http://books.google.com/books?id=ZEkCzBfMX...ion&f=false

 

"Lack of fibrous scarring is the primary feature of fetal wound healing. Even for longer periods, HA content in fetal wounds is still higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore leading to reduced scarring.[65] This suggestion is in agreement with the research of West et al., who showed that in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring.[66] Though the exact role of HA in skin scarring is still under investigation, based on all the facts that have been observed, it must be a great contributor to the less fibrous scarring."

I've seen a cite somewhere too that puts forward HA as a carrier for decorin...

Ok boys, exactly one year is absent to see the new photos of phase 3 juvista.

LOL

There are ways to get scar free healing when scarred. Dissolve the scar;

remove the scar and apply anon denatured ECMa (I do not mean the marketing term of denatured. Note what I mean by non denatured ECM, is ECM that the body doesnat reject the ECM, and because it doesnat reject it you get no scar whatso ever the body resorbs the ECM and the body uses the fibrils like it does in you non wounded tissues. );

Remove the scar and use something that stops the over expression of collagen, like decorin. etc.

This is one of the things I'll talk to surgeons about once I am able to make the time. Btw, how do you imagine the decorin to be applied, seabs135?

There are ways to get scar free healing when scarred. Dissolve the scar;

remove the scar and apply anon denatured ECMa (I do not mean the marketing term of denatured. Note what I mean by non denatured ECM, is ECM that the body doesnat reject the ECM, and because it doesnat reject it you get no scar whatso ever the body resorbs the ECM and the body uses the fibrils like it does in you non wounded tissues. );

Remove the scar and use something that stops the over expression of collagen, like decorin. etc.

 

This is one of the things I'll talk to surgeons about once I am able to make the time. Btw, how do you imagine the decorin to be applied, seabs135?

 

Your to be disappointed.

The doctors not to be updated, do not know anything, generally only they know what they study when they are students, and when a new drug newly goes out to the sale.

Do you want to make something really good?

To manage to speak with some student of biology that this experiencing, or some scientist who experiments on the topic skin(leather).

Your to be disappointed.

 

The doctors not to be updated, do not know anything, generally only they know what they study when they are students, and when a new drug newly goes out to the sale.

 

Do you want to make something really good?

 

To manage to speak with some student of biology that this experiencing, or some scientist who experiments on the topic skin(leather).

Your English is getting better, eterna.

Thanks for the advice. There appears to be a research institute in Utrecht, The Netherlands... Maybe I can speak with them... And I'll look for similar places... Maybe I'll speak to surgeons as well, though... I've spoken to some in the past (I was inquiring about lasers) and they were quite willing to listen to me and help me and even seemed open to suggestions.

I'm going to do everything I can. Stay positive.

Ok, good luck

There are ways to get scar free healing when scarred. Dissolve the scar;

remove the scar and apply anon denatured ECMa (I do not mean the marketing term of denatured. Note what I mean by non denatured ECM, is ECM that the body doesnat reject the ECM, and because it doesnat reject it you get no scar whatso ever the body resorbs the ECM and the body uses the fibrils like it does in you non wounded tissues. );

Remove the scar and use something that stops the over expression of collagen, like decorin. etc.

 

This is one of the things I'll talk to surgeons about once I am able to make the time. Btw, how do you imagine the decorin to be applied, seabs135?

 

@I do not have acne

Getting logic out of this:

Scarring is a result of fibroblasts over proliferating and producing excess collagen which blocks off regeneration;

Decorin at 100nM to 200nM completely inhibits the fibroblasts from over proliferating;

When we are not wounded our bodies have decorin;

When we are wounded in the new wound our decorin levels go down, we basically have no decorin in the wound;

When we heal over the next 12 or so months at the begining our decorin levels are low, then slowly over the next 12 months our decorin levels reach normal levels;

In this 12month period when our decorin levels are low, our wounds accumilate excess collagen, this results in a scar.

Using the above logic I'd say keeping our decorin levels up for 12 month after injury.

Getting logic out of this:

 

Scarring is a result of fibroblasts over proliferating and producing excess collagen which blocks off regeneration;

Decorin at 100nM to 200nM completely inhibits the fibroblasts from over proliferating;

When we are not wounded our bodies have decorin;

When we are wounded in the new wound our decorin levels go down, we basically have no decorin in the wound;

When we heal over the next 12 or so months at the begining our decorin levels are low, then slowly over the next 12 months our decorin levels reach normal levels;

In this 12month period when our decorin levels are low, our wounds accumilate excess collagen, this results in a scar.

