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I really don't have the time to read this lovely 106 page long post, okay maybe I do since I'm not working or anything, but anyway... I'm becoming really impatient on indented acne scar treatments! Does anyone have a clue how close/far we are to finding something that actually works? 
If thats you in the pic, then a shrink would do wonders, I hear some run cheap now, because of all the unemployment. But if that fails, then im sorry to say that even if anything real comes out of the current research, it would take a long time for it to reach any of us.
If thats you in the pic, then a shrink would do wonders, I hear some run cheap now, because of all the unemployment. But if that fails, then im sorry to say that even if anything real comes out of the current research, it would take a long time for it to reach any of us.
Lol, she really is beautiful isnt she? 
But that doesn't mean that she doesn't have scarring. Make up and the lighting could be hiding her scars.
I use lighting techniques in my pictures all the time to hide the scars. 
Here's something I found from 2001 regarding decorin:
http://www.ncbi.nlm.nih.gov/pubmed/11685698
It concludes that "Increased decorin expression is associated with both skin development and scar formation. Conversely, decreased decorin expression is associated with scarless repair".
I've read that cite too.
From reading it a reader could assume scar free healing is solely the result of embronic regeneration, but this is wrong. 'Your unscarred adult tissues that are flooded with decorin also do not scar.'
Also leading to an impression that scar free healing is a result of decreaasing decorin, they also twist so that it sounds as if decorin levels are down in the embryonic tissue after wounding in embryonic scar free healing when in fact the decorin is actually 'up after wounding' when compared to adult skin (I think they mention it decreases 42% after wounding) (making it sound like decorin decrease is what keeps the tissues scar free), at the same time completely forgetting to note that in adult fresh wound decorin levels are 'non existant.' Therefor if you read between the lines this does not show decorin decrease is a factor involved in scar free healing.
(In embronic new fresh wounds that cite says the decorin level is to levels 41% to 58%; however it ddoes not point out that in adult fresh wounds it is virtually 0%. It takes days for decorin levels to go to normal in embroynic embryos, it takes at least 12month in adult tissue, by that time the scar has formed)
I'm sure a year later, or even that year, someone called produced scar free healing with decorin. etc. etc
I really don't have the time to read this lovely 106 page long post, okay maybe I do since I'm not working or anything, but anyway... I'm becoming really impatient on indented acne scar treatments! Does anyone have a clue how close/far we are to finding something that actually works?
I agree with the other people here who say you're gorgeous! haha 
In any case, one product will possibly come out in 2014... But it may be postponed again. 
And it's probably not going to work for everyone to the same degree. Then there's another thing that appears to be being developed as we speak but that's all kind of vague. I should know more about that in the next week or so... So I'll keep you updated on that.
I don't know exactly how close we are. But I hope to find out soon enough as I'm looking into things a lot.
I've read that cite too.
From reading it a reader could assume scar free healing is solely the result of embronic regeneration, but this is wrong. 'Your unscarred adult tissues that are flooded with decorin also do not scar.'
Also leading to an impression that scar free healing is a result of decreaasing decorin, they also twist so that it sounds as if decorin levels are down in the embryonic tissue after wounding in embryonic scar free healing when in fact the decorin is actually 'up after wounding' when compared to adult skin (I think they mention it decreases 42% after wounding) (making it sound like decorin decrease is what keeps the tissues scar free), at the same time completely forgetting to note that in adult fresh wound decorin levels are 'non existant.' Therefor if you read between the lines this does not show decorin decrease is a factor involved in scar free healing.
(In embronic new fresh wounds that cite says the decorin level is to levels 41% to 58%; however it ddoes not point out that in adult fresh wounds it is virtually 0%. It takes days for decorin levels to go to normal in embroynic embryos, it takes at least 12month in adult tissue, by that time the scar has formed)
I'm sure a year later, or even that year, someone called produced scar free healing with decorin. etc. etc
Hmmm, interesting.
