Acne.org Products
Someone needs to obtain some acell powder or find a way to grind the sheets into powder and then cut out a scar(test on leg or chest or something) and apply every 2 days. Then report back to this forum. Acell is touted for it's ability to produce normal regenerated tissue where scar tissue would form otherwise. That's it's job. Let's find out if it can do its job. Who here can get some of acell's product known as "matristem?" If you can't get it in powdered form then we need to find a way to powderize it ourselves. Let's get shit done guys. I'm so sick of the way we've been treated by science. Let's be ridiculously proactive and get what we want or make life like hell for surgeons and scientists everywhere by annoying the shit out of them.
Someone needs to obtain some acell powder or find a way to grind the sheets into powder and then cut out a scar(test on leg or chest or something) and apply every 2 days. Then report back to this forum. Acell is touted for it's ability to produce normal regenerated tissue where scar tissue would form otherwise. That's it's job. Let's find out if it can do its job. Who here can get some of acell's product known as "matristem?" If you can't get it in powdered form then we need to find a way to powderize it ourselves. Let's get shit done guys. I'm so sick of the way we've been treated by science. Let's be ridiculously proactive and get what we want or make life like hell for surgeons and scientists everywhere by annoying the shit out of them.
Acell is not work for anything, is only marketing (i hope juvista not the same thing).
Someone needs to obtain some acell powder or find a way to grind the sheets into powder and then cut out a scar(test on leg or chest or something) and apply every 2 days. Then report back to this forum. Acell is touted for it's ability to produce normal regenerated tissue where scar tissue would form otherwise. That's it's job. Let's find out if it can do its job. Who here can get some of acell's product known as "matristem?" If you can't get it in powdered form then we need to find a way to powderize it ourselves. Let's get shit done guys. I'm so sick of the way we've been treated by science. Let's be ridiculously proactive and get what we want or make life like hell for surgeons and scientists everywhere by annoying the shit out of them.
Well said whadup. I share the sentiment merely because to my knowledge scar free healing is cited. I'm with you as who says anyone has a final say above free thinking just because of a title?
BTW I'm not to sure of acell as in some of the photos this ECM looks like it brings denatured fibrotic encapsulation to the fibrils.
Acell is not work for anything, is only marketing (i hope juvista not the same thing).
some time back i saw a picture of a scar treated with juvista. it was in one of their presentations i think. i really wasnt impressed. there definitely was some improvement but not as much as i had hoped for. i really dont think juvista is the answer for complete resolution, but i think it will help.
personally, none of these treatments would be practical in my case at all. i literally have stretch marks over my entire body. you really cant count them as there are thousands, some big, some small, far too many to count. a treatment involving injections is out of the question as for me it would be very time consuming and extremely expensive im guessing. excising the scarred skin and then using some matrix to help the skin heal itself better is also out of the question for me as you would have to remove huge amounts of skin.
personally i think my only options would be a cream/lotion or some form of oral medication.
I know juvista only 'help', it's not the answer i know that.
i'm only say, is the only we have. what other thing is a promise? i only see juvista in a couple of years, exc001....and nothing else
juvista in my opinion reduces 20% a scar (and that is great, because is the only we have)
unfortunate i don't think that a solution for us. maybe in the next 200 years? unfortunate to late for us.
the only hope we have is, some day read a news 'scientis discover a new drog anti scar' path, we must wait 30 years of tests , etc.
Scar free healing has been done, cited.no.
some people healing betther than others...some people healing so fine like a embryon.
maybe that woman (in the photo you say seabs) whit apligraf , well she have a very big power of healing.
Seabs, this is very complicated.
It has been done cited. Scar free healing is past tense.
Decorin at 200mn stops fibroblasts (fibroblasts lay down excess collagen) from over expressing collagen (scar) this leaves the tissues with one option which is to regenerate. On top of this we've seen scar free healing, Atala done scar free healing over ten year ago,P21, doctors talked about seeing scar free yealing over ten years ago etc. etc.
Scar free healing has been done, cited.no.
some people healing betther than others...some people healing so fine like a embryon.
maybe that woman (in the photo you say seabs) whit apligraf , well she have a very big power of healing.
Seabs, this is very complicated.
It has been done cited. Scar free healing is past tense.
