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I found another hospital which is doing research to "unravel the mechanism of wound repair and to provide new wound healing strategies". So I'm going to contact them, as well.
I may also contact the people who discovered the "mother of all skin cells" a while ago:
http://www.acne.org/messageboard/Mother-sk...l&hl=mother
Stay tuned!
There is some drug new antiscar in phases of test?
We need new hopes.
One institute I'm going to call is actually patenting treatments and working on bringing them to clinics so that patients can be treated with them. They say they're working on things which treat "skin disorders". I'm going to ask them about scar treatments since I don't know if they have those in the pipeline or not. They say they mean to create three companies a year which actually develop and produce treatments which can then be marketed. Maybe I can convince them to start developing an actual cure for scars, in the case they aren't yet, instead of something which only "improves" scars.
Here's a description I found on the internet of the institute I mentioned earlier:
MIRA is the University of Twente s Research Institute for Biomedical Technology and Technical Medicine. In healthcare, technology is the catalyst for innovation. MIRA s research starts with fundamental concepts and culminates in successful clinical application. The institute is successful in this translational approach thanks to its integration of technical and medical knowledge. This unique combination enables the rapid introduction of new treatment methods. MIRA works closely with hospitals, the business community and government organizations and aims to secure a leading position within Europe. MIRA s research will result in the development of new techniques to repair damaged tissue, such as bone, skin or muscle tissue.
I found another hospital which is doing research to "unravel the mechanism of wound repair and to provide new wound healing strategies". So I'm going to contact them, as well.
I just found out that these people are experimenting with an approach which seems similar to what seabs135 says often regarding the decorin. They are trying to increase their knowledge of scar prevention, wound healing and tissue regeneration and want to provide new wound healing strategies ultimately. Here's what it says they're experimenting with on their website:
...we have access to matrix therapy technology, a new field in regenerative medicine. aoeRGTAa (ReGeneraTing Agent), are engineered biopolymers that optimize the natural potential of mammals to regenerate tissues by replacing the natural sugars that are destroyed in wounds. RGTA is a new therapeutic class of product based on protecting the natural signals needed for tissue regeneration by preservation of the cellular environment or extra-cellular matrix.
Sounds very exciting! They've been researching wound repair since 2006 and they are currently still trying to figure certain things out it seems. I mean to call them this week with some questions.
good
Thank you for being kept informed.
I'm still kind of reading up on certain things so that I'll be properly prepared for a conversation with the researchers. So that's why I haven't called them yet. But I will do my best to try and call them before the end of the week.
It's very interesting and it would be cool if they are able to treat people in the near future. In any case, I'll let you know what they said, everybody! 
good
Thank you for being kept informed.
I'm still kind of reading up on certain things so that I'll be properly prepared for a conversation with the researchers. So that's why I haven't called them yet. But I will do my best to try and call them before the end of the week.
It's very interesting and it would be cool if they are able to treat people in the near future. In any case, I'll let you know what they said, everybody!
Thx keep us posted. Im very interested in the Lrg6 stem cell.
The product that the hospital I mentioned earlier says it is experimenting with, was made by a French company called OTR3. On their website they have a video in which they explain how it works. And in it, you can see photos of different stages of regeneration of a wound which has been treated. It looks pretty good to me, I have to say. However, I do find it a bit strange that the last photo clearly isn't the end result. 
In any case, you can see it by clicking on the link below. The photos show up at the 1:56 mark. But be warned: the photos can be distressing to some as some of the photos basically show a large open wound, ok? So they maybe aren't for the faint at heart.
http://www.otr3.com/gb/Cacipliq.html
Impressive, eh? It's interesting to see how they explain the effect of the extracellular matrix in the video, too.
Thx keep us posted. Im very interested in the Lrg6 stem cell.
Hey you're welcome. If I end up calling the people here in Holland who discovered the "mother of all stem cells" I'll of course let you know what they said.