Here's something else I found whilst surfing the other day. lol
http://boards.straightdope.com/sdmb/showthread.php?t=519846
Somebody mentioned scarless healing and subsequently a "certified pathologist" said that it was unlikely that it was real at that very time as medicine would never deny the existence of it. If I remember correctly it's from 2009. I'm not making any point by posting this I just thought it was interesting.
Anyway, no reply from MIRA yet, everyone. Maybe (or hopefully) I'll get one in the next few days...
If thats you in the pic, then a shrink would do wonders, I hear some run cheap now, because of all the unemployment. But if that fails, then im sorry to say that even if anything real comes out of the current research, it would take a long time for it to reach any of us.
Lol, she really is beautiful isnt she?
But that doesn't mean that she doesn't have scarring. Make up and the lighting could be hiding her scars.
I use lighting techniques in my pictures all the time to hide the scars.
Scars4Life, thanks for that indirected what I'll take as a compliment. I will be honest and say I do have a psychologist. But unfortunately talking to him doesn't help heal my scarring : ) lol
Fraz, yeah it's amazing what make up and the right lighting can do! But that picture was also taken 5 months ago. Thanks for the compliment by the way 
In any case, one product will possibly come out in 2014... But it may be postponed again.
I don't know exactly how close we are. But I hope to find out soon enough as I'm looking into things a lot.
Ugh, that is a very long time to wait. Please do keep us updated 
What do y'all think thus far is the most effective on scarring? I'm thinking TCA Cross but unfortunately that only truly works on icepick scars.
sapphire, that was fraz complementing you and not scars4life, lol. fraz is always nice though, whats not to love. im not too sure what works on "other kinds of scarring". i know if i had rolling scars, id so go for the permanent fillers. but i love an easy way out. other than that, probably rolling.
sapphire, that was fraz complementing you and not scars4life, lol. fraz is always nice though, whats not to love. im not too sure what works on "other kinds of scarring". i know if i had rolling scars, id so go for the permanent fillers. but i love an easy way out. other than that, probably rolling.
Haha, aww shucks, i'm not that nice.
Yeah, I know what you mean about wanting an easy way out.
Can you get perminant fillers? I thought they all only lasted a certain amount of time.
Would be great to plump up these scars permanently!
sapphire, that was fraz complementing you and not scars4life, lol. fraz is always nice though, whats not to love. im not too sure what works on "other kinds of scarring". i know if i had rolling scars, id so go for the permanent fillers. but i love an easy way out. other than that, probably rolling.
Haha, aww shucks, i'm not that nice.
Yeah, I know what you mean about wanting an easy way out.
Can you get perminant fillers? I thought they all only lasted a certain amount of time.
Would be great to plump up these scars permanently!
u are, ur always spreading nice words around these boards. hmm i think the permanent ones last forever. i remember reading they were still in peoples faces nine years out from the procedure. people fear they move around over time, or stay the same shape, whilst the face ages around it making the places where its done look funny.
i wouldnt mind getting it done if i had rolling scars. i just wish theyd invent something that destroys the substance if needed in the future - esp if something better comes along. from my understanding u need to get it cut out if you want them out again...scary !
sapphire, that was fraz complementing you and not scars4life, lol. fraz is always nice though, whats not to love. im not too sure what works on "other kinds of scarring". i know if i had rolling scars, id so go for the permanent fillers. but i love an easy way out. other than that, probably rolling.
Haha, aww shucks, i'm not that nice.
Yeah, I know what you mean about wanting an easy way out.
Can you get perminant fillers? I thought they all only lasted a certain amount of time.
Would be great to plump up these scars permanently!
u are, ur always spreading nice words around these boards. hmm i think the permanent ones last forever. i remember reading they were still in peoples faces nine years out from the procedure. people fear they move around over time, or stay the same shape, whilst the face ages around it making the places where its done look funny.
i wouldnt mind getting it done if i had rolling scars. i just wish theyd invent something that destroys the substance if needed in the future - esp if something better comes along. from my understanding u need to get it cut out if you want them out again...scary !
