Acne.org Products
Good to know this is all still going on. I'm having a bout out right now with Retin-A and AHA's, hoping to reduce myself to a person of merely scarring. I'm curious about the relationship between scar reduction and skin damage in general. If a treatment were made that caused wound healing to recover the damaged matrix of the skin, would it return exactly to the state before the wound? That seems unlikely. Would it improve the skin from its pre-wound state, or would the matrix be more ill formed than before, but such that to the eye no scar was shown? I suppose it all depends on what the particular treatment attempts to counteract.
well then... science
I haven't given up on ACELL. I just know my doctor will shoot me down. I am on warfarin for life, because of a DVT. I would have to stop taking the warfarin, and take lovenox shots in the gut for 5 days, until the warfarin is out of my system, and then go one day without the lovenox, and then I could exercise the scars I wanted to treat with ACELL. Unlike Solo over there I would go for the powder stuff, because I've heard too many unpositive things about the sheets- but I'm not sure I trust the web-source he provides. I've read bad things about the that site.
Also if I was in solos shoes right now. I would not leave the wound alone after it dried out. I would apply medihoney on it and use a silicone sheet over it for a long, long time. Maybe not as long as 3 months, because that is a wicked long time and costly, but at least several weeks. That wound solo has is still healing. You can see it in the latest pic. It needs some medihoney. I use this stuff on regular wounds because my healing time sucks on the blood thinners. I cant praise it enough. Don't let a healing wound dry out! Medihoney should be applied 3-4 times a day and covered with a bandaid or sheeting.
Regular honey is a no-no. It has bacteria and it may have spores in it that could hurt you.
This is why I'm seeking the Apitoxin stuff out. I don't think I'll have to stop the bloodthinners to use it- If I use it sparingly. I wont use just any powdered version of apitoxin.
I need to find a place that irradiates the bacteria out of it first. Same as what is done to the medihoney to kill spores and bacteria.
I found a russian site that sells it at $35 a gram but they wont sell less than 100 grams per order. I don't have 3,500 to dish out to see if it works. If I knew it worked. I would gladly pay as much, but I dont.
So the hunt continues.
http://www.physorg.com/news201355203.html
"Researchers, who used rat models, grew stem cells from the thymus - an organ important for our immune systems - in the laboratory using conditions for growing hair follicle skin stem cells.
...
When the cells were transplanted into developing skin, they were able to maintain skin and hair for more than a year.
The transplanted follicles outperformed naturally-produced hair follicle stem cells, which are only able to heal and repair skin for three weeks.
Once they were transplanted, the genetic markers of the cells changed to be more similar to those of hair follicle stem cells."
I find this very interesting. Stem cells have huge possibilities. And we are at the very beginning in understanding how stem cells behave.
I am really interested in seeing what the next years will bring us, besides Juvista.
NEO
I am really interested in seeing what the next years will bring us, besides Juvista.
NEO
Juvista is about 3 years away now. Although Shire's website states that it can come around a year sooner...or two years later namely in 2016. The Ferguson guy says it's going to be 2014, though. I guess we'll see. I wonder if they'll publish photos of the third trial next year. That would be way cool. 
I am really interested in seeing what the next years will bring us, besides Juvista.
NEO
Juvista is about 3 years away now. Although Shire's website states that it can come around a year sooner...or two years later namely in 2016. The Ferguson guy says it's going to be 2014, though. I guess we'll see. I wonder if they'll publish photos of the third trial next year. That would be way cool.
I'm waiting results of phase 3 , i hope see good photos
I will never understand that takes in both test phases, it gives me the feeling that he had not been positive result in many occasions
I'm waiting results of phase 3 , i hope see good photos
I will never understand that takes in both test phases, it gives me the feeling that he had not been positive result in many occasions
Well, it isn't 100% sure if there will be photos. There weren't any of the second one either, as far as I know. But they had used a lower dosage then and now...they've got the right dosage and the right times to inject them all figured out, apparently. So better results will be achieved now and a higher succes rate will be realized as well, they say. They did a lot of experimenting with the second trial.
