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i think there needs to be a way to stop the scar healing and then put the acell on there to make new skin, because the scar crap might get in there idk though.
i heard some people cant heal there wounds, maybe because scar formation isnt trigger? so if you do that and use acell maybe it will work.
That Acell "regrew" a man's fingertip is really not the reason to be excited about the product:
http://www.badscience.net/?p=664
That Acell "regrew" a man's fingertip is really not the reason to be excited about the product:
your probly right. i try to believe in this buts to hard, doesnt seem realistic to me. theres no real proven answers thats what really brothers me and this dr jones thing isnt working. seems like it doesnt work.
does anyone here think that the acell helped it heal a little bit on the bald guys head even tho theres a scar?
i think it made it heal better.
from what i heard, this is a new type of medicine that has just hit the market. its not like its being discover, we've seen it work. now its just time before they can refine it.
its like the ipod, first ipod was a piece of shit but it was pretty fucking amazing during the time, now today theres ipods that have over 80,000 songs.
Where is there a scar? it is still healing. And that photo was to blury.
BTW I think there will be fibrous encapsulation though, down to fibrin clotting (scabbing).
I've been thinking about hyaluronic acid on ECM instead of saline, saline and ECM which has proven to get scar free healing in mammals. And I question whether it would be good to put it on the ECM wound in the first 48hours.
I've read a cite that says apparently hyaluronic (which moists the ecmin the womb) makes plasmin ineffective.
Now in the womb plasmin is not needed to inhibit fibrin because fibrin clotting does not happen. This means it doesnat make much difference if hyaluronic acid affects plasmin or not.
However plasmin is used to balance out fibrin clotting in the adult tissue. Now if Hyaluronic acid makes plasmin ineffective over the first 48 hours, then I reckon, and I may be wrong, that might give fibrin clotting a free reign to ruin the ECM.
So what I reckon they should do is maybe try a wound with Hyaluronic but after 48hours. But to make sure the wound is kept moist with saline etc. and covered from the off to stop scabbing (fibrin clot) which would enable the ECM to not be corrupted enabling regeneration.
To be honest though, in a not broken donat fix it way, currently, Iam not fussed if they used hyaluronic as saline used with earlier versions of ECM has completely regenerated tissue.
To be honest though, in a not broken donat fix it way, currently, Iam not fussed if they used hyaluronic as saline used with earlier versions of ECM has completely regenerated tissue.
Is not the aim of H.A. substitution to aid in the proliferation of new cells via complementing the additional ECM? If applied after two days as mentioned, it sounds as if it would be an ideal addendum to the already brilliant procedure.
To be honest though, in a not broken donat fix it way, currently, Iam not fussed if they used hyaluronic as saline used with earlier versions of ECM has completely regenerated tissue.Is not the aim of H.A. substitution to aid in the proliferation of new cells via complementing the additional ECM? If applied after two days as mentioned, it sounds as if it would be an ideal addendum to the already brilliant procedure.
Do we require plasmin throughout the entire healing process or just within the first 48 hours of healing? If plasmin is required throughout the entire healing process, than using HA at any time while healing, will degrade fibrin and seem to be detrimental to achieving optimal results.
To be honest though, in a not broken donat fix it way, currently, Iam not fussed if they used hyaluronic as saline used with earlier versions of ECM has completely regenerated tissue.Is not the aim of H.A. substitution to aid in the proliferation of new cells via complementing the additional ECM? If applied after two days as mentioned, it sounds as if it would be an ideal addendum to the already brilliant procedure.
Well I suppose they could try it over time on different patients. Time will tell if it is better than saline. Perhaps these people have already tested it?
To be honest though, in a not broken donat fix it way, currently, Iam not fussed if they used hyaluronic as saline used with earlier versions of ECM has completely regenerated tissue.Is not the aim of H.A. substitution to aid in the proliferation of new cells via complementing the additional ECM? If applied after two days as mentioned, it sounds as if it would be an ideal addendum to the already brilliant procedure.
Do we require plasmin throughout the entire healing process or just within the first 48 hours of healing? If plasmin is required throughout the entire healing process, than using HA at any time while healing, will degrade fibrin and seem to be detrimental to achieving optimal results.
Thats a good question.
My current thinking is no we dont need much plasmin after 48hours but I haven't fully researched it.
Anyway going on this evidence,
ECM in the embryo has no fibrin clots to contend with.
fresh adult wounds want to fibrin clot, to stem blood leakage ASAP, and without plasmin they can hyper clot in the time which will spoil the ecm.
My thinking is at later phases they wont fibrin clot and thus would need less plasmin. But does plasmin have other uses? I dont yet know.
However as seen with the Dr Jones patient, because the wound was not kept moist or covered, or there was some other denaturing, the wound had fibrin scabs for many weeks, which it shouldnt have had, even when he cleaned it once, so perhaps plasmin is needed for a longer time if the wound is not kept moist in the worst case scenarios? This suggest plasmin has some longer term role. But my thinking is if HA, saline or some dressing keeps it moist then the wound does not need an emergancy expression of plasmin.
i heard from another thread that human acell will be out summer 2009, can anyone confirm this?
It's been out for months. (FDA approved for humans) You can get it if you go through a derm or ps.
why isnt there more info about people using it and results of it on the website?
why isnt there more info about people using it and results of it on the website?
Cuz it isn't very well known or accepted yet. Many who HAVE tried apparently get shot down by derms unwilling to try it.
so your saying that i can get a dermotogist to order me some for my face today?
why isnt there more info about people using it and results of it on the website?
Cuz it isn't very well known or accepted yet. Many who HAVE tried apparently get shot down by derms unwilling to try it.
so your saying that i can get a dermotogist to order me some for my face today?
You could, but you have to have some pretty good resources to convince any doctor to order a new product that hasn't been on the market for very long. Get some literature together to support your claims that the ECM would help and give it a go. If you've got the cash, it's not cheap and it's the only thing holding me back from visiting a doc anytime soon.
why isnt there more info about people using it and results of it on the website?
Cuz it isn't very well known or accepted yet. Many who HAVE tried apparently get shot down by derms unwilling to try it.
so your saying that i can get a dermotogist to order me some for my face today?
You could, but you have to have some pretty good resources to convince any doctor to order a new product that hasn't been on the market for very long. Get some literature together to support your claims that the ECM would help and give it a go. If you've got the cash, it's not cheap and it's the only thing holding me back from visiting a doc anytime soon.
+1
me and won won agree for once lol =P jk
I wonder if there is a company like vet-stem ( http://www.vet-stem.com/ ) that is applying this technology to humans like Acell is trying to do. BRD, any thought?
anymore news on this?
Yes
FDA allows first test of human stem cell therapy
"The U.S. Food and Drug Administration has cleared the way for the first trial to see if human embryonic stem cells can treat people safely"
http://www.newsdaily.com/stories/tre50m2u9-us-stemcells/
As have said in this news: http://www.kpbs.org/news/local?id=13654
"Stem cells come from many different sources in the body, and they can come from adults. But Snyder says embryonic cells are still the gold standard. He says no other stem cells are as flexible or malleable."
If the scar repair Vs regeneration mechanisms of body tissues like nervous tissue are all the same, as discovered by the stanford-scar-war team, we will stand to benefit from research into spinal cord injuries, joint damage due to rheumatoid arthritis, myelin sheath destruction due to multiple sclerosis, occular scarring, or other severe ailments.