 

Using the above logic I'd say keeping our decorin levels up for 12 month after injury.

 

Yes, I understand but how would one keep one's decorin levels up?

Getting logic out of this:

 

Scarring is a result of fibroblasts over proliferating and producing excess collagen which blocks off regeneration;

Decorin at 100nM to 200nM completely inhibits the fibroblasts from over proliferating;

When we are not wounded our bodies have decorin;

When we are wounded in the new wound our decorin levels go down, we basically have no decorin in the wound;

When we heal over the next 12 or so months at the begining our decorin levels are low, then slowly over the next 12 months our decorin levels reach normal levels;

In this 12month period when our decorin levels are low, our wounds accumilate excess collagen, this results in a scar.

 

Using the above logic I'd say keeping our decorin levels up for 12 month after injury.

 

 

Yes, I understand but how would one keep one's decorin levels up?

 

Paste, injection. BTW I do not think you would have to keep the levels up for 12month as you would've regenerated by then if there is no excess collagen blocking regeneration off. Once healed your body would look after your decorin levels again.

Something funny. Lol how wrong.

http://www.independent.co.uk/news/medicine...re-1265000.html

But this is preety cool. Havent heard about it before.

http://scopeblog.stanford.edu/archives/201...r-free-fut.html

Getting logic out of this:

 

Scarring is a result of fibroblasts over proliferating and producing excess collagen which blocks off regeneration;

Decorin at 100nM to 200nM completely inhibits the fibroblasts from over proliferating;

When we are not wounded our bodies have decorin;

When we are wounded in the new wound our decorin levels go down, we basically have no decorin in the wound;

When we heal over the next 12 or so months at the begining our decorin levels are low, then slowly over the next 12 months our decorin levels reach normal levels;

In this 12month period when our decorin levels are low, our wounds accumilate excess collagen, this results in a scar.

 

Using the above logic I'd say keeping our decorin levels up for 12 month after injury.

 

 

Yes, I understand but how would one keep one's decorin levels up?

 

 

Paste, injection. BTW I do not think you would have to keep the levels up for 12month as you would've regenerated by then if there is no excess collagen blocking regeneration off. Once healed your body would look after your decorin levels again.

 

I see. Ok, I'll talk to people about this and other things once I'm able.

Seabs, it does not treat itself only of decorin.

Something will explain to you , will treat of that you understand me:

Your you say to all ' decorin freezes the collagen and it does that the cells could grow and to generate new fabric '

Ok, It this one clear.

But I see that there is something that you do not know that it is 50% remaining ( The first half is to avoid the excess of collagen as your you say).

In order that there is no scar, it is not a question only that does not grow the collagen.

A very important factor is the 'scaffolding' that the mesh of fibrills of collagen they have the same orientation that in the normal skin. With this normal orientation not only it can grow the cells if not, the skin the same aspect has that the normal skin.

I explain to you, when you do a scar to yourself, the body never believes the fibrills of collagen as like in the normal skin , alone believe a few fibrills in straight or perpendicular forms, because of it on not having had good scaffolding the cells cannot reproduce well (beyond having to freeze to the collagen).

Without the fibrills of collagen in the same direction as like in the normal skin, the skin never have a normal aspect.

Many laboratories in the world have created membranes of collagen but none could direction the collagen as(like) in the normal skin.

There is a laboratory in the world that I believe(create) a membrane of collagen that it orientates and direction the fibrills of collagen, as in the normal skin. But are frozen the phases of test.

Remember it, you need 2 things, to freeze the collagen (decorin) and the mesh of collagen with his fibrills direction as(like) in the normal skin, in order that the skin grows and has the same aspect that the normal skin. Not only it treats itself of decorin.

I hope that it has helped you.

Seabs, it does not treat itself only of decorin.

 

 

Something will explain to you , will treat of that you understand me:

 

 

Your you say to all ' decorin freezes the collagen and it does that the cells could grow and to generate new fabric '

 

Ok, It this one clear.

 

 

But I see that there is something that you do not know that it is 50% remaining ( The first half is to avoid the excess of collagen as your you say).