Damn!.... That is scary! 
I read up some reviews and most people were unhappy about the results, so I think I would give the silicone injections a miss.
I've read that cite too.
From reading it a reader could assume scar free healing is solely the result of embronic regeneration, but this is wrong. 'Your unscarred adult tissues that are flooded with decorin also do not scar.'
Also leading to an impression that scar free healing is a result of decreaasing decorin, they also twist so that it sounds as if decorin levels are down in the embryonic tissue after wounding in embryonic scar free healing when in fact the decorin is actually 'up after wounding' when compared to adult skin (I think they mention it decreases 42% after wounding) (making it sound like decorin decrease is what keeps the tissues scar free), at the same time completely forgetting to note that in adult fresh wound decorin levels are 'non existant.' Therefor if you read between the lines this does not show decorin decrease is a factor involved in scar free healing.
(In embronic new fresh wounds that cite says the decorin level is to levels 41% to 58%; however it ddoes not point out that in adult fresh wounds it is virtually 0%. It takes days for decorin levels to go to normal in embroynic embryos, it takes at least 12month in adult tissue, by that time the scar has formed)
I'm sure a year later, or even that year, someone called produced scar free healing with decorin. etc. etc
Hmmm, interesting.
Here's something else I found whilst surfing the other day. lol
http://boards.straightdope.com/sdmb/showthread.php?t=519846
Somebody mentioned scarless healing and subsequently a "certified pathologist" said that it was unlikely that it was real at that very time as medicine would never deny the existence of it. If I remember correctly it's from 2009. I'm not making any point by posting this I just thought it was interesting.
Anyway, no reply from MIRA yet, everyone. Maybe (or hopefully) I'll get one in the next few days...
Without using the word of authority ('appealing to authority') or pointing to someone in a whitecoat who is developing something for the future, you can see scar free healing has been done scientifically. Also they cant deny the existance of it.
Decorin at 200nm (suppressing inflammationetc. ect. stopping contraction of ECM ect. ) which stops the fibroblasts from laying down thick collagen bundles on your fibrils (scar), at the same time when this is done (suppression of the scar) your normal tissues do not suffer massive apoptosis which enables your intercellular cells and stem cells to continue to regenerate.
I haven't posted here for awhile already, haven't had time to read through the past posts. But let me guess, we are still at square one?
Excuse me, but sometimes I think my life is one complete joke..On the bright side, at least you guys are doing something worthwhile trying to make scarless healing a reality..
I really don't have the time to read this lovely 106 page long post, okay maybe I do since I'm not working or anything, but anyway... I'm becoming really impatient on indented acne scar treatments! Does anyone have a clue how close/far we are to finding something that actually works?
Lily, why u're not working? Just wondering. Anyway seems like you're new here. Nobody knows how near/far we have to something that works 100% though. It is said we do have the method to do so already, but it might be obscured.
Anyway, you're impantient with acne scar treatments. And honestly I can tell you most of them don't really work. I've been through it all. Just see my date joined, back in 07. Lasers,peels,needling. You name it, I tried it. I can safely say I see at most (being a very generous) 20% improvement in my scars. Still, there is no way of verifying whether that improvement was through the treatments or the scar improving itself over time..
There's really nothing much we can do though, I just learn to live through my depression..
I haven't posted here for awhile already, haven't had time to read through the past posts. But let me guess, we are still at square one?
Excuse me, but sometimes I think my life is one complete joke..On the bright side, at least you guys are doing something worthwhile trying to make scarless healing a reality..
Well one thing I learned about recently is the fact that I can get treated with an ECM as soon as I'd like. For me, that was a pretty big discovery and I'm actually considering having it done at one time or another.
But what I don't understand...is why all of the pieces of the puzzle seem to be there yet it still isn't possible to fix scars. I mean really. What is missing? What are they trying to figure out? What is the big mystery at this point? If there is one, I hope to find the answer to that question as I'm still contacting people all over the place.
