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[Sticky] Scarless Healing

 
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(@reddragon)

Posted : 09/14/2010 11:52 am

hey thaank you all for your reply. Due to my problems i have been severly picking the skin on my face back upper aqrm thighs. i have these red mark scarring all over these area. Do you think in 5 to 10 years there will be somnething that can help me get rid of all these marks and bring my skin back close to what it was like when i was younger and before picking. im now 22 and searching for4 happiness.

thnks

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(@mies)

Posted : 09/14/2010 12:54 pm

hey thaank you all for your reply. Due to my problems i have been severly picking the skin on my face back upper aqrm thighs. i have these red mark scarring all over these area. Do you think in 5 to 10 years there will be somnething that can help me get rid of all these marks and bring my skin back close to what it was like when i was younger and before picking. im now 22 and searching for4 happiness.

thnks

Do you have actual scars or red marks only? If you have only red marks, they can be treated completely at the moment. If you have actual scars, I strongly believe that scarless healing can be achieved in 5 to 10 years.

 

Although scarless healing isn't available yet there is many treatments available that bring satisfying results --> http://www.acne.org/messageboard/Combo-Tre...io-t256333.html .

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(@lapis-lazuli)

Posted : 09/14/2010 1:01 pm

hey thaank you all for your reply. Due to my problems i have been severly picking the skin on my face back upper aqrm thighs. i have these red mark scarring all over these area. Do you think in 5 to 10 years there will be somnething that can help me get rid of all these marks and bring my skin back close to what it was like when i was younger and before picking. im now 22 and searching for4 happiness.

thnks

 

Hard to say. It all depends. People are experimenting with things right now...so who knows? There's a few promising things going on right now so I'd say just wait and see how those turn out... Maybe it will be possible sooner than 5 years from now. It would be quite something but, you know, we'll see.

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(@reddragon)

Posted : 09/18/2010 5:34 am

hi thnks for all your replies i very much aprreciate it. Since i have scars/ bad skin on large areas of my body. whole back arms face neck thighs. do u think ehen something does come out to provie new skin / scarless healing will it invole cutting and removing all this skin then applaying whatever it may be to create new scarfree skin. Will surgeon cut remove this skin by damaging it somehow. thnks again

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101
(@lapis-lazuli)

Posted : 09/18/2010 9:45 am

How is the wound of the third ACell trial now, solo_premium? Do you think it's still improving or does it still look exactly the same as last month?

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101
(@lapis-lazuli)

Posted : 09/18/2010 10:03 am

hi thnks for all your replies i very much aprreciate it. Since i have scars/ bad skin on large areas of my body. whole back arms face neck thighs. do u think ehen something does come out to provie new skin / scarless healing will it invole cutting and removing all this skin then applaying whatever it may be to create new scarfree skin. Will surgeon cut remove this skin by damaging it somehow. thnks again

 

Yes, the existing scar(s) would have to be cut out in order for any treatment to work. This is all discussed at length in the previous pages of this thread.

 

There's also the possibiliy of an enzyme which would be applied to the scar which would then remove the tissue but excising the scar(s) is probably going to be a more often seen approach if you ask me.

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(@papayawhip)

Posted : 09/19/2010 2:01 am

solo_premium.... Ive been hoping acell will be the answer to my stretch marks. Ive read a post of someone putting Acell's powder into emu oil and using it on his stretch marks after a strong peel. Have you considered dissolving a sheet into emu oil and applying that to your excised scar and a dressing over top. Ive been considering trying this, but if you have some Acell left I would be really interested if you could try this out and let us know the resutls.

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(@ai3forever)

Posted : 09/19/2010 9:06 am

So..has anyone removed their acne scars with acell..yet?

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(@mies)

Posted : 09/19/2010 9:44 am

So..has anyone removed their acne scars with acell..yet?

Not to my knowledge.

 

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48
(@ai3forever)

Posted : 09/19/2010 10:05 am

So..has anyone removed their acne scars with acell..yet?

Not to my knowledge.

 

 

Isn't that a bad sign. :cry:

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(@mies)

Posted : 09/19/2010 10:21 am

So..has anyone removed their acne scars with acell..yet?

Not to my knowledge.

