports in H1 2011 it expects to have a cash balance of ‚£25 ‚œ 30M, and that it has the possibility of licensing Juvista in all countries of the world, except USA, Mexico and Canada, which are licensed to Shire"
@Lapis:
They do not need 2 efficacy trials. They are only doing it because of other indications for juvista and their phase 2 results.
The most laser devices have an fda approval for something else than acne scarring but they are also used for this indication. What I want to tell you is, that the they do only need one trial for the approval not two.
Another important aspect is, that the approval in europe will be sooner than the fda approval.
Shire has the promotion rights only for America. Renovo has the rights for distribution in Europe.
In my opinion we will see the results in the 1 quarter of 2011. This is not the distant future. And maybe in the middle of the next year we can use Juvista for our well-being.
I hope Ferguson is right with his mean 60% improvement statement. This would be awesome.
I will test it immediately when on sale.
From this point on, everything will only get better. Interesting times. I believe in this product because Ferguson said in an interview that he is using every medical drug they sell on himself first and so nobody has to fear that it won't work.
NEO
Yeah, I heard that too about him having used Juvista on himself. haha It's pretty cool. Anyway, let's keep our fingers crossed then that it comes around sooner than I thought it would... It's true what you say about the fact that it should become availabe sooner in Europe...so we'll see what happens.
http://www.pipelinereview.com/index.php/20...in-H1-2011.html
"Renovo reconfirms that when the first Juvista EU Phase III trial reports in H1 2011 it expects to have a cash balance of ‚£25 ‚œ 30M, and that it has the possibility of licensing Juvista in all countries of the world, except USA, Mexico and Canada, which are licensed to Shire"
That problematic are these people to get the sale this medication
Anybody ever see this?
http://news.bbc.co.uk/2/hi/health/7685909.stm
It's about how insulin can reduce scarring, as well. It seems to actually work judging by the pic at the bottom of the article. If only for a bit. Anyway, it's just an interesting read. Other treatments are probably (or hopefully?) superior to this one.
Diabetics do not produce insulin, maybe be why they do not cure their scars
Juvidex (-tgf b1), contains some sort of sugar
Renovo web: Juvidex is a topical formulation of the sugar Mannose-6-Phosphate (M-6-P).
I think we are in a key point with the theme of insulin, the images remind me to the modulator of growth factors.
Hi to all and a shout-out to Lapis (This is the same Cambree from Dr Lam's forum; you were mistaken about the gender though. tsk)
Anyway, I wanted to say this does appear very promising! If you think about it we do know that diabetics have a problem with wound healing. Impaired would healing frequently results in complications as severe as amputations. If you put it in this context, it does make a lot of sense.
I tried to run a search for this in pubmed, it just strikes me as mildly odd that not many have done related work in this regard....what do you guys think of this?
Also, about Justiva debuting in Europe in Y2011....I can't wait! But I am trying to be a realist here; there's nothing definitive that Renovo has put out on this, so its mere speculation at this point in time. I do know that more often than not, delays do occur and often drug companies are not able to deliver and make good on their timelines. Any thoughts?
MH
Hi all,
I posted this on another forum and sought a dr's opinion on the above link
I think it might be of interest to someone so I am posting it here
www.drsamlamfaceforum.com/post7014.html#p7014
In that forum dr lam type this:
interesting. i just got back from Boston for my hair meeting and I learned that ACE inhibitors (used for blood pressure) can help with hypertrophic and keloid scarring. for example, topical 5% captopril used on the scar and/or 10 mg enalopril once a day for 6 months. i found it fascinating.
best,
sml
http://www.drsamlamfaceforum.com/juvista-p...t-t1735-15.html
This is very interesting, i wonder if there are registered experiments on this.
Hi to all and a shout-out to Lapis (This is the same Cambree from Dr Lam's forum; you were mistaken about the gender though. tsk)
Hey, Cambree. Welcome to acne.org!
About the 2011 release date... Yes it depends on the outcome of the trial and of course things can happen which cause delays but...all things considered I think it's fairly safe to say that we needn't worry. It's just what I think, seeing that they keep saying they're on schedule and the new year is as close as it is. Also, Mark Ferguson in a recent interview was very jolly and positive. He certainly didn't strike me as someone who was worried about the upcoming deadline... Far from it, really. They also did a lot of experimenting during the previous trial where they found out a lot of things about the best way to use Juvista, so like I said all things considered I personally see it happening that it will come around somewhere in 2011. But that's just what I think. Anyway, I'm super curious about the Phase 3 results.
News about JUVIDEX:
Renovo eyes deal to license Juvidex in cosmetics-INTERVIEW
Trade the News
RENOVO/ (INTERVIEW, CORRECTED)(Corrects pounds to pence in paragraph 8)
* Expects low single-digit royalty payments for Juvidex
* To opt between high-end cosmetics cos and mass players
* Says licensing partner should help to get drug to market
By Aditi Samajpati
BANGALORE, Sept 29 (Reuters) - British anti-scarring specialist Renovo is in talks to license its experimental skin cream Juvidex as a cosmetic component and could reach a deal this year or early in 2011, its chief said.
The company would focus on royalties, rather than upfront or milestone payments, to bring in a few million pounds a year and help Renovo with its cash burn, CEO Mark Ferguson told Reuters.
"I'm hoping the choice will be either with a company or companies that would put it into expensive cosmetics -- like L'Oreal, Estee Lauder or Elizabeth Arden -- or people like Unilever, who typically sell cosmetics in a more affordable range all over the world," Ferguson said.
Renovo, which had previously licensed its key drug candidate Juvista, an injectable anti-scarring agent, to Shire for sale in the United States, Canada and Mexico, has had enquiries about Juvidex from cosmetics firms and ingredients suppliers, he said.
