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Wow 10 days of absolutely nothing. Where is everybody? "I do not", have you talked to anyone else? You know what shocks me? We haven't discovered absolute scar free healing. I mean we can grow fucking organs from scratch but it's not possible to prevent a relatively small wound from scarring. Where the fuck are these scientists who have supposedly created a blastema equivilent? Where can I find out about their experiments and similar experiments by others? Why the fuck hasn't Acell updated their god damn site in over 7 months? Why is it so fucking hard for us to hear about someone who had a scar excised and then applied the powder liberally until they were completely and scarlessly healed? Fuck the system. I want new news. That Oprah finger shit was like 2 years ago! I want to hear about someone growing their dick back or a hand or a burn victim with no scars. Let's fucking go!
haha You made me laugh there. Regrowing a 'dick'? hahaha That's funny.
Anyway, no I haven't spoken to anyone...because I've not been doing so well in terms of...well a whole bunch of things. 
So I haven't been able to invest any time into contacting anyone regarding SH.
I have, however found this article on pubmed which I thought was interesting. It's from 1994(!). Here's an excerpt:
There are a number of ways in which the matrix and cellular
response of the healing adult wound might be manipulated
to reduce scarring- i.e., inhibiting the wound
inflammatory response by blocking inflammatory cytokines
such as TGF-f, basic fibroblast growth factor, and
platelet-derived growth factor; adding exogenous tenascin
to facilitate keratinocyte and fibroblast migration
into the wound; transplanting fibroblasts with fetal characteristics
to the adult wound site; providing a more porous
wound scaffold by addition of hyaluronic acid or
hyaluronic acid-stimulating activity to enhance fibroblast
migration and promote regeneration of a normal
reticular collagen organization in the wounded dermis.
Although all of these potential therapeutic strategies require
rigorous scientific testing, adult wound healing
may be altered toward a scar-free, fetal-like phenotype
by modifying one or more of the components that are
different between fetal and adult repair.
It was written 16 years ago! lol 
Can you believe that? SO MUCH was already known back then...and now it's still not here.
I also heard this radio interview with Hans Clevers. The guy who supposedly discovered the mother of all stem cells. He said that the fact that his work ends up in discoveries that contribute to the solvement of problems is very beautiful but it's not the main reason he does his work. The main reasons are his fascination with science and the fact that his publications give him recognition and the thrill of trying something out and having it work. Those things are the main things that keep him working from day to day. And the fact that e.g. a cure for cancer becomes real at some point, partly due to him, is sort of a side effect.
He also said that he also sees this attitude in most of his collegues. He said that it is often thought scientists do their work out of altruism but it's actually not the reality of things in most cases. So maybe that's one of the reasons we don't have SH yet.
I've also found that the person I spoke to earlier, called E. Middelkoop, actually works at the hospital in Amsterdam I've been meaning to contact. So I already spoke to the people there! And as you can see in the post in which I quoted her earlier (a few pages back) she basically said "Juvista is coming eventually" and "Using an ECM in general results in an aesthetic improvement" and "Scarless healing might be real at some point". I asked her about decorin at 200nm in that e-mail but she didn't really say anything about that in her reply. Although now that I think of it...I think "Juvista is coming eventually" was her reply to that. At least that's how it seemed to me. She said that the use of growth factors was being considered in the form of Juvista. But decorin isn't a growth factor...it's a proteoglycan if I remember correctly. So that's why I said that she didn't really say anything about decorin.
Also, she has a publication on pubmed saying that the conclusion of one of her experiments was that a speedy wound healing plays a role in scarless healing. This was interesting to me as this is not a new discovery. It was already known... 
In any case, I still want to talk to someone about decorin... I've spoken to a few people at this point but I have to say that I found them difficult to talk to. You sometimes ask a short, simple, direct question and you get a long, mysterious, indirect answer. So it's a challenge. lol
Once I get some problems in my personal life worked out I'll be continuing research.
http://www.lifesitenews.com/ldn/2010/jun/10062913.html
off topic but at least it shows we are advancing in some areas.
http://www.physorg.com/news195316392.html
its getting late and i have only skimmed over this article so i apologise if it has no relevance.
I like the last link.
Here's another ECM:
And here's a doctor who uses it for heart tissue repair:
You should know that there's footage of an operation in that last video...
Anyway, seeing that scarring works the same supposedly in skin as it does in heart tissue...could it be used for skin regeneration, as well? I wonder.
Here's another ECM:
And here's a doctor who uses it for heart tissue repair:
You should know that there's footage of an operation in that last video...
Anyway, seeing that scarring works the same supposedly in skin as it does in heart tissue...could it be used for skin regeneration, as well? I wonder.
doubt it. skin and heart tissue is very different. the tissue used in the heart is myocardial muscle tissue which is not like epithelial tissue found on the skin. since they are completely differentiated there is no way for the myocardial tissue can convert to epithelial tissue unless you are talking about the epithelial tissue of the heart, which i doubt.