 

 

Isn't that a bad sign. :cry:

 

I assume that Acell's MatriStem doesn't heal scars by itself. The scar tissue must be removed first by laser and MatriStem should be used after the treatment in order to make scarless healing possible in theory. In short, you cannot just buy MatriStem powder/sheet and apply it on existing scars and expect scarless healing which is propably the main reason that nobody has even tried if MatriStem would help the appearance of their scars.

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(@solo_premium)

Posted : 09/19/2010 4:58 pm

well yes, thats what weve been talking about; scarless wound healing requires a wound.. which is created by removing the scar tissue. but for my trials, im sacrificing normal skin to examine whether acell can induce scarless healing or not. im ruling out the possibility that remaining (failed to remove) scar tissue disables (in one way or another) scarless regeneration.

 

solo_premium.... Ive been hoping acell will be the answer to my stretch marks. Ive read a post of someone putting Acell's powder into emu oil and using it on his stretch marks after a strong peel. Have you considered dissolving a sheet into emu oil and applying that to your excised scar and a dressing over top. Ive been considering trying this, but if you have some Acell left I would be really interested if you could try this out and let us know the results.

well, pics or it didnt happen... personally, i dont intend to do that; im trying to follow the instructions as good as possible and theres no mentioning about emu oil, sorry.

 

 

How is the wound of the third ACell trial now, solo_premium? Do you think it's still improving or does it still look exactly the same as last month?

img267.imageshack.us/g/bild001wfh.jpg/

its still a scar as expected. blends nicely in with the surrounding skin though.

 

maybe ill try again. and i did. started 2 hours ago.

anyone still interested?

img826.imageshack.us/g/bild001gz.jpg/

well, this one was so small it was closed in 4 days. it just looks weird as of now. i think its a scar again.

 

img843.imageshack.us/g/bild002hn.jpg/

new proper trial.. i applied new ecm every 3 days disregarding the ecm that was already lying on the wound bed (and it still seemed to be absorbed, which is good) last picture was taken today. scar, no scar? i cant tell anymore. does definitely not look like normal skin.

 

i so wish i would have stumbled upon the remedy for this nightmare that has no end.

people say im negative. im realistic.

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(@papayawhip)

Posted : 09/19/2010 5:30 pm

Understandable. Maybe check out some info on emu oil before you rule it out. It is natural and completely non irritating, even to new wounds, absorbs to all layers of the skin, and has been shown to improve skin healing and speed by quite a bit. If not, maybe Ill just go ahead and test it out, if I do I will post my progress.

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0
(@Anonymous)

Posted : 09/19/2010 7:37 pm

i have to say solo_premium thank you very much for sharing your experiments here. i think its safe to say that we are all very much still interested.

 

some of your wounds actually look to be healing up really well. its hard to say really because without a control i'm not sure how the wounds would heal up if the acell wasn't used.

 

how are you managing to cut out these chunks of skin? must be painful even with a numbing cream i would of thought.

 

personally im trying to treat stretch marks. my problem is that even if an ecm does work, id have to have huge chunks of skin removed which just isnt possible. so im not sure where to lie my hopes at the moment.

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(@papayawhip)

Posted : 09/19/2010 9:24 pm

Hi Pepo... Im hoping acell is the answer to my stretch marks too. I think if you applied it after a strong peel, or an intense dermaroll you would get results if Acell does work. Id think better results with dermarolling... probably have to wait 6 weeks or so and do another roll to get best results.

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MemberMember
101
(@lapis-lazuli)

Posted : 09/20/2010 2:19 pm

How is the wound of the third ACell trial now, solo_premium? Do you think it's still improving or does it still look exactly the same as last month?

img267.imageshack.us/g/bild001wfh.jpg/

its still a scar as expected. blends nicely in with the surrounding skin though.

 

maybe ill try again. and i did. started 2 hours ago.

anyone still interested?

img826.imageshack.us/g/bild001gz.jpg/

well, this one was so small it was closed in 4 days. it just looks weird as of now. i think its a scar again.

 

img843.imageshack.us/g/bild002hn.jpg/

new proper trial.. i applied new ecm every 3 days disregarding the ecm that was already lying on the wound bed (and it still seemed to be absorbed, which is good) last picture was taken today. scar, no scar? i cant tell anymore. does definitely not look like normal skin.

 

i so wish i would have stumbled upon the remedy for this nightmare that has no end.

people say im negative. im realistic.