I found another hospital which is doing research to "unravel the mechanism of wound repair and to provide new wound healing strategies". So I'm going to contact them, as well.
I just found out that these people are experimenting with an approach which seems similar to what seabs135 says often regarding the decorin. They are trying to increase their knowledge of scar prevention, wound healing and tissue regeneration and want to provide new wound healing strategies ultimately. Here's what it says they're experimenting with on their website:
...we have access to matrix therapy technology, a new field in regenerative medicine. aoeRGTAa (ReGeneraTing Agent), are engineered biopolymers that optimize the natural potential of mammals to regenerate tissues by replacing the natural sugars that are destroyed in wounds. RGTA is a new therapeutic class of product based on protecting the natural signals needed for tissue regeneration by preservation of the cellular environment or extra-cellular matrix.
Sounds very exciting! They've been researching wound repair since 2006 and they are currently still trying to figure certain things out it seems. I mean to call them this week with some questions.
Anything that does not bring complete scar free healing is not decorin at 200nM. Decorin stops the over proliferation of fibroblasts.
Anything that does not bring complete scar free healing is not decorin at 200nM. Decorin stops the over proliferation of fibroblasts.
Well, they mention that their product works by "replacing the natural sugars that are destroyed in wounds". And Wikipedia says that decorin is a proteoglycan and that those fall under the umbrella of glycobiology which is "the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans)".
http://en.wikipedia.org/wiki/Glycobiology
So they might be talking about the same thing as you are, seabs. I'll of course ask them about this when I call them on the phone.
thanks for the info. looking forward to your updates.
the most frustrating thing is hearing about all these up and coming treatments but they never seem to come into fruition. they seem to hold a lot of promise but then they seem to almost disappear and we dont hear about them for a while. there seems to be a lot of companies researching the area but none of them actively achieving positive results as yet.
whilst it all seems like a step in the right direction, i cant help but feel its all baby steps at the moment.
i just cant stand sitting around helplessly, waiting for someone to come up with something.
anyway, i look forward to your updates, keep us posted.
Well, I called a hospital which is currently testing with that ECM I mentioned earlier. I spoke to a man who is currently conducting a trial which is still ongoing and of which the results won't be published until a year from now. Anyway, he was VERY reluctant to answer "Yes" to the question "Does it work?" as he has seen varying results. However, he has seen some very good results. But even in those cases, the treated areas didn't look entirely like they looked before the damage was done. He, as a biologist, was skeptical regarding the entire possibility of a treatment which could reverse damage completely, as well. But in the cases that the thing worked to an extent, the results were "very beautiful". He said that he had seen things which were very, very promising but there wasn't a guarantee that this thing works everytime for everybody.
Also, he said that if someone would come out with a treatment which worked for everybody then that would be a HUGE thing. Because if that were so, then that would be a HUGE change as firstly, problems like wounds which have trouble healing or scars would disappear and no longer occur which would improve the quality of life for millions of people on the planet. And secondly, all the lasers and scar creams and everything would no longer be of use, causing a big commercial change, as well. He said that the fact that there are still e.g. laser centers out there is an indication of the fact that there isn't a treatment like that at this point in time.
But nevertheless, this treatment is still very promising, he said. He didn't want to be quoted as saying that it works, so I'm not saying that he did nor have I. All he said was that it could perhaps work. And that results at this point in time vary.
I can get treated if I wanted to. That is, if the plastic surgeon of the hospital sees it happening, as well. If so, I can get my scar cut out and then they'll apply the ECM, in the hope that it "looks better" than it does now after it is healed. The man on the phone said that it wouldn't reverse the damage done 100% but it could be beneficial. With the emphasis on the word 'could'.
I don't know if I'll go and have it done. I mean like I told him; I have things to lose. Maybe I'll wait until something comes along of which they say I'd be crazy not to have it done as opposed to what they're saying now. I mean he agreed that I had things to lose so he advised me to take the time to think about it before I decided. Anyway, I might go over there and talk to the plastic surgeon at least.
