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The "after" pic of trial 3 looked pretty promising to me. It looks like some of the tissue actually regenerated fully there. But you say that its all a scar? In any case, it's not 100% scarless and that's very disappointing but maybe there's a different way ACell can be used to either further increase the chances of that or to perhaps even ensure that it happens. It would be very interesting to hear what Dr. Cooley thinks of this. Maybe he can give you advice as to how it can be applied best. You already kept it moist and you applied a second piece of ACell in the healing period but maybe he can tell you more? I wouldn't know what he'd be able to tell you but I'm not a doctor. Maybe you can ask him for advice?
I'd also be interested in contacting Cooley as he must have some photos by now of patients he has treated. It would be very interesting to see obviously and maybe if it isn't too much of a bother for him he could come on here and share a few. 
uhm yeah, anything that does not look like normal skin but instead is red and smooth i regard as scar tissue. but indeed it is a little smaller than the original wound. as for cooley, i think he uses powder too but you cant buy that anywhere on the internet, although it would be much more convenient to apply. (excise the scar, fill the wound with the powder then put sheet on top) and were not sure when he publishes his results in october if we will we able to see anything i even wrote him an email but he didnt answer
hello, ive been experimenting with acells product.
Firstly, THANK YOU so much very much Solo_Premium for not only taking the time to carry out this 'experiment' but to also document and post your results on here. Finally we have someone, who appears to be just like one of us, who can actually document the real performance of A-Cell because so much has been written about this product but there has been virtually no proper visual documentation of its 'benefits' in treating scarring.
Secondly, may I ask where you purchased the Matristem (A-cell) box as I have been trying for ages to order some. Despite your results I would still like to prove to myself that this stuff does not work (so I can just cancel it off the list)!
I can't say, however, that I'm surprised by the results you have experienced with A-Cell. If you look back through my posts I have always maintained my scepticism. I think the hype around the product has turned A-Cell into a guaranteed panacea, causing many to overlook the fact that there is a distinct lack of photo documentation. We have just seen the same stories & photos posted over and over again...the guy who's fingertip grew back, the animals etc..
That said, I have not entirely discounted ECM or A-Cell. It could just be the wound healing process that needs modification rather than the product, eg. it may need to be applied continuously until the skin as heal.
Could you elaborate a bit more on how you went about doing the scar revision. Did you excise the scar yourself with a scalpel? Did you stitch the wound together yourself and did you definitely keep the wound clean and moisturised at all times?
Sorry for the info overload but if you can take 2secs to answer these, it would be appreciated.
Guys, I've talked to a doctor about solo_premium's third ACell trial and he told me that the redness visible in the "after" photo is not from scarring but from new blood vessels. And that it will take three whole months before the actual results are seen...
So solo_premium, I would recommend you to wait and see how it looks then.
Lapis, a lot of doctors say that it takes between 3-6 months for the wound to fully heal and to see whether scar tissue has formed. However, I believe this is only to assure that the wound has completely healed. In my case, whenever I have excised my scar tissue and can easily tell whether or not the process has been successful because within about 7-10 days the scar tissue has already reformed; yes, the wound may be a little red but the scar tissue is present. In solo_premium's case I think the same thing has occurred. You can see that the scar tissue has already started to reform. He/she can wait a few months to see how the wound changes during its healing stage, but once there is scar tissue then the skin won't change much.
Could you elaborate a bit more on how you went about doing the scar revision. Did you excise the scar yourself with a scalpel? Did you stitch the wound together yourself and did you definitely keep the wound clean and moisturised at all times?
well yes i used a scalpel for the 1st trial on the scar on my leg, i didnt use any stitches (why would i need them), i just put the ecm on top and looked at what was happening. well not much, because no, i didnt use a hydrogel dressing to keep it moist.it dried out, scab formed, fail (beginning of the learning process, you know)
2nd trial i used tiny scissors to cut scar tissue away but only superficially, hence the wound bed consisted mostly of scar tissue (because the scar is very deep, a 40 year old dog bite, and well, i couldnt cut everything out. im no surgeon.) again, no stitches used but this time it was kept moist at all time. (-> no scab formed) but it failed again and i concluded that there must not be any scar tissue because i believe its too thick and prevents stem cells from getting to the wound.
