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[Sticky] Scarless Healing

 
MemberMember
14
(@waitingforacure)

Posted : 08/18/2010 2:37 am

whadupp ur the fuken man..im 150% with u!

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MemberMember
54
(@scars4life)

Posted : 08/18/2010 8:19 am

Your words have trully touched me :cry:

Respect brother

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MemberMember
1
(@leo-messi)

Posted : 08/18/2010 9:40 am

Sorry for this digression:

I just need to say this. IF we find the cure for our scars(and I hope it's in less than 2 years) I will still return to this thread and I hope you do to. I would love to come back here and remember my struggles, yet remember the group of people who were right there beside me, people who scratched and clawed their way through years of information and failure just so they could be there when 1 success came along. You are all some of the toughest fucking grinders on this earth and I hope you know that. I'd go to war with you people because you, like me, know nothing is impossible. Let's show the world what we're made of during this stretch run. Let's get all the info we can. Let us be bold and experiment ourselves since nobody else will. Let us change our faces but not ourselves. I won't rest until everyone on here is satisfied. Who's with me?

 

 

You so rock, dude! I'm totally with ya!

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MemberMember
48
(@ai3forever)

Posted : 08/18/2010 2:57 pm

we are stuck, years pass and nothing changes.but there is hope, maybe tomorrow they accidentally discover a cure for this.

 

Nonnegative, if realistic.

 

Actually there are already "news" that has claimed blastema in humans are created, ECM has potential to regenerate full thickness wounds. But there isn't treatments for us, that is the sh1tty part..

 

As from a post mentioned by lazuli, the doctor says the ECM can regenerate wounds to healthy skin instead of scarring, but it doesn't happen all the time.

 

To me, it feels that ECM can regenerate totally, but the doctors are still unsure of "what factors" would contribute to a pefect healing scenario thus unwilling to try it on scars.

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MemberMember
73
(@seabs135)

Posted : 08/18/2010 9:52 pm

Whoa blastema? for humans? succesful?

where did you read that, something of that magnitude would mean we are nearing limb regeneration, scars is a childs play for blastema. As for Acell, who knows.

 

I seriously read that somewhere on the net. I showed it to seabs, maybe he had saved the link. Anyway fishy right? Since they said they have already created it yet we still have no news? Unless they were misquoted.

 

 

Yes it was about creating a blastema from skin I think.

 

But anyway, scar free heeling is here and that is a fact. eg. Decorin at 200nm stops the thing that causes scarring from proliferating (it stops the fibroblasts). You have things like 'non denatured' ECM with regenerates to normal tissue, you have p21, and they can even create a blastema from skin. Scar free healing has been done outside in and inside out.

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MemberMember
16
(@maldition)

Posted : 08/19/2010 4:16 am

we are stuck, years pass and nothing changes.but there is hope, maybe tomorrow they accidentally discover a cure for this.

 

Nonnegative, if realistic.

 

Actually there are already "news" that has claimed blastema in humans are created, ECM has potential to regenerate full thickness wounds. But there isn't treatments for us, that is the sh1tty part..

 

As from a post mentioned by lazuli, the doctor says the ECM can regenerate wounds to healthy skin instead of scarring, but it doesn't happen all the time.

 

To me, it feels that ECM can regenerate totally, but the doctors are still unsure of "what factors" would contribute to a pefect healing scenario thus unwilling to try it on scars.

 

 

 

I hope the user above have reason and in 2 years there is a solution. The problem is not to find a magic poison, if not all the years after that must pass for this to the sale. As 10 years that juvista this test phase and even does not come to the sale.

I think it is more to expect the test phases to a medication this to the sale, to discover.

 

All the best for all.

 

 

 

 

 

 

 

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MemberMember
101
(@lapis-lazuli)

Posted : 08/19/2010 5:55 am

As from a post mentioned by lazuli, the doctor says the ECM can regenerate wounds to healthy skin instead of scarring, but it doesn't happen all the time.

 

To me, it feels that ECM can regenerate totally, but the doctors are still unsure of "what factors" would contribute to a pefect healing scenario thus unwilling to try it on scars.

 

Yep. It's true. Jerry E. Cooley has used ACell to achieve scarless healing in a number of his patients. And he's now, as we speak, working with ACell to determine the best way to use it, so that every patient has the maximum chance at full regeneration.

 

"The actual protocol, the technique, the amount... Those are all things that we're working with ACell to help determine so we're not ready to go to the surgical community and say "this is the best way to handle this problem"."

 

- Jerry E. Cooley MD

 

If he and his collegues publish the results of his research I'd be very interested what E. Middelkoop thinks of it as she seems to not use ACell as far as I know. She seems to be experimenting with less effective approaches. Anyway, when Cooley and his co-workers can show that ACell, when used in a certain way gives patients a, say, 97% chance at 100% regeneration that would be very interesting. We'll see in October or a little while after that what his findings are.

