Acne.org Products
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
Non denatured as in pure in essence. Not tempered with. Is anyone able to get hold of acell? Excise your scars, use the ecm and you have scarless healing..
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
Non denatured as in pure in essence. Not tempered with. Is anyone able to get hold of acell? Excise your scars, use the ecm and you have scarless healing..
i think you can just order it off their website. you have to fill in a form and they will contact you back. If its only avaible to doctors /dermatlogists etc then i can get my aunt to get it.
im talking bout the MatriStem wound care matrix sheeet/powder. - is that the right stuff?
this - http://www.acell.com/pandr_surgery.html
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
When ECM is not denatured the intercellular cells crawl through the slender fibrils (fibers) in the ECM. When it is denatured (crosslinked) these micropores are blocked. This causes the body to reject the ECM in the places were it is blocked and would bring fibrotic encapsulation were ever the micropores have been crosslinked (blocked off).
Think of it like a book, when a book is glued together we cannot read it. The intercellular cells cant read the ECM when it is blocked.
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
When ECM is not denatured the intercellular cells crawl through the slender fibrils (fibers) in the ECM. When it is denatured (crosslinked) these micropores are blocked. This causes the body to reject the ECM in the places were it is blocked and would bring fibrotic encapsulation were ever the micropores have been crosslinked (blocked off).
Think of it like a book, when a book is glued together we cannot read it. The intercellular cells cant read the ECM when it is blocked.
are there any non - dentatured ECM that are avaible ?
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
When ECM is not denatured the intercellular cells crawl through the slender fibrils (fibers) in the ECM. When it is denatured (crosslinked) these micropores are blocked. This causes the body to reject the ECM in the places were it is blocked and would bring fibrotic encapsulation were ever the micropores have been crosslinked (blocked off).
Think of it like a book, when a book is glued together we cannot read it. The intercellular cells cant read the ECM when it is blocked.
are there any non - dentatured ECM that are avaible ?
Acell claims there ECM is non crosslinked.
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
When ECM is not denatured the intercellular cells crawl through the slender fibrils (fibers) in the ECM. When it is denatured (crosslinked) these micropores are blocked. This causes the body to reject the ECM in the places were it is blocked and would bring fibrotic encapsulation were ever the micropores have been crosslinked (blocked off).
Think of it like a book, when a book is glued together we cannot read it. The intercellular cells cant read the ECM when it is blocked.
are there any non - dentatured ECM that are avaible ?
Acell claims there ECM is non crosslinked.
thanks ... well i spoke to my aunt and she said she is able to get hold of the Acell product (not sure how) and she will do the treatment on me if i want to, but ive decided not to do it because i need to read up more on scarless healing and read through this entire thread. wot i dont get it how come no-one else has tried it yet. this thread is over 2 years old so people have known about it for a while. mabey the Acell stuff is not able to produce scarless healing as of yet. i just saw on their website under the MatriStem description that it 'MAY REDUCE scar tissue formation'. it doesnt say that it prevents scar tissue formation. anyway when i find out more about what Acell can do i will get the treatment done to see if it actually works for acne scars. Or i might just wait a while for Acell to develop fully then get it done. mabey a year or so.
ok i havnt read the whole thread and i dont fully understand how this Acell stuff works. my basic understanding of how to remove scars is to first get the scar tissue completely removed by excision and then apply the Acell powder/sheet over the area directly after the treatment. does this mean that stiches should not be used ?. My aunt is a dermatologist who works with Dr Tony Chu at Hammersmith hospital which many of you from the u.k will know. i dont mind actually testing this acell stuff out and se if it really does prevent scar tissue formation and allow the skin to return back to normal (before the acne scar). if i can get hold of this stuff somehow i will tell my aunt and Dr Chu about it and they can test it out on me. i wont get it done on my face though becuase im stil skeptical. i dont mind getting it done on my back though. only problem is i dont have any scars on my back. excision alone can cause scar tissue right? if stiches are not used. mabey i could just get excision on an area of normal skin and apply Acell and see how it heals. i could also get another area or normal skin excised as if there was a scar, but not apply the Acell powder/sheet. i could then compare and see how the skin heals with and without Acell.
theres alot of talk on these boards about scarless healing, stem cells etc but no-one has actually tested it out yet. mabey i should i try it out lol.