thats why i tried again a 3rd time, and this time i created a new wound (scissors) with no scar tissue present, just healthy, normal tissue. again, no stitches, i just put the ecm sheet on the wound, then applied the hydrogel dressing and it didnt dry out. (no scab) and im pretty sure it was clean the whole time as well because when i applied the ecm and when i changed the dressing (and applied new ecm), i always irrigated the wound with much sterile saline.
and when i can prove that the ecm lets a normal wound heal without a scar, then theoretically, you can cut out any scar (entirely!) and use the ecm to regenerate. then i may contact a surgeon to do the job
Lapis, a lot of doctors say that it takes between 3-6 months for the wound to fully heal and to see whether scar tissue has formed. However, I believe this is only to assure that the wound has completely healed. In my case, whenever I have excised my scar tissue and can easily tell whether or not the process has been successful because within about 7-10 days the scar tissue has already reformed; yes, the wound may be a little red but the scar tissue is present. In solo_premium's case I think the same thing has occurred. You can see that the scar tissue has already started to reform.
i agree, im pretty sure its a scar and will stay that way, its pink, its smooth and theres no structure (if the structure was like skin structure, with all the tiny gaps, id say its skin too and just red). just compare it to the final pictures of the first trial, its pink and smooth too and that ones definitely a scar.
in my opinion, when a wound heals and gets smaller, either the defect is filled up with scar tissue or with new, healthy tissue. (well of course that doesnt occur normally) so i doubt it will change much over the next few months, a scar remains a scar (well it gets white over time)
motherboard.tv/2009/10/15/q-a-with-alan-russell-regrowing-the-human-body
"Iave seen some pictures, which we canat publish due to doctor-patient confidentiality, of open wounds that heal in a few weeks without leaving a single scar."
there you go, i believe once the the wound is closed, thats the final result. (skin or scar, all or nothing)
if you look at Dr. Hitzigs website nyhairloss.com he has pictures of acell used on scars
yea and this trial looks excellent skin-wise. rest is meh
nyhairloss.com/slide18.htm
but 6 months?
The doctor I referred to earlier who viewed solo_premium's photos was Jerry E. Cooley. He said that the redness in the last picture isn't scar tissue.
I've spoken to Dr. Cooley for a bit through e-mail and he said that he doesn't promise people 'scar free' as that would imply a completely normal look. He said that he can't promise this as there are certain tissue distortions, volume losses and asymmetries which are beyond the capabilities of ACell too correct. In these cases fillers and Fraxel are things he might suggest to enhance the results.
He is considering using ACell for treating acne scars as he has had "great results" using it for hair transplant procedures, as AI3forever mentioned too.
He also recommends using imiquimod after punch excisions of acne scars to minimize/eliminate scar formation. I've looked on Wikipedia and the article on imiquimod is interesting.
http://en.wikipedia.org/wiki/Imiquimod
"New research has shown that imiquimod's anti-proliferative effect is totally independent of immune system activation or function. Imiquimod exerts its effect by increasing levels of the opioid growth factor receptor (OGFr). Blocking OGFr function with siRNA technology resulted in loss of any antiproliferative effect of imiquimod."
Note the siRNA technology. Didn't someone mention an upcoming product earlier for scarless healing which uses this?
Here's another quote from the Wiki page:
"Fortunately, after completion of the therapy, the skin often heals with barely any scarring."
Solo I hope your wound settles in a month or so...
But whether Acell works or not:
The fact remains that 'non denatured' ECM brings scar free healing.
The fact remains with denatured ECM you will get scar.
The ECM in my non scarred skin is intact, the fibers have micro pathways to allow my skin to regenerate hairs were needed, sweat glands were needed etc.
However, lets say, if I put chemicals on my non wounded skin, which denatured my ECM, fibroblasts would proliferate in an emergency, the fibers in the skin would join, my tissue would not be able to regenerate and over time I'd get encapsulated scar in the places my fibers have crosslinked.
scar free healing must have an intact ECM.
The doctor I referred to earlier who viewed solo_premium's photos was Jerry E. Cooley. He said that the redness in the last picture isn't scar tissue.