This photo which is from before the second trial (and has been posted before) does show a large reduction of scar formation:
I mean sure, it is not 100% scarless...but it has gone from a very much visible scar to a barely visible scar. And now, they say they've improved the protocol and are getting even better results. So I'm very curious to see the outcome of the third trial.
@lapis:
Where did Renovo mention, that it will take another 3 years? Nothing on their website.
This does not make sense. Maybe for US bechause of FDA approval.
They do not need 2 phase 3 trials. In an interview they mentioned that they
are doing this because of the problems in the phase 2 trials.
That's all. The final trial will report back in 1 quarter 2011 and then the
product will be ready, if the success is there.
NEO
@lapis:
Where did Renovo mention, that it will take another 3 years? Nothing on their website.
This does not make sense. Maybe for US bechause of FDA approval.
They do not need 2 phase 3 trials. In an interview they mentioned that they
are doing this because of the problems in the phase 2 trials.
That's all. The final trial will report back in 1 quarter 2011 and then the
product will be ready, if the success is there.
NEO
Really? That would be awesome. But Shire's site states 2013-2016:
http://www.shire.com/shireplc/en/rd/pipeline
And Wiki says 2014:
http://en.wikipedia.org/wiki/Renovo_plc
Wiki also says regarding clinical trials that "While not required in all cases, it is typically expected that there be at least two successful Phase III trials, demonstrating a drug's safety and efficacy, in order to obtain approval from the appropriate regulatory agencies such as FDA (USA), or the EMA (European Union), for example.". And I think read in a few places that a second phase III trial is already planned after this one. And that people in the US as well as in Europe will only be able to get treated with Juvista after that and not sooner.
I could be wrong, though. It would be way cool if it would be ready sooner, for sure.
Here it's mentioned e.g. that further trials may be necessary. It's on page six of the pdf.
http://pdf.edocr.com/30567e04cef967018ec45...f456d2c3c5a.pdf
Speaking at the annual Piper Jaffray Europe Conference in London last week, Renovo‚„s chief executive Mark Ferguson said the company‚„s ‚£90m of cash was enough to cover the current phase three trial. However, if a second trial is needed, which analysts said is quite likely, more money will have to be found. ‚Å“What we have now is sufficient to get the first phase three trial
complete in Europe,‚ he said, adding: ‚Å“There will need to be additional capital generated to carry out further trials.‚
It's kinda ancient, though. From 2008... Oh wait here's something more recent:
http://www.stockmarketsreview.com/news/36720/
Juvista is in Phase III of clinical development for prophylactic improvement of the appearance of disfiguring scars following scar revision surgery. The company plans for further efficacy trials for Juvista in additional indications such as primary surgeries, Keloids and trauma following the successful completion of the EU Phase III scar revision trials.
So I guess there will be further trials but when this first one is done, the product can at least be used for scar revision surgery? 
That would be cool.
As a commentary, he noted that the zinc increases drastically the healing wounds.but are not really if a healing of wounds faster implies regenerate with less scar.
In some pages say that zinc improves the scars of acne taking 50mg daily.
In some pages say that zinc improves the scars of acne taking 50mg daily.Doesn't it say that zinc prevents scars from forming rather than improves existing scars?
Zinc accelerates wound healing dramatically, so it would be feasible in theory (but do not think it possible in all cases) to improvise new scars.
About on improving existing scars, would have to undergo long-term.
There is no clear scientific studies on this subject but it does not hurt to try.
from that link:
Most of the time, it is recommended that you take between 50mg and 100mg of zinc per day to help with the prevention and treatment of acne scarring.
Oh wait here's something more recent:
http://www.stockmarketsreview.com/news/36720/
Juvista is in Phase III of clinical development for prophylactic improvement of the appearance of disfiguring scars following scar revision surgery. The company plans for further efficacy trials for Juvista in additional indications such as primary surgeries, Keloids and trauma following the successful completion of the EU Phase III scar revision trials.