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MemberMember
16
(@maldition)
MemberMember
48
(@ai3forever)

Posted : 08/20/2010 6:26 am

Yep. It's true. Jerry E. Cooley has used ACell to achieve scarless healing in a number of his patients. And he's now, as we speak, working with ACell to determine the best way to use it, so that every patient has the maximum chance at full regeneration.

 

where did u hear from

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MemberMember
101
(@lapis-lazuli)

Posted : 08/20/2010 7:04 am

where did u hear from

 

The interview I mentioned earlier:

 

If you scroll down a little bit on the page which the link below leads to, you can find an audio file which is an interview with Jerry E. Cooley regarding ACell:

 

http://www.thebaldtruth.com/articles/hair-...n-breakthrough/

 

He said in that interview from January that he had treated almost 100 people back then. And when asked what some of the results were he said this:

 

In your experiments you were using it in donor sites, you were using it in recipient sites and what were you seeing?

 

Well, initially you see more redness and a little bit more swelling. And what's happening is, this process is being stimulated where stem cells are being brought in, new blood vessels are being stimulated... And then ultimately when everything heals, you're seeing either no scarring or less scarring and what appears to be normal tissue.

 

He's also saying in that interview that he's working with ACell to find the best treatment protocol i.e. how much ACell should be applied and if a solitary implant is enough or another one is needed a few days into the post op period and so forth.

 

He's been actively recruiting so-called "repair cases" where the "need is desperate" for some time because he's "excited enough" about the results so far that he thinks these people can benefit from ACell and on top of that it enables him to learn more about the best way to use ACell.

 

So anyway, Jerry E. Cooley has achieved scarless healing in some cases but it's not 100% certain that when you get treated with ACell you'll get 100% regeneration. He said it is, however, safe to say that it's 100% certain that you get a reduction of scarring. But like I said, he's been doing a lot of research in order to find the right protocol which will maximize the results for all patients.

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MemberMember
48
(@ai3forever)

Posted : 08/21/2010 1:43 pm

Have you guys tried emailing to Dr Jerry E. Cooley?

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MemberMember
101
(@lapis-lazuli)

Posted : 08/21/2010 2:18 pm

Have you guys tried emailing to Dr Jerry E. Cooley?

 

I've thought about calling him on the phone until I found that interview in which he said a lot about ACell. On top of that he's going to publish his results soon anyway, so I'm just going to wait for that. But if anybody else wants to contact him, you can contact him through here:

 

http://www.haircenter.com/contact.html

 

I'm sure he won't mind answering any questions anyone might have.

 

Here...

 

http://www.hairtransplantnetwork.com/consu...tors.asp?DrID=4

 

...it says his e-mail adress is jcooley65@aol.com but I'm not 100% sure if that's true.

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MemberMember
0
(@thulsa-doom)

Posted : 08/22/2010 12:30 pm

Sorry for this digression:

I just need to say this. IF we find the cure for our scars(and I hope it's in less than 2 years) I will still return to this thread and I hope you do to. I would love to come back here and remember my struggles, yet remember the group of people who were right there beside me, people who scratched and clawed their way through years of information and failure just so they could be there when 1 success came along. You are all some of the toughest fucking grinders on this earth and I hope you know that. I'd go to war with you people because you, like me, know nothing is impossible. Let's show the world what we're made of during this stretch run. Let's get all the info we can. Let us be bold and experiment ourselves since nobody else will. Let us change our faces but not ourselves. I won't rest until everyone on here is satisfied. Who's with me?

 

Amen, brother.

And I totally agree with your earlier post (the one about regrowing a dick, etc.): These researchers need to get their asses in gear and make this a reality. A tangible, real product that real people can use. Let's get this shit done already and alleviate this immense cause of human suffering.

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MemberMember
16
(@maldition)

Posted : 08/28/2010 7:19 pm

so where is the miracle?

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MemberMember
54
(@scars4life)

Posted : 08/29/2010 3:25 am

Well seabs claims that there already is a cure. Wish I could believe it, would make life alot easier till the cure comes, and the upcoming college semester, curse you education.

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MemberMember
0
(@xoteamo)

Posted : 08/29/2010 3:53 am

there's a cure for acne scars? is there really? /:

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MemberMember
54
(@scars4life)

Posted : 08/29/2010 10:37 am

Dont get all excited, nothing has yet to have been proven to work, just have to wait I guess.