If you look at the landmarks we have had you should be OK if you use non denatured ECM. We have seen regeneration with earlier technology.
Ok i deff need to read up on this Acell stuff and ECM. i know what ECM is but what do you mean by denatured ECM. Is the Acell MatriStem powder/sheet the right thing i need ?
When ECM is not denatured the intercellular cells crawl through the slender fibrils (fibers) in the ECM. When it is denatured (crosslinked) these micropores are blocked. This causes the body to reject the ECM in the places were it is blocked and would bring fibrotic encapsulation were ever the micropores have been crosslinked (blocked off).
Think of it like a book, when a book is glued together we cannot read it. The intercellular cells cant read the ECM when it is blocked.
are there any non - dentatured ECM that are avaible ?
Acell claims there ECM is non crosslinked.
thanks ... well i spoke to my aunt and she said she is able to get hold of the Acell product (not sure how) and she will do the treatment on me if i want to, but ive decided not to do it because i need to read up more on scarless healing and read through this entire thread. wot i dont get it how come no-one else has tried it yet. this thread is over 2 years old so people have known about it for a while. mabey the Acell stuff is not able to produce scarless healing as of yet. i just saw on their website under the MatriStem description that it 'MAY REDUCE scar tissue formation'. it doesnt say that it prevents scar tissue formation. anyway when i find out more about what Acell can do i will get the treatment done to see if it actually works for acne scars. Or i might just wait a while for Acell to develop fully then get it done. mabey a year or so.
Following Spievacks patent if it has fibrotic encapsulation then it is cross-linked...
http://www.pharmcast.com/Patents/Yr2003/Ju...issue061703.htm
Acell is a non crosslinked ECM.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Scar free healing. Your body has scar free healing now. Your intercellular cells have been making scar free healing since you were born. They have been growing through your slender fibrils in your collagen since you were born. Your intercellular cells grow through ECM, and these intercellular cells have been doing this for millions of years.
You can not have scar free healing without the ECM scaffold. Also, the scaffold to the intercellular cell is like what a car manual is to a car mechanic.
Imagine if I said to the car mechanic, fuck the car manual, lets take it apart one by one and put it together in three year.
If the ECM did not work then it was denatured, hence crosslinked.
I'll reiterate again, ECM has regenerated skin, sexual organs etc.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Scar free healing. Your body has scar free healing now. Your intercellular cells have been making scar free healing since you were born. They have been growing through your slender fibrils in your collagen since you were born. Your intercellular cells grow through ECM, and these intercellular cells have been doing this for millions of years.
You can not have scar free healing without the ECM scaffold. Also, the scaffold to the intercellular cell is like what a car manual is to a car mechanic.
Imagine if I said to the car mechanic, fuck the car manual, lets take it apart one by one and put it together in three year.
If the ECM did not work then it was denatured, hence crosslinked.
I'll reiterate again, ECM has regenerated skin, sexual organs etc.
So basically what your saying is, if Acell is non-crosslinked / non-denatured then applying it to an area of skin where an acne scar have been fully cut out, the skin will grow back perfectly without anyscar tissue and at the same level of the normal surrounding skin. ??
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Scar free healing. Your body has scar free healing now. Your intercellular cells have been making scar free healing since you were born. They have been growing through your slender fibrils in your collagen since you were born. Your intercellular cells grow through ECM, and these intercellular cells have been doing this for millions of years.
You can not have scar free healing without the ECM scaffold. Also, the scaffold to the intercellular cell is like what a car manual is to a car mechanic.
Imagine if I said to the car mechanic, fuck the car manual, lets take it apart one by one and put it together in three year.
If the ECM did not work then it was denatured, hence crosslinked.
I'll reiterate again, ECM has regenerated skin, sexual organs etc.
So basically what your saying is, if Acell is non-crosslinked / non-denatured then applying it to an area of skin where an acne scar have been fully cut out, the skin will grow back perfectly without anyscar tissue and at the same level of the normal surrounding skin. ??
Yes I am. Scarring = crosslinked collagen fibrils, regeneration = slender collagen fibrils and intercellular cells being able to create site specific tissue.