Here's another ECM:
And here's a doctor who uses it for heart tissue repair:
You should know that there's footage of an operation in that last video...
Anyway, seeing that scarring works the same supposedly in skin as it does in heart tissue...could it be used for skin regeneration, as well? I wonder.
doubt it. skin and heart tissue is very different. the tissue used in the heart is myocardial muscle tissue which is not like epithelial tissue found on the skin. since they are completely differentiated there is no way for the myocardial tissue can convert to epithelial tissue unless you are talking about the epithelial tissue of the heart, which i doubt.
ECM is completely decellularized, it has no cellular bias as to what it can fix.
What ECM is, is a scaffold for your bodies stem cells and intercellular cells to grow into and create site specific tissue.
The only thing holding back an ECM is denaturing, which brings a slower healing response and encapsulated crosslinking of the fibrils (scar).
Hey thanks for replying. I read on that website today that the ECM is different for different tissue types yet it's composed of basically the same things in all cases. They also appear to be developing different versions of CorMatrix for different applications regarding the heart. So judging by that you'd think that an ECM would have to be developed specifically for skin, as well. But I also came across this on their website:
An estimated 500,000 patients worldwide have been implanted with a manufactured extracellular matrix device for repairs done in all areas of the body.
So that may indicate otherwise. I also found this!
The cells produce new matrix, replacing the implanted patch which is resorbed over time. This leaves remodeled, functional tissue instead of scar tissue or injured tissue.
Sounds pretty good. I may ask them if their ECM can be used for skin. And if their ECM is non-denatured or not. They claim that their ECM provides 100% scarless healing, though, if I understood correctly but I'll ask them anyway.
Hey thanks for replying. I read on that website today that the ECM is different for different tissue types yet it's composed of basically the same things in all cases. They also appear to be developing different versions of CorMatrix for different applications regarding the heart. So judging by that you'd think that an ECM would have to be developed specifically for skin, as well. But I also came across this on their website:
An estimated 500,000 patients worldwide have been implanted with a manufactured (CorMatrix) extracellular matrix device for repairs done in all areas of the body.
So that may indicate otherwise. I also found this!
The cells produce new matrix, replacing the implanted patch which is resorbed over time. This leaves remodeled, functional tissue instead of scar tissue or injured tissue.
Sounds pretty good. I may ask them if their ECM can be used for skin. And if their ECM is non-denatured or not. They claim that their ECM provides 100% scarless healing, though, if I understood correctly but I'll ask them anyway.
thanks in advance...
I may ask them if their ECM can be used for skin. And if their ECM is non-denatured or not. They claim that their ECM provides 100% scarless healing, though, if I understood correctly but I'll ask them anyway.
I just sent the e-mail so maybe/hopefully next week I'll have a reply.
you did deserve the cup this year btw, good game! ur team need's more luck perhaps...
lol I'm not the biggest soccer fan. 
I did see bits of the final and I remember one Dutch "tackle" which resembled a karate kick! lol So I dunno, they got to the final which is good but they could have been better losers, imo. hahaha
No reply yet from the CorMatrix people. I doubt they'll reply so I might call them. In any case I'm also going to call the University of Pittsburgh's McGowan Institute for Regenerative medicine to hopefully get some definate answers here. I think scarless healing can be achieved by using an ECM as has been said many times here and elsewhere. Decorin at 200nm may also be a way to achieve it... I don't know. But it's much, much, much easier to get a doctor to use an ECM than it is to get a doctor to use the decorin at 200nm approach as I think the former is so much more available and known. There are a few ECMs out on the market today and according to E. Middelkoop whom I mentioned earlier none of those are put together in the way that an ECM needs to be in order to achieve 100% scarless healing and we have to wait for one to come along that is put together the right way. Yet e.g. CorMatrix seemingly claims their ECM can do it... And so does OTR3. So I'll look into that and try to get some confirmation.
Btw, I changed my nickname from "I do not have acne" to this new one (which is the name of a gemstone, btw). I thought I'd mention that just so no one gets confused. haha
No reply yet from the CorMatrix people. I doubt they'll reply so I might call them. In any case I'm also going to call the University of Pittsburgh's McGowan Institute for Regenerative medicine to hopefully get some definate answers here. I think scarless healing can achieved by using an ECM as has been said many times here and elsewhere. Decorin at 200nm may also be a way to achieve it... I don't know. But it's much, much, much easier to get a doctor to use an ECM than it is to get a doctor to use the decorin at 200nm approach as I think the former is so much more available and known. There are a few ECMs out on the market today and according to E. Middelkoop whom I mentioned earlier none of those are put together in the way that an ECM needs to be in order to achieve 100% scarless healing and we have to wait for one to come along that is put together the right way. Yet e.g. CorMatrix seemingly claims their ECM can do it... And so does OTR3. So I'll look into that and try to get some confirmation.
