Acne.org Products
@i do not have acne:
hey you,
yeah they told me that TGF-beta 3 will indeed heal a wound by scar-free healing.
I mentioned Renovo and Juvista and they already knew it. They are doing research
for themself in the case of TGF-beta 3, so they are very optimistic that scar-free healing
using growthfactors will be reality in the near future.
One interesting fact, in this clinic they are doing research during their ordinary work. What
I want to say is, patients can immediately have the newest therapies while they are exploring
it. So you have not to wait till the end of clinical trials, because they are doing it all the time.
NEO
And where they do these experiments to be listed?
I was just Googling around and came across the company TR Bio. And they say the same as you guys are saying, if I understood correctly:
ADVANCED TISSUE REPAIR: Without Using Stem Cells
We have plenty of existing stem cells within our body; then why don't we regenerate tissue? As it turns out, cells require the right environment to repair and regenerate tissue. This environment, called the extra-cellular matrix, changes as we age and limits the ability of existing tissue repair cells (like stem cells) to repair and regenerate tissue.
TR BioSurgical is changing regenerative medicine by developing bioscaffold implants (medical devices) that mimic the optimal tissue environment for our existing cells to repair and regenerate tissue; a breakthrough approach to tissue regeneration.
Here's their website:
http://www.trbio.com/index.html
I know it says "veterinary tissue repair" on their homepage but somewhere else on their site it also says their work "enhances both veterinary and human medicine". Anyway, do you guys think these people do anything that's of use to us? They do mention dermatological disorders? I just thought I'd put this in the thread as I thought it was interesting. Sorry if it was already mentioned before. I did a search and nothing came up.
Anyway, I'll keep you updated on my talks with surgeons and other people.
These products are to the sale? I do not see price-list.
I think these guys have been slacking for far too long, all they came up with is juvista? that thing is a joke. I say everyone on earth who has scars, which should be way above a billion, throw up a dollar, and then we make a contest to give all the money to who ever is first to produce and demonstrate real scar free healing. Don't you think by the end of the year we will have something nice.
@i do not have acne:
hey you,
yeah they told me that TGF-beta 3 will indeed heal a wound by scar-free healing.
I mentioned Renovo and Juvista and they already knew it. They are doing research
for themself in the case of TGF-beta 3, so they are very optimistic that scar-free healing
using growthfactors will be reality in the near future.
One interesting fact, in this clinic they are doing research during their ordinary work. What
I want to say is, patients can immediately have the newest therapies while they are exploring
it. So you have not to wait till the end of clinical trials, because they are doing it all the time.
NEO
Interesting. So they intend to take it further than Juvista, eh? Seeing that Juvista only improves things and doesn't completely reverse the damage done? Let's hope they succeed. 
One question; how is it possible for them to treat people without the new therapies going through the whole official FDA approval, clinical trials thing, so to speak?
I believe that juvista can work much better, which happens is that for 'safety' they put insufficient doses.
Only to put one day before and one day after the wound juvista seems to me to be very small, I believe that must be applied several weeks before and after the wound, and in doses more high.
But as he said neo, to be experimenting newly now with the doses, they can use it like. Anyhow always to put a recommended low dose for safety of 'fda' bs and things like that.
FDA is our enemy, everything delays it.
I think these guys have been slacking for far too long, all they came up with is juvista? that thing is a joke. I say everyone on earth who has scars, which should be way above a billion, throw up a dollar, and then we make a contest to give all the money to who ever is first to produce and demonstrate real scar free healing. Don't you think by the end of the year we will have something nice.
BTW and this is a fact, scar free healing has been done. Decorin at 200nM stops fibroblast proliferation. (A metaphor for you, if you went for a meal, and you ordered your meal, would you get your meal if someone locked the fridge, turned off the cookers and locked up the chef?. Well decorin locks up the fibroblasts, it locks up the thing that makes scar.) Non denatured ECM/mesh etc. would also bring site specific tissue by the fact it would not get rejected by the body (When things get rejected by the body this creates inflammation and scarring). It would resorb like the other non denatured in your body, and you get site specific tissue.
