Acne.org Products
I spoke to DutchForm today and the person I spoke to said that she couldn't inform me about the current status of scarless healing but she was going to look around to find the person who could. So that I would be on the right track, she said. Anyway, she will send me an e-mail next week.
There is artificial recombinant decorin from various sources if you type it in google. I do not know if they'd sell it to you saying you do not work in a lab, I'm assuming, and I also do not know were you'd get a Dr to use it on you.
I found a hospital that says it wants to try new things. So who knows, maybe they'd consider using this approach.
I'll keep you updated.
Any of you lot seen this, Xiaflex.
It breaks down scar tissue in a rapid and aggressive fashion.
Xiaflex
has been shown to release the contracted cords of Duputryenas within a day after injection. Xiaflex is a collagenase enzyme derived from the clostridium histolyticum bacteria. It breaks down scar tissue in a rapid and aggressive fashion.
Any of you lot seen this, Xiaflex.
It breaks down scar tissue in a rapid and aggressive fashion.
Xiaflex
has been shown to release the contracted cords of Duputryenas within a day after injection. Xiaflex is a collagenase enzyme derived from the clostridium histolyticum bacteria. It breaks down scar tissue in a rapid and aggressive fashion.
That is not for scarless healing, that only destroy fribrosys.
Don't mix the thing. 1 thing is destroy fribrosys, like do 'kitoscell' or ensymes in pills, or xiaflex.
and other thing is a droug can regenerate skin like tgf b3 or juvista.
if you only destroy fibrosys, you only give a hole un your skin, nothing else. thats why i say 'decorin' only regulate fibrosys, path we need regenerate power like tgf b3.
Any of you lot seen this, Xiaflex.
It breaks down scar tissue in a rapid and aggressive fashion.
Xiaflex
has been shown to release the contracted cords of Duputryen‚„s within a day after injection. Xiaflex is a collagenase enzyme derived from the clostridium histolyticum bacteria. It breaks down scar tissue in a rapid and aggressive fashion.
That is not for scarless healing, that only destroy fribrosys.
Don't mix the thing. 1 thing is destroy fribrosys, like do 'kitoscell' or ensymes in pills, or xiaflex.
and other thing is a droug can regenerate skin like tgf b3 or juvista.
if you only destroy fibrosys, you only give a hole un your skin, nothing else. thats why i say 'decorin' only regulate fibrosys, path we need regenerate power like tgf b3.
cool product but also sounds very scary. i can imagine it leaving a hole too. if anyone wants to be a test bunny and give it a go, you're more than welcome 
Yes, and I think 'juvista' is gonna be on sale , by 2015, 2016 unfurtenly.
One time an user in this topic say, that scientist say in a conference 'juvista works in only a 30 % of all people'
I don't know why this, path is very dissappointed.
Hey Eterna, what do you think about OTR3's RGTA which I mentioned a lot a few pages back?
Yes, and I think 'juvista' is gonna be on sale , by 2015, 2016 unfurtenly.
One time an user in this topic say, that scientist say in a conference 'juvista works in only a 30 % of all people'
I don't know why this, path is very dissappointed.
Hey Eterna, what do you think about OTR3's RGTA which I mentioned a lot a few pages back?
Hi, I think is some like acell, path I don't see any pic about regeneration whit this product.
Maybe is more like 'Apligraf' ,incredibly Apligraf is for sale and was the only product that gave a scarless healing. (1 pic say that).
I think everything deserves a chance, but those products are out of the abyss and start acting, either with evidence or pictures.
Expect to see a light in these years.
Any of you lot seen this, Xiaflex.
It breaks down scar tissue in a rapid and aggressive fashion.
Xiaflex
has been shown to release the contracted cords of Duputryenas within a day after injection. Xiaflex is a collagenase enzyme derived from the clostridium histolyticum bacteria. It breaks down scar tissue in a rapid and aggressive fashion.
That is not for scarless healing, that only destroy fribrosys.
Don't mix the thing. 1 thing is destroy fribrosys, like do 'kitoscell' or ensymes in pills, or xiaflex.
and other thing is a droug can regenerate skin like tgf b3 or juvista.
if you only destroy fibrosys, you only give a hole un your skin, nothing else. thats why i say 'decorin' only regulate fibrosys, path we need regenerate power like tgf b3.
No you are wrong, scarring and regeneration are linked, scarring is a wall that stops regeneration, it blocks off (denatures) the ECM fibrils.
'regeneration/scarring'
An example for you, look at your unscarred skin, the reason you are unscarred is because you do not have an adhesive fibrotic 'wall' blocking off the fibrils in your ECM inturn which would block off regeneration.
Our bodies are the only thing that knows how to regenerate 'not humans,' the only thing humans can do is stop the scar wall.