 

In order that there is no scar, it is not a question only that does not grow the collagen.

 

A very important factor is the 'scaffolding' that the mesh of fibrills of collagen they have the same orientation that in the normal skin. With this normal orientation not only it can grow the cells if not, the skin the same aspect has that the normal skin.

I explain to you, when you do a scar to yourself, the body never believes the fibrills of collagen as like in the normal skin , alone believe a few fibrills in straight or perpendicular forms, because of it on not having had good scaffolding the cells cannot reproduce well (beyond having to freeze to the collagen).

 

Without the fibrills of collagen in the same direction as like in the normal skin, the skin never have a normal aspect.

 

Many laboratories in the world have created membranes of collagen but none could direction the collagen as(like) in the normal skin.

 

There is a laboratory in the world that I believe(create) a membrane of collagen that it orientates and direction the fibrills of collagen, as in the normal skin. But are frozen the phases of test.

 

Remember it, you need 2 things, to freeze the collagen (decorin) and the mesh of collagen with his fibrills direction as(like) in the normal skin, in order that the skin grows and has the same aspect that the normal skin. Not only it treats itself of decorin.

 

 

I hope that it has helped you.

This is what I think I understand what you have written?:

You say?

1. we need to keep the fibrils slender so our intercellular cells can grow through the fibrils (with decorin)?

2. We need an ECM with the fibril mesh as well so the intercellular cells can transport themselves to create the tissue.?

You say I'm talking about no.1 but missing out on the no.2 aspect?

If so you have my position wrong, my logic factors in the number 2 aspect in two ways.

If the wound gap is bigger you could factor in the mesh. If it is small decorin by itself may do. With regards to number 2 aspect, I have a cite somewhere with regards to decorin that states that in the first six days of healing decorin enables the body to create the collagen mesh. Also this comes back to the a non denatured mesh/ECM...

No.

I am not in disagreement, only I say that decorin is 50 %.

Other one 50 % is a scaffolding is necessary of fibrills of collagen, but it must be orientated of the same way as this one in his normal skin.

You say ' it is not necessary to place scaffolding if the scar is small '

you wrong, for you maybe a scar of acne is small. But for a molecule/protein that takes charge regenerating the skin it is something enormous.

The skin when he is formed a wound cannot form the fibrills of collagen in the same direction as like in the healthy skin.

Though it is a small scar and put decorin, you are going to have scar. You need a membrane of collagen that direction the fibrills of collagen in the same direction that the normal skin.

You must see in images like they see the fibrills of collagen in the normal skin. And since(as,like) they are seen when a scar is formed.

I am investigating in Internet many years ago, and that the important thing is the scaffolding, to orientate the collagen, apart from preventing that it he grows.

Something funny. Lol how wrong.

 

http://www.independent.co.uk/news/medicine...re-1265000.html

That is why never believe in future predictions. Mostly, they are wrong.

http://renovo.com/itemdetails.asp?c_id=31&news_id=67

Something new from Renovo.

"The primary endpoint for this trial is a Clinical Panel assessment of standardised photographs at

12 months after surgery, assessed for scar improvement by the Global Scar Comparison Scale.

Following the last patient visit at 12 months post surgery, the standardised photographs will be

prepared, scored by an independent Clinical Panel and the data analysed, which means that

Renovo is on schedule to report the results of this trial in H1 2011, as previously guided."

We are on track. I hope the results will be very good in H1 2011.

Something new from me. Today I was at a clinical university because of my scars. I talked to a doctor because they did great research in percutane collagene induction therapy for burn scars and there on. And they explore tgf-beta 3 outcome of the needling process. They made a new paper on the effect of tgf-beta 3. I talked about the possibility of complete scarless healing. And the doctor agreed that with tgf-beta 3 and other growth factors we will see scarless healing.

I will do medical needling on all of my scars and stretchmarks and then I will see, what it is all about. Meanwhile I am doing lugols treatment on a large area and hope it will work.

NEO

Good info Neo.

No.

 

I am not in disagreement, only I say that decorin is 50 %.

 

Other one 50 % is a scaffolding is necessary of fibrills of collagen, but it must be orientated of the same way as this one in his normal skin.

 

You say ' it is not necessary to place scaffolding if the scar is small '

 

you wrong, for you maybe a scar of acne is small. But for a molecule/protein that takes charge regenerating the skin it is something enormous.