I think these guys have been slacking for far too long, all they came up with is juvista? that thing is a joke. I say everyone on earth who has scars, which should be way above a billion, throw up a dollar, and then we make a contest to give all the money to who ever is first to produce and demonstrate real scar free healing. Don't you think by the end of the year we will have something nice.
BTW and this is a fact, scar free healing has been done. Decorin at 200nM stops fibroblast proliferation. (A metaphor for you, if you went for a meal, and you ordered your meal, would you get your meal if someone locked the fridge, turned off the cookers and locked up the chef?. Well decorin locks up the fibroblasts, it locks up the thing that makes scar.) Non denatured ECM/mesh etc. would also bring site specific tissue by the fact it would not get rejected by the body (When things get rejected by the body this creates inflammation and scarring). It would resorb like the other non denatured in your body, and you get site specific tissue.
Now we have to devote to obtain decorin, and to experiment with our skin.
The already this theory, we must obtain now the products.
Some doctors currently use decorin for athletes who get muscles injuries and such, apparently it actually regenerates it to an extent rather than normal healing but this is a whole different topic. So it shouldn't be too hard to obtain, but decorin alone is not gonna do much for your scars. As for non denatured ecm, I don't know where you would get that.
These products are to the sale? I do not see price-list.
Now that you mention it, I don't see any prices either. Maybe they don't mean to sell these things to consumers like us but only to medical staff? I'm not sure.
It's true they only sell it to medical staff. Here's their distributor but they only sell it to veterinarians:
Some doctors currently use decorin for athletes who get muscles injuries and such, apparently it actually regenerates it to an extent rather than normal healing but this is a whole different topic. So it shouldn't be too hard to obtain, but decorin alone is not gonna do much for your scars. As for non denatured ecm, I don't know where you would get that.
Decorin stops scarring completely. It stops the thing that creates scarring from proliferating, the fibroblast cited. Therefor scar free healing with decorin is a fact. When your body lacks decorin, fibroblasts over proliferate, and your fibrils in your tissues that lack decorin get fibrosis.cited.
Regarding regeneration and scarring being different topics, the two are the same topic. Scarring blocks regeneration/and at the same time if something regenerates it is because there is no scarring. Think of it as a spectrum at one end you have regeneration and at the other end you have scarring (denaturing of collagen fibrils). And in the spectrum if you stop scarring (i.e. decorin completely stops scarring), and the fibrils in the collagen are the right size, your body will do the rest and regenerate completely. E.g. in your non wounded state, with your non wounded tissues that are currently not scarred, decorin keeps your fibrils slender, your body then creates the site specific tissue.
Some doctors currently use decorin for athletes who get muscles injuries and such, apparently it actually regenerates it to an extent rather than normal healing but this is a whole different topic. So it shouldn't be too hard to obtain, but decorin alone is not gonna do much for your scars. As for non denatured ecm, I don't know where you would get that.
Decorin stops scarring completely. It stops the thing that creates scarring from proliferating, the fibroblast cited. Therefor scar free healing with decorin is a fact. When your body lacks decorin, fibroblasts over proliferate, and your fibrils in your tissues that lack decorin get fibrosis.cited.
Regarding regeneration and scarring being different topics, the two are the same topic. Scarring blocks regeneration/and at the same time if something regenerates it is because there is no scarring. Think of it as a spectrum at one end you have regeneration and at the other end you have scarring (denaturing of collagen fibrils). And in the spectrum if you stop scarring (i.e. decorin completely stops scarring), and the fibrils in the collagen are the right size, your body will do the rest and regenerate completely. E.g. in your non wounded state, with your non wounded tissues that are currently not scarred, decorin keeps your fibrils slender, your body then creates the site specific tissue.