I'll keep you updated on my further talks with hospitals/surgeons/researchers, everyone.
Btw, I asked him about decorin and he said he didn't know anything about it as that wasn't his field. He also said that it doesn't matter if the product was 100% non-denatured or not as that only becomes an issue with grafts from donors and such. Not with this. But he did say that this ECM had one thing which was different so I guess it isn't 100% non-denatured. But seabs135 said that the point is that the ECM isn't rejected by the patient's body and that is the case here, so I don't think it matters then.
Also, this thing only works when there is no contraction in the wound, he suspected. So that's why the plastic surgeon has to take a look, in the case I decide to want to go through with it, because contraction may prevent it from working. But there are perhaps ways to take the tension out of the wound site by using various surgical methods, he said, in the case it in fact prevents the treatment from working. But it reminds me of something I remembered reading about decorin, namely that it prevents wounds from contracting? But this ECM may have decorin in it, I feel. Like I mentioned earlier; the company that makes the product mentions that their product works by "replacing the natural sugars that are destroyed in wounds". And Wikipedia says that decorin is in fact a sugar... Anyway, I might go over there and talk to the plastic surgeon about all of this.
Btw, I asked him about decorin and he said he didn't know anything about it as that wasn't his field. He also said that it doesn't matter if the product was 100% non-denatured or not as that only becomes an issue with grafts from donors and such. Not with this. But he did say that this ECM had one thing which was different so I guess it isn't 100% non-denatured. But seabs135 said that the point is that the ECM isn't rejected by the patient's body and that is the case here, so I don't think it matters then.
Also, this thing only works when there is no contraction in the wound, he suspected. So that's why the plastic surgeon has to take a look, in the case I decide to want to go through with it, because contraction may prevent it from working. But there are perhaps ways to take the tension out of the wound site by using various surgical methods, he said, in the case it in fact prevents the treatment from working. But it reminds me of something I remembered reading about decorin, namely that it prevents wounds from contracting? But this ECM may have decorin in it, I feel. Like I mentioned earlier; the company that makes the product mentions that their product works by "replacing the natural sugars that are destroyed in wounds". And Wikipedia says that decorin is in fact a sugar... Anyway, I might go over there and talk to the plastic surgeon about all of this.
Good posts and researching, I do not have acne.
From some cites I have seen, decorin does indeed inhibit contraction, it also inhibits inflammation and it also stops fibroblast proliferation which creates the excess collagen...
Regarding denaturing of ECM here is how I define it, he/you maybe different:
Denaturing is either an ECM inserted that already has the fibrils over expressed with collagen(scar) which blocks the fibril pathways, Or it is an ECM inserted (maybe with certain chemicals that create inflammation, get the body to reject part of the ECM etc.) that allows the body to over experess collagen(scar) on the fibril matrix inside the ECM. If you have no denaturing you have no scar.
Good posts and researching, I do not have acne.
From some cites I have seen, decorin does indeed inhibit contraction, it also inhibits inflammation and it also stops fibroblast proliferation which creates the excess collagen...
Regarding denaturing of ECM here is how I define it, he/you maybe different:
Denaturing is either an ECM inserted that already has the fibrils over expressed with collagen(scar) which blocks the fibril pathways, Or it is an ECM inserted (maybe with certain chemicals that create inflammation, get the body to reject part of the ECM etc.) that allows the body to over experess collagen(scar) on the fibril matrix inside the ECM. If you have no denaturing you have no scar.
I'm doing what I can, seabs135. I'll see if I can call another hospital tomorrow as the hospital I called today is only one of many in Holland who are doing research.
I'm going to try to get a hold of a plastic surgeon to talk to as he/she should know about decorin. I was a little surprised that the person I spoke to today didn't, btw. Anyway, I'm curious to hear what other hospitals will say about everything.
Hey if you guys could get treated with that ECM I mentioned earlier would you do it? Just curious. 