 

The skin when he is formed a wound cannot form the fibrills of collagen in the same direction as like in the healthy skin.

 

Though it is a small scar and put decorin, you are going to have scar. You need a membrane of collagen that direction the fibrills of collagen in the same direction that the normal skin.

 

You must see in images like they see the fibrills of collagen in the normal skin. And since(as,like) they are seen when a scar is formed.

 

 

I am investigating in Internet many years ago, and that the important thing is the scaffolding, to orientate the collagen, apart from preventing that it he grows.

I do not know what you are saying 100%. We are problably talking the same way and share the same understandings, but translation has messed up somewhere?

But what I'm saying is fact.

But let me clarify my understanding for you.

Scars are the over production of collagen on the collagen fibrils inside the collagen, this over production of collagen, blocks of and disrupts any opportunity for stem cells and intercellular cells to correctly use the fibrils to make site specific tissue like it does in non wounded tissue.

Scars happen 'when fibroblast over proliferate'.

Decorin at 200nM completely 'stops the fibroblasts from proliferating' (this means, if the fibroblasts can't over proliferate in a wound, no excess collagen can be created to block off the fibrils. decorin stops excess collagen from happening)

To have site specific tissue (interchangable with scar free healing) you need scaffold/ECM/Mesh with 'slender fibrils,' these fibrils need to stay slender (non denatured), when the fibrils are the correct size, your own stemcells and intercellular cells know what they are doing.

IMO I think we are talking the same thing, from the same sheet. I have always included the membrane of collagen/ECM/mesh in my understanding of scar free healing like you are...

Something funny. Lol how wrong.

 

http://www.independent.co.uk/news/medicine...re-1265000.html

The same person in this article in 2010 is now plugging some other future drug.

You mean that gel that knocks down the osteopontin gene? I still don't know how impressive its suppose to be, but I'm sure its far off than what he was predicting in that article.

You mean that gel that knocks down the osteopontin gene? I still don't know how impressive its suppose to be, but I'm sure its far off than what he was predicting in that article.

I believe that excaliard 'EXC 001' ,the technology uses recessive gene osteoporin, they even do not want to say anything of the method of action of the drug, but I have a feeling that it is for this route.

Something new from me. Today I was at a clinical university because of my scars. I talked to a doctor because they did great research in percutane collagene induction therapy for burn scars and there on. And they explore tgf-beta 3 outcome of the needling process. They made a new paper on the effect of tgf-beta 3. I talked about the possibility of complete scarless healing. And the doctor agreed that with tgf-beta 3 and other growth factors we will see scarless healing.

Did they happen to say anything regarding when? I mean is it in their opinion still far off or could it be just around the corner?

I was just Googling around and came across the company TR Bio. And they say the same as you guys are saying, if I understood correctly:

ADVANCED TISSUE REPAIR: Without Using Stem Cells

We have plenty of existing stem cells within our body; then why don't we regenerate tissue? As it turns out, cells require the right environment to repair and regenerate tissue. This environment, called the extra-cellular matrix, changes as we age and limits the ability of existing tissue repair cells (like stem cells) to repair and regenerate tissue.

TR BioSurgical is changing regenerative medicine by developing bioscaffold implants (medical devices) that mimic the optimal tissue environment for our existing cells to repair and regenerate tissue; a breakthrough approach to tissue regeneration.

Here's their website:

http://www.trbio.com/index.html

I know it says "veterinary tissue repair" on their homepage but somewhere else on their site it also says their work "enhances both veterinary and human medicine". Anyway, do you guys think these people do anything that's of use to us? They do mention dermatological disorders? I just thought I'd put this in the thread as I thought it was interesting. Sorry if it was already mentioned before. I did a search and nothing came up.

Anyway, I'll keep you updated on my talks with surgeons and other people.

@i do not have acne:

hey you,

yeah they told me that TGF-beta 3 will indeed heal a wound by scar-free healing.

I mentioned Renovo and Juvista and they already knew it. They are doing research

for themself in the case of TGF-beta 3, so they are very optimistic that scar-free healing

using growthfactors will be reality in the near future.

One interesting fact, in this clinic they are doing research during their ordinary work. What

I want to say is, patients can immediately have the newest therapies while they are exploring

it. So you have not to wait till the end of clinical trials, because they are doing it all the time.

NEO