I've spoken to Dr. Cooley for a bit through e-mail and he said that he doesn't promise people 'scar free' as that would imply a completely normal look. He said that he can't promise this as there are certain tissue distortions, volume losses and asymmetries which are beyond the capabilities of ACell too correct. In these cases fillers and Fraxel are things he might suggest to enhance the results.
He is considering using ACell for treating acne scars as he has had "great results" using it for hair transplant procedures, as AI3forever mentioned too.
He also recommends using imiquimod after punch excisions of acne scars to minimize/eliminate scar formation. I've looked on Wikipedia and the article on imiquimod is interesting.
http://en.wikipedia.org/wiki/Imiquimod
"New research has shown that imiquimod's anti-proliferative effect is totally independent of immune system activation or function. Imiquimod exerts its effect by increasing levels of the opioid growth factor receptor (OGFr). Blocking OGFr function with siRNA technology resulted in loss of any antiproliferative effect of imiquimod."
Note the siRNA technology. Didn't someone mention an upcoming product earlier for scarless healing which uses this?
Here's another quote from the Wiki page:
"Fortunately, after completion of the therapy, the skin often heals with barely any scarring."
10 Years ago when investigating with hope, to investigate the effect of imiquimod, said that operated in keloids, to flatten scars above.
A few years ago went a study scientific which showed that no toward effect in the majority of people with keloids,this on google.
It seems that in some people works and sometimes not,speaking of keloids only.
In normal scars were not made investigations.
Who knows? Perhaps in some serve.
The imiquimod is sold as a treatment for vaginal warts, not to be difficult buy imiquidod , made a hole and view as regenerates skin
It is time to begin to experiment, good for solo_premiun...
Okay. I think the main problem is that we need to get this acell product into powdered form. I have tried to use the sheets myself(available at amazon and therx.com) and they contour to the wound terribly. Unfortunately, you can't buy the powdered version for whatever reason so we have to find a way to powderize it ourselves. I had previously thought this wasn't possible but I think it can be done. All you need is Acell sheets, liquid nitrogen, and a mortar and pestle. I know the liquid nitrogen part sounds weird, but acell does the same thing(that's what they use to cryogenically freeze their product. right?). So liquid nitrogen should have no negative effect on the integrity of the matrix. My question to everyone here is "how do we get liquid nitrogen?" I think you can buy it in a spray can similar to the kind that people use for warts. I researched but had a tough time finding a spray can that would spray directly(sort of like windex) onto anything that isn't related to wart removal. Please help me out here and research or suggest a spray can you know will work and I will then buy it and all other materials and begin trials. Let's go let's go let's go! I want a scarless Christmas!
Okay. I think the main problem is that we need to get this acell product into powdered form. I have tried to use the sheets myself(available at amazon and therx.com) and they contour to the wound terribly. Unfortunately, you can't buy the powdered version for whatever reason so we have to find a way to powderize it ourselves. I had previously thought this wasn't possible but I think it can be done. All you need is Acell sheets, liquid nitrogen, and a mortar and pestle. I know the liquid nitrogen part sounds weird, but acell does the same thing(that's what they use to cryogenically freeze their product. right?). So liquid nitrogen should have no negative effect on the integrity of the matrix. My question to everyone here is "how do we get liquid nitrogen?" I think you can buy it in a spray can similar to the kind that people use for warts. I researched but had a tough time finding a spray can that would spray directly(sort of like windex) onto anything that isn't related to wart removal. Please help me out here and research or suggest a spray can you know will work and I will then buy it and all other materials and begin trials. Let's go let's go let's go! I want a scarless Christmas!
Did anyone see the story on CNN.com tonight about acell? It was about a woman who grew a pinky back with this product, the moral of the story was to never give up and push your doctors. This woman was devasted by her pinky amputation and never gave up!!! Do not do this yoourself find a doctor willing to try something new like she did!! Her Doctor had never used the product before and it was a complete sucess. The link is here: http://www.cnn.com/2010/HEALTH/09/09/pinky...dex.html?hpt=C2
Ya know you can't do this yourself anyway. Your scar would need to first be totally excised then this acell product would have to be used. The product needs to be used on a fresh wound - that is why a healed scar is debrided before this product is used. It will not react with healed tissue simply being injected
Okay. I think the main problem is that we need to get this acell product into powdered form. I have tried to use the sheets myself(available at amazon and therx.com) and they contour to the wound terribly. Unfortunately, you can't buy the powdered version for whatever reason so we have to find a way to powderize it ourselves. I had previously thought this wasn't possible but I think it can be done. All you need is Acell sheets, liquid nitrogen, and a mortar and pestle. I know the liquid nitrogen part sounds weird, but acell does the same thing(that's what they use to cryogenically freeze their product. right?). So liquid nitrogen should have no negative effect on the integrity of the matrix. My question to everyone here is "how do we get liquid nitrogen?" I think you can buy it in a spray can similar to the kind that people use for warts. I researched but had a tough time finding a spray can that would spray directly(sort of like windex) onto anything that isn't related to wart removal. Please help me out here and research or suggest a spray can you know will work and I will then buy it and all other materials and begin trials. Let's go let's go let's go! I want a scarless Christmas!