Decorin at 200mn stops fibroblasts (fibroblasts lay down excess collagen) from over expressing collagen (scar) this leaves the tissues with one option which is to regenerate. On top of this we've seen scar free healing, Atala done scar free healing over ten year ago,P21, doctors talked about seeing scar free yealing over ten years ago etc. etc.
It is simple
If some doctor found or have the 'solution', why is not for sale? the day when a doctor found the real solution for scars, believe me it's gonna be millionare.
This is not what any of us want to hear but accounting for the time it takes for research & development, various clinical trials, commercialisation/distribution arrangements and official approval from authorities, we are about 10 years away from any type of product that could potentially eliminate or dramatically reduce scarring (I'm talking at least 75% reduction). That time period is probably a rather optimistic figure as well. It's more likely to be about 15-20 years.
Renovo's Juvista, in my eyes, is a very limited and ineffective product when it comes scar reduction. The before and after pictures really are not impressive at all. And the success rate amongst the patients on clinical trials is pretty poor. The clinical trial data of the drug states that only approx. 30% of users experienced a 'good' improvement in their scarring ('Good' is defined as a scar appearing to be 30%-35% better than the control). Another 30% or so of users experienced low-moderate improvement (which means that the scar appeared only 'slightly' better than the control). The remaining 40% of users experienced no improvement in their scarring whatsoever (NOTE: all this figures are from memory so they may be slightly different). Renovo are looking to charge between $250-$500 (Botox prices) for what appears to be a rather ineffective treatment.
If you look back through the earlier posts in this thread you will find that I had high hopes for Juvista but now I have realised that it is useless. On a positive note, at least it is a little step towards scar-free healing at least.
As for A-cell, I am now absolutely unconvinced by it. There has been plenty of time to release some before and after photos of scar revision using this product to prove its effectiveness but we've seen nothing. What's stranger is that it is apparently available to the US public on prescription for at least a year and a half now and yet no one has tried it!
Basically, we are a long long way off being able to use a drug to prevent/remove scarring. That is not to say there aren't/won't be any products that can help diminish or hide our scarring, especially since drugs that require repurchasing/reusing are more profitable than ones that provide immediate cures.
I don't want to be a doomsayer, but we do need to be realistic.
This is not what any of us want to hear but accounting for the time it takes for research & development, various clinical trials, commercialisation/distribution arrangements and official approval from authorities, we are about 10 years away from any type of product that could potentially eliminate or dramatically reduce scarring (I'm talking at least 75% reduction). That time period is probably a rather optimistic figure as well. It's more likely to be about 15-20 years.
Renovo's Juvista, in my eyes, is a very limited and ineffective product when it comes scar reduction. The before and after pictures really are not impressive at all. And the success rate amongst the patients on clinical trials is pretty poor. The clinical trial data of the drug states that only approx. 30% of users experienced a 'good' improvement in their scarring ('Good' is defined as a scar appearing to be 30%-35% better than the control). Another 30% or so of users experienced low-moderate improvement (which means that the scar appeared only 'slightly' better than the control). The remaining 40% of users experienced no improvement in their scarring whatsoever (NOTE: all this figures are from memory so they may be slightly different). Renovo are looking to charge between $250-$500 (Botox prices) for what appears to be a rather ineffective treatment.
If you look back through the earlier posts in this thread you will find that I had high hopes for Juvista but now I have realised that it is useless. On a positive note, at least it is a little step towards scar-free healing at least.
As for A-cell, I am now absolutely unconvinced by it. There has been plenty of time to release some before and after photos of scar revision using this product to prove its effectiveness but we've seen nothing. What's stranger is that it is apparently available to the US public on prescription for at least a year and a half now and yet no one has tried it!
Basically, we are a long long way off being able to use a drug to prevent/remove scarring. That is not to say there aren't/won't be any products that can help diminish or hide our scarring, especially since drugs that require repurchasing/reusing are more profitable than ones that provide immediate cures.
I don't want to be a doomsayer, but we do need to be realistic.
What is your opinion about exc001? do you investigated?
If juvista reduce a scar in 20 % after a scar revision, we can do 3 revision scar on the same scar each 1 year, and after 3 years we have 60 % reduction.
I hope we can do that, i don't know if juvista works that, in teory yes.
If juvista reduce a scar in 20 % after a scar revision, we can do 3 revision scar on the same scar each 1 year, and after 3 years we have 60 % reduction.
