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2 hours ago, gueste said:Verteporfin is being tested for other types of stuff other than scarring due to it being a YAP inhibitor. Interesting stuff for sure. Also,I saw an article where it stated thatVerteporfin market is predictedto have an overwhelming hike in revenues between 2021 and 2027. Only time will tell how effective it will be. It seems like the pig trials are taking forever lmao
Can you please try and find that article? I'm very interested to see what it says.
https://stanmed.stanford.edu/2021issue2/upfront/prevent-scarring-mice-eye-disease-drug.html
Same old story, just re-published.
I don't see the amount of skin being cored out being a problem, remember that skin is elastic as it stretches and maintains it's shape according to our musculature. This ability decreases with old age but then again microcoring removes redundant skin of that nature so it's a solid win in my book and for my type of scarring.
Can anyone try and find the complete research paper for this?
https://www.sciencedirect.com/science/article/abs/pii/S1534580721007620
Delay your HTs, or get scared for life (Breakthrough!). Transplants
A few months back Stanford researchers broke the internet by releasing a study of the usage of Verteporfin in wounds in mice. As many of you probably already know it produced amazing results. Verteporfin treated mice had virtually no scarring, and hair regrew with blood vessels and glands.
Obviously amazing news. However, mice skin is very different from human skin. So the next step for the Stanford researchers was pig trials. Pig skin is very similar to human skin. And is considered the gold standard of skin models.
What many people dont know, is that the stanford researchers have already succeeded in scarless wound healing in pigs!
This was with another medication called VS-6062, a Focal Adhesion Kinase inhibitor. FAK inhibitors inhibit YAP, which is the target of Verteporfin. In other words FAK inhibitors targets the fibrosis chain one step ahead of Verteporfin.
Wound tissue treated with FAKI exhibited dramatic regrowth of hair follicles and subcutaneous glands (sweat and sebaceous) (Fig. 1h), as well as newly regenerated peri-follicular adipose tissue
This is huge news. Especially for those considering FUTs or FUEs.
Look at the latest Hairlosscure2020 post. The pictures are incredibly impressive!
20 hours ago, Diamond9199 said:
Delay your HTs, or get scared for life (Breakthrough!). Transplants
A few months back Stanford researchers broke the internet by releasing a study of the usage of Verteporfin in wounds in mice. As many of you probably already know it produced amazing results. Verteporfin treated mice had virtually no scarring, and hair regrew with blood vessels and glands.
Obviously amazing news. However, mice skin is very different from human skin. So the next step for the Stanford researchers was pig trials. Pig skin is very similar to human skin. And is considered the gold standard of skin models.
What many people dont know, is that the stanford researchers have already succeeded in scarless wound healing in pigs!
This was with another medication called VS-6062, a Focal Adhesion Kinase inhibitor. FAK inhibitors inhibit YAP, which is the target of Verteporfin. In other words FAK inhibitors targets the fibrosis chain one step ahead of Verteporfin.
Wound tissue treated with FAKI exhibited dramatic regrowth of hair follicles and subcutaneous glands (sweat and sebaceous) (Fig. 1h), as well as newly regenerated peri-follicular adipose tissue
This is huge news. Especially for those considering FUTs or FUEs.
Look at the latest Hairlosscure2020 post. The pictures are incredibly impressive!
My god , our nightmare is almost over , i feel like crying , god thank you !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
20 hours ago, Diamond9199 said:
Delay your HTs, or get scared for life (Breakthrough!). Transplants
A few months back Stanford researchers broke the internet by releasing a study of the usage of Verteporfin in wounds in mice. As many of you probably already know it produced amazing results. Verteporfin treated mice had virtually no scarring, and hair regrew with blood vessels and glands.
Obviously amazing news. However, mice skin is very different from human skin. So the next step for the Stanford researchers was pig trials. Pig skin is very similar to human skin. And is considered the gold standard of skin models.
What many people dont know, is that the stanford researchers have already succeeded in scarless wound healing in pigs!
This was with another medication called VS-6062, a Focal Adhesion Kinase inhibitor. FAK inhibitors inhibit YAP, which is the target of Verteporfin. In other words FAK inhibitors targets the fibrosis chain one step ahead of Verteporfin.
Wound tissue treated with FAKI exhibited dramatic regrowth of hair follicles and subcutaneous glands (sweat and sebaceous) (Fig. 1h), as well as newly regenerated peri-follicular adipose tissue
This is huge news. Especially for those considering FUTs or FUEs.
Look at the latest Hairlosscure2020 post. The pictures are incredibly impressive!
The pig trials with VS-6062 weren't completely scarless right? Or am I wrong? It wasn't complete regenerationbut it was just reduced scarring.
On 10/22/2021 at 5:48 PM, giddy said:We did comment the study of FAKI on pigs amonth or twoago.
What I am curious about, is weather they are doing verteporfin on pigs right now or what. Like why is it taking so long?
Apparently they are/werefinishing up the trials on pigs, who knows how long until they release the results though.
Take a look: (scroll down to where it says verteporfin wound healing update 8/29/21) [Edited link out]
How have we not heard at least one case of tgis being used on someone off label yet?
On a hair loss forum someone mentioned a couple of surgeons in NY were using it on FUE and getting complete regenration of hair follicles. Could be BS who knows
On 10/23/2021 at 6:35 AM, dermaldamage said:Apparently they are/werefinishing up the trials on pigs, who knows how long until they release the results though.
Take a look: (scroll down to where it says verteporfin wound healing update 8/29/21) [Edited link out]
These news came before pig studies with FAKI was published. Was wondering if he meant that study
https://www.instagram.com/p/CVfvpIRlCwd/
microcoring
More info
https://www.instagram.com/p/CR1Y6S8LMsd/
4 hours ago, Binga said:If this doesn't get rids of scar tissue I don't know what will....looks pretty intense
It does look so aggressive. It probably won't do miracles but it is better than CO2 laser. Does anybody know what the doctorssaid about microcoring at their eventearlier this fall?
35 minutes ago, Scarredfacee said:It does look so aggressive. It probably won't do miracles but it is better than CO2 laser. Does anybody know what the doctorssaid about microcoring at their eventearlier this fall?
How do u know its better then CO2 laser ? And better for what ?
1 hour ago, Miro said:How do u know its better then CO2 laser ? And better for what ?
CO2 laser works by damaging the scar tissue underneath the scar hoping that it will heal to improve scar appearance. Microcoring works by getting ridof the scar tissue itself. It's similar to excision which is done by surgeons currently but at a micro level. If there is no scar tissue there won't be any scar.
8 hours ago, Miro said:How do u know its better then CO2 laser ? And better for what ?
Both can remove skin but microcoring does it without the heat-related side effects making it safer in darker skin and in general. I do not expect a night and day difference though. Maybe with many sessions.
If they approve microcoring for scars I would very much like to try it instead of laser first.