Did anyone see the story on CNN.com tonight about acell? It was about a woman who grew a pinky back with this product, the moral of the story was to never give up and push your doctors. This woman was devasted by her pinky amputation and never gave up!!! Do not do this yoourself find a doctor willing to try something new like she did!! Her Doctor had never used the product before and it was a complete sucess. The link is here: http://www.cnn.com/2010/HEALTH/09/09/pinky...dex.html?hpt=C2
how many times i have to say ' the fingers can grow up, regenerated, WHITOUT acell'.
is the only part of the body can do this.
when acell shows regenerated on a simple scar skin. let me know.
@ eternal:
You are wrong. Fingertips can only be regenerated till tha age of 1 or 2. Adult persons cannot
regenerate fingertips. Read the article, the doctor told the woman that it is impossible to transplant
the missing part, why should he tell his patient this if regeneration would happen?
Because it does not happen.
NEO
@ eternal:
You are wrong. Fingertips can only be regenerated till tha age of 1 or 2. Adult persons cannot
regenerate fingertips. Read the article, the doctor told the woman that it is impossible to transplant
the missing part, why should he tell his patient this if regeneration would happen?
Because it does not happen.
NEO
Many doctors have already experienced with acell in skin.
why has not been a case of skin regenerated even?
Acell was only a speculation for actions raise up mars.
I believe in photos of real proving the effectiveness of something, and that only saw with juvista, kitoscell, and apligraf (for the time being ).
Look at google long ago i read that doctors say 'sometimes' the tip of the fingers in people can regenerate alone.
hi everyone im new here.
I believe the future is looking bright in term of scarless healing/stem cells/ regenarative medicine. For years i have been suffering with depression and due to this i have been picking my skin badly. Do you think that when scarless healing comes out it will alos apply to people like me who have damaged their own skin due to self harm. thank you for giving hope.
hi everyone im new here.I believe the future is looking bright in term of scarless healing/stem cells/ regenarative medicine. For years i have been suffering with depression and due to this i have been picking my skin badly. Do you think that when scarless healing comes out it will alos apply to people like me who have damaged their own skin due to self harm. thank you for giving hope.
Hi and welcome to the wonderful place that is acne.org.
I'd say scarless healing won't really "come out" as a single, garuanteed-to-always-work, sure fire treatment. There's a bunch of different products out there which all have the potential, it seems, to achieve scarless healing when used properly. I think every person's problem is sorta unique. I mean one scar isn't 100% like the other scar, you know? So I don't think any doctor can ever give anyone the promise of full regeneration. Chances may be large at one point for every patient, but still... Anyway, I've spoken to one doctor who said that the approach he uses, has been used by him to treat a variety of problems. So yeah, it's probably also so that your problem can be fixed/improved by "scarless healing".
hi everyone im new here.I believe the future is looking bright in term of scarless healing/stem cells/ regenarative medicine. For years i have been suffering with depression and due to this i have been picking my skin badly. Do you think that when scarless healing comes out it will alos apply to people like me who have damaged their own skin due to self harm. thank you for giving hope.
These are the facts reddraggon,
-Scar free healing has been done. Decorin.
-There are products being developed that do not bring scar free healing.
-Scar free healing is the result of fibroblast proliferation which creates excess collagen, this collagen blockage stops regeneration. Decorin at 200nm stops fibroblast proliferation.
-On this page we have seen examples of scar free healing, e.g appligraf ECM. On this page we have seen things that do not bring scar free healing.