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MemberMember
48
(@ai3forever)

Posted : 08/30/2010 1:35 pm

I actually emailed Dr Cooley regarding about treating acne scars with acell. This is what he replied:

 

Iave treated acne scarring and photoaging in various ways, including dermabrasion, excision, microneedling, fractional laser, needle subcision, silicone injections, PRP, imiquod, etc. Iave used ACell to reduce facial scarring for other things Iave done, but Iave never tried it on acne scarring.

 

Without seeing you, I canat tell you exactly what Iad recommend but Iam sure there are things that can be done that will improve the situation. It may be that combining one or more of the above techniques with ACell would work well. Do you have a photo that shows the scarring? I would be happy to take a look at this.

 

Best regards

 

 

Key word: He said "reduce" facial scarring. Why is everyone being so conservative about its potential?

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MemberMember
101
(@lapis-lazuli)

Posted : 08/30/2010 2:46 pm

I actually emailed Dr Cooley regarding about treating acne scars with acell. This is what he replied:

 

I‚„ve treated acne scarring and photoaging in various ways, including dermabrasion, excision, microneedling, fractional laser, needle subcision, silicone injections, PRP, imiquod, etc. I‚„ve used ACell to reduce facial scarring for other things I‚„ve done, but I‚„ve never tried it on acne scarring.

 

Without seeing you, I can‚„t tell you exactly what I‚„d recommend but I‚„m sure there are things that can be done that will improve the situation. It may be that combining one or more of the above techniques with ACell would work well. Do you have a photo that shows the scarring? I would be happy to take a look at this.

 

Best regards

 

 

Key word: He said "reduce" facial scarring. Why is everyone being so conservative about its potential?

 

Omg, that's so interesting! :surprised: You actually e-mailed him? Wow. Interesting read... But yeah, he said "reduce" and on top of that he said "improve". :think: It's still a while before he'll publish his results. I'm still interested in seeing them... So are you going to send some photographs to him? Or are you going to see him in person?

 

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MemberMember
54
(@scars4life)

Posted : 08/30/2010 3:54 pm

Hopefully his results won't be as dissapointing as juvista. But I wonder whats happening on the other end of the spectrum, decorin, p21, osteopontin maybe even stem cells, but maybe ACell will do the trick.

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MemberMember
0
(@solo_premium)

Posted : 08/30/2010 4:22 pm

hello, ive been experimenting with acells product.

like many, ive been suffering due to my scars for a long time (and i still do) , tried everything in existence and after 2 years of procedures and continuous disappointment,i figured that, once a scar is there, no topical procedure can remove it. the only way to remove it is to have it excised. being cut out. then its gone. (as for acne scars, dermabrasion maybe) and the trick is to have the skin regenerate, create new skin, then win.

 

i decided to get proactive and used acell myself. of course ive READ that the ecm attracts stem cells that turn into normal tissue which guarantees scarless healing and all that, but thats only text. i havent seen pictures. and pictures are worth 1000 words. yes, there are pictures on the acell website but they dont impress me. i havent seen a wound that healed without a scar. obviously, its an advancement that diabetic ulcers can be closed, but thats not what were aiming for. we want scarless skin.

 

i cant post links the way i want to. they just get deleted. so you gotta copy paste

 

and here are my results.

thats the boxing and the ecm.

a.imageshack.us/img80/2762/image255m.jpg

a.imageshack.us/img130/497/image259t.jpg

 

after a few failed attempts, i realized its important to keep the wound moist with a hydrogel dressing. else, a scab would form and prevent the from ecm getting absorbed at all. that was basically my first trial.

img819.imageshack.us/g/image254.jpg/

 

i tested on another scar, and even with a hydrogel dressing, it still scarred. maybe because the scar was very deep and i was unable to remove the entire scar tissue. and the scar tissue prevented stem cells to get to the injury site. i didnt take as many pictures because the dressing covered the wound most of the time. obviously.

img261.imageshack.us/g/image295g.jpg/

 

i also figured that it should be important which side of the ecm is in contact with the wound bed and which isnt. because it says that theres the basement membrane on the top of the ecm sheet where the epithelial cells migrate onto. but then again, the powdered version shouldnt do much because this organization is lost. and im assuming that the way they put the ecm in the wrapping is the way it should be put on the wound (basement membrane on top). and i even found a link on how to create the powder.

medlineindustriesincorporated.com/wound-skin-care/matristem/lit/Gilbert%20et%20al%20%20Biomaterials%20ECM%20Powder%202005(1).pdf

 

so i tried again. this time i created a new wound, just consisting of healthy tissue. it should work there, right?

hydrogel dressing used again. no scab formed.

img267.imageshack.us/g/bild001wfh.jpg/

 

the first 3 pictures show the wound. - cleaned, ecm applied with sterile saline, hydrogel dressing applied. its a triangle with the size of 8mm each side.

the next 2 pictures (3 days) show the ecm lying in the wound bed, being absorbed, i suppose. size: 7mm each side.

the next 3 pictures (6 days) suggest that the ecm was absorbed because it was gone. cleaned the wound, new ecm applied. size: 7mm, 6mm, 6mm

the next 3 pictures (10 days) show the wound being almost closed. (again, the ecm was gone) but it looks like a scar. i still had hopes because it looks like that, from the edges, epithelization is occuring with the epidermis laying itself over the area

but i was wrong. because it is a scar as the last picture clearly shows. size is still 7mm, 6mm, 6mm.