So I guess there will be further trials but when this first one is done, the product can at least be used for scar revision surgery?
Just found this pdf on the Renovo site where it states this on page twenty five:
Phase of development Juvista EU: PhIII in scar revision surgery (1st of 2 efficacy trials for approval)
It's from May 2010 if I remember correctly.
@lapis:
Where did Renovo mention, that it will take another 3 years? Nothing on their website.
This does not make sense. Maybe for US bechause of FDA approval.
They do not need 2 phase 3 trials. In an interview they mentioned that they
are doing this because of the problems in the phase 2 trials.
That's all. The final trial will report back in 1 quarter 2011 and then the
product will be ready, if the success is there.
NEO
Here's another quote from their website:
"Agreed EU Phase 3 Programme
Renovo sought and obtained written scientific advice from the EMEA concerning the Juvista Phase 3 programme for the indication of "improvement in scar appearance of disfiguring scars". Renovo currently plans the programme to include:
Two within patient design trials with a 12 month assessment endpoint to establish efficacy. The first of these Phase 3 trials is underway and is expected to report data in H1 2011. The second Phase 3 efficacy trial is expected to commence in H2 2011 and report data in 2013."
Could be things have changed, though and we'll see it sooner. But it looks like it will 2013/2014 to me.
@Lapis:
They do not need 2 efficacy trials. They are only doing it because of other indications for juvista and their phase 2 results.
The most laser devices have an fda approval for something else than acne scarring but they are also used for this indication. What I want to tell you is, that the they do only need one trial for the approval not two.
Another important aspect is, that the approval in europe will be sooner than the fda approval.
Shire has the promotion rights only for America. Renovo has the rights for distribution in Europe.
In my opinion we will see the results in the 1 quarter of 2011. This is not the distant future. And maybe in the middle of the next year we can use Juvista for our well-being.
I hope Ferguson is right with his mean 60% improvement statement. This would be awesome.
I will test it immediately when on sale.
From this point on, everything will only get better. Interesting times. I believe in this product because Ferguson said in an interview that he is using every medical drug they sell on himself first and so nobody has to fear that it won't work.
NEO
@Lapis:
They do not need 2 efficacy trials. They are only doing it because of other indications for juvista and their phase 2 results.
The most laser devices have an fda approval for something else than acne scarring but they are also used for this indication. What I want to tell you is, that the they do only need one trial for the approval not two.
Another important aspect is, that the approval in europe will be sooner than the fda approval.
Shire has the promotion rights only for America. Renovo has the rights for distribution in Europe.
In my opinion we will see the results in the 1 quarter of 2011. This is not the distant future. And maybe in the middle of the next year we can use Juvista for our well-being.
I hope Ferguson is right with his mean 60% improvement statement. This would be awesome.
I will test it immediately when on sale.
From this point on, everything will only get better. Interesting times. I believe in this product because Ferguson said in an interview that he is using every medical drug they sell on himself first and so nobody has to fear that it won't work.
NEO
Yeah, I heard that too about him having used Juvista on himself. haha It's pretty cool. Anyway, let's keep our fingers crossed then that it comes around sooner than I thought it would... It's true what you say about the fact that it should become availabe sooner in Europe...so we'll see what happens.
I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012! 
I know, this is offtopic but isn't it fascinating that those scarless healing solutions are coming on the market near in the future? Think about it this way: If human being is 200 000 years old and the average lifetime is 70 years, there have been around 3000 generations that haven't had even a possibility to dream about scarless healing. (Yes, I know that lifetime hasn't always been that high etc. so don't take my calculations too seriously!) Consequently, remember that we are very lucky even if those solutions won't come on the market 2011 or 2012!
Non denatured ECM, or decorin at 200nm = Scar Free Healing, not scar less healing.