 

 

?! That looks so much better than last month! I don't see any redness? :surprised: I mean compare that to the photo of last month; it's even further improved! Judging by that photo, I'd be very interested to know how it looks three months after the initial wound... Like Cooley said. But you say it's a scar... Even if that's true...it looks pretty good to me. :think:

 

This is all very interesting!

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0
(@mies)

Posted : 09/20/2010 2:41 pm

How is the wound of the third ACell trial now, solo_premium? Do you think it's still improving or does it still look exactly the same as last month?

img267.imageshack.us/g/bild001wfh.jpg/

its still a scar as expected. blends nicely in with the surrounding skin though.

 

maybe ill try again. and i did. started 2 hours ago.

anyone still interested?

img826.imageshack.us/g/bild001gz.jpg/

well, this one was so small it was closed in 4 days. it just looks weird as of now. i think its a scar again.

 

img843.imageshack.us/g/bild002hn.jpg/

new proper trial.. i applied new ecm every 3 days disregarding the ecm that was already lying on the wound bed (and it still seemed to be absorbed, which is good) last picture was taken today. scar, no scar? i cant tell anymore. does definitely not look like normal skin.

 

i so wish i would have stumbled upon the remedy for this nightmare that has no end.

people say im negative. im realistic.

 

 

?! That looks so much better than last month! I don't see any redness? :surprised: I mean compare that to the photo of last month; it's even further improved! Judging by that photo, I'd be very interested to know how it looks three months after the initial wound... Like Cooley said. But you say it's a scar... Even if that's true...it looks pretty good to me. :think:

 

This is all very interesting!

 

I agree to some extent but what would be even more interesting to see is the MatriStem powder combined with laser treatment for actual scars. Satisfying results can be achieved by laser and combined with that powder the results could be excellent. :rolleyes:

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MemberMember
48
(@ai3forever)

Posted : 09/21/2010 2:30 pm

Since theoratically acell should induce scarless healing while solo premium's experiment does not show that, we can assume that this batch of acell is not scarless healing which also corresponds to Dr Jones' results.

 

Guys, remember the photo where they show a person's knuckle skin completely missing exposing the bones underneath? Which ECM was it? I believe that will be the answer to our problems not acell.

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101
(@lapis-lazuli)

Posted : 09/23/2010 7:29 am

I haven't given up on ACell just yet.

 

Btw, here's an interview from about a year ago with someone from Sirnaomics who are developing Cutasil which has been mentioned before:

 

http://www.trademarkia.com/cutasil-77916521.html

 

It's interesting. Scarless healing gets mentioned in that interview a bit in the second video on that page. They start talking about it around 4:30 I think. But if you don't want to go through the hassle of clicking on the link etc. here it is in text form:

 

Patrick: So we understand the difficulty of certain delivery issues so we go after a relatively low hanging fruit approach.

 

BeiBei: ...such as the virus... :nod:

 

Patrick: Such as wound healing program. There's less hurdles to adress for delivery issue because it can easily be delivering to the wounds... It's already opened... And it has tremendous unmet needs. Especially for, we call it, scarless wound healing. So I think for...ladies like you maybe you are really interested in those kinds of topics. lol

BeiBei: LOL! Hopefully I won't need it! hahaha

 

Patrick: But another one is for influenza treatment. [...]

 

BeiBei: Oh so how does that work? You... These multi-targets...you apply for approval at the same time? Simultanious? How does...that work?

 

Patrick: [...] It is a question if FDA will finally pass this kind of strategy. We know FDA is very keen on multi-targeted approach for oncology for anti-viral. So this is nothing new for them. They really encourage us to do that. We have interaction with FDA. I believe for anti-viral and anti-cancer application we have very easy way to go through it. For wound healing we still need to communicate with them see what's really going to happen. But I'm quite optimistic about all those issues. But as any scientific endevour you need to work hard on the real science same time when you make a drug you have to go through the regulatory bodies to make sure your thing is safe.