Humans can never ever get to understand or beat what our bodies can do at the microscopic detail.
Our stem cells and 'non denatured ECM,' know the exact factors that are needed at the precise approximate time and at the precise micoscopic detail, they switch on and off factors at appropriate times in one part of the wound while switching them on at another microscopic part of the wound, they have been doing this for millions and millions of years.
Our stem cells and intercellular cells know what they are doing, it is very simple for them on a microscopic level when they do not have scarred fibrils.
Something recent for you guys.
http://www.sciencedaily.com/releases/2010/...00610154459.htm
Good information, unfortunately enjoyed solutions based on these recent discoveries our grandchildrens.
I've received a reply from DutchForm, everybody. They gave me an e-mail adress of a scientist who's expertise is skin regeneration and who's currently doing research.
I've learned that he's currently working on a skin stretching technique. Here's a description from a website:
Evaluating the skin stretching technique for acute burn wounds and scar reconstructions; Clarify working mechanisms of skin stretching. Anticipated result: Acute burn wounds and scar reconstruction wounds may heal as small (linear) scars in a one-step procedure by skin stretching. Consequently, complications of scarring will be reduced considerably and less reconstructive procedures may be necessary. The results of the experimental study may improve the understanding of the working mechanisms of the technique.
The fact that he's working on this obviously means that he's either unaware of the way in which scarless healing can be achieved or he believes there is no way at the moment to achieve it.
I'll send him an e-mail soon so stay tuned to hear what his reply was.
Something recent for you guys.
http://www.sciencedaily.com/releases/2010/...00610154459.htm
I really appreciate you posting this but I can't be excited about the article. I mean these things pop up all the time and if it were true that they discovered what it says they did in all of the ones I've read then we probably wouldn't be posting in this thread. lol We'd be scarless instead.
I've gotten a reply and he turned out to be a she. haha Anyway, I asked her in my e-mail yesterday about the possibility of scarless healing. About what she thought of the possibility of keeping the decorin level up in fresh wounds in order to stop a scar from forming and about using an ECM in order to have the wound heal up in the best way possible...and here's what she said in her reply.
By using an ECM (or scaffold or dermis replacer as it's also called) in general an improvement is achieved, aesthetically. Which has been proven scientifically. Scarless healing is not yet being achieved by this.
Whether or not you'll see an improvement depends on a great number of things. Of which the depth of the wound and possible complications such as an infection are the foremost ones.
Then I think she made a reference to Juvista as she said that apart from using an ECM there's also the possiblity of using growth factors to stop the formation of scars. However this was still being researched and not yet available as a commercial product...
If an excision and the subsequent application/usage of an ECM would be an option for me she couldn't say without first having seen me in person. Other options, she said, could be smoothing out the surface with a special technique, techniques which apply pressure through the use of silicones and other things but it all depended on what my unique problem was like.
At the end of e-mail she then said that if I wanted to, I could come over and a team of surgeons would all look at me and together decide what would be my options.
In any case, that's what her reply was... I might reply to her and ask again about the decorin as she hasn't really said anything about that.
Next up: MIRA and a dermatologist from Amsterdam. Stay tuned...
Hey guys,
what's up?
I know i have been missing a lot of the discussion here in the last weeks, but now I want to bring you new informations:
"RegeneRx is focused on the development of a novel therapeutic peptide, Thymosin beta 4, or TB4, for tissue and organ protection, repair and regeneration. Currently, RegeneRx has formulated three product candidates in clinical development: RGN-137, a topically applied gel for chronic dermal wounds and reduction of scar tissue that is currently in a Phase 2 clinical trial for the treatment of epidermolysis bullosa"
SOme new drug.
http://www.wired.com/dangerroom/2010/05/ex...-trials-rushed/
The most important post. Pentagon is pushing regenerative therapies to get to the end in the next 2 years. *g*
SO guys. Go on looking for therapies. No scientist knows everything. All are specialists. So don't give up.
Greets
edit: something from mid 2009
http://www.wired.com/dangerroom/2009/03/darpa-muscle-re/
Blastema realized. 😉
Here's something I found from 2001 regarding decorin:
http://www.ncbi.nlm.nih.gov/pubmed/11685698
It concludes that "Increased decorin expression is associated with both skin development and scar formation. Conversely, decreased decorin expression is associated with scarless repair".
I also came across this ten year old book regarding scarless wound healing:
http://www.amazon.com/Scarless-Wound-Heali...y/dp/0824702859
It mentions decorin too. Could be an interesting read.
Anyway, I'm gonna e-mail MIRA today and ask them what they're developing, to what extent it can help us and when it will be available to us.
Great find Lavish.