Yes, Eterna_maldicion, continuously excising the scar tissue and injecting juvista into the dermis each year until the scar has completely disappeared would be ideal. This would probably be the most effective way to use the drug. I, too, am hoping this will prove successful. However, I can't really say whether this approach will work or not as the clinical trials have only looked at the drug's effectiveness when performing scar revision on a scar once, rather than repeatedly.
sorry neca but that is a really negative posthow do you know there isnt something already in the making?
or other treatments?
I know the outlook appears negative; believe me, I hate acknowledging how long we are away from finding a 'cure'. But it is based on the reasons outlined in my post (eg length of time for R&D, trials, approval etc.) as well as the various contacts I spoken to in the medical field, both surgical and academic.
How do I know there isn't something already in the making? Well, as I indicated in my post, it's not the lack of treatments available that is the problem, it is the effectiveness of these treatments that is the issue. R&D is an iterative process; a cure isn't just instantly released, it takes time as current products are slowly 'upgraded'. So what is being developed now will reduce your scars by 20-30% (assuming you are one of the lucky few that the drug works on) yet we will only experience such results in 2-3 years when the product is officially released. By that time, another product will undergo R&D and we will get to use in 4-6 years from now....and so on. Eventually the drug(s) will reach a point of peak effectiveness where we can say it will work on 90%+ of users and they will experience almost complete removal of their scars permanently...thus a cure will be reached. That time is a long way off from now.
Take for example, Prof. Mark Ferguson, the guy who invented Juvista and started Renovo. He discovered the theory behind the drug over 20 years ago in the late 1980s. He founded Renovo in 2000 and now in 2010 the company still doesn't have a commercial product yet. It has taken all that time to get near to producing a drug that provides only 30% scar improvement in ONLY 30% of users. So you can see it takes a LOT of time for only very little gain.
In the meantime, we can at least be grateful that the field of regenerative medicine is receiving huge inflows of funds, thus the quality of the R&D should be excellent. In addition, with the advances in technology and the internet, development time may speed up. Pressure from celebrities to look 'perfect' that will spill over to the public as well should also increase demand for a proper 'cure'.
All is not negative!
Scar free healing has been done, cited.no.
some people healing betther than others...some people healing so fine like a embryon.
maybe that woman (in the photo you say seabs) whit apligraf , well she have a very big power of healing.
Seabs, this is very complicated.
It has been done cited. Scar free healing is past tense.
Decorin at 200mn stops fibroblasts (fibroblasts lay down excess collagen) from over expressing collagen (scar) this leaves the tissues with one option which is to regenerate. On top of this we've seen scar free healing, Atala done scar free healing over ten year ago,P21, doctors talked about seeing scar free yealing over ten years ago etc. etc.
It is simple
If some doctor found or have the 'solution', why is not for sale? the day when a doctor found the real solution for scars, believe me it's gonna be millionare.
Development and scar fre heling are not logically connected. E.g. I could design a flying car, but it may not be developed.
I go on facts. Fact scar free healing has been done. cited. I say this with confidence. Because it is cited. Decorin at 200nm stops fibroblast proliferation, which means your tiussues only have two routes left, regeneration or a diabetic ulcer scenario. Now you can also rule the diabetic ulcer scenario logically out by the fact that our bodies are flooded with decorin. And we dont usually spontaneously stop regenerating when our bodies have decorin. In fact it is known when our bodies have less decorin than normal our tissues produce fibrosis. As you can see now there is only one route left which is regeneration.
I'm only going to discuss facts: scar free healing has been done. And that is a fact.
This is not what any of us want to hear but accounting for the time it takes for research & development, various clinical trials, commercialisation/distribution arrangements and official approval from authorities, we are about 10 years away from any type of product that could potentially eliminate or dramatically reduce scarring (I'm talking at least 75% reduction). That time period is probably a rather optimistic figure as well. It's more likely to be about 15-20 years.
The same shit was said ten years ago, when they were 'developing.' They get the average person to think on future tense of developing, then when they get this they own the perception of precedents. In fact somewhere in my researching I came across someone completely different to those mentioned in your post, in 1997 this guy said [i'm paraphrasing], "scar free healing would be here in 5 year," he is now plugging another drug in 2010 he wants developed to the next generation after most of the previous generation became apathetic.
I'm factual, scar free healing has been done, at the same time things are being developed that do not bring scar free healing.