Hence a indented/bumpy spot is were you have collagen irregularities and crosslinking (fibrotic encapsulation) were the intercellular cells cant fit through the micro pores (fibrils to thick to climb through). It came after a wound, -->>were decorin was lost, the fibrils then got excess collagen, which denied the billion years experienced mechanics (intercellular cells) the chance to do the job they do when fibrotic encapsulation is not around.
sounds promising, this is the reply i got from mike manning from acell about scar treatment
Dear Mr. Singh,
Thank you for your interest in ACell's regenerative medicine products and technology. Our MatriStemA medical products are now available by prescription through your physician, hospital or clinic. Please visit our website, www.acell.com, for additional information.
We have successfully treated surgical scar revisions but no studies have been conducted to determine how much, if any scar tissue exists in the regenerated tissue.
Regulations require us to communicate with physicians directly concerning medical questions. We would be happy to address any of your physicianas questions or concerns and provide technical information on ACell's products and procedures.
Best regards,
I have to get my aunt to send him an email since he can only communicate with physicians directly.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Scar free healing. Your body has scar free healing now. Your intercellular cells have been making scar free healing since you were born. They have been growing through your slender fibrils in your collagen since you were born. Your intercellular cells grow through ECM, and these intercellular cells have been doing this for millions of years.
You can not have scar free healing without the ECM scaffold. Also, the scaffold to the intercellular cell is like what a car manual is to a car mechanic.
Imagine if I said to the car mechanic, fuck the car manual, lets take it apart one by one and put it together in three year.
If the ECM did not work then it was denatured, hence crosslinked.
I'll reiterate again, ECM has regenerated skin, sexual organs etc.
So basically what your saying is, if Acell is non-crosslinked / non-denatured then applying it to an area of skin where an acne scar have been fully cut out, the skin will grow back perfectly without anyscar tissue and at the same level of the normal surrounding skin. ??
Yes I am. Scarring = crosslinked collagen fibrils, regeneration = slender collagen fibrils and intercellular cells being able to create site specific tissue.
Hence a indented/bumpy spot is were you have collagen irregularities and crosslinking (fibrotic encapsulation) were the intercellular cells cant fit through the micro pores (fibrils to thick to climb through). It came after a wound, -->>were decorin was lost, the fibrils then got excess collagen, which denied the billion years experienced mechanics (intercellular cells) the chance to do the job they do when fibrotic encapsulation is not around.
You can't just cut out your scars, apply 'Acell' or any other ecm or other product for that matter, and expect complete regeneration, if any. It may reduce scarring - and it seems to inhibit infection - but so far that's about it. If complete skin regeneration were possible that would be extremely huge news. The US military looked into conducting clinical trials with Acell where it would be used to regenerate skin graft donor sites (not even the wound) , but decided to abandon the trial in favor of another product. They also attempted to regrow fingers for soldiers that sustained injuries in Iraq, but that experiment was unsuccessful. The first soldier they tried it on - Staff Sgt Shiloh Harris - regrew a very minuscule portion (how minuscule I'm unsure) of his finger back, and the wound still scarred. They are still involved with Acell and their scientific advisors through AFIRM (armed forces institute of regenerative medicine) along with many other researchers and institutions. When the media reported that a man regrew the tip of his finger people thought Acell was their answer to hairloss, acne scars, and stretch marks. A couple years ago a guy on another forum lied and said that he obtained some Acell from a vet friend and that he completely healed a stretch mark with Acell. Many people believed him and I think that is why a lot of people seem to have this belief that Acell is able to regenerate human skin, hair follicles, sweat glands, etc. I think Acell has tremendous promise and will one day accomplish these feats, but at this time their products are unable to heal skin wounds that are scar free. It should also be mentioned that ECM based treatments have been performed since the 90s - torn rotator cuffs, tendon repairs, hernias, etc so the technology isn't exactly new.