I hope everyone is staying positive.
Thanks for being proactive "i do not have acne scars." You have advanced this thread big time. Questions though: Do you guys fuind it strange that the doctor you spoke to said you can't heal anything 100%? Haven't we heard from acell and seabs that if the ECM is denatured, you will get perfect regeneration? lol it's actually funny because we can grow entire organs from scratch by seeding a scaffold shaped like the organ with our own stem cells. But we can't heal skin abrasions by laying down a powdered scaffold which will attract the stem cells from within our bodies? Can you drill the rest of the people you call about this please? Ask them if it will provide 100% regeneration and if they say no, ask why not and mention that organ example. It's ridiculous that people say this is not possible IMO
Thanks for being proactive "i do not have acne scars." You have advanced this thread big time. Questions though: Do you guys fuind it strange that the doctor you spoke to said you can't heal anything 100%? Haven't we heard from acell and seabs that if the ECM is denatured, you will get perfect regeneration? lol it's actually funny because we can grow entire organs from scratch by seeding a scaffold shaped like the organ with our own stem cells. But we can't heal skin abrasions by laying down a powdered scaffold which will attract the stem cells from within our bodies? Can you drill the rest of the people you call about this please? Ask them if it will provide 100% regeneration and if they say no, ask why not and mention that organ example. It's ridiculous that people say this is not possible IMO
Yeah, do that for us. I really want to know the answer.
Thanks for being proactive "i do not have acne scars." You have advanced this thread big time. Questions though: Do you guys fuind it strange that the doctor you spoke to said you can't heal anything 100%? Haven't we heard from acell and seabs that if the ECM is denatured, you will get perfect regeneration? lol it's actually funny because we can grow entire organs from scratch by seeding a scaffold shaped like the organ with our own stem cells. But we can't heal skin abrasions by laying down a powdered scaffold which will attract the stem cells from within our bodies? Can you drill the rest of the people you call about this please? Ask them if it will provide 100% regeneration and if they say no, ask why not and mention that organ example. It's ridiculous that people say this is not possible IMO
Yeah, do that for us. I really want to know the answer.
I've just gotten started, folks. I mean to call a whole bunch of people as there's so much going on regarding regenerative medicine right now. There is one institute e.g. which is going to make so-called "health farms" in Holland where people can get all sorts of specialized treatments which is very interesting. Here are a couple of videos from that institute:
Check out the Dutch accent of the people talking. lol 
Also, check out the architecture of the health farm; isn't it awesome?!
As far as the biologist having said that he's skeptical of the possibility of 100% regeneration... I was surprised to hear that, too. He drew the following comparison. He said that of all the cars that Mercedes makes, there's bound to be a few with manufacturing defects. Which sort of implied that not everybody reacts the same way to the treatment. The way I understood it, at least. But the trial is still ongoing, so therefore they are still testing the ECM out. He was very reluctant to say anything conclusive about pretty much anything as everything was still being studied. Bear in mind that he was skeptical. He didn't say that it wasn't possible. Quite the contrary; he said he thought it could very well be possible even though he was skeptical. On top of that, I also got the impression that he wasn't as up to date on the advancements made in regenerative medicine as some people are. That's nothing against him, though. I mean he was very kind and helpful to me on the phone. And we spoke for 45 minutes so he was very generous, too.
Incidentally, he also said that after the brain, the process of wound healing is the most complex part of the human anatomy and it is not understood 100% at this moment in time. But they are very, very close to finding out the last bits which aren't understood yet. Just something I remembered him say which I thought was interesting, that's all. lol
Anyway, I mean to call a plastic surgeon next. I'll ask him what he thinks, ok?
I hope everyone has a nice day!