"We have to be realistic about the kind of deal we would do and I'd say it would be a low single-digit royalty," said Ferguson, who has been a dentist and an alligator biologist.
A key factor in choosing a licensing partner would be the ability to get Juvidex to the market within 18 months of signing a deal, he added.
Renovo shares have jumped by a third since the company announced earlier this month that Juvista had met safety objectives in a Phase I trial to treat keloids -- which can form within scar tissue when collagen, used in wound repair, overgrows and produces a lump larger than the original scar.
But the stock, trading at around 29 pence, dropped sharply in 2007-08 from a mid-2007 peak of above 250 pence a share.
This time last year, Renovo said it failed to reach a deal in takeover talks, prompting it to cut its headcount by over a third, pare down its operations and concentrate on getting its key drugs to market. (Reporting by Aditi Samajpati in Bangalore, Editing by Ian Geoghegan)
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http://www.forexyard.com/en/news/Renovo-ey...2949Z-INTERVIEW
Enalapril in the Treatment of Cutaneous Hypertrophic Scar and Keloid: Discussion
It seems that acts as antifibrotic from inside, and completely eliminates the scars, in addition to the enalapril is for sale in any pharmacy as medication for the arterial pressure.
Perhaps had the solution more easy of what we expected.
Heres the full thing: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868346/
I find this really interesting. I'd be willing to try it given that the side effects of enalapril aren't very severe generally, so worst case scenario is that it just doesn't work, and if it doesn't work then it doesn't really matter as its not very time consuming, you're just taking a pill everyday.
my only problem is that the research was done with keloid and hypertrophic scars. I'm looking to treat stretch marks. I'm not sure how different keloid scars and stretch marks are, so I'm not sure if enalapril would help.
does anybody have any idea if this could work on stretch marks aswell as keloids?
Enalapril in the Treatment of Cutaneous Hypertrophic Scar and Keloid: Discussion
It seems that acts as antifibrotic from inside, and completely eliminates the scars, in addition to the enalapril is for sale in any pharmacy as medication for the arterial pressure.
Perhaps had the solution more easy of what we expected.
More cites. Decorin which at 200nm completely keeps the fibroblast proliferation dormant, non denatured ECM, enalapril...
Moreover, the old hypertrophic scar (due to cesarean sections) completely disappeared after 3a4 months of enalapril treatment.
Enalapril in the Treatment of Cutaneous Hypertrophic Scar and Keloid: Discussion
It seems that acts as antifibrotic from inside, and completely eliminates the scars, in addition to the enalapril is for sale in any pharmacy as medication for the arterial pressure.
Perhaps had the solution more easy of what we expected.
Heres the full thing: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868346/
I find this really interesting. I'd be willing to try it given that the side effects of enalapril aren't very severe generally, so worst case scenario is that it just doesn't work, and if it doesn't work then it doesn't really matter as its not very time consuming, you're just taking a pill everyday.
my only problem is that the research was done with keloid and hypertrophic scars. I'm looking to treat stretch marks. I'm not sure how different keloid scars and stretch marks are, so I'm not sure if enalapril would help.
does anybody have any idea if this could work on stretch marks aswell as keloids?
All are scars so that should help.
Maybe could be grinding a pill of enalapril and mix it with some gel, and rub on the scar.
All are scars so that should help.
Maybe could be grinding a pill of enalapril and mix it with some gel, and rub on the scar.
I think I'm going to print out the paper and go see my doctor this week.
Are all ACE inhibitors equal? Is enalapril the best option?
It says in the paper:
"On the other hand, the angiotensin II receptor blockers are reported to be equally effective in antifibrotic capacity to any ACE inhibitor with or without SH-radical, reaffirming the role of angiotensin II in the modulation of collagen synthesis.[44] Thus, the mechanism of ACE inhibitors remains to be clarified."
So I think any ACE inhibitor should do the job.
All are scars so that should help.
Maybe could be grinding a pill of enalapril and mix it with some gel, and rub on the scar.
I think I'm going to print out the paper and go see my doctor this week.
Are all ACE inhibitors equal? Is enalapril the best option?
It says in the paper:
"On the other hand, the angiotensin II receptor blockers are reported to be equally effective in antifibrotic capacity to any ACE inhibitor with or without SH-radical, reaffirming the role of angiotensin II in the modulation of collagen synthesis.[44] Thus, the mechanism of ACE inhibitors remains to be clarified."
So I think any ACE inhibitor should do the job.
The news that a medication as enalapril, can eat the fibrosis of the scars is a story very amazing.
Now we need to know which medicine is more effective and which has fewer side effects,the enalapril, or the other medication.
Now we need to know which medicine is more effective and which has fewer side effects,the enalapril, or the other medication.
I'm going to go to my doctors tomorrow or the day after so if anyone can give me any details as to which ACE inhibitor would be the most effective and which has the least side effects it would be much appreciated.
Now we need to know which medicine is more effective and which has fewer side effects,the enalapril, or the other medication.
I'm going to go to my doctors tomorrow or the day after so if anyone can give me any details as to which ACE inhibitor would be the most effective and which has the least side effects it would be much appreciated.
Cambree's link shows a referenced Dr saying
for example, topical 5% captopril used on the scar and/or 10 mg enalopril once a day for 6 months. i found it fascinating.
Now we need to know which medicine is more effective and which has fewer side effects,the enalapril, or the other medication.
I'm going to go to my doctors tomorrow or the day after so if anyone can give me any details as to which ACE inhibitor would be the most effective and which has the least side effects it would be much appreciated.
Cambree's link shows a referenced Dr saying
for example, topical 5% captopril used on the scar and/or 10 mg enalopril once a day for 6 months. i found it fascinating.
I believe that enalapril is as kitoscell but acts from inside, the problem is that operates slow leads 6 months.