This is not what any of us want to hear but accounting for the time it takes for research & development, various clinical trials, commercialisation/distribution arrangements and official approval from authorities, we are about 10 years away from any type of product that could potentially eliminate or dramatically reduce scarring (I'm talking at least 75% reduction). That time period is probably a rather optimistic figure as well. It's more likely to be about 15-20 years.
The same shit was said ten years ago, when they were 'developing.' They get the average person to think on future tense of developing, then when they get this they own the perception of precedents. In fact somewhere in my researching I came across someone completely different to those mentioned in your post, in 1997 this guy said [i'm paraphrasing], "scar free healing would be here in 5 year," he is now plugging another drug in 2010 he wants developed to the next generation after most of the previous generation became apathetic.
I'm factual, scar free healing has been done, at the same time things are being developed that do not bring scar free healing.
Yes, and by the 2020 sure is some news 'scar free is here' and the years happens and nothing work.
Hi everyone. I just thought I'd post this to tell you all what I'm up to. I haven't been able to do any research as things have been very hectic again in my life but here's what I'm going to do as soon as I can; I'm going to contact DutchForm. An organisation which has united 20 Dutch hospitals/universities/companies to all work together on making new regenerative treatments real and available to people. Next to that I'm going to call MIRA from the university of Twente who state without ambiguity on their website that their research will result in new techniques to repair damaged skin. Other than that, I'm going to call a dermatologist and/or a plastic surgeon, probably from a hospital in Amsterdam and inquire about all of this. So in due time I'll report back here to say what I learned from talking to all these people.
Hi everyone. I just thought I'd post this to tell you all what I'm up to. I haven't been able to do any research as things have been very hectic again in my life but here's what I'm going to do as soon as I can; I'm going to contact DutchForm. An organisation which has united 20 Dutch hospitals/universities/companies to all work together on making new regenerative treatments real and available to people. Next to that I'm going to call MIRA from the university of Twente who state without ambiguity on their website that their research will result in new techniques to repair damaged skin. Other than that, I'm going to call a dermatologist and/or a plastic surgeon, probably from a hospital in Amsterdam and inquire about all of this. So in due time I'll report back here to say what I learned from talking to all these people.
Hello.
I hope you found a really good answer, all the best.
Scar free healing has been done, cited.no.
some people healing betther than others...some people healing so fine like a embryon.
maybe that woman (in the photo you say seabs) whit apligraf , well she have a very big power of healing.
Seabs, this is very complicated.
Decorin at 200mn stops fibroblasts (fibroblasts lay down excess collagen) from over expressing collagen (scar) this leaves the tissues with one option which is to regenerate.
Where can I get this Decorin? LOL!
Scar free healing has been done, cited.no.
some people healing betther than others...some people healing so fine like a embryon.
maybe that woman (in the photo you say seabs) whit apligraf , well she have a very big power of healing.
Seabs, this is very complicated.
Decorin at 200mn stops fibroblasts (fibroblasts lay down excess collagen) from over expressing collagen (scar) this leaves the tissues with one option which is to regenerate.
Where can I get this Decorin? LOL!
It is not available.
I sound like a broken record here, in future I should use a cut and paste. 
There is artificial recombinant decorin from various sources if you type it in google. I do not know if they'd sell it to you saying you do not work in a lab, I'm assuming, and I also do not know were you'd get a Dr to use it on you.
this artificial decorin at a certain Nm suppressed scarring in spinal cords by 90%
If you research scarring you will see that a scar forms when the fibroblasts over proliferate and lay down excess collagen (scar). Decorin at 200nm has completely arrested fibroblast proliferation, and at the same time the normal tissues did not suffer massive apoptosis. This is a logical connection that decorin brings scar free healing IMO.
Also to collaborate with this cite above when you are injured your decorin levels become virtually non existant, and over the next twelve months your body builds an adhesive (a scar), at the same time as this it take 12month+ for the decorin levels to get back to normal after injury.
I sound like a broken record here, in future I should use a cut and paste.
I appreciate the repeated info. Sometimes in a long thread, even when the answers are right in front of you; you still intend to reply to a poster. Also sometimes you want to talk to a person, not necessary search the "libraries" of google all the time!
I am sure with great expense this may be experimented for acne scaring. But even very wealthy people would struggle to organize and convince a medical team to work on their faces! Interesting to note that internal scarring is very troublesome, and I am sure the similar techniques would work for external scarring.