Thanks for being proactive "i do not have acne scars." You have advanced this thread big time. Questions though: Do you guys fuind it strange that the doctor you spoke to said you can't heal anything 100%? Haven't we heard from acell and seabs that if the ECM is denatured, you will get perfect regeneration? lol it's actually funny because we can grow entire organs from scratch by seeding a scaffold shaped like the organ with our own stem cells. But we can't heal skin abrasions by laying down a powdered scaffold which will attract the stem cells from within our bodies? Can you drill the rest of the people you call about this please? Ask them if it will provide 100% regeneration and if they say no, ask why not and mention that organ example. It's ridiculous that people say this is not possible IMO
Yeah, do that for us. I really want to know the answer.
I've just gotten started, folks. I mean to call a whole bunch of people as there's so much going on regarding regenerative medicine right now. There is one institute e.g. which is going to make so-called "health farms" in Holland where people can get all sorts of specialized treatments which is very interesting. Here are a couple of videos from that institute:
Check out the Dutch accent of the people talking. lol
As far as the biologist having said that he's skeptical of the possibility of 100% regeneration... I was surprised to hear that, too. He drew the following comparison. He said that of all the cars that Mercedes makes, there's bound to be a few with manufacturing defects. Which sort of implied that not everybody reacts the same way to the treatment. The way I understood it, at least. But the trial is still ongoing, so therefore they are still testing the ECM out. He was very reluctant to say anything conclusive about pretty much anything as everything was still being studied. Bear in mind that he was skeptical. He didn't say that it wasn't possible. Quite the contrary; he said he thought it could very well be possible even though he was skeptical. On top of that, I also got the impression that he wasn't as up to date on the advancements made in regenerative medicine as some people are. That's nothing against him, though. I mean he was very kind and helpful to me on the phone. And we spoke for 45 minutes so he was very generous, too.
Incidentally, he also said that after the brain, the process of wound healing is the most complex part of the human anatomy and it is not understood 100% at this moment in time. But they are very, very close to finding out the last bits which aren't understood yet. Just something I remembered him say which I thought was interesting, that's all. lol
Anyway, I mean to call a plastic surgeon next. I'll ask him what he thinks, ok?
I hope everyone has a nice day!
All scarring is, is over expression of collagen on the fibrils, which blocks off the fibril mesh pathway for your stem cells and intercellular cells to crawl through to create the site specific tissue etc.
What scarring is, is basically a wall that builds itself in the fibril mesh, which joins and contracts together the fibrils. And if you do scar free healing on one tissue you will it on all soft tissues. Again decorin stops the fibrils from being over expressed with collagen. BTW If you look at your normal unscarred tissues your fibril paths are clear and your stemcells regenerate all the time.
Good posts and researching, I do not have acne.
From some cites I have seen, decorin does indeed inhibit contraction, it also inhibits inflammation and it also stops fibroblast proliferation which creates the excess collagen...
Regarding denaturing of ECM here is how I define it, he/you maybe different:
Denaturing is either an ECM inserted that already has the fibrils over expressed with collagen(scar) which blocks the fibril pathways, Or it is an ECM inserted (maybe with certain chemicals that create inflammation, get the body to reject part of the ECM etc.) that allows the body to over experess collagen(scar) on the fibril matrix inside the ECM. If you have no denaturing you have no scar.
I'm doing what I can, seabs135. I'll see if I can call another hospital tomorrow as the hospital I called today is only one of many in Holland who are doing research.
I'm going to try to get a hold of a plastic surgeon to talk to as he/she should know about decorin. I was a little surprised that the person I spoke to today didn't, btw. Anyway, I'm curious to hear what other hospitals will say about everything.
Hey if you guys could get treated with that ECM I mentioned earlier would you do it? Just curious.
I hope everyone is staying positive.
I want non denatured ECM, but if this improved the defects I'd do it.
Someone should really make an introduction thread or an explanatory opening post of these promising scar treatments that is available now or near in the future if there isn't one already. Especially for people like me whose mother language is other than English it would be much easier to seek information compared to reading a thread which has over 100 pages. I know this http://www.acne.org/scars.php but it's rather narrow. 