Acell won't help at all. There's been quite a few great things mentioned in this discussion as well as the one about autologous mesenchymal stem cells science fact not science fiction, or something like that. A few researchers have been looking into the reasons why fetuses don't scar and have been trying to replicate that process in humans. Juvista by Renovo is based on the fact that transforming growth factor beta 3 (tgfb3) is abundant in fetuses while tfgb1+2 are suppressed, and the opposite is true in adults. I don't think Renovo is having much success at all - I think it's only one piece of the puzzle. Another researcher - Paul Martin, a leading scar researcher from the University of Bristol has found that the same is true of osteopontin antisense (opn). Roy Kimble of the University of Queensland has found that the same is also true of Fetuin. Scientists in The Netherlands have found that a protein in saliva called Histatin can cut wound healing time in half. The problem is that none of these researchers collaborate. They all publish their work in peer reviewed publications - so they're certainly aware of what's going on. If they combined all their findings, which wouldn't be difficult at all, we would be a lot closer to scarless healing. They also need to look into skin remodeling - I'm unaware of any legitimate research looking into this. When I was a no older than 7 I had a partial thickness burn on my entire elbow that healed perfectly, im not sure if it even scarred in the first place, however I also had a small burn on my forearm when I was 7 that healed normall - that is to say it scarred and it still looks the same. About 6 months ago my boston terrier (who was 1 1/2 at the time) was roughhousing with my other dog, was bitten around her nose and sustained a cut that produced a raised white scar 5 mm x 2 mm. Within 2 months it slowly dissolved and there is no sign of injury whatsoever - it completely remodeled into her normal black skin. Skin regeneration/remodeling certainly is possible - if skin can grow it can regenerate, but who knows when it will ever come to fruition. Some have said within 10 years, I hope they're right - I remember hearing that 12 years ago.
ECM wont help???
Fact, non crosslinked ECM is responsible for remodelling your unscarred skin.
Fact non crross linked ECm has regenerrated sexual organs ans skin.
Fact regeneration or remodelling is proof positive of scar free healing. Be it scarring stops remodelling and regeneration.
ECM with slender collagen fibrils is a critical component of your body, it allows the intercellular cells to crawl through. And if the collagen fibril in your ECM collagen are over expressed with collagen and crosslinked you have fibrotic encapsulation which means all the intercellular cells can not comunicate to remodell and regenerate skin, hence scarring... ECM is the book our intercellular cells use to remodel tissue.
obviously ecm is a huge part of connective tissue, so it could very well play an important role in regeneration, but if you think you can excise a scar, apply acell , and have scar free healing its not going to happen. I've seen it used in a few situations including wound healing of an excised scar and it didn't work at all...so take it easy
Scar free healing. Your body has scar free healing now. Your intercellular cells have been making scar free healing since you were born. They have been growing through your slender fibrils in your collagen since you were born. Your intercellular cells grow through ECM, and these intercellular cells have been doing this for millions of years.
You can not have scar free healing without the ECM scaffold. Also, the scaffold to the intercellular cell is like what a car manual is to a car mechanic.
Imagine if I said to the car mechanic, fuck the car manual, lets take it apart one by one and put it together in three year.
If the ECM did not work then it was denatured, hence crosslinked.
I'll reiterate again, ECM has regenerated skin, sexual organs etc.
So basically what your saying is, if Acell is non-crosslinked / non-denatured then applying it to an area of skin where an acne scar have been fully cut out, the skin will grow back perfectly without anyscar tissue and at the same level of the normal surrounding skin. ??
Yes I am. Scarring = crosslinked collagen fibrils, regeneration = slender collagen fibrils and intercellular cells being able to create site specific tissue.
Hence a indented/bumpy spot is were you have collagen irregularities and crosslinking (fibrotic encapsulation) were the intercellular cells cant fit through the micro pores (fibrils to thick to climb through). It came after a wound, -->>were decorin was lost, the fibrils then got excess collagen, which denied the billion years experienced mechanics (intercellular cells) the chance to do the job they do when fibrotic encapsulation is not around.