 

That Cutasil is interesting. They have a pretty bold(!) statement on their website! hahaha ;)

 

STP705 (Cutasil‚®)

 

siRNA Therapeutics for Skin Scarless Wound Healing (SSWH)

 

According to The Mattson Jack Group, an independent research group, the US commercial market for reduction of scarring in the skin is valued at approximately US$4 billion a year. There are some 42 million patients each year who could potentially benefit from pharmaceuticals that prevent or reduce scarring in the skin. There are 41.8 million surgical procedures to the skin each year in Europe and 70 million procedures annually in the United States involving wounds, which could benefit from a drug that improves the appearance of the scar. Currently there are no related pharmaceuticals available in the market either in the US or Europe. Sirnaomics plans to be the first internationally to launch a marketed siRNA pharmaceutical drug for the reduction of scarring. What is needed for this space is a product that can accelerate the rate of wound closure while reducing the scar that typically forms in adult skin and which decreases the strength of the repair. Sirnaomics has demonstrated accelerated wound closure with a topically applied siRNA mixture that results in wound repair and a return of normal skin morphology (without a scar and with return of follicles). This product will have utility in treatment of wounds incurred on the battlefield, wounds from burns, or wounds from surgical intervention and may have utility in treatment of diabetic wounds ‚œ many of which require limb amputation as a cure. This product can be positioned within the armed forces for battlefield medical use, within hospitals for traumatic wounds and eventually into clinics and plastic surgery offices to improve healing in elective surgery. The candidate siRNA drug (Cutasil‚®) targeting both TGF޲1 and Cox-2 and packaged in HK polymer nanoparticles has been tested in mouse and swine skin excision wound models and demonstrated remarkable therapeutic benefit superior to the existing standard treatment. STP705 represents the First-in-Class drug with clear mechanism of action. It accelerates wound closure, minimizes scar formation, and decreases pain with anti-fungi activity.

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MemberMember
16
(@maldition)

Posted : 09/23/2010 6:22 pm

Good info Lapiz.

 

Cutasil (STP705)

 

http://sirnaomics.com/products2.html

 

 

 

 

And some news about EXCOO1 (Excaliard) on phase 2:

 

 

http://www.news-medical.net/news/20100804/...r-severity.aspx

 

 

 

 

 

 

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(@katiekat)

Posted : 09/24/2010 11:58 pm

You guys are awesome with all the research you do!!!!

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(@snowqueen)

Posted : 09/26/2010 8:51 pm

I haven't given up on ACell just yet.

 

Btw, here's an interview from about a year ago with someone from Sirnaomics who are developing Cutasil which has been mentioned before:

 

 

 

It's interesting. Scarless healing gets mentioned in that interview a bit in the second video on that page. They start talking about it around 4:30 I think. But if you don't want to go through the hassle of clicking on the link etc. here it is in text form:

 

Patrick: So we understand the difficulty of certain delivery issues so we go after a relatively low hanging fruit approach.

 

BeiBei: ...such as the virus... :nod:

 

Patrick: Such as wound healing program. There's less hurdles to adress for delivery issue because it can easily be delivering to the wounds... It's already opened... And it has tremendous unmet needs. Especially for, we call it, scarless wound healing. So I think for...ladies like you maybe you are really interested in those kinds of topics. lol

BeiBei: LOL! Hopefully I won't need it! hahaha

 

Patrick: But another one is for influenza treatment. [...]

 

BeiBei: Oh so how does that work? You... These multi-targets...you apply for approval at the same time? Simultanious? How does...that work?

 

Patrick: [...] It is a question if FDA will finally pass this kind of strategy. We know FDA is very keen on multi-targeted approach for oncology for anti-viral. So this is nothing new for them. They really encourage us to do that. We have interaction with FDA. I believe for anti-viral and anti-cancer application we have very easy way to go through it. For wound healing we still need to communicate with them see what's really going to happen. But I'm quite optimistic about all those issues. But as any scientific endevour you need to work hard on the real science same time when you make a drug you have to go through the regulatory bodies to make sure your thing is safe.

 

That Cutasil is interesting. They have a pretty bold(!) statement on their website! hahaha ;)

 

STP705 (Cutasil‚®)

 

siRNA Therapeutics for Skin Scarless Wound Healing (SSWH)

 