 

as for me, acell fails. i doubt that i did anything wrong this time. well im not sure.

maybe ill try again. and i did. started 2 hours ago.

 

 

 

 

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0
(@Anonymous)

Posted : 08/30/2010 5:40 pm

wow absolutely awesome post solo_premium.

 

i cant really help you or comment much on your post as i dont know enough myself but i did find it incredibly interesting and im sure some of the guys who post here will find it equally interesting and have more to say about it.

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MemberMember
101
(@lapis-lazuli)

Posted : 08/30/2010 6:16 pm

Omg, that's amazing! It's 01:15AM right now, so I have to get some sleep as I have to be somewhere tomorrow morning. But I'll see if I can reply tomorrow after I looked at the pics properly. Very interesting! :)

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MemberMember
73
(@seabs135)

Posted : 08/30/2010 6:36 pm

hello, ive been experimenting with acells product.

like many, ive been suffering due to my scars for a long time (and i still do) , tried everything in existence and after 2 years of procedures and continuous disappointment,i figured that, once a scar is there, no topical procedure can remove it. the only way to remove it is to have it excised. being cut out. then its gone. (as for acne scars, dermabrasion maybe) and the trick is to have the skin regenerate, create new skin, then win.

 

i decided to get proactive and used acell myself. of course ive READ that the ecm attracts stem cells that turn into normal tissue which guarantees scarless healing and all that, but thats only text. i havent seen pictures. and pictures are worth 1000 words. yes, there are pictures on the acell website but they dont impress me. i havent seen a wound that healed without a scar. obviously, its an advancement that diabetic ulcers can be closed, but thats not what were aiming for. we want scarless skin.

 

i cant post links the way i want to. they just get deleted. so you gotta copy paste

 

and here are my results.

thats the boxing and the ecm.

a.imageshack.us/img80/2762/image255m.jpg

a.imageshack.us/img130/497/image259t.jpg

 

after a few failed attempts, i realized its important to keep the wound moist with a hydrogel dressing. else, a scab would form and prevent the from ecm getting absorbed at all. that was basically my first trial.

img819.imageshack.us/g/image254.jpg/

 

i tested on another scar, and even with a hydrogel dressing, it still scarred. maybe because the scar was very deep and i was unable to remove the entire scar tissue. and the scar tissue prevented stem cells to get to the injury site. i didnt take as many pictures because the dressing covered the wound most of the time. obviously.

img261.imageshack.us/g/image295g.jpg/

 

i also figured that it should be important which side of the ecm is in contact with the wound bed and which isnt. because it says that theres the basement membrane on the top of the ecm sheet where the epithelial cells migrate onto. but then again, the powdered version shouldnt do much because this organization is lost. and im assuming that the way they put the ecm in the wrapping is the way it should be put on the wound (basement membrane on top). and i even found a link on how to create the powder.

medlineindustriesincorporated.com/wound-skin-care/matristem/lit/Gilbert%20et%20al%20%20Biomaterials%20ECM%20Powder%202005(1).pdf

 

so i tried again. this time i created a new wound, just consisting of healthy tissue. it should work there, right?

hydrogel dressing used again. no scab formed.

img267.imageshack.us/g/bild001wfh.jpg/

 

the first 3 pictures show the wound. - cleaned, ecm applied with sterile saline, hydrogel dressing applied. its a triangle with the size of 8mm each side.

the next 2 pictures (3 days) show the ecm lying in the wound bed, being absorbed, i suppose. size: 7mm each side.

the next 3 pictures (6 days) suggest that the ecm was absorbed because it was gone. cleaned the wound, new ecm applied. size: 7mm, 6mm, 6mm

the next 3 pictures (10 days) show the wound being almost closed. (again, the ecm was gone) but it looks like a scar. i still had hopes because it looks like that, from the edges, epithelization is occuring with the epidermis laying itself over the area

but i was wrong. because it is a scar as the last picture clearly shows. size is still 7mm, 6mm, 6mm.

 

as for me, acell fails. i doubt that i did anything wrong this time. well im not sure.

maybe ill try again. and i did. started 2 hours ago.

 

Good images, I appreciate your researching.

 

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MemberMember
73
(@seabs135)

Posted : 08/30/2010 6:36 pm

edit posted twice...

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