You can't just cut out your scars, apply 'Acell' or any other ecm or other product for that matter, and expect complete regeneration, if any. It may reduce scarring - and it seems to inhibit infection - but so far that's about it. If complete skin regeneration were possible that would be extremely huge news. The US military looked into conducting clinical trials with Acell where it would be used to regenerate skin graft donor sites (not even the wound) , but decided to abandon the trial in favor of another product. They also attempted to regrow fingers for soldiers that sustained injuries in Iraq, but that experiment was unsuccessful. The first soldier they tried it on - Staff Sgt Shiloh Harris - regrew a very minuscule portion (how minuscule I'm unsure) of his finger back, and the wound still scarred. They are still involved with Acell and their scientific advisors through AFIRM (armed forces institute of regenerative medicine) along with many other researchers and institutions. When the media reported that a man regrew the tip of his finger people thought Acell was their answer to hairloss, acne scars, and stretch marks. A couple years ago a guy on another forum lied and said that he obtained some Acell from a vet friend and that he completely healed a stretch mark with Acell. Many people believed him and I think that is why a lot of people seem to have this belief that Acell is able to regenerate human skin, hair follicles, sweat glands, etc. I think Acell has tremendous promise and will one day accomplish these feats, but at this time their products are unable to heal skin wounds that are scar free. It should also be mentioned that ECM based treatments have been performed since the 90s - torn rotator cuffs, tendon repairs, hernias, etc so the technology isn't exactly new.
What has propogating information got to do with tyhe truth? You mention the media as is anything progated as truth. You should investigate for yourself. So is the biggest propogator of information the truth? Completely fallacious.
Witches were put on the stake by mass propogating of information, they weere thought of as evil. Were they really evil?
Land mark facts for you which I can cite:
Right earlier ECM technology produces scar free skin, complete regeneration.
ECM has regenerated sexual organs 100%.
Earlier ECM has regenarated skin from a melonoma removal we have seen this visually.
The mammalian ECM is the same and all our intercellular cells nit tissue with it. Every second of the day.
We have had experts who claim they can make ECM by electrospinning.
Incremental artificial ECM which was denatured has nearly regenerated skin (This is the stuff you are on about).
In adult skin the reason why we do not scar is the colagen fibrils become over expressed with collagen, making the collagen fibrils (fibers) crosslinked, this denies the intercellular cells the chance to nit the tissue they have been knitting for billions of years, when this happens you get lumpy scar tissue on tissues.
Man can never compete with the intercellular cells on a micro level.
If the collagen was not cross linked, the fibrils were just right not to thin or too thick, which would allow the intercellular cells to crawl through the ECM, you'd get regeneration like you have in your unsacarred tissues.
In non denatured ECM Decorin flourishes:
Methods of preventing or reducing scarring with decorin or biglycanDecorin-treated wounds have been found to exhibit essentially no detectable scarring compared to control wounds not treated with decorin. The TGF-I-induced scarring process has been shown to be unique to adults and third trimester human fetuses, but is essentially absent in fetuses during the first two trimesters. The absence of scarring in fetal wounds has been correlated with the absence of TGFI in the wound bed. In contrast, the wound bed of adult tissue is heavily deposited with TGF-I and the fully healed wound is replaced by a reddened, furrowed scar containing extensively fibrous, collagenous matrix. The decorin-treated wounds were histologically normal and resembled fetal wounds in the first two trimesters.
ECM's Decorin keeps the ECM fibrils slender. Decorin has also stopped over expression of collagen in Keliod wounds at 100nM. decorin is absent in full thickness wounds and burns but here by the bucket loads in our unwounded adult tissues which have regeneration.
Regeneration can only happen when there is no scarring. Scarring stops regeneration.
Why are people trying to do the micro job of the intercellular cells?
We have had experts who in the past propogate scar free healing in past tense, and those who propogate it in future tense. You propogate it in future tense.
check this out stats.org/stories/2008/silliest_science_story_2008_dec_2008.html
If you remember we discussed this earlier in the thread. And we seen it for what the finger tip regeneration was. which was regeneration of skin and vessels. We did not say it was the regeneration of half a finger (like the BBC article built up, which this guy knocks down), we also discussed the fact that this finger tip regeneration can happen in the young.
seabs135 - have your tried using Acell for your scars ?
Has anyone tried Acell ?
No, it is not available where I live.
I meant the other part of the article where it discusses the healing abilities of hands (regarding the acell photos of the mohs procedure to remove melanoma from a woman's hand) . Feet also have a similar ability.
So does every tissue on your body have a similar ability. The ECM is tyhe same in your feet as it is on your torso, heart or face.
I was talking about an earlier ECM that regenerated the skin on a face BTW.