According to The Mattson Jack Group, an independent research group, the US commercial market for reduction of scarring in the skin is valued at approximately US$4 billion a year. There are some 42 million patients each year who could potentially benefit from pharmaceuticals that prevent or reduce scarring in the skin. There are 41.8 million surgical procedures to the skin each year in Europe and 70 million procedures annually in the United States involving wounds, which could benefit from a drug that improves the appearance of the scar. Currently there are no related pharmaceuticals available in the market either in the US or Europe. Sirnaomics plans to be the first internationally to launch a marketed siRNA pharmaceutical drug for the reduction of scarring. What is needed for this space is a product that can accelerate the rate of wound closure while reducing the scar that typically forms in adult skin and which decreases the strength of the repair. Sirnaomics has demonstrated accelerated wound closure with a topically applied siRNA mixture that results in wound repair and a return of normal skin morphology (without a scar and with return of follicles). This product will have utility in treatment of wounds incurred on the battlefield, wounds from burns, or wounds from surgical intervention and may have utility in treatment of diabetic wounds ‚œ many of which require limb amputation as a cure. This product can be positioned within the armed forces for battlefield medical use, within hospitals for traumatic wounds and eventually into clinics and plastic surgery offices to improve healing in elective surgery. The candidate siRNA drug (Cutasil‚®) targeting both TGF޲1 and Cox-2 and packaged in HK polymer nanoparticles has been tested in mouse and swine skin excision wound models and demonstrated remarkable therapeutic benefit superior to the existing standard treatment. STP705 represents the First-in-Class drug with clear mechanism of action. It accelerates wound closure, minimizes scar formation, and decreases pain with anti-fungi activity.

 

wow, this is amazing!

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MemberMember
3
(@neomike)

Posted : 10/02/2010 1:54 pm

http://www.azooptics.com/details.asp?newsID=11145

 

Here is a new laser treatment what promises 50 % better results for surgical scars.

They speak of scarless laser treatment. hm. :-)

 

What do think about it? Something promising?

 

I believe that lasers in general do not have a good standing in the scar sufferer crowd.

 

NEO

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MemberMember
101
(@lapis-lazuli)

Posted : 10/02/2010 2:40 pm

http://www.azooptics.com/details.asp?newsID=11145

 

Here is a new laser treatment what promises 50 % better results for surgical scars.

They speak of scarless laser treatment. hm. :-)

 

What do think about it? Something promising?

 

I believe that lasers in general do not have a good standing in the scar sufferer crowd.

 

NEO

 

lol I think the term scarless is being used too easily by companies. It implies just that; scarless. But it's actually not that, obviously. You've also got scarless breast surgery or liposuction which is also misleading as they just hide the scar, they don't prevent it.

 

So this thing produces 50% better results and they call it scarless, eh? Hmmm, they should call it something else. So let's see... Scarless is eight letters. So let's take half off to make it more fitting to the results achieved. How about the last half? Those last four letters? Yes, that would be good. Much more fitting. Scar laser treatment is much better. lol I'm sorry, I'm being kinda silly.

 

It's cool that this thing is around, though. It could benefit some.

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MemberMember
11
(@2001)

Posted : 10/02/2010 5:53 pm

I caught wind of juvista many moons ago maybe around 2001. I don't have any faith in Renovo at all. Waited like everyone else for those 3 FDA required clinical phases to pass and now that it has. Well Marks promise on scar-less healing was a lie.

 

Then I caught wind of ACELL- long before it got on Oprah. No phases since ECM has been used for a long time now on rotator cuffs. FDA approved, Prescription only (That sucks!!!!!) Expensive (that also sucks) No powder suppliers- only sheets (super suck!)

 

So far no scar revision results worth a damn. Some hair guy playing camera games to make us think otherwise (thief!)

 

It regrows fingers, but that is something we could do as children so I only see that result as a reawakening of something we could already do, but lost because of the genetic changes we go through due to age.

 

It does however work well with scarless healing in animals, and healing wounds on the elderly with circulation issues. It also works well on rotator cuffs and hearts.

 

We need to see a "Skin Injury" specific version of this ECM, and we need easier access to it- More specifically the powder "pixie dust" version.

 

Anything can be harmful if it's misused. The FDA approves lots of things like the meat in my freezer. I didn't need a doctors note to get that.

 

ACELL we are talking about a billion dollar per year market here. You need to partner with Johnson and Johnson and make a salve/neosporin version of this and other "Over the counter" treatments for wounds that don't require a doctors consent to purchase, as well as a price drop.

 

Take if from a 9 + year searcher. This is something I believe the human race will sort out, but it sucks that some of you Companies are either ignoring us outright or making it to harder for us to get what you offer. Stop it! We have money. We want to give that money to someone who will help. Come get this money! Help us!

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