This theory we all know it already.
Seabs, now we need to start debating like to obtain decorin, to experiment with our skin.
Yay post #2000. This was probably mentioned before, but has anyone read this article? Apparently deep second and third degree burns, which are usually treated with skin grafts, were able to heal on their own by applying a lab grown fetal skin construct. The wounds healed "with skin that appeared more or less normal, with normal pigment and mobility. "It was supple; there was no scarring or retraction - it was really different than grafted skin," Dr. Hohlfeld said." However, this was 5 years ago, and I haven't seen any pictures of what the healed wounds looked like.
Edit: For some reason I can't get the link to work
www.nytimes.com/2005/08/17/world/europe/17iht-stem.html
Ok, so I've found people here in The Netherlands from a university who claim to be working on finding a way to realize tissue regeneration. Here's an excerpt from their website:
TR's innovative methods stimulate the body to generate new tissue by itself, exactly where needed. An example is growing a substantial mass tissue with cells that belong to the patient himself. The strategy is to combine the cells with a biomaterial. First, the tissue will grow on a biodegradable material that is placed in the body. This so-called scaffold gradually amelts awaya during the healing process.
TR is the name of their research program. Anyway, it all sounds pretty spot on, eh? So I'm going to call these people soon and ask them about scarless healing.
By the way, in my research I found out that there seems to be a lot going on right now in Holland regarding regenerative medicine. Many hospitals and universities seem to be in contact with each other while they're working on a whole bunch of things.
I'll let you guys know what that university I mentioned said.
Ok, so I've found people here in The Netherlands from a university who claim to be working on finding a way to realize tissue regeneration. Here's an excerpt from their website:
TR's innovative methods stimulate the body to generate new tissue by itself, exactly where needed. An example is growing a substantial mass tissue with cells that belong to the patient himself. The strategy is to combine the cells with a biomaterial. First, the tissue will grow on a biodegradable material that is placed in the body. This so-called scaffold gradually amelts awaya during the healing process.
TR is the name of their research program. Anyway, it all sounds pretty spot on, eh? So I'm going to call these people soon and ask them about scarless healing.
By the way, in my research I found out that there seems to be a lot going on right now in Holland regarding regenerative medicine. Many hospitals and universities seem to be in contact with each other while they're working on a whole bunch of things.
I'll let you guys know what that university I mentioned said.
You are in the good way.
Ok, so I've found people here in The Netherlands from a university who claim to be working on finding a way to realize tissue regeneration. Here's an excerpt from their website:
TR's innovative methods stimulate the body to generate new tissue by itself, exactly where needed. An example is growing a substantial mass tissue with cells that belong to the patient himself. The strategy is to combine the cells with a biomaterial. First, the tissue will grow on a biodegradable material that is placed in the body. This so-called scaffold gradually amelts awaya during the healing process.
TR is the name of their research program. Anyway, it all sounds pretty spot on, eh? So I'm going to call these people soon and ask them about scarless healing.
By the way, in my research I found out that there seems to be a lot going on right now in Holland regarding regenerative medicine. Many hospitals and universities seem to be in contact with each other while they're working on a whole bunch of things.
I'll let you guys know what that university I mentioned said.
You are in the good way.
if juvista is going to become "the product" it had better get a move on....all these delays and look at least 5 other companies are dealing with scar regeneration. all that money will be wasted unless they actually try and release the product at some point.....if we are waiting so long maybe it doesnt work...
if juvista is going to become "the product" it had better get a move on....all these delays and look at least 5 other companies are dealing with scar regeneration. all that money will be wasted unless they actually try and release the product at some point.....if we are waiting so long maybe it doesnt work...
Well, I think they must be aware of "competition" so I'd be surprised if they didn't take that into consideration.
Here's another excerpt from their website:
The patients‚„ welfare, both in health and during treatments, is always the central objective.
Aww. lol Anyway, unless I get hindered I'll probably call them later this week.