Btw, still no reply from MIRA. Maybe they're too busy having fun in the sun as the weather is really nice? lol I don't think they'll reply. Maybe I'll call them next week and see what they say.
Anyway, I'm sorry to hear that your scarring is getting you down, AI3. My scarring still gives me trouble now and then, as well. I don't let it get me down anymore but it does make me uncomfortable in certain situations. But hey, that's life it seems. Keep your chin up, mate.
Posted this up on a dermatology forum:
http://www.medhelp.org/posts/Dermatology/S...ng/show/1273609
Why didn't I think of that sooner?! lol Anyway, there's a doctor there who answers questions...so it'd be interesting to hear what he/she will reply to the question. In the case he/she does...
I was just looking on pubmed yesterday and I found this:
http://www.ncbi.nlm.nih.gov/pubmed/17650091
Now, do you see that name E. Middelkoop? That's the same person I e-mailed earlier. She's the person DutchForm directed me to. The person who's e-mail I quoted in post #2098. Anyway, I just thought that was interesting.
I also read this article in which Renovo was quoted saying they were in it for the money. But, they said, Juvista was something that did help a bit...and its ultimate existence would give everybody hope for even better products which would be available in the future. Which I'm sure will also cost a lot of money. lol
I'll keep y'all updated on any new findings as usual. Don't know what I'm going to do next, though. MIRA hasn't felt the need to reply so I'm somewhat reluctant to call them on the phone. Uhm, I might call the hospital from Amsterdam and ask them what they think of decorin at 200nm, though. It'd be interesting to hear what they say in the case that they have the knowledge needed to give a proper answer.
I'm also still considering excision in combination with an ECM, btw. I might inquire at least at that hospital in Rotterdam. Should I go through with it I'll of course post photographs...but it's quite the step to take so I'm not 100% sure yet.
Anyway, until next time. lol
Look, that RGTA from France is mentioned on pubmed, too:
I was just looking on pubmed yesterday and I found this:
http://www.ncbi.nlm.nih.gov/pubmed/17650091
Now, do you see that name E. Middelkoop? That's the same person I e-mailed earlier. She's the person DutchForm directed me to. The person who's e-mail I quoted in post #2098. Anyway, I just thought that was interesting.
I also read this article in which Renovo was quoted saying they were in it for the money. But, they said, Juvista was something that did help a bit...and its ultimate existence would give everybody hope for even better products which would be available in the future. Which I'm sure will also cost a lot of money. lol
I'll keep y'all updated on any new findings as usual. Don't know what I'm going to do next, though. MIRA hasn't felt the need to reply so I'm somewhat reluctant to call them on the phone. Uhm, I might call the hospital from Amsterdam and ask them what they think of decorin at 200nm, though. It'd be interesting to hear what they say in the case that they have the knowledge needed to give a proper answer.
I'm also still considering excision in combination with an ECM, btw. I might inquire at least at that hospital in Rotterdam. Should I go through with it I'll of course post photographs...but it's quite the step to take so I'm not 100% sure yet.
Anyway, until next time. lol
Hi
I'm starting to believe as when they first began to investigate years ago, that the ECM is a good treatment.
The only picture we have in this site is a complete regeneration ECM APLIGRAF.
Apligraf achieved if a 100 percent regeneration as we have seen, we should deepen on this product may 
Apligraf ECM site: http://www.apligraf.com/
Hi
I'm starting to believe as when they first began to investigate years ago, that the ECM is a good treatment.
The only picture we have in this site is a complete regeneration ECM APLIGRAF.
Apligraf achieved if a 100 percent regeneration as we have seen, we should deepen on this product may
Apligraf ECM site: http://www.apligraf.com/
Very interesting. I'll look into this.
Even in the case an ECM can't completely regenerate everything, I'm still interested as it seems that a big aesthetic improvement is very much possible through its use. But like I said, I'm not 100% sure yet and I'm going to look into things more.