Btw, I changed my nickname from "I do not have acne" to this new one (which is the name of a gemstone, btw). I thought I'd mention that just so no one gets confused. haha
Great. Im wishing i'm going to hear good news this time.
I've been looking around for different ECMs which are on the market today and it raised a lot of questions again which I'm going to try to find the answers to by calling some people but I haven't had the time to call anyone yet as I have been too busy. I'll try to make the phone calls in the next week or so.
Looks like its almost herewww . grl-inc.com/Wound_Care. html
www . sirnaomics.com/products. html
For some reason the links I post are not displayed, so you need to delete the blank spaces in the links above.
Wow, it actually says "scarless healing"! They seem to use a different approach. Interesting.
I'll say a bit then about what I'm wondering about. You see, CorMatrix supposedly completely prevents scars from forming in heart tissue. Now, obviously this ECM which is made of porcine material has been developed for the heart, so it is probably safe to say that it is not possible or advised to use it for skin.
But I learned of another currently available ECM the other day which is also made of porcine material which is intended for skin. So I was wondering...suppose it is true that CorMatrix can prevent scars from forming...why couldn't this one as well?
Anyway, here's the ECM I'm referring to:
http://www.oasiswoundmatrix.com/about
Btw, in that list of components of Oasis on their site it says that it contains our old friend decorin.
Personally I'd be more interested in using an ECM than in getting treated with Juvista... I mean Juvista themselves have supposedly said that using their product is not going to result in complete regeneration. And using an ECM just seems so much more effective to me. But I'm not an expert. lol Anyway, as I said before I'm going to try to get some definate answers regarding all of this by contacting certain researchers/doctors. I'd say stay tuned (and positive).
Here's another ECM I came across:
http://www.citagenix.com/en/dynamatrix.html
"The biologic material guides the patients soft tissue to form organized tissue, not scar tissue. This tissue becomes functional, without a foreign substance left behind."
That's a quote from their site. That reminds me... Earlier I said that I didn't want to get treated with e.g. ACell as it is made from porcine material but I changed my mind when I learned that eventually the ECM gets replaced completely with your body's own cells.
I'll say a bit then about what I'm wondering about. You see, CorMatrix supposedly completely prevents scars from forming in heart tissue. Now, obviously this ECM which is made of porcine material has been developed for the heart, so it is probably safe to say that it is not possible or advised to use it for skin.
But I learned of another currently available ECM the other day which is also made of porcine material which is intended for skin. So I was wondering...suppose it is true that CorMatrix can prevent scars from forming...why couldn't this one as well?
Anyway, here's the ECM I'm referring to:
http://www.oasiswoundmatrix.com/about
Btw, in that list of components of Oasis on their site it says that it contains our old friend decorin.
Personally I'd be more interested in using an ECM than in getting treated with Juvista... I mean Juvista themselves have supposedly said that using their product is not going to result in complete regeneration. And using an ECM just seems so much more effective to me. But I'm not an expert. lol Anyway, as I said before I'm going to try to get some definate answers regarding all of this by contacting certain researchers/doctors. I'd say stay tuned (and positive).
Lapis lazuli,
Appreciate all the time and effort you've put into this. I believe we discussed Oasis on this thread a while back and the conclusion was that it is inferior to ACell. Oasis were the ones who prevented ACell from releasing their product for years due to litigation.
Lapis lazuli,
Appreciate all the time and effort you've put into this. I believe we discussed Oasis on this thread a while back and the conclusion was that it is inferior to ACell. Oasis were the ones who prevented ACell from releasing their product for years due to litigation.
Ah, you're right. I did a search just now and I saw that it was discussed in a time when I didn't read this thread yet. Thanks for the heads up, FT.
You guys ever check out the threads about acell treatments on there site? I looked at there wound healing pictures and some aren't that great. wonder why?
Actually I haven't. I haven't seen any threads on ACell's site. I have, however, seen a photo in an ACell brochure which didn't look all that great the other day. I'll see if I can post a link later on. In that brochure, btw, it said that ACell doesn't regenerate skin but just creates a new scar which looks more like normal skin. Contrary to what they claim on their site, if I understood correctly. Weird. Anyway, if I find a link to that brochure I'll post it.
would you say there is hope? Right now i am at rock bottom, been dealing with these scars for 6 years now, feels like i am living in a horrific dream that just wont end. I did an acid peel on my cheeks and that made my skin all white and rough and dry, along with the actual acne scars i have.
Hey guys,
maybe you want some new studies. 😉 Here we go!
http://www.nature.com/news/2010/100805/ful...s.2010.392.html
A brand new nature article, for those who believe in limb regeneration.
I wish you all a good sunday.
NEO
would you say there is hope? Right now i am at rock bottom, been dealing with these scars for 6 years now, feels like i am living in a horrific dream that just wont end. I did an acid peel on my cheeks and that made my skin all white and rough and dry, along with the actual acne scars i have.
hard to say if we will ever have scarless healing, I'